Publications by authors named "Stephen N Floor"

22Publications

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Authors:
David E Gordon Gwendolyn M Jang Mehdi Bouhaddou Jiewei Xu Kirsten Obernier Kris M White Matthew J O'Meara Veronica V Rezelj Jeffrey Z Guo Danielle L Swaney Tia A Tummino Ruth Hüttenhain Robyn M Kaake Alicia L Richards Beril Tutuncuoglu Helene Foussard Jyoti Batra Kelsey Haas Maya Modak Minkyu Kim Paige Haas Benjamin J Polacco Hannes Braberg Jacqueline M Fabius Manon Eckhardt Margaret Soucheray Melanie J Bennett Merve Cakir Michael J McGregor Qiongyu Li Bjoern Meyer Ferdinand Roesch Thomas Vallet Alice Mac Kain Lisa Miorin Elena Moreno Zun Zar Chi Naing Yuan Zhou Shiming Peng Ying Shi Ziyang Zhang Wenqi Shen Ilsa T Kirby James E Melnyk John S Chorba Kevin Lou Shizhong A Dai Inigo Barrio-Hernandez Danish Memon Claudia Hernandez-Armenta Jiankun Lyu Christopher J P Mathy Tina Perica Kala Bharath Pilla Sai J Ganesan Daniel J Saltzberg Ramachandran Rakesh Xi Liu Sara B Rosenthal Lorenzo Calviello Srivats Venkataramanan Jose Liboy-Lugo Yizhu Lin Xi-Ping Huang YongFeng Liu Stephanie A Wankowicz Markus Bohn Maliheh Safari Fatima S Ugur Cassandra Koh Nastaran Sadat Savar Quang Dinh Tran Djoshkun Shengjuler Sabrina J Fletcher Michael C O'Neal Yiming Cai Jason C J Chang David J Broadhurst Saker Klippsten Phillip P Sharp Nicole A Wenzell Duygu Kuzuoglu-Ozturk Hao-Yuan Wang Raphael Trenker Janet M Young Devin A Cavero Joseph Hiatt Theodore L Roth Ujjwal Rathore Advait Subramanian Julia Noack Mathieu Hubert Robert M Stroud Alan D Frankel Oren S Rosenberg Kliment A Verba David A Agard Melanie Ott Michael Emerman Natalia Jura Mark von Zastrow Eric Verdin Alan Ashworth Olivier Schwartz Christophe d'Enfert Shaeri Mukherjee Matt Jacobson Harmit S Malik Danica G Fujimori Trey Ideker Charles S Craik Stephen N