Stephen W Hoag

Stephen W Hoag

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Stephen W Hoag

Stephen W Hoag

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Understanding the impact of magnesium stearate variability on tableting performance using a multivariate modeling approach.

Pharm Dev Technol 2020 Jan 24;25(1):76-88. Epub 2019 Oct 24.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/10837450.2019.1673774DOI Listing
January 2020

Physical Barrier Type Abuse-Deterrent Formulations: Mechanistic Understanding of Sintering-Induced Microstructural Changes in Polyethylene Oxide Placebo Tablets.

AAPS PharmSciTech 2020 Jan 29;21(3):86. Epub 2020 Jan 29.

School of Pharmacy, University of Maryland, 20 N. Pine St., Baltimore, Maryland, 21201, USA.

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http://dx.doi.org/10.1208/s12249-019-1594-6DOI Listing
January 2020

Utility of Films to Anticipate Effect of Drug Load and Polymer on Dissolution Performance from Tablets of Amorphous Itraconazole Spray-Dried Dispersions.

AAPS PharmSciTech 2019 Nov 1;20(8):331. Epub 2019 Nov 1.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, 21201, USA.

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http://dx.doi.org/10.1208/s12249-019-1541-6DOI Listing
November 2019

Probing Thermal Stability of Proteins with Temperature Scanning Viscometer.

Mol Pharm 2019 08 25;16(8):3687-3693. Epub 2019 Jul 25.

Department of Pharmaceutical Sciences , University of Maryland , 20 North Pine Street , Baltimore , Maryland 21201 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00598DOI Listing
August 2019

Decision Support for Excipient Risk Assessment in Pharmaceutical Manufacturing.

AAPS PharmSciTech 2019 Jun 18;20(6):223. Epub 2019 Jun 18.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1208/s12249-019-1440-xDOI Listing
June 2019

Prediction of Dissolution of Sustained Release Coated Ciprofloxacin Beads Using Near-infrared Spectroscopy and Process Parameters: a Data Fusion Approach.

AAPS PharmSciTech 2019 Jun 18;20(6):222. Epub 2019 Jun 18.

Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 N. Pine Street, Baltimore, Maryland, 21201, USA.

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http://dx.doi.org/10.1208/s12249-019-1401-4DOI Listing
June 2019

Elucidating the Variability of Magnesium Stearate and the Correlations With Its Spectroscopic Features.

J Pharm Sci 2019 04 4;108(4):1569-1580. Epub 2018 Dec 4.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, Maryland 21201. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183078
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http://dx.doi.org/10.1016/j.xphs.2018.11.041DOI Listing
April 2019

Early detection of capping risk in pharmaceutical compacts.

Int J Pharm 2018 Dec 24;553(1-2):338-348. Epub 2018 Oct 24.

Photo-Acoustics Research Laboratory, Department of Mechanical and Aeronautical Engineering, Clarkson University, Potsdam, NY 13699-5725, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183079
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http://dx.doi.org/10.1016/j.ijpharm.2018.10.052DOI Listing
December 2018

Physical barrier type abuse-deterrent formulations: monitoring sintering-induced microstructural changes in polyethylene oxide placebo tablets by near infrared spectroscopy (NIRS).

Drug Dev Ind Pharm 2018 Nov 5;44(11):1885-1894. Epub 2018 Sep 5.

a School of Pharmacy , University of Maryland Baltimore , Baltimore , USA.

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http://dx.doi.org/10.1080/03639045.2018.1504965DOI Listing
November 2018

Comparing a Statistical Model and Bayesian Approach to Establish the Design Space for the Coating of Ciprofloxacin HCl Beads at Different Scales of Production.

AAPS PharmSciTech 2018 Nov 2;19(8):3809-3828. Epub 2018 Oct 2.

School of Pharmacy, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 20 N Pine Street, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1208/s12249-018-1116-yDOI Listing
November 2018

Developing a stable aqueous enteric coating formulation with hydroxypropyl methylcellulose acetate succinate (HPMCAS-MF) and colloidal silicon dioxide as anti-tacking agent.

Int J Pharm 2018 May 16;542(1-2):108-116. Epub 2018 Feb 16.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183010
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http://dx.doi.org/10.1016/j.ijpharm.2018.02.025DOI Listing
May 2018

Impact of formulation excipients on the thermal, mechanical, and electrokinetic properties of hydroxypropyl methylcellulose acetate succinate (HPMCAS).

