Publications by authors named "Stephen P Jackson"

100Publications

Trajectory and uniqueness of mutational signatures in yeast mutators.

Proc Natl Acad Sci U S A 2020 10 23;117(40):24947-24956. Epub 2020 Sep 23.

Institut Curie, Paris Sciences et Lettres Research University, CNRS, UMR3244, 75248 Paris Cedex 05, France;

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http://dx.doi.org/10.1073/pnas.2011332117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547211PMC
October 2020

Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials.

Cardiol Ther 2020 Dec 30;9(2):363-376. Epub 2020 Aug 30.

UCL MRC Unit for Lifelong Health and Ageing, University College London, Fitzrovia, London, WC1E 7HB, UK.

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http://dx.doi.org/10.1007/s40119-020-00199-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584719PMC
December 2020

Chronic irradiation of human cells reduces histone levels and deregulates gene expression.

Sci Rep 2020 02 10;10(1):2200. Epub 2020 Feb 10.

Wellcome/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1038/s41598-020-59163-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010678PMC
February 2020

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.

Nat Commun 2020 02 10;11(1):819. Epub 2020 Feb 10.

Wellcome Trust CRUK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1038/s41467-020-14563-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010753PMC
February 2020

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.

Nat Commun 2019 11 15;10(1):5191. Epub 2019 Nov 15.

Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1038/s41467-019-12929-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858307PMC
November 2019

Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway.

ACS Chem Biol 2019 10 23;14(10):2148-2154. Epub 2019 Sep 23.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry , University of Cambridge , Cambridge CB2 1QN , United Kingdom.

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http://dx.doi.org/10.1021/acschembio.9b00570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804243PMC
October 2019

Derivation and maintenance of mouse haploid embryonic stem cells.

Nat Protoc 2019 07 3;14(7):1991-2014. Epub 2019 Jun 3.

UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41596-019-0169-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997032PMC
July 2019

A Compendium of Mutational Signatures of Environmental Agents.

Cell 2019 05 11;177(4):821-836.e16. Epub 2019 Apr 11.

Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193026
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http://dx.doi.org/10.1016/j.cell.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506336PMC
May 2019

Retraction Note: KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

Nature 2019 Apr;568(7753):576

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41586-019-1142-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554193PMC
April 2019

Retraction.

Science 2019 04 11;364(6437):247. Epub 2019 Apr 11.

The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1126/science.aax4558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558281PMC
April 2019

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.

Cell Rep 2019 01;26(3):582-593.e5

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK; Alzheimer's Research UK Stem Cell Research Centre, University of Cambridge, CB2 1QN, UK; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183204
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http://dx.doi.org/10.1016/j.celrep.2018.12.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335264PMC
January 2019

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.

Mol Cell 2018 11 25;72(4):625-635.e4. Epub 2018 Oct 25.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242705PMC
November 2018

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.

Sci Signal 2018 07 3;11(537). Epub 2018 Jul 3.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1126/scisignal.aar5401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331045PMC
July 2018

Validating the concept of mutational signatures with isogenic cell models.

Nat Commun 2018 05 1;9(1):1744. Epub 2018 May 1.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.

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http://dx.doi.org/10.1038/s41467-018-04052-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931590PMC
May 2018

Detection of functional protein domains by unbiased genome-wide forward genetic screening.

Sci Rep 2018 04 18;8(1):6161. Epub 2018 Apr 18.

The Wellcome/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, CB2 1QN, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-018-24400-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906580PMC
April 2018

Deubiquitylating enzymes and drug discovery: emerging opportunities.

Nat Rev Drug Discov 2018 01 29;17(1):57-78. Epub 2017 Sep 29.

Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1038/nrd.2017.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097658PMC
January 2018

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Mol Cell 2017 Jun;66(6):801-817

Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.015DOI Listing
June 2017

Chromatin determinants impart camptothecin sensitivity.

EMBO Rep 2017 06 7;18(6):1000-1012. Epub 2017 Apr 7.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.15252/embr.201643560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452016PMC
June 2017

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.

