Publications by authors named "Stephen T Holgate"

100Publications

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial.

Authors:
Phillip D Monk Richard J Marsden Victoria J Tear Jody Brookes Toby N Batten Marcin Mankowski Felicity J Gabbay Donna E Davies Stephen T Holgate Ling-Pei Ho Tristan Clark Ratko Djukanovic Tom M A Wilkinson

Lancet Respir Med 2020 Nov 12. Epub 2020 Nov 12.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK. Electronic address:

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November 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

J Physiol 2020 Sep 14;598(18):3793-3801. Epub 2020 Jul 14.

Professor for Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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September 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

Exp Physiol 2020 Sep 14;105(9):1459-1466. Epub 2020 Jul 14.

Professor for Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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September 2020

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

Authors:
Nathalie Percie du Sert Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Viki Hurst Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

PLoS Biol 2020 07 14;18(7):e3000411. Epub 2020 Jul 14.

Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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July 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

PLoS Biol 2020 07 14;18(7):e3000410. Epub 2020 Jul 14.

Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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July 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

J Cereb Blood Flow Metab 2020 Sep 14;40(9):1769-1777. Epub 2020 Jul 14.

Professor for Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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September 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

Br J Pharmacol 2020 Aug 14;177(16):3617-3624. Epub 2020 Jul 14.

Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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August 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Authors:
Nathalie Percie du Sert Viki Hurst Amrita Ahluwalia Sabina Alam Marc T Avey Monya Baker William J Browne Alejandra Clark Innes C Cuthill Ulrich Dirnagl Michael Emerson Paul Garner Stephen T Holgate David W Howells Natasha A Karp Stanley E Lazic Katie Lidster Catriona J MacCallum Malcolm Macleod Esther J Pearl Ole H Petersen Frances Rawle Penny Reynolds Kieron Rooney Emily S Sena Shai D Silberberg Thomas Steckler Hanno Würbel

BMC Vet Res 2020 Jul 14;16(1):242. Epub 2020 Jul 14.

Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

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July 2020

Overcoming fragmentation of health research in Europe: lessons from COVID-19.

Authors:
Karin R Sipido Fernando Antoñanzas Julio Celis Laurent Degos Richard Frackowiak Valentin Fuster Detlev Ganten Steffen Gay Hans Hofstraat Stephen T Holgate Gabriel Krestin Michael Manns Francoise Meunier Wolfgang Oertel Susanna Palkonen Dainius Pavalkis Helga Rübsamen-Schaeff Ulf Smith Bente Merete Stallknecht Tomáš Zima

Lancet 2020 06 16;395(10242):1970-1971. Epub 2020 Jun 16.

Charles University, Prague, Czech Republic.

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June 2020

Reducing the hidden burden of severe asthma: recognition and referrals from primary practice.

Authors:
Marc Humbert Arnaud Bourdin Nikolaos G Papadopoulos Stephen T Holgate Nicola A Hanania David M G Halpin Kenneth R Chapman Marcela Gavornikova David B Price Alan Kaplan Liam G Heaney

J Asthma 2020 May 13:1-6. Epub 2020 May 13.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

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May 2020

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed.

Authors:
Marc Feldmann Ravinder N Maini James N Woody Stephen T Holgate Gregory Winter Matthew Rowland Duncan Richards Tracy Hussell

Lancet 2020 05 9;395(10234):1407-1409. Epub 2020 Apr 9.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

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May 2020

The health effects of fine particulate air pollution.

Authors:
Matthew Loxham Donna E Davies Stephen T Holgate

BMJ 2019 11 27;367:l6609. Epub 2019 Nov 27.

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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November 2019

Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma.

Authors:
William W Busse Marc Humbert Tmirah Haselkorn Benjamin Ortiz Benjamin L Trzaskoma Patricia Stephenson Lorena Garcia Conde Farid Kianifard Stephen T Holgate

Ann Allergy Asthma Immunol 2020 02 22;124(2):190-196. Epub 2019 Nov 22.

University of Southampton, Southampton, United Kingdom.

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February 2020

A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

Authors:
Nicole Bedke Emily J Swindle Camelia Molnar Patrick G Holt Deborah H Strickland Graham C Roberts Ruth Morris Stephen T Holgate Donna E Davies Cornelia Blume

J Immunol Methods 2020 02 9;477:112703. Epub 2019 Nov 9.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address:

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February 2020

Air pollution: The time has arrived for the medical profession to take ownership of the problem and act.

Authors:
Stephen T Holgate

Respirology 2019 12 10;24(12):1138-1139. Epub 2019 Sep 10.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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December 2019

The Future of Asthma Care: Personalized Asthma Treatment.