Int J Pharm 2018 May 16;542(1-2):132-141. Epub 2018 Feb 16.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2018.02.024DOI Listing
May 2018

In Vitro Assessment of Nasal Insufflation of Comminuted Drug Products Designed as Abuse Deterrent Using the Vertical Diffusion Cell.

AAPS PharmSciTech 2018 May 26;19(4):1744-1757. Epub 2018 Mar 26.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, Maryland, 21201, USA.

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http://dx.doi.org/10.1208/s12249-017-0947-2DOI Listing
May 2018

Investigation of Polymer/Surfactant Interactions and Their Impact on Itraconazole Solubility and Precipitation Kinetics for Developing Spray-Dried Amorphous Solid Dispersions.

Mol Pharm 2018 03 5;15(3):962-974. Epub 2018 Feb 5.

Vertex Pharmaceutical Incorporated , Boston , Massachusetts 02210 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00902DOI Listing
March 2018

Lubricant-Sensitivity Assessment of SPRESS B820 by Near-Infrared Spectroscopy: A Comparison of Multivariate Methods.

J Pharm Sci 2017 02 7;106(2):537-545. Epub 2016 Nov 7.

Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, North Carolina 27506. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.09.018DOI Listing
February 2017

To investigate the influence of machine operating variables on formulations derived from lactose types in capsule filling: part 2.

Drug Dev Ind Pharm 2016 13;42(4):624-35. Epub 2015 Jul 13.

a School of Pharmacy, University of Maryland , Baltimore , MD , USA .

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http://dx.doi.org/10.3109/03639045.2015.1062511DOI Listing
December 2016

Characterization and selection of suitable grades of lactose as functional fillers for capsule filling: part 1.

Drug Dev Ind Pharm 2015 21;41(9):1452-63. Epub 2015 Jul 21.

a School of Pharmacy , University of Maryland , Baltimore , MD , USA .

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http://dx.doi.org/10.3109/03639045.2014.957703DOI Listing
June 2016

Analysis of curing of a sustained release coating formulation by application of NIR spectroscopy to monitor changes associated with glyceryl monostearate.

Drug Dev Ind Pharm 2015 20;41(8):1263-73. Epub 2014 Aug 20.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy , Baltimore, MD , USA and.

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http://www.tandfonline.com/doi/full/10.3109/03639045.2014.94
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http://dx.doi.org/10.3109/03639045.2014.947505DOI Listing
May 2016

Quality-by-Design II: Application of Quantitative Risk Analysis to the Formulation of Ciprofloxacin Tablets.

AAPS PharmSciTech 2016 Apr 23;17(2):233-44. Epub 2015 Jul 23.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.

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http://dx.doi.org/10.1208/s12249-015-0349-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984889PMC
April 2016

Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir.

J Pharm Sci 2016 Feb 12;105(2):996-1005. Epub 2016 Jan 12.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland 21201. Electronic address:

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http://dx.doi.org/10.1002/jps.24643DOI Listing
February 2016

Development and In Vivo Evaluation of a Novel Histatin-5 Bioadhesive Hydrogel Formulation against Oral Candidiasis.

Antimicrob Agents Chemother 2016 Feb 23;60(2):881-9. Epub 2015 Nov 23.

Department of Molecular Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, Maryland, USA

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http://aac.asm.org/content/early/2015/11/17/AAC.02624-15.ful
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http://aac.asm.org/content/60/2/881.full.pdf
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http://aac.asm.org/lookup/doi/10.1128/AAC.02624-15
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http://dx.doi.org/10.1128/AAC.02624-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750700PMC
February 2016

Restricted sedation and absence of cognitive impairments after administration of intranasal scopolamine.

J Psychopharmacol 2015 Dec 12;29(12):1231-5. Epub 2015 Aug 12.

Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), Antwerp University Hospital and University of Antwerp, Antwerp, Belgium

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http://dx.doi.org/10.1177/0269881115598414DOI Listing
December 2015

Application of Multivariate Strategies to the Classification of Pharmaceutical Excipient Manufacturers Based on Near-Infrared (NIR) Spectra.

