Publications by authors named "Stephen T Holgate"

100Publications

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial.

Lancet Respir Med 2020 Nov 12. Epub 2020 Nov 12.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK. Electronic address:

View Article and Find Full Text PDF
November 2020

Reducing the hidden burden of severe asthma: recognition and referrals from primary practice.

J Asthma 2020 May 13:1-6. Epub 2020 May 13.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

View Article and Find Full Text PDF
May 2020

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed.

Lancet 2020 05 9;395(10234):1407-1409. Epub 2020 Apr 9.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

View Article and Find Full Text PDF
May 2020

The health effects of fine particulate air pollution.

BMJ 2019 11 27;367:l6609. Epub 2019 Nov 27.

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
November 2019

A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

J Immunol Methods 2020 02 9;477:112703. Epub 2019 Nov 9.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address:

View Article and Find Full Text PDF
February 2020

Air pollution: The time has arrived for the medical profession to take ownership of the problem and act.

Respirology 2019 12 10;24(12):1138-1139. Epub 2019 Sep 10.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
December 2019

The Future of Asthma Care: Personalized Asthma Treatment.

Clin Chest Med 2019 03;40(1):227-241

Asthma UK, 18 Mansell Street, London E1 8AA, UK.

View Article and Find Full Text PDF
March 2019

Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time.

Respirology 2019 03 25;24(3):286-287. Epub 2019 Jan 25.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
March 2019

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Lancet Respir Med 2018 01 14;6(1):19-28. Epub 2017 Dec 14.

NIHR Southampton Biomedical Research Centre, Southampton, UK; Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Asthma UK Centre for Applied Research, University of Edinburgh, Edinburgh, UK. Electronic address:

View Article and Find Full Text PDF
January 2018

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Exp Lung Res 2017 03 3;43(2):82-92. Epub 2017 Apr 3.

a Academic Unit of Clinical and Experimental Sciences , University of Southampton Faculty of Medicine, University Hospital Southampton , Southampton , United Kingdom.

View Article and Find Full Text PDF
March 2017

'Every breath we take: the lifelong impact of air pollution' - a call for action.

Clin Med (Lond) 2017 Feb;17(1):8-12

Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
February 2017

The era of research collaborations: new models for working together.

Eur Respir J 2017 01 3;49(1). Epub 2017 Jan 3.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

View Article and Find Full Text PDF
January 2017

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

JCI Insight 2016 Jul;1(11)

The Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.; Institute for Life Sciences, Stem Cells and Regeneration, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
July 2016

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

PLoS One 2016 21;11(4):e0153926. Epub 2016 Apr 21.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

View Article and Find Full Text PDF
September 2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

J Allergy Clin Immunol 2016 07 28;138(1):294-297.e4. Epub 2016 Feb 28.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, Fla. Electronic address:

View Article and Find Full Text PDF
July 2016

The expanding role of immunopharmacology: IUPHAR Review 16.

Br J Pharmacol 2015 Sep 21;172(17):4217-27. Epub 2015 Jul 21.

Pharmacology Unit, Faculty of Medicine, School of Pharmacy Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel.

View Article and Find Full Text PDF
September 2015

Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial).

Curr Pharm Des 2015 ;21(26):3835-43

Department of Internal Medicine, University of Brescia, Spedali Civili. Pzza Spedali Civili 1. 25100 Brescia -Italy.

View Article and Find Full Text PDF
June 2016

Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

PLoS One 2015 20;10(3):e0120510. Epub 2015 Mar 20.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
March 2016

A comment on "Scientometrics in a changing research landscape".

EMBO Rep 2015 Mar 20;16(3):261. Epub 2015 Jan 20.

Faculty of Medicine, Southampton General Hospital, Southampton, UK Chair on behalf of Main Panel A of REF 2014.

View Article and Find Full Text PDF
March 2015

Asthma.

Nat Rev Dis Primers 2015 09 10;1:15025. Epub 2015 Sep 10.

Queensland Children's Medical Research Institute and Centre for Child Health Research, University of Queensland, Brisbane, Australia.

View Article and Find Full Text PDF
September 2015

Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients.

Immunol Lett 2014 Nov 3;162(1 Pt A):2-10. Epub 2014 Sep 3.

Allergy and Respiratory Diseases Unit, Dpt. of Internal Medicine, University of Genoa, IRCCS-IST AOU San Martino, Genoa, Italy. Electronic address:

View Article and Find Full Text PDF
November 2014

New strategies with anti-IgE in allergic diseases.

World Allergy Organ J 2014 29;7(1):17. Epub 2014 Jul 29.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mail point 810, Level F, South Block, Southampton SO166YD, UK.