Authors:
Stephen T Holgate Samantha Walker Brigitte West Kay Boycott

Clin Chest Med 2019 03;40(1):227-241

Asthma UK, 18 Mansell Street, London E1 8AA, UK.

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March 2019

Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time.

Authors:
Stephen T Holgate

Respirology 2019 03 25;24(3):286-287. Epub 2019 Jan 25.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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March 2019

Evaluating the long-term consequences of air pollution in early life: geographical correlations between coal consumption in 1951/1952 and current mortality in England and Wales.

Authors:
David I W Phillips Clive Osmond Humphrey Southall Paula Aucott Alexander Jones Stephen T Holgate

BMJ Open 2018 04 27;8(4):e018231. Epub 2018 Apr 27.

Department of Medicine, University of Southampton, Southampton, UK.

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April 2018

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Authors:
Anne Bruton Amanda Lee Lucy Yardley James Raftery Emily Arden-Close Sarah Kirby Shihua Zhu Manimekalai Thiruvothiyur Frances Webley Lyn Taylor Denise Gibson Guiqing Yao Mark Stafford-Watson Jenny Versnel Michael Moore Steve George Paul Little Ratko Djukanovic David Price Ian D Pavord Stephen T Holgate Mike Thomas

Lancet Respir Med 2018 01 14;6(1):19-28. Epub 2017 Dec 14.

NIHR Southampton Biomedical Research Centre, Southampton, UK; Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Asthma UK Centre for Applied Research, University of Edinburgh, Edinburgh, UK. Electronic address:

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January 2018

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Authors:
Fabio Bucchieri Alessandro Pitruzzella Alberto Fucarino Antonella Marino Gammazza Celeste Caruso Bavisotto Vito Marcianò Massimo Cajozzo Giorgio Lo Iacono Roberto Marchese Giovanni Zummo Stephen T Holgate Donna E Davies

Exp Lung Res 2017 03 3;43(2):82-92. Epub 2017 Apr 3.

a Academic Unit of Clinical and Experimental Sciences , University of Southampton Faculty of Medicine, University Hospital Southampton , Southampton , United Kingdom.

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March 2017

'Every breath we take: the lifelong impact of air pollution' - a call for action.

Authors:
Stephen T Holgate

Clin Med (Lond) 2017 Feb;17(1):8-12

Faculty of Medicine, University of Southampton, Southampton, UK.

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February 2017

The era of research collaborations: new models for working together.

Authors:
Ratko Djukanović Guy Bruselle Samantha Walker Stephen T Holgate Sabina Škrgat Piotr Kuna Liam G Heaney G Walter Canonica Jørgen Vestbo

Eur Respir J 2017 01 3;49(1). Epub 2017 Jan 3.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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January 2017

The ever-expanding ERS fellowship programmes: achievements over the past 3 years.

Authors:
Maria G Belvisi Rory E Morty Gernot Rohde Marc Miravitlles Kathryn A Forrest Céline Genton Nathalie Ritter Nikoleta Luludi Albert Jimenez David Rigau Thomy Tonia Valérie Vaccaro Carine Pannetier Guy G Brusselle Stephen T Holgate

Eur Respir J 2016 09;48(3):595-9

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.

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September 2016

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Authors:
Elizabeth R Davies Joanne F C Kelly Peter H Howarth David I Wilson Stephen T Holgate Donna E Davies Jeffrey A Whitsett Hans Michael Haitchi

JCI Insight 2016 Jul;1(11)

The Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.; Institute for Life Sciences, Stem Cells and Regeneration, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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July 2016

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

Authors:
Wiparat Manuyakorn David E Smart Antonio Noto Fabio Bucchieri Hans Michael Haitchi Stephen T Holgate Peter H Howarth Donna E Davies

PLoS One 2016 21;11(4):e0153926. Epub 2016 Apr 21.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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September 2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

Authors:
Steven S An Wayne Mitzner Wan-Yee Tang Kwangmi Ahn A-Rum Yoon Jessie Huang Onur Kilic Hwan Mee Yong Jed W Fahey Sarvesh Kumar Shyam Biswal Stephen T Holgate Reynold A Panettieri Julian Solway Stephen B Liggett

J Allergy Clin Immunol 2016 07 28;138(1):294-297.e4. Epub 2016 Feb 28.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, Fla. Electronic address:

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July 2016

The European Respiratory Society evaluates its 2013-2018 strategic plan implementation.

Authors:
Giovanni Battista Migliori Elisabeth Bel Guy Joos Mark Elliott Gernot Rohde Stephen T Holgate Christina Gratziou Dan Smyth Mina Gaga Carlos Robalo Cordeiro Otto C Burghuber Guy Brusselle Fernando Martin-Burrieza Werner Bill Betty Sax Jørgen Vestbo

Eur Respir J 2016 Mar;47(3):693-8

Centre for Respiratory Medicine and Allergy, The University of Manchester and University Hospital South Manchester NHS Foundation Trust, Manchester, UK.