Appl Spectrosc 2015 Nov;69(11):1257-70

University of Maryland, Department of Pharmaceutical Sciences, Baltimore, MD 21201 USA.

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http://dx.doi.org/10.1366/15-07859DOI Listing
November 2015

Intranasal scopolamine affects the semicircular canals centrally and peripherally.

J Appl Physiol (1985) 2015 Aug 7;119(3):213-8. Epub 2015 May 7.

Antwerp University Research Centre for Equilibrium and Aerospace, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium;

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http://jap.physiology.org/content/jap/119/3/213.full.pdf
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http://jap.physiology.org/lookup/doi/10.1152/japplphysiol.00
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http://dx.doi.org/10.1152/japplphysiol.00149.2015DOI Listing
August 2015

Quality of antiretroviral and opportunistic infection medications dispensed from developing countries and Internet pharmacies.

J Clin Pharm Ther 2015 Feb 10;40(1):68-75. Epub 2014 Nov 10.

Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/jcpt.12226DOI Listing
February 2015

Understanding pharmaceutical quality by design.

AAPS J 2014 Jul 23;16(4):771-83. Epub 2014 May 23.

Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993, USA,

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http://dx.doi.org/10.1208/s12248-014-9598-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070262PMC
July 2014

Novel extraction and application of okra gum as a film coating agent using theophylline as a model drug.

J Adv Pharm Technol Res 2014 Apr;5(2):70-7

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine Street, Baltimore MD 21201, USA.

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http://dx.doi.org/10.4103/2231-4040.133427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065467PMC
April 2014

Plasticizer effects on physical-mechanical properties of solvent cast Soluplus® films.

AAPS PharmSciTech 2013 Sep 21;14(3):903-10. Epub 2013 May 21.

School of Pharmacy, University of Maryland Baltimore, 20 N Pine St, Baltimore, Maryland, 21201, USA.

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http://dx.doi.org/10.1208/s12249-013-9971-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755169PMC
September 2013

Analysis of curing of a sustained release coating formulation by application of NIR spectroscopy to monitor changes physical-mechanical properties.

Int J Pharm 2013 Aug 22;452(1-2):82-91. Epub 2013 Apr 22.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2013.04.035DOI Listing
August 2013

Application of in-line near infrared spectroscopy and multivariate batch modeling for process monitoring in fluid bed granulation.

Int J Pharm 2013 Aug 22;452(1-2):63-72. Epub 2013 Apr 22.

School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2013.04.039DOI Listing
August 2013

Investigation of the physical-mechanical properties of Eudragit(®) RS PO/RL PO and their mixtures with common pharmaceutical excipients.

Drug Dev Ind Pharm 2013 Jul 20;39(7):1113-25. Epub 2012 Sep 20.

St. John Fisher College, Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY 14618, USA.

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http://dx.doi.org/10.3109/03639045.2012.714786DOI Listing
July 2013

Grewia gum as a potential aqueous film coating agent. I: Some physicochemical characteristics of fractions of grewia gum.

J Pharm Bioallied Sci 2013 Jan;5(1):53-60

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, PMB 2084, JOS, Nigeria ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20N Pine Street, Baltimore MD 21201, USA.

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http://dx.doi.org/10.4103/0975-7406.106575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612340PMC
January 2013

A Novel Extraction Method and Some Physicochemical Properties of Extractives of Irvingia Gabonensis seeds.

J Young Pharm 2012 Apr;4(2):66-72

Department of Pharmaceutical Technology, University of Jos, Jos, Plateau State, Nigeria.

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http://www.jyoungpharm.org/article/594
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http://dx.doi.org/10.4103/0975-1483.96612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385219PMC
April 2012

Effect of grewia gum as a suspending agent on ibuprofen pediatric formulation.

AAPS PharmSciTech 2011 Jun 14;12(2):507-13. Epub 2011 Apr 14.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201, USA.

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http://link.springer.com/10.1208/s12249-011-9606-1
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http://dx.doi.org/10.1208/s12249-011-9606-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134643PMC
June 2011

NIR spectroscopy applications in the development of a compacted multiparticulate system for modified release.

AAPS PharmSciTech 2011 Mar 15;12(1):262-78. Epub 2011 Jan 15.

