Stephen Pickup

Stephen Pickup

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Stephen Pickup

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Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport.

J Bone Miner Res 2020 Mar 16. Epub 2020 Mar 16.

Translational Musculoskeletal Research Center, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jbmr.4009DOI Listing
March 2020

Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.

J Vasc Interv Radiol 2017 Jul 9;28(7):1043-1050.e2. Epub 2017 May 9.

Penn Image-Guided Interventions Laboratory, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104; Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104. Electronic address:

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http://dx.doi.org/10.1016/j.jvir.2017.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593422PMC
July 2017

Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice.

Alzheimer Dis Assoc Disord 2015 Jul-Sep;29(3):184-191

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1097/WAD.0000000000000075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543576PMC
August 2016

Correlations between quantitative T2 and T1ρ MRI, mechanical properties and biochemical composition in a rabbit lumbar intervertebral disc degeneration model.

J Orthop Res 2016 08 10;34(8):1382-8. Epub 2016 Aug 10.

Department of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jor.23269DOI Listing
August 2016

Segmental Transarterial Embolization in a Translational Rat Model of Hepatocellular Carcinoma.

J Vasc Interv Radiol 2015 Aug 8;26(8):1229-37. Epub 2015 Apr 8.

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, 421 Curie Boulevard, 438 BRB II/III, Philadelphia, PA 19104-6160; Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, 421 Curie Boulevard, 438 BRB II/III, Philadelphia, PA 19104-6160. Electronic address:

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http://dx.doi.org/10.1016/j.jvir.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853022PMC
August 2015

Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors.

Mol Cancer Ther 2015 Apr 5;14(4):899-908. Epub 2015 Feb 5.

Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Cellular and Molecular Physiology, Institute of Regenerative Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394035PMC
April 2015

Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma.

J Ultrasound Med 2015 Feb;34(2):275-87

Department of Radiology (S.J.H., T.G., M.C.S., S.P., C.M.S.), Penn Image-Guided Interventions Laboratory (S.J.H., T.G.), and Penn Ultrasound Research Laboratory (S.J.H., C.M.S.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania USA.

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http://dx.doi.org/10.7863/ultra.34.2.275DOI Listing
February 2015

Tongue fat infiltration in obese versus lean Zucker rats.

Sleep 2014 Jun 1;37(6):1095-102, 1102A-1102C. Epub 2014 Jun 1.

Center for Sleep and Circadian Neurobiology ; Division of Sleep Medicine.

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http://dx.doi.org/10.5665/sleep.3768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015383PMC
June 2014

High-resolution magnetic resonance microscopy and diffusion tensor imaging to assess brain structural abnormalities in the murine mucopolysaccharidosis VII model.

J Neuropathol Exp Neurol 2014 Jan;73(1):39-49

From the Departments of Radiology (MK, IMN, RI, SP, HP), Neurology (JL), and Pediatrics (JHW), Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania; W.F. Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania (MKP, JHW); Department of Radiology, New York University School of Medicine, New York, New York (SK); and Research Institute of the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (MKP, JHW).

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
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http://dx.doi.org/10.1097/NEN.0000000000000023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120119PMC
January 2014

Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces.

Anesthesiology 2013 Dec;119(6):1402-9

* Assistant Professor, Department of Anesthesiology and Critical Care, † Research Specialist, ‡ Project Manager, § Student, ‖ Research Assistant Professor, # Technical Director, ‡‡ Professor, Department of Radiology, †† Professor, Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, Pennsylvania. ** Professor, Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e3182a9b0c1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987989PMC
December 2013

Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs.

Crit Care Med 2013 Feb;41(2):527-35

Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/CCM.0b013e31826ab1f2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557664PMC
February 2013

Mechanisms of blood flow and hypoxia production in rat 9L-epigastric tumors.

Tumor Microenviron Ther 2013 Jan;1:1-13

University of Pennsylvania, Department of Radiation Oncology, Perelman School of Medicine, Philadelphia, PA, 19104.

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http://dx.doi.org/10.2478/tumor-2012-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247177PMC
January 2013

Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism.

Brain Res 2012 May 25;1455:56-67. Epub 2012 Mar 25.

Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.brainres.2012.03.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340503PMC
May 2012

Association between sociability and diffusion tensor imaging in BALB/cJ mice.

NMR Biomed 2012 Jan 25;25(1):104-12. Epub 2011 May 25.

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/nbm.1722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188421PMC
January 2012

Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model.

Lasers Surg Med 2011 Sep;43(7):663-75

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA.

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http://dx.doi.org/10.1002/lsm.21102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676899PMC
September 2011

NMR metabolic and physiological markers of therapeutic response.

Adv Exp Med Biol 2011 ;701:129-35

Laboratory of Molecular Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/978-1-4419-7756-4_18DOI Listing
August 2011

Respiratory modulation of the pharyngeal airway in lean and obese mice.

Respir Physiol Neurobiol 2011 Feb 16;175(2):296-302. Epub 2010 Dec 16.