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March 2016

Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.

Authors:
William W Busse Stephen T Holgate Sally W Wenzel Paul Klekotka Yun Chon JingYuan Feng Edward P Ingenito Ajay Nirula

Chest 2015 Dec;148(6):1489-1496

Amgen Inc, Thousand Oaks, CA.

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December 2015

Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.

Authors:
Gennaro D'Amato Stephen T Holgate Ruby Pawankar Dennis K Ledford Lorenzo Cecchi Mona Al-Ahmad Fatma Al-Enezi Saleh Al-Muhsen Ignacio Ansotegui Carlos E Baena-Cagnani David J Baker Hasan Bayram Karl Christian Bergmann Louis-Philippe Boulet Jeroen T M Buters Maria D'Amato Sofia Dorsano Jeroen Douwes Sarah Elise Finlay Donata Garrasi Maximiliano Gómez Tari Haahtela Rabih Halwani Youssouf Hassani Basam Mahboub Guy Marks Paola Michelozzi Marcello Montagni Carlos Nunes Jay Jae-Won Oh Todor A Popov Jay Portnoy Erminia Ridolo Nelson Rosário Menachem Rottem Mario Sánchez-Borges Elopy Sibanda Juan José Sienra-Monge Carolina Vitale Isabella Annesi-Maesano

World Allergy Organ J 2015 14;8(1):25. Epub 2015 Jul 14.

Epidemiology of Respiratory and Allergic Disease Department (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136, INSERM, Paris, France ; UPMC, Sorbonne Universités, Medical School Saint-Antoine, 803-804-806, 8 etage/Floor 27, Rue Chaligny, CEDEX 12, 75571 Paris, France.

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July 2015

The expanding role of immunopharmacology: IUPHAR Review 16.

Authors:
Ekaterini Tiligada Masaru Ishii Carlo Riccardi Michael Spedding Hans-Uwe Simon Mauro Martins Teixeira Mario Landys Chovel Cuervo Stephen T Holgate Francesca Levi-Schaffer

Br J Pharmacol 2015 Sep 21;172(17):4217-27. Epub 2015 Jul 21.

Pharmacology Unit, Faculty of Medicine, School of Pharmacy Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel.

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September 2015

Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial).

Authors:
Mario Malerba Massimo D Amato Alessandro Radaeli Giampaolo Giacovelli Lucio Rovati Sayed H Arshad Stephen T Holgate

Curr Pharm Des 2015 ;21(26):3835-43

Department of Internal Medicine, University of Brescia, Spedali Civili. Pzza Spedali Civili 1. 25100 Brescia -Italy.

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June 2016

Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

Authors:
Fabio Bucchieri Antonella Marino Gammazza Alessandro Pitruzzella Alberto Fucarino Felicia Farina Peter Howarth Stephen T Holgate Giovanni Zummo Donna E Davies

PLoS One 2015 20;10(3):e0120510. Epub 2015 Mar 20.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

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March 2016

A comment on "Scientometrics in a changing research landscape".

Authors:
Stephen T Holgate

EMBO Rep 2015 Mar 20;16(3):261. Epub 2015 Jan 20.

Faculty of Medicine, Southampton General Hospital, Southampton, UK Chair on behalf of Main Panel A of REF 2014.

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March 2015

Asthma.

Authors:
Stephen T Holgate Sally Wenzel Dirkje S Postma Scott T Weiss Harald Renz Peter D Sly

Nat Rev Dis Primers 2015 09 10;1:15025. Epub 2015 Sep 10.

Queensland Children's Medical Research Institute and Centre for Child Health Research, University of Queensland, Brisbane, Australia.

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September 2015

Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients.

Authors:
Pierluigi Mauri Anna Maria Riccio Rossana Rossi Dario Di Silvestre Louise Benazzi Laura De Ferrari Roberto Walter Dal Negro Stephen T Holgate Giorgio Walter Canonica

Immunol Lett 2014 Nov 3;162(1 Pt A):2-10. Epub 2014 Sep 3.

Allergy and Respiratory Diseases Unit, Dpt. of Internal Medicine, University of Genoa, IRCCS-IST AOU San Martino, Genoa, Italy. Electronic address:

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November 2014

Asthma in the elderly: what we know and what we have yet to know.

Authors:
Anahí Yáñez Sang-Hoen Cho Joan B Soriano Lanny J Rosenwasser Gustavo J Rodrigo Klaus F Rabe Stephen Peters Akio Niimi Dennis K Ledford Rohit Katial Leonardo M Fabbri Juan C Celedón Giorgio Walter Canonica Paula Busse Louis-Phillippe Boulet Carlos E Baena-Cagnani Qutayba Hamid Claus Bachert Ruby Pawankar Stephen T Holgate

World Allergy Organ J 2014 30;7(1). Epub 2014 May 30.