Cancer Discov 2017 01 21;7(1):20-37. Epub 2016 Dec 21.

Royal Marsden NHS Foundation Trust, London, United Kingdom.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-16-0860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300099PMC
January 2017

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Nat Chem Biol 2017 Jan 31;13(1):12-14. Epub 2016 Oct 31.

The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nchembio.2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164930PMC
January 2017

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.

J Biol Chem 2016 Nov 4;291(47):24377-24389. Epub 2016 Oct 4.

From the Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology and the Section of Molecular & Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 and

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http://dx.doi.org/10.1074/jbc.M116.752329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114395PMC
November 2016

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.

Nat Commun 2016 09 19;7:12889. Epub 2016 Sep 19.

Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, 31077 Toulouse, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031800PMC
http://dx.doi.org/10.1038/ncomms12889DOI Listing
September 2016

Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin.

Genome Res 2016 10 28;26(10):1376-1387. Epub 2016 Jul 28.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom.

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http://dx.doi.org/10.1101/gr.209106.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052058PMC
October 2016

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.

Aging Cell 2016 Dec 27;15(6):1039-1050. Epub 2016 Jul 27.

The James Black Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.

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http://dx.doi.org/10.1111/acel.12506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114580PMC
December 2016

G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.

Cancer Lett 2016 10 16;380(2):467-75. Epub 2016 Jul 16.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011428PMC
October 2016

DNA REPAIR. Drugging DNA repair.

Science 2016 Jun;352(6290):1178-9

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aab0958DOI Listing
June 2016

CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.

Sci Rep 2016 Apr 15;6:24356. Epub 2016 Apr 15.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/srep24356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832145PMC
April 2016

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Mol Cell 2016 Feb 31;61(3):449-460. Epub 2015 Dec 31.

Genome Stability and Tumourigenesis Group, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901PMC
February 2016

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

Nat Cell Biol 2015 Nov 26;17(11):1458-1470. Epub 2015 Oct 26.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN Cambridge, UK.

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http://www.nature.com/articles/ncb3260
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http://dx.doi.org/10.1038/ncb3260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894550PMC
November 2015

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Mol Cell 2015 Nov 8;60(3):362-73. Epub 2015 Oct 8.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK; The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643306PMC
November 2015

Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.

Nucleic Acids Res 2015 Dec 8;43(21):10264-76. Epub 2015 Sep 8.

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), BP 64182, 205 route de Narbonne, F-31077 Toulouse, Cedex4, France Université de Toulouse, UPS, IPBS, F-31077 Toulouse, France Equipe labellisée Ligue Nationale Contre le Cancer, France

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http://nar.oxfordjournals.org/content/early/2015/09/07/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv894
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http://dx.doi.org/10.1093/nar/gkv894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666393PMC
December 2015

A flow cytometry-based method to simplify the analysis and quantification of protein association to chromatin in mammalian cells.

Nat Protoc 2015 Sep 30;10(9):1297-307. Epub 2015 Jul 30.

1] The Wellcome Trust/Cancer Research UK (CRUK) Gurdon Institute, University of Cambridge, Cambridge, UK. [2] Department of Biochemistry, University of Cambridge, Cambridge, UK. [3] , University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2015.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743064PMC
September 2015

Ubiquitin regulates dissociation of DNA repair factors from chromatin.

Oncotarget 2015 Jun;6(17):14727-8

The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558107PMC
http://dx.doi.org/10.18632/oncotarget.4410DOI Listing
June 2015

Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.

Cell Rep 2015 May 23;11(5):704-14. Epub 2015 Apr 23.

The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge 2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431666PMC
May 2015

Synthetic viability genomic screening defines Sae2 function in DNA repair.

EMBO J 2015 Jun 21;34(11):1509-22. Epub 2015 Apr 21.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK The Wellcome Trust Sanger Institute, Hinxton Cambridge, UK

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http://dx.doi.org/10.15252/embj.201590973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474527PMC
June 2015

Ubiquitylation, neddylation and the DNA damage response.