School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1208/s12249-010-9580-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066347PMC
March 2011

Use of flexible weighted nasal spray dip tubes to improve product performance.

J Aerosol Med Pulm Drug Deliv 2010 Apr;23(2):69-75

Department of Pharmaceutical Sciences, University of Maryland , Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1089/jamp.2008.0727DOI Listing
April 2010

Sustained release dosage forms dissolution behavior prediction: a study of matrix tablets using NIR spectroscopy.

Int J Pharm 2009 Dec 4;382(1-2):1-6. Epub 2009 Aug 4.

School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, MD 21201, United States.

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http://dx.doi.org/10.1016/j.ijpharm.2009.07.029DOI Listing
December 2009

Evaluation of the mechanical properties of extrusion-spheronized beads and multiparticulate systems.

Drug Dev Ind Pharm 2009 Jun;35(6):683-93

School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1080/03639040802526797DOI Listing
June 2009

Quality by design, part I: application of NIR spectroscopy to monitor tablet manufacturing process.

J Pharm Sci 2008 Sep;97(9):4040-51

School of Pharmacy, University of Maryland, 20 N Pine Street, Baltimore, Maryland 21201, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491632684
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http://dx.doi.org/10.1002/jps.21303DOI Listing
September 2008

Quality by design, part III: study of curing process of sustained release coated products using NIR spectroscopy.

J Pharm Sci 2008 Sep;97(9):4067-86

School of Pharmacy, University of Maryland, 20 N Pine Street, Baltimore, Maryland 21201, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491632685
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http://dx.doi.org/10.1002/jps.21420DOI Listing
September 2008

Evaluation of the deformation behavior of binary systems of methacrylic acid copolymers and hydroxypropyl methylcellulose using a compaction simulator.

Int J Pharm 2008 Feb 7;348(1-2):46-53. Epub 2007 Jul 7.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2007.07.002DOI Listing
February 2008

The analysis and prediction of functional robustness of inhaler devices.

J Aerosol Med 2007 ;20(1):19-37

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, USA.

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http://dx.doi.org/10.1089/jam.2006.0564DOI Listing
May 2007

Microenvironmental pH modulation based release enhancement of a weakly basic drug from hydrophilic matrices.

J Pharm Sci 2006 Jul;95(7):1459-68

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, 21201, USA.

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http://dx.doi.org/10.1002/jps.20612DOI Listing
July 2006

Influence of methacrylic and acrylic acid polymers on the release performance of weakly basic drugs from sustained release hydrophilic matrices.

J Pharm Sci 2004 Sep;93(9):2319-31

School of Pharmacy, University of Maryland, Baltimore, 20 N. Pine Street, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1002/jps.20129DOI Listing
September 2004

Characterization of excipient and tableting factors that influence folic acid dissolution, friability, and breaking strength of oil- and water-soluble multivitamin with minerals tablets.

Drug Dev Ind Pharm 2003 Nov;29(10):1137-47

Department of HACO, Wyle Laboratories, Life Sciences Systems and Services, Houston, Texas, USA.

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http://dx.doi.org/10.1081/ddc-120025871DOI Listing
November 2003

Swelling behavior of a genetically engineered silk-elastinlike protein polymer hydrogel.

Biomaterials 2002 Nov;23(21):4203-10

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/s0142-9612(02)00164-3DOI Listing
November 2002

Solute diffusion in genetically engineered silk-elastinlike protein polymer hydrogels.

J Control Release 2002 Aug;82(2-3):277-87

University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences, 20 N. Pine Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/s0168-3659(02)00134-7DOI Listing
August 2002

Influence of polyethylene glycol and povidone on the polymorphic transformation and solubility of carbamazepine.

Int J Pharm 2002 Jun;240(1-2):11-22

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/s0378-5173(02)00083-2DOI Listing
June 2002

Characterization of the thermal properties of microcrystalline cellulose by modulated temperature differential scanning calorimetry.

J Pharm Sci 2002 Feb;91(2):342-9

Martin-Luther-University Halle-Wittenberg, Institute of Pharmaceutical Technology and Biopharmacy, Wolfgang-Langenbeck-Str. 4, 06120 Halle/Saale, Germany.

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http://dx.doi.org/10.1002/jps.10018DOI Listing
February 2002