Faculty of Medicine Clinical and Experimental Sciences, University of Southampton, Hampshire, United Kingdom.

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August 2014

New strategies with anti-IgE in allergic diseases.

Authors:
Stephen T Holgate

World Allergy Organ J 2014 29;7(1):17. Epub 2014 Jul 29.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mail point 810, Level F, South Block, Southampton SO166YD, UK.

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August 2014

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Authors:
Ratko Djukanović Tim Harrison Sebastian L Johnston Flic Gabbay Peter Wark Neil C Thomson Robert Niven Dave Singh Helen K Reddel Donna E Davies Richard Marsden Christine Boxall Sarah Dudley Vincent Plagnol Stephen T Holgate Phillip Monk

Am J Respir Crit Care Med 2014 Jul;190(2):145-54

1 NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

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July 2014

A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma.

Authors:
Zahra Aryan Stephen T Holgate Danuta Radzioch Nima Rezaei

Int Arch Allergy Immunol 2014 21;164(1):46-63. Epub 2014 May 21.

Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran, Iran.

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August 2014

Asthma genetics and personalised medicine.

Authors:
Deborah A Meyers Eugene R Bleecker John W Holloway Stephen T Holgate

Lancet Respir Med 2014 May 2;2(5):405-15. Epub 2014 May 2.

Human Development and Health, and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. Electronic address:

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May 2014

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model.

Authors:
Julie A Cakebread Hans Michael Haitchi Yunhe Xu Stephen T Holgate Graham Roberts Donna E Davies

PLoS One 2014 4;9(4):e94010. Epub 2014 Apr 4.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.

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December 2014

The European Respiratory Society plans its future: the 2013-2018 strategic plan.

Authors:
Giovanni Battista Migliori Klaus F Rabe Elisabeth Bel Mark Elliott Mina Gaga Stephen T Holgate Guy Joos Fernando Martin Burrieza Betty Sax Jean-Paul Sculier Anita K Simonds Francesco Blasi Peter J Barnes

Eur Respir J 2014 Apr;43(4):927-32

Fondazione S. Maugeri, Care and Research Institute, Tradate.

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April 2014

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Authors:
Sam Parnia Lynnsey M Hamilton Sarah M Puddicombe Stephen T Holgate Anthony J Frew Donna E Davies

Respir Res 2014 Feb 20;15:22. Epub 2014 Feb 20.

The Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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February 2014

Mechanisms of asthma and implications for its prevention and treatment: a personal journey.

Authors:
Stephen T Holgate

Allergy Asthma Immunol Res 2013 Nov 25;5(6):343-7. Epub 2013 Jun 25.

Faculty of Medicine University of Southampton, UK.

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November 2013

The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

Authors:
Allison-Lynn Andrews Ida Karin Nordgren Gemma Campbell-Harding John W Holloway Stephen T Holgate Donna E Davies Ali Tavassoli

Mol Biosyst 2013 Dec 20;9(12):3009-14. Epub 2013 Sep 20.

Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.

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December 2013

Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.

Authors:
Marina S Leino Matthew Loxham Cornelia Blume Emily J Swindle Nivenka P Jayasekera Patrick W Dennison Betty W H Shamji Matthew J Edwards Stephen T Holgate Peter H Howarth Donna E Davies

PLoS One 2013 23;8(8):e71278. Epub 2013 Aug 23.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, South Block, University Hospital Southampton, Southampton, United Kingdom.

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April 2014

Immune circuits in asthma.

Authors:
Stephen T Holgate

Curr Opin Pharmacol 2013 Jun 29;13(3):345-50. Epub 2013 Apr 29.

Clinical and Experimental Sciences, Mail Point 810, Level F South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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June 2013

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

Authors:
Michelle A Hardyman Emily Wilkinson Emma Martin Nivenka P Jayasekera Cornelia Blume Emily J Swindle Neil Gozzard Stephen T Holgate Peter H Howarth Donna E Davies Jane E Collins

J Allergy Clin Immunol 2013 Sep 28;132(3):665-675.e8. Epub 2013 Apr 28.

Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom; Southampton NIHR Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom. Electronic address:

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September 2013

Airway remodelling in asthma and novel therapy.

Authors:
Wiparat Manuyakorn Peter H Howarth Stephen T Holgate

Asian Pac J Allergy Immunol 2013 Mar;31(1):3-10

Department of Pediatrics, Mahidol University, Bangkok, Thailand.

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March 2013

Stratified approaches to the treatment of asthma.

Authors:
Stephen T Holgate

Br J Clin Pharmacol 2013 Aug;76(2):277-91

Faculty of Medicine, University of Southampton, Southampton, UK.