Open Biol 2015 Apr;5(4):150018

The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK

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http://dx.doi.org/10.1098/rsob.150018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422126PMC
April 2015

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Mol Cell 2015 Mar;57(6):1133-1141

The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374139PMC
March 2015

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Nat Protoc 2015 Jan 31;10(1):205-15. Epub 2014 Dec 31.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2015.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806852PMC
January 2015

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nat Cell Biol 2014 Oct 7;16(10):1016-26, 1-8. Epub 2014 Sep 7.

1] The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK [2] The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1038/ncb3028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183562PMC
October 2014

A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.

Genes Dev 2014 Sep 4;28(18):1977-82. Epub 2014 Sep 4.

The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom; The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom

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http://dx.doi.org/10.1101/gad.246272.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173157PMC
September 2014

Keeping 53BP1 out of focus in mitosis.

Cell Res 2014 Jul 9;24(7):781-2. Epub 2014 May 9.

1] The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, England, UK [2] The Wellcome Trust Sanger Institute, CB10 1SA Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/cr.2014.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085762PMC
July 2014

Chemical inhibition of NAT10 corrects defects of laminopathic cells.

Science 2014 May;344(6183):527-32

The Wellcome Trust/Cancer Research UK (CRUK) Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN Cambridge, UK.

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http://dx.doi.org/10.1126/science.1252651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246063PMC
May 2014

Confinement and deformation of single cells and their nuclei inside size-adapted microtubes.

Adv Healthc Mater 2014 Nov 25;3(11):1753-8. Epub 2014 Apr 25.

Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstraße 20, Dresden, D-01069, Germany.

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http://dx.doi.org/10.1002/adhm.201300678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227890PMC
November 2014

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

Nat Struct Mol Biol 2014 Apr 23;21(4):366-74. Epub 2014 Mar 23.

1] Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération, Université de Toulouse, Université Paul Sabatier, Toulouse, France. [2] CNRS, Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération, Toulouse, France.

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http://dx.doi.org/10.1038/nsmb.2796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300393PMC
April 2014

Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies.

Nano Lett 2014 Aug 10;14(8):4197-204. Epub 2014 Mar 10.

Institute for Integrative Nanosciences, IFW Dresden , Helmholtzstrasse 20, D-01069 Dresden, Germany.

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http://dx.doi.org/10.1021/nl4042565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133182PMC
August 2014

A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.

J Cell Biol 2013 Aug 29;202(3):579-95. Epub 2013 Jul 29.

The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, England, UK.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201303073
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http://dx.doi.org/10.1083/jcb.201303073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734090PMC
August 2013

Deubiquitylating enzymes and DNA damage response pathways.

Cell Biochem Biophys 2013 Sep;67(1):25-43

MISSION Therapeutics Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1007/s12013-013-9635-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756857PMC
September 2013

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

Nature 2013 Jun 26;498(7452):70-4. Epub 2013 May 26.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nature12201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859897PMC
June 2013

On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair.

Cell 2013 Apr;153(3):513-5

The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.cell.2013.04.018DOI Listing
April 2013

RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures.

Cell Cycle 2013 Apr 2;12(8):1161-2. Epub 2013 Apr 2.

The Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.4161/cc.24402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674078PMC
April 2013

Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins.

Cell Cycle 2013 Mar 26;12(6):1000-8. Epub 2013 Feb 26.

The Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.4161/cc.23947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637335PMC
March 2013

Regulation of DNA damage responses by ubiquitin and SUMO.

Mol Cell 2013 Mar 14;49(5):795-807. Epub 2013 Feb 14.

The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765130005
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http://dx.doi.org/10.1016/j.molcel.2013.01.017DOI Listing
March 2013

ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage.

Cell Cycle 2013 Feb 23;12(4):698-704. Epub 2013 Jan 23.

DNA Damage Response Group, Basic Medical Science Department, St. George's University of London, London, UK.

