Publications by authors named "Stephen O"

6 Publications

  • Page 1 of 1

VAVASC study: Clinical trial protocol.

J Vasc Access 2021 Sep 2:11297298211042677. Epub 2021 Sep 2.

Division of Vascular Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: VAVASC study (Validation of Arterio Venous Access Stage Classification) is a multicentre, international, prospective study. The study aims to validate the AVAS classification, which is a classification system describing vascular status of patients indicated for creation of arteriovenous access on the upper limb.

Methods: Observational, prospective, multicentre, international study starting in March 2021. Participant recruitment has commenced. Basic demographic data, risk factors and vascular mapping parameters are collected via an online platform. The outcome measures are class of AVAS, predicted arteriovenous access, final arteriovenous access that has been created and a functionality of the arteriovenous access. Predictive models will be used for statistical analysis.

Current Status: A total of 140 patients from 4 centres in Great Britain, Czech Republic, Brazil and Slovakia are already included and undergoing evaluation.

Conclusions: The study is registered in the Clinical trials registry (NCT04796558), https://register.clinicaltrials.gov/. Study is still open for collaboration with other centres that can register via www.vavasc.com.
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http://dx.doi.org/10.1177/11297298211042677DOI Listing
September 2021

Morphological and molecular characterization of freshwater prawn of genus in the coastal area of Cameroon.

Ecol Evol 2019 Dec 8;9(24):14217-14233. Epub 2019 Dec 8.

USOMI Limited Nairobi Kenya.

(Bate, 1868) is a large and cosmopolitan crustacean genus of high economic importance worldwide. We investigated the morphological and molecular identification of freshwater prawns of the genus in South, South West, and Littoral regions of Cameroon. A total of 1,566 specimens were examined morphologically using a key described by Konan (Diversité morphologique et génétique des crevettes des genres Atya Leach, 1816 et Macrobrachium Bate, 1868 de Côte d'Ivoire, 2009, Université d'Abobo Adjamé, Côte d'Ivoire), leading to the identification of seven species of : (Herklots, 1857); (Herklots, 1851); (De Man, 1912); (Lenz, 1910); (Roux, 1935); (Holthuis, 1949); and an undescribed species .sp. To validate the genetic basis of the identified species, 94 individuals representing the species were selected and subjected to genetic characterization using 1,814 DArT markers. The admixture analysis revealed four groups: and ; ; and .sp; and and . But, the principal component analysis (PCA) separated .sp and to create additional group (i.e., five groups). Based on these findings, and may be conspecific, as well as and , while and .sp seems to be different species, suggesting a potential conflict between the morphological identification key and the genetic basis underlying speciation and species allocation for . These results are valuable in informing breeding design and genetic resource conservation programs for in Africa.
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http://dx.doi.org/10.1002/ece3.5854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953584PMC
December 2019

Psychoactive substance use and its predictors among commercial tricycle operators in Jos north local government area of Plateau State.

J Med Trop 2020 Jan-Jun;22(1):51-56. Epub 2020 May 20.

Department of Community Medicine, Jos University Teaching Hospital, Jos Plateau State, Nigeria.

Background: According to United Nations Office on Drugs and Crime (UNODC) around 243 million people, aged 15-64 consumed an illicit substance making this a public health problem of global dimensions with attendant physical, social, and psychological problems. Studies have shown that 59.5% of road traffic accident among commercial tricycle operator has been associated with the use of psychoactive substances. Hence, this study was conducted to assess the prevalence and pattern of psychoactive substance use and its predictors among tricycle operators in Jos north local government area of Plateau State.

Methodology: This was a cross sectional study conducted among 220 commercial tricycle operators selected from a cluster of five operational units of Tricycle Riders Union using quantitative data collection instrument consisted of three sections through an interviewer's administration method.

Results: The mean age of the respondents in the study was 34 ± 10 years with the prevalence of current use of psychoactive substance being 43.2%. The predictors of psychoactive substance use were tertiary level of education (AOR = 0.06; 95% CI = 0.0074-0.4806) and family history of use of psychoactive substance (AOR = 3.30; 95% CI = 1.7164-6.3611).