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August 2013

Barrier responses of human bronchial epithelial cells to grass pollen exposure.

Authors:
Cornelia Blume Emily J Swindle Patrick Dennison Nivenka P Jayasekera Sarah Dudley Phillip Monk Heidrun Behrendt Carsten B Schmidt-Weber Stephen T Holgate Peter H Howarth Claudia Traidl-Hoffmann Donna E Davies

Eur Respir J 2013 Jul 8;42(1):87-97. Epub 2012 Nov 8.

Brooke Laboratory, Clinical and Experimental Sciences, Faculty of Medicine, University Hospital Southampton, Southampton, UK.

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July 2013

The future of technologies for personalised medicine.

Authors:
Alison Harvey Angela Brand Stephen T Holgate Lars V Kristiansen Hans Lehrach Aarno Palotie Barbara Prainsack

N Biotechnol 2012 Sep;29(6):625-33

Finchley Court, Norwich, UK.

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September 2012

The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.

Authors:
Gemma Campbell-Harding Hannah Sawkins Nicole Bedke Stephen T Holgate Donna E Davies Allison-Lynn Andrews

J Allergy Clin Immunol 2013 Mar 12;131(3):849-55. Epub 2012 Oct 12.

Academic Unit of Clinical and Experimental Sciences and the Southampton NIHR Respiratory Biomedical Research Unit, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom.

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March 2013

Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response.

Authors:
Nicole Bedke David Sammut Ben Green Valia Kehagia Patrick Dennison Gisli Jenkins Amanda Tatler Peter H Howarth Stephen T Holgate Donna E Davies

PLoS One 2012 6;7(9):e44580. Epub 2012 Sep 6.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, University Hospital Southampton, Southampton, United Kingdom.

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March 2013

Aspirin exacerbated respiratory disease.

Authors:
Luis M Teran Stephen T Holgate Hae-Sim Park Anthony P Sampson

J Allergy (Cairo) 2012 14;2012:473863. Epub 2012 Aug 14.

Department of Immunogenetics and Allergy, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

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August 2012

Air pollution and lung health: an epilogue.

Authors:
Ian A Yang Stephen T Holgate

Respirology 2013 Jan;18(1):3-4

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January 2013

Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review.

Authors:
Alison M Gowers Paul Cullinan Jon G Ayres H Ross Anderson David P Strachan Stephen T Holgate Inga C Mills Robert L Maynard

Respirology 2012 Aug;17(6):887-98

Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, UK.

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August 2012

Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration.

Authors:
Fabio Bucchieri Alberto Fucarino Antonella Marino Gammazza Alessandro Pitruzzella Vito Marciano Carlo Paderni Viviana De Caro Maria Gabriella Siragusa Lorenzo Lo Muzio Stephen T Holgate Donna E Davies Felicia Farina Giovanni Zummo Yasusei Kudo Italo Libero Giannola Giuseppina Campisi

Curr Pharm Des 2012 ;18(34):5421-30

Dpt di Biomedicina Sperimentale e Neuroscienze Cliniche Universita di Palermo, Italy.

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April 2013

Medium-term culture of primary oral squamous cell carcinoma in a three- dimensional model: effects on cell survival following topical 5-fluororacile delivery by drug-loaded matrix tablets.

Authors:
Giuseppina Campisi Libero Italo Giannola Alberto Fucarino Antonella Marino Gammazza Alessandro Pitruzzella Vito Marciano Viviana De Caro Maria Gabriella Siragusa Giulia Giandalia Domenico Compilato Stephen T Holgate Donna E Davies Felicia Farina Giovanni Zummo Carlo Paderni Fabio Bucchieri

Curr Pharm Des 2012 ;18(34):5411-20

Dipartimento di Discipline Chirurgiche ed Oncologiche, Università di Palermo, Italy.

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April 2013

Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma.

Authors:
Chuan Wang Matthew J Rose-Zerilli Gerard H Koppelman Johanna K Sandling John W Holloway Dirkje S Postma Stephen T Holgate Vincent Bours Ann-Christine Syvänen Vinciane Dideberg

Gene 2012 Aug 18;504(2):220-5. Epub 2012 May 18.

Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden.

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August 2012

Innate and adaptive immune responses in asthma.

Authors:
Stephen T Holgate

Nat Med 2012 May 4;18(5):673-83. Epub 2012 May 4.

Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Southampton General Hospital, UK.

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May 2012

Function of the airway epithelium in asthma.

Authors:
Teal S Hallstrand Prescott G Woodruff Stephen T Holgate Darryl A Knight

J Allergy (Cairo) 2012 22;2012:160586. Epub 2012 Mar 22.