View Article and Find Full Text PDF
August 2014

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Am J Respir Crit Care Med 2014 Jul;190(2):145-54

1 NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

View Article and Find Full Text PDF
July 2014

A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

Int Arch Allergy Immunol 2014 21;164(1):46-63. Epub 2014 May 21.

Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran, Iran.

View Article and Find Full Text PDF
August 2014

Asthma genetics and personalised medicine.

Lancet Respir Med 2014 May 2;2(5):405-15. Epub 2014 May 2.

Human Development and Health, and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. Electronic address:

View Article and Find Full Text PDF
May 2014

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model.

PLoS One 2014 4;9(4):e94010. Epub 2014 Apr 4.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
December 2014

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Respir Res 2014 Feb 20;15:22. Epub 2014 Feb 20.

The Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

View Article and Find Full Text PDF
February 2014

Mechanisms of asthma and implications for its prevention and treatment: a personal journey.

Allergy Asthma Immunol Res 2013 Nov 25;5(6):343-7. Epub 2013 Jun 25.

Faculty of Medicine University of Southampton, UK.

View Article and Find Full Text PDF
November 2013

Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.

PLoS One 2013 23;8(8):e71278. Epub 2013 Aug 23.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, South Block, University Hospital Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
April 2014

Immune circuits in asthma.

Curr Opin Pharmacol 2013 Jun 29;13(3):345-50. Epub 2013 Apr 29.

Clinical and Experimental Sciences, Mail Point 810, Level F South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

View Article and Find Full Text PDF
June 2013

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

J Allergy Clin Immunol 2013 Sep 28;132(3):665-675.e8. Epub 2013 Apr 28.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton NIHR Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom. Electronic address:

View Article and Find Full Text PDF
September 2013

Airway remodelling in asthma and novel therapy.

Asian Pac J Allergy Immunol 2013 Mar;31(1):3-10

Department of Pediatrics, Mahidol University, Bangkok, Thailand.

View Article and Find Full Text PDF
March 2013

Stratified approaches to the treatment of asthma.

Br J Clin Pharmacol 2013 Aug;76(2):277-91

Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
August 2013

Barrier responses of human bronchial epithelial cells to grass pollen exposure.

Eur Respir J 2013 Jul 8;42(1):87-97. Epub 2012 Nov 8.

Brooke Laboratory, Clinical and Experimental Sciences, Faculty of Medicine, University Hospital Southampton, Southampton, UK.

View Article and Find Full Text PDF
July 2013

The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.

J Allergy Clin Immunol 2013 Mar 12;131(3):849-55. Epub 2012 Oct 12.

Academic Unit of Clinical and Experimental Sciences and the Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom.

View Article and Find Full Text PDF
March 2013

Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response.

PLoS One 2012 6;7(9):e44580. Epub 2012 Sep 6.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
March 2013

Aspirin exacerbated respiratory disease.

J Allergy (Cairo) 2012 14;2012:473863. Epub 2012 Aug 14.

Department of Immunogenetics and Allergy, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

View Article and Find Full Text PDF
August 2012

Innate and adaptive immune responses in asthma.

Nat Med 2012 May 4;18(5):673-83. Epub 2012 May 4.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Southampton General Hospital, UK.

View Article and Find Full Text PDF
May 2012

Function of the airway epithelium in asthma.

J Allergy (Cairo) 2012 22;2012:160586. Epub 2012 Mar 22.

Division of Pulmonary and Critical Care Medicine, University of Washington, P.O. Box 356522, 1959 NE Pacific Street, Seattle, WA 98195-6522, USA.

View Article and Find Full Text PDF
August 2012

Trials and tribulations in identifying new biologic treatments for asthma.

Trends Immunol 2012 May 20;33(5):238-46. Epub 2012 Mar 20.

Inflammation, Infection and Immunity Division, Sir Henry Wellcome Laboratories, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

View Article and Find Full Text PDF
May 2012

Discovery of new treatments in the context of delivering personalized medicine.

Per Med 2012 Mar;9(2):101-104

Wellcome Trust Sanger Institute, Helsinki, Finland and The Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.

View Article and Find Full Text PDF
March 2012

Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?

J Allergy Clin Immunol 2011 Sep 31;128(3):495-505. Epub 2011 Jul 31.

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

View Article and Find Full Text PDF
September 2011

Chronic fatigue syndrome: understanding a complex illness.

Nat Rev Neurosci 2011 Jul 27;12(9):539-44. Epub 2011 Jul 27.

University of Southampton, Infection, Inflammation and Immunity Division, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.

View Article and Find Full Text PDF
July 2011

Animal models of asthma: value, limitations and opportunities for alternative approaches.

Drug Discov Today 2011 Aug 23;16(15-16):659-70. Epub 2011 Jun 23.