Department of Medicine, School of Medicine, University of Pennsylvania, 3624 Market St., Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.resp.2010.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032032PMC
February 2011

Effects of cardiac pulsation in diffusion tensor imaging of the rat brain.

J Neurosci Methods 2010 Dec 14;194(1):116-21. Epub 2010 Oct 14.

Department of Radiology, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993847PMC
December 2010

Improved technique for measurement of regional fractional ventilation by hyperpolarized 3He MRI.

Magn Reson Med 2010 Jan;63(1):137-50

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA.

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http://dx.doi.org/10.1002/mrm.22186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285263PMC
January 2010

In vivo assessment of hepatic triglycerides in murine non-alcoholic fatty liver disease using magnetic resonance spectroscopy.

Biochim Biophys Acta 2009 Aug 6;1791(8):757-63. Epub 2009 Mar 6.

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1016/j.bbalip.2009.02.014DOI Listing
August 2009

Enhanced delineation of white matter structures of the fixed mouse brain using Gd-DTPA in microscopic MRI.

NMR Biomed 2009 Apr;22(3):303-9

Department of Radiology, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1002/nbm.1324DOI Listing
April 2009

In vivo (1)H MRS of WSU-DLCL2 human non-Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP.

NMR Biomed 2009 Apr;22(3):259-65

Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/nbm.1316DOI Listing
April 2009

Quantitative estimation of dynamic contrast enhanced MRI parameters in rat brain gliomas using a dual surface coil system.

Acad Radiol 2009 Mar;16(3):341-50

Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.acra.2008.09.010DOI Listing
March 2009

A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 T.

Neuroimage 2009 Jan 18;44(2):385-98. Epub 2008 Sep 18.

Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2008.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650508PMC
January 2009

Altered upper airway and soft tissue structures in the New Zealand Obese mouse.

Am J Respir Crit Care Med 2009 Jan 7;179(2):158-69. Epub 2008 Nov 7.

Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200809-1435O
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http://dx.doi.org/10.1164/rccm.200809-1435OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633061PMC
January 2009

Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI.

NMR Biomed 2008 Nov;21(10):1021-9

Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/nbm.1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594105PMC
November 2008

In vivo MRS markers of response to CHOP chemotherapy in the WSU-DLCL2 human diffuse large B-cell lymphoma xenograft.

NMR Biomed 2008 Aug;21(7):723-33

Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania, and NMR Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4011, USA.

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http://dx.doi.org/10.1002/nbm.1250DOI Listing
August 2008

Lactate imaging with Hadamard-encoded slice-selective multiple quantum coherence chemical-shift imaging.

Magn Reson Med 2008 Aug;60(2):299-305

Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/mrm.21659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701382PMC
August 2008

Diffusion tensor MRI in rat models of invasive and well-demarcated brain tumors.

NMR Biomed 2008 Mar;21(3):208-16

Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/nbm.1183DOI Listing
March 2008

In vivo monitoring response to chemotherapy of human diffuse large B-cell lymphoma xenografts in SCID mice by 1H and 31P MRS.

Acad Radiol 2007 Dec;14(12):1531-9

Molecular Imaging Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.acra.2007.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148497PMC
December 2007

Phasic respiratory pharyngeal mechanics by magnetic resonance imaging in lean and obese zucker rats.

Am J Respir Crit Care Med 2006 May 26;173(9):1031-7. Epub 2006 Jan 26.

Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200505-705OC
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http://dx.doi.org/10.1164/rccm.200505-705OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662913PMC
May 2006

Artificial tumor model suitable for monitoring 31P and 13C NMR spectroscopic changes during chemotherapy-induced apoptosis in human glioma cells.

Magn Reson Med 2005 Jul;54(1):67-78

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.

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http://dx.doi.org/10.1002/mrm.20545DOI Listing
July 2005

Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells.

Biochim Biophys Acta 2005 May 24;1734(1):1-12. Epub 2005 Feb 24.

Department of Radiology, University of Pennsylvania School of Medicine, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbalip.2005.01.008DOI Listing
May 2005

Gadodiamide T1 relaxivity in brain tissue in vivo is lower than in saline.

Magn Reson Med 2005 Jan;53(1):35-40

Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/mrm.20336DOI Listing
January 2005

Pharyngeal airway wall mechanics using tagged magnetic resonance imaging during medial hypoglossal nerve stimulation in rats.

J Physiol 2004 Dec 7;561(Pt 2):597-610. Epub 2004 Oct 7.

Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1113/jphysiol.2004.073502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665366PMC
December 2004

Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange.

Magn Reson Med 2004 Aug;52(2):248-57

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/mrm.20143DOI Listing
August 2004

A novel method for analysis of TOMROP data.

J Magn Reson Imaging 2004 Apr;19(4):508-12

Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/jmri.20027DOI Listing
April 2004

MRI estimation of the arterial input function in mice.

Acad Radiol 2003 Sep;10(9):963-8

Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s1076-6332(03)00291-5DOI Listing
September 2003

Assessment of global and regional myocardial function in the mouse using cine and tagged MRI.

Magn Reson Med 2003 Apr;49(4):760-4

Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/mrm.10423DOI Listing
April 2003