Division of Pulmonary and Critical Care Medicine, University of Washington, P.O. Box 356522, 1959 NE Pacific Street, Seattle, WA 98195-6522, USA.

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August 2012

Trials and tribulations in identifying new biologic treatments for asthma.

Authors:
Stephen T Holgate

Trends Immunol 2012 May 20;33(5):238-46. Epub 2012 Mar 20.

Inflammation, Infection and Immunity Division, Sir Henry Wellcome Laboratories, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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May 2012

Discovery of new treatments in the context of delivering personalized medicine.

Authors:
Stephen T Holgate Aarno Palotie

Per Med 2012 Mar;9(2):101-104

Wellcome Trust Sanger Institute, Helsinki, Finland and The Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.

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March 2012

The importance of primary care research in the management of respiratory disease.

Authors:
Stephen T Holgate

Prim Care Respir J 2012 Mar;21(1):1-3

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March 2012

Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-β.

Authors:
Youwen Yang James Wicks Hans Michael Haitchi Robert M Powell Wiparat Manuyakorn Peter H Howarth Stephen T Holgate Donna E Davies

Am J Respir Cell Mol Biol 2012 May 6;46(5):633-40. Epub 2012 Jan 6.

Southampton General Hospital, Southampton, UK.

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May 2012

Allergic diseases and asthma: a major global health concern.

Authors:
Ruby Pawankar Giorgio W Canonica Stephen T Holgate Richard F Lockey

Curr Opin Allergy Clin Immunol 2012 Feb;12(1):39-41

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February 2012

Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?

Authors:
Stephen T Holgate

J Allergy Clin Immunol 2011 Sep 31;128(3):495-505. Epub 2011 Jul 31.

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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September 2011

Chronic fatigue syndrome: understanding a complex illness.

Authors:
Stephen T Holgate Anthony L Komaroff Dennis Mangan Simon Wessely

Nat Rev Neurosci 2011 Jul 27;12(9):539-44. Epub 2011 Jul 27.

University of Southampton, Infection, Inflammation and Immunity Division, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.

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July 2011

Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood.

Authors:
Unnur S Bjornsdottir Stephen T Holgate Padmalatha S Reddy Andrew A Hill Charlotte M McKee Cristina I Csimma Amy A Weaver Holly M Legault Clayton G Small Renee C Ramsey Debra K Ellis Conor M Burke Philip J Thompson Peter H Howarth Andrew J Wardlaw Phillip G Bardin David I Bernstein Louis B Irving Geoffrey L Chupp George W Bensch Gregory W Bensch Jon E Stahlman Monroe Karetzky James W Baker Rachel L Miller Brad H Goodman Donald G Raible Samuel J Goldman Douglas K Miller John L Ryan Andrew J Dorner Frederick W Immermann Margot O'Toole

PLoS One 2011 14;6(7):e21902. Epub 2011 Jul 14.

Department of Allergy/Clinical Immunology, University of Iceland, Reykjavík, Iceland.

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November 2011

Defective epithelial barrier function in asthma.

Authors:
Chang Xiao Sarah M Puddicombe Sarah Field Joel Haywood Victoria Broughton-Head Ilaria Puxeddu Hans Michael Haitchi Elizabeth Vernon-Wilson David Sammut Nicole Bedke Catherine Cremin Jody Sones Ratko Djukanović Peter H Howarth Jane E Collins Stephen T Holgate Phillip Monk Donna E Davies

J Allergy Clin Immunol 2011 Sep 12;128(3):549-56.e1-12. Epub 2011 Jul 12.

Synairgen Research Ltd, Southampton General Hospital, Southampton, United Kingdom.

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September 2011

Animal models of asthma: value, limitations and opportunities for alternative approaches.

Authors:
Anthony M Holmes Roberto Solari Stephen T Holgate

Drug Discov Today 2011 Aug 23;16(15-16):659-70. Epub 2011 Jun 23.

National Centre for the Replacement, Refinement and Reduction of Animals in Research, 20 Park Crescent, London, W1B 1AL, UK.

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August 2011

Identification of ATPAF1 as a novel candidate gene for asthma in children.

Authors:
Eric M Schauberger Susan L Ewart Syed H Arshad Marianne Huebner Wilfried Karmaus John W Holloway Karen H Friderici Julie T Ziegler Hongmei Zhang Matthew J Rose-Zerilli Sheila J Barton Stephen T Holgate Jeffrey R Kilpatrick John B Harley Stephane Lajoie-Kadoch Isaac T W Harley Qutayba Hamid Ramesh J Kurukulaaratchy Max A Seibold Pedro C Avila William Rodriguez-Cintrón Jose R Rodriguez-Santana Donglei Hu Christopher Gignoux Isabelle Romieu Stephanie J London Esteban G Burchard Carl D Langefeld Marsha Wills-Karp

J Allergy Clin Immunol 2011 Oct 22;128(4):753-760.e11. Epub 2011 Jun 22.