National Centre for the Replacement, Refinement and Reduction of Animals in Research, 20 Park Crescent, London, W1B 1AL, UK.

View Article and Find Full Text PDF
August 2011

The sentinel role of the airway epithelium in asthma pathogenesis.

Immunol Rev 2011 Jul;242(1):205-19

Allergy & Inflammation Research, Division of Infection, Inflammation & Immunity, School of Medicine, Southampton University and General Hospital, Southampton, Hampshire, UK.

View Article and Find Full Text PDF
July 2011

Asthma: a simple concept but in reality a complex disease.

Eur J Clin Invest 2011 Dec 26;41(12):1339-52. Epub 2011 May 26.

School of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
December 2011

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

Am J Respir Crit Care Med 2011 Aug;184(4):421-9

Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

View Article and Find Full Text PDF
August 2011

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma.

Clin Immunol 2011 Jul 13;140(1):18-25. Epub 2011 Mar 13.

The Brooke Laboratories, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.

View Article and Find Full Text PDF
July 2011

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

J Allergy Clin Immunol 2011 May 16;127(5):1148-54.e9. Epub 2011 Feb 16.

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom.

View Article and Find Full Text PDF
May 2011

The acetaminophen enigma in asthma.

Am J Respir Crit Care Med 2011 Jan;183(2):147-8

View Article and Find Full Text PDF
January 2011

ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.

Drug News Perspect 2010 Jul-Aug;23(6):381-7

Infection, Inflammation and Immunity Division, Southampton General Hospital, Southampton, UK.

View Article and Find Full Text PDF
November 2010

Using genetics to predict the natural history of asthma?

J Allergy Clin Immunol 2010 Aug;126(2):200-9; quiz 210-1

Division of Infection, Inflammation & Immunity, School of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
August 2010

A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis.

Allergy Asthma Immunol Res 2010 Jul 6;2(3):165-71. Epub 2010 May 6.

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
July 2010

A look at the pathogenesis of asthma: the need for a change in direction.

Discov Med 2010 May;9(48):439-47

Infection, Inflammation and Immunity Division, Southampton General Hospital, School of Medicine, University of Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
May 2010

Exposure, uptake, distribution and toxicity of nanomaterials in humans.

J Biomed Nanotechnol 2010 Feb;6(1):1-19

IIR Division, School of Medicine, Level F, Southampton General Hospital, Southampton, SO16 6YD, UK.

View Article and Find Full Text PDF
February 2010

Genetics of allergic disease.

J Allergy Clin Immunol 2010 Feb;125(2 Suppl 2):S81-94

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

View Article and Find Full Text PDF
February 2010

The role of histamine in asthma.

Adv Exp Med Biol 2010 ;709:53-66

Department of Immunology, Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, California 92121, USA.

View Article and Find Full Text PDF
July 2011

A new look at the pathogenesis of asthma.

Clin Sci (Lond) 2009 Dec 23;118(7):439-50. Epub 2009 Dec 23.

University of Southampton, Southampton General Hospital, UK.

View Article and Find Full Text PDF
December 2009

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis.

Proc Am Thorac Soc 2009 Dec;6(8):655-9

Infection, Inflammation and Immunity Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton SO166YD, UK.

View Article and Find Full Text PDF
December 2009

Has the time come to rethink the pathogenesis of asthma?

Curr Opin Allergy Clin Immunol 2010 Feb;10(1):48-53

University of Southampton, Hampshire, UK.

View Article and Find Full Text PDF
February 2010

Rethinking the pathogenesis of asthma.

Immunity 2009 Sep;31(3):362-7

III Division, School of Medicine, University of Southampton, Southampton S016 61D, UK.

View Article and Find Full Text PDF
September 2009

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.

Am J Respir Crit Care Med 2009 Nov 3;180(10):929-35. Epub 2009 Sep 3.

Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

View Article and Find Full Text PDF
November 2009

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

J Allergy Clin Immunol 2009 Sep 8;124(3):590-7, 597.e1-11. Epub 2009 Aug 8.

Division of Infection Inflammation and Immunity, Roger Brooke Laboratory, School of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF
September 2009

Adamalysins in biology and disease.

J Pathol 2009 Nov;219(3):277-86

Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands.

View Article and Find Full Text PDF
November 2009

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

Biochem Soc Trans 2009 Aug;37(Pt 4):873-6

School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

View Article and Find Full Text PDF
August 2009

Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

Int Arch Allergy Immunol 2009 17;149(4):343-9. Epub 2009 Mar 17.

Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland.

View Article and Find Full Text PDF
August 2009

Contribution of bronchial fibroblasts to the antiviral response in asthma.

J Immunol 2009 Mar;182(6):3660-7

Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

View Article and Find Full Text PDF
March 2009