Stephen Laryea Quaye - Navrongo Health Research Centre - Biomedical Scientist

Stephen Laryea Quaye

Navrongo Health Research Centre

Biomedical Scientist

Accra | Ghana

Additional Specialties: Biomedical Science

Stephen Laryea Quaye - Navrongo Health Research Centre - Biomedical Scientist

Stephen Laryea Quaye

Introduction

Primary Affiliation: Navrongo Health Research Centre - Accra , Ghana

Additional Specialties:

Publications

5Publications

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30PubMed Central Citations

A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt.

PLoS One 2016 12;11(2):e0147928. Epub 2016 Feb 12.

Faculty of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. Seroprevalence by age was used in a catalytic model to determine the force of infection. Meningococcal serogroup A IgG antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. The geometric mean concentration (GMC) was highest in Ghana (9.09 ?g/mL [95% CI 8.29, 9.97]) and lowest in Ethiopia (1.43 ?g/mL [95% CI 1.31, 1.57]) on the margins of the belt. The force of infection was lowest in Ethiopia (? = 0.028). Variables associated with a concentration above the putative protective level of 2 ?g/mL were age, urban residence and a history of recent vaccination with a meningococcal vaccine. Prior to vaccination with the serogroup A meningococcal conjugate vaccine, meningococcal serogroup A IgG antibody concentrations were high across the African meningitis belt and yet the region remained susceptible to epidemics.

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http://search.proquest.com/openview/d8b134f1a9060b40f4c2f57f
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http://dx.plos.org/10.1371/journal.pone.0147928
Publisher Site
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147928PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752490PMC
July 2016
37 Reads
3.234 Impact Factor

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London School of Hygiene and Tropical Medicine

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London School of Hygiene and Tropical Medicine

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Aldiouma Diallo
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Université Paris Descartes

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Ray Borrow
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University of Bristol

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Olivier Manigart
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Emory University

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