Michigan State University, East Lansing, MI, USA.

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October 2011

The sentinel role of the airway epithelium in asthma pathogenesis.

Authors:
Stephen T Holgate

Immunol Rev 2011 Jul;242(1):205-19

Allergy & Inflammation Research, Division of Infection, Inflammation & Immunity, School of Medicine, Southampton University and General Hospital, Southampton, Hampshire, UK.

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July 2011

Asthma: a simple concept but in reality a complex disease.

Authors:
Stephen T Holgate

Eur J Clin Invest 2011 Dec 26;41(12):1339-52. Epub 2011 May 26.

School of Medicine, University of Southampton, Southampton, UK.

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December 2011

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

Authors:
Yutaka Maeda Gang Chen Yan Xu Hans Michael Haitchi Lingling Du Angela R Keiser Peter H Howarth Donna E Davies Stephen T Holgate Jeffrey A Whitsett

Am J Respir Crit Care Med 2011 Aug;184(4):421-9

Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

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August 2011

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma.

Authors:
Suresh K Babu Sarah M Puddicombe Hasan H Arshad Susan J Wilson John Ward Neil Gozzard Gerry Higgs Stephen T Holgate Donna E Davies

Clin Immunol 2011 Jul 13;140(1):18-25. Epub 2011 Mar 13.

The Brooke Laboratories, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.

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July 2011

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

Authors:
Julie A Cakebread Yunhe Xu Chris Grainge Valia Kehagia Peter H Howarth Stephen T Holgate Donna E Davies

J Allergy Clin Immunol 2011 May 16;127(5):1148-54.e9. Epub 2011 Feb 16.

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom.

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May 2011

The acetaminophen enigma in asthma.

Authors:
Stephen T Holgate

Am J Respir Crit Care Med 2011 Jan;183(2):147-8

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January 2011

Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma.

Authors:
Jean Bousquet Eva Mantzouranis Alvaro A Cruz Nadia Aït-Khaled Carlos E Baena-Cagnani Eugene R Bleecker Chris E Brightling Peter Burney Andrew Bush William W Busse Thomas B Casale Moira Chan-Yeung Rongchang Chen Badrul Chowdhury Kian Fan Chung Ronald Dahl Jeffrey M Drazen Leonardo M Fabbri Stephen T Holgate Francine Kauffmann Tari Haahtela Nikolaï Khaltaev James P Kiley Mohammad R Masjedi Yousser Mohammad Paul O'Byrne Martyn R Partridge Klaus F Rabe Alkis Togias Christiaan van Weel Sally Wenzel Nanshan Zhong Torsten Zuberbier

J Allergy Clin Immunol 2010 Nov;126(5):926-38

University Hospital, Hôpital Arnaud de Villeneuve, Montpellier, France.

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November 2010

ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.

Authors:
Stephen T Holgate

Drug News Perspect 2010 Jul-Aug;23(6):381-7

Infection, Inflammation and Immunity Division, Southampton General Hospital, Southampton, UK.

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November 2010

Using genetics to predict the natural history of asthma?

Authors:
John W Holloway Syed H Arshad Stephen T Holgate

J Allergy Clin Immunol 2010 Aug;126(2):200-9; quiz 210-1

Division of Infection, Inflammation & Immunity, School of Medicine, University of Southampton, Southampton, UK.

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August 2010

Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma.

Authors:
Lena Uller Marina Leino Nicole Bedke David Sammut Ben Green Laurie Lau Peter H Howarth Stephen T Holgate Donna E Davies

Thorax 2010 Jul;65(7):626-32

The Brooke Laboratories, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.

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July 2010

A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis.

Authors:
Stephen T Holgate

Allergy Asthma Immunol Res 2010 Jul 6;2(3):165-71. Epub 2010 May 6.

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

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July 2010

A look at the pathogenesis of asthma: the need for a change in direction.

Authors:
Stephen T Holgate

Discov Med 2010 May;9(48):439-47

Infection, Inflammation and Immunity Division, Southampton General Hospital, School of Medicine, University of Southampton, Southampton, United Kingdom.

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May 2010

Exposure, uptake, distribution and toxicity of nanomaterials in humans.

Authors:
Stephen T Holgate

J Biomed Nanotechnol 2010 Feb;6(1):1-19

IIR Division, School of Medicine, Level F, Southampton General Hospital, Southampton, SO16 6YD, UK.

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February 2010

Genetics of allergic disease.

Authors:
John W Holloway Ian A Yang Stephen T Holgate

J Allergy Clin Immunol 2010 Feb;125(2 Suppl 2):S81-94

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

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February 2010

The role of histamine in asthma.