Conclusion: This study has demonstrated a high level of illicit psychoactive substance use among commercial tricycle operators with higher level of education negatively influence its use and a positive family history potentiating it.
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http://dx.doi.org/10.4103/jomt.jomt_44_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177076PMC
May 2020

An Efficient Deep Learning Approach to Pneumonia Classification in Healthcare.

J Healthc Eng 2019 27;2019:4180949. Epub 2019 Mar 27.

Division of Computer Engineering, Dongseo University, Busan, Republic of Korea.

This study proposes a convolutional neural network model trained from scratch to classify and detect the presence of pneumonia from a collection of chest X-ray image samples. Unlike other methods that rely solely on transfer learning approaches or traditional handcrafted techniques to achieve a remarkable classification performance, we constructed a convolutional neural network model from scratch to extract features from a given chest X-ray image and classify it to determine if a person is infected with pneumonia. This model could help mitigate the reliability and interpretability challenges often faced when dealing with medical imagery. Unlike other deep learning classification tasks with sufficient image repository, it is difficult to obtain a large amount of pneumonia dataset for this classification task; therefore, we deployed several data augmentation algorithms to improve the validation and classification accuracy of the CNN model and achieved remarkable validation accuracy.
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http://dx.doi.org/10.1155/2019/4180949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458916PMC
May 2020

OMNIgene SPUTUM: A good transport and decontaminating reagent for tuberculosis testing.

Int J Mycobacteriol 2018 Jul-Sep;7(3):222-227

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Background: Sputum culture is limited to centralized facilities. Thus, samples require transportation from peripheral laboratories to these facilities, compromising specimen quality since it is difficult to maintain cold chain. We evaluated OMNIgene SPUTUM Reagent (OMS) for transporting sputum samples for tuberculosis (TB) testing. The study was carried out at Noguchi Memorial Institute for Medical Research using sputa from Korle Bu Teaching Hospital and La General Hospital in Ghana.

Methods: In a laboratory-based controlled experiment (CE), sputum contaminants were determined on blood agar before treatment with OMS and N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH). TB testing included smear microscopy, culture, and Xpert MTB/RIF. Afterward, two peripheral laboratories were trained to transport sputum samples with OMS without cold chain. Positivity, negativity, and contamination rates were compared between both methods using Chi-square and Fisher's exact tests. Cohen's Kappa was also used to determine agreements.

Results: Among 104 sputum samples analyzed in the CE, 93 (89.4%) had bacterial growth on blood agar before decontamination, while 6 (5.8%) and 5 (4.8%) contaminated after NALC-NaOH and OMS treatment, respectively. Contamination was high with NALC-NaOH (12.8%) than OMS (4.3%) on Lowenstein-Jensen media (P < 0.001), but mycobacterial positivity was comparable: NALC-NaOH of 74.5% and OMS of 78.7%. Smear positivity after NALC-NaOH treatment was 89.4% and OMS was 75.9% (P = 0.491). All except one of the samples tested positive by Xpert MTB/RIF after both treatment. Sixteen samples were evaluated in the field experiment and 81.3% yielded positive culture, and no contamination on LJ was observed.

Conclusion: Our findings indicate that OMS works well as a transport and decontaminating reagent of samples for TB testing.
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http://dx.doi.org/10.4103/ijmy.ijmy_102_18DOI Listing
May 2019

Jaundice syndrome in African sharp-tooth catfish, Clarias gariepinus (Burchell), associated with haemolytic Staphylococcus aureus.

J Fish Dis 2012 Dec 23;35(12):945-7. Epub 2012 Aug 23.

Poultry and Fish Diseases Diagnostic Laboratory, Animal Care Services Konsult Nig Ltd, Ogere Remo, Ogun State, Nigeria.

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http://dx.doi.org/10.1111/j.1365-2761.2012.01426.xDOI Listing
December 2012
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