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http://dx.doi.org/10.4161/cc.23592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594270PMC
February 2013

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

Nucleic Acids Res 2013 Feb 18;41(3):1669-83. Epub 2012 Dec 18.

Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Seville, Spain.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561951PMC
February 2013

Systematic identification of functional residues in mammalian histone H2AX.

Mol Cell Biol 2013 Jan 29;33(1):111-26. Epub 2012 Oct 29.

Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1128/MCB.01024-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536310PMC
January 2013

Chromothripsis and cancer: causes and consequences of chromosome shattering.

Nat Rev Cancer 2012 Oct 13;12(10):663-70. Epub 2012 Sep 13.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nrc3352DOI Listing
October 2012

A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells.

Cytometry A 2012 Oct 14;81(10):922-8. Epub 2012 Aug 14.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN Cambridge, United Kingdom.

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http://doi.wiley.com/10.1002/cyto.a.22155
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http://dx.doi.org/10.1002/cyto.a.22155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601416PMC
October 2012

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

Genes Dev 2012 Jun;26(11):1179-95

The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1101/gad.188284.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371407PMC
June 2012

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination.

EMBO Rep 2012 Jun;13(6):561-8

Department of Biochemistry, Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2012.58
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http://dx.doi.org/10.1038/embor.2012.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367243PMC
June 2012

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.

J Cell Sci 2012 Aug 2;125(Pt 15):3529-34. Epub 2012 May 2.

Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.105353
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http://dx.doi.org/10.1242/jcs.105353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445322PMC
August 2012

Histone marks: repairing DNA breaks within the context of chromatin.

Biochem Soc Trans 2012 Apr;40(2):370-6

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, U.K.

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http://dx.doi.org/10.1042/BST20110747DOI Listing
April 2012

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.

Mol Cell 2012 Apr 15;46(2):212-25. Epub 2012 Mar 15.

The NNF Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molcel.2012.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565437PMC
April 2012

CtIP Mutations Cause Seckel and Jawad Syndromes.

PLoS Genet 2011 Oct 6;7(10):e1002310. Epub 2011 Oct 6.

Department of Human Genetics and Department of Biomedicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1371/journal.pgen.1002310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188555PMC
October 2011

Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.

PLoS One 2011 17;6(8):e23517. Epub 2011 Aug 17.

The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157403PMC
February 2012

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

Genome Biol 2011 Aug 18;12(8):R78. Epub 2011 Aug 18.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1186/gb-2011-12-8-r78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245618PMC
August 2011

Regulation of Rad51 function by phosphorylation.

EMBO Rep 2011 Jul 8;12(8):833-9. Epub 2011 Jul 8.

Department of Biochemistry, Wellcome Trust and Cancer Research UK, Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/embor.2011.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147262PMC
July 2011

Replication stress induces 53BP1-containing OPT domains in G1 cells.

J Cell Biol 2011 Apr 28;193(1):97-108. Epub 2011 Mar 28.

The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, England, UK.

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http://dx.doi.org/10.1083/jcb.201011083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082192PMC
April 2011

Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events.

Cell Cycle 2011 Apr 15;10(8):1215-21. Epub 2011 Apr 15.

The Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117133PMC
http://dx.doi.org/10.4161/cc.10.8.15334DOI Listing
April 2011

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.

Genes Dev 2011 Mar;25(5):409-33

The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB21QN, United Kingdom.

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http://dx.doi.org/10.1101/gad.2021311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049283PMC
March 2011

Human SIRT6 promotes DNA end resection through CtIP deacetylation.

Science 2010 Sep;329(5997):1348-53

Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1126/science.1192049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276839PMC
September 2010

DAY NEUTRAL FLOWERING does not act through GIGANTEA and FKF1 to regulate CONSTANS expression and flowering time.

Plant Signal Behav 2010 Sep 1;5(9):1105-7. Epub 2010 Sep 1.

Warwick HRI, Warwick University, Wellesbourne, Warwick, UK.

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http://dx.doi.org/10.4161/psb.5.9.12416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115077PMC
September 2010