Authors:
Paul J Dunford Stephen T Holgate

Adv Exp Med Biol 2010 ;709:53-66

Department of Immunology, Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, California 92121, USA.

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July 2011

A new look at the pathogenesis of asthma.

Authors:
Stephen T Holgate Hasan S Arshad Graham C Roberts Peter H Howarth Philipp Thurner Donna E Davies

Clin Sci (Lond) 2009 Dec 23;118(7):439-50. Epub 2009 Dec 23.

University of Southampton, Southampton General Hospital, UK.

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December 2009

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis.

Authors:
Stephen T Holgate Graham Roberts Hasan S Arshad Peter H Howarth Donna E Davies

Proc Am Thorac Soc 2009 Dec;6(8):655-9

Infection, Inflammation and Immunity Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton SO166YD, UK.

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December 2009

Has the time come to rethink the pathogenesis of asthma?

Authors:
Stephen T Holgate

Curr Opin Allergy Clin Immunol 2010 Feb;10(1):48-53

University of Southampton, Hampshire, UK.

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February 2010

Rethinking the pathogenesis of asthma.

Authors:
Stephen T Holgate Donna E Davies

Immunity 2009 Sep;31(3):362-7

III Division, School of Medicine, University of Southampton, Southampton S016 61D, UK.

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September 2009

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.

Authors:
Gerard H Koppelman Deborah A Meyers Timothy D Howard S Lilly Zheng Greg A Hawkins Elizabeth J Ampleford Jianfeng Xu Henk Koning Marcel Bruinenberg Ilja M Nolte Cleo C van Diemen H Marike Boezen Wim Timens Paul A Whittaker O Colin Stine Sheila J Barton John W Holloway Stephen T Holgate Penelope E Graves Fernando D Martinez Antoon J van Oosterhout Eugene R Bleecker Dirkje S Postma

Am J Respir Crit Care Med 2009 Nov 3;180(10):929-35. Epub 2009 Sep 3.

Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

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November 2009

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

Authors:
Hans Michael Haitchi David J P Bassett Fabio Bucchieri Xiufeng Gao Robert M Powell Neil A Hanley David I Wilson Stephen T Holgate Donna E Davies

J Allergy Clin Immunol 2009 Sep 8;124(3):590-7, 597.e1-11. Epub 2009 Aug 8.

Division of Infection Inflammation and Immunity, Roger Brooke Laboratory, School of Medicine, University of Southampton, Southampton, UK.

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September 2009

Adamalysins in biology and disease.

Authors:
Harry van Goor Wynand B W H Melenhorst Anthony J Turner Stephen T Holgate

J Pathol 2009 Nov;219(3):277-86

Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands.

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November 2009

Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways.

Authors:
Anne B Knol Jeroen J de Hartog Hanna Boogaard Pauline Slottje Jeroen P van der Sluijs Erik Lebret Flemming R Cassee J Arjan Wardekker Jon G Ayres Paul J Borm Bert Brunekreef Kenneth Donaldson Francesco Forastiere Stephen T Holgate Wolfgang G Kreyling Benoit Nemery Juha Pekkanen Vicky Stone H-Erich Wichmann Gerard Hoek

Part Fibre Toxicol 2009 Jul 24;6:19. Epub 2009 Jul 24.

Dutch National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

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July 2009

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

Authors:
Allison-Lynn Andrews Ida Karin Nordgren Isabelle Kirby John W Holloway Stephen T Holgate Donna E Davies Ali Tavassoli

Biochem Soc Trans 2009 Aug;37(Pt 4):873-6

School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.

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August 2009

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

Authors:
Sheila J Barton Gerard H Koppelman Judith M Vonk Claudia A Browning Ilja M Nolte Ceri E Stewart Sue Bainbridge Stacey Mutch Matthew J Rose-Zerilli Dirkje S Postma Nikolas Maniatis Amanda P Henry Ian P Hall Stephen T Holgate Patrick Tighe John W Holloway Ian Sayers

J Allergy Clin Immunol 2009 Jun 13;123(6):1391-400.e17. Epub 2009 May 13.

Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom.

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June 2009

Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

Authors:
Aleksandra Szczepankiewicz Matthew J Rose-Zerilli Sheila J Barton Stephen T Holgate John W Holloway

Int Arch Allergy Immunol 2009 17;149(4):343-9. Epub 2009 Mar 17.

Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Third Department of Pediatrics, Poznan University of Medical Sciences, PL-60-572 Poznan, Poland.

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August 2009

Contribution of bronchial fibroblasts to the antiviral response in asthma.

Authors:
Nicole Bedke Hans Michael Haitchi Mara Xatzipsalti Stephen T Holgate Donna E Davies

J Immunol 2009 Mar;182(6):3660-7

Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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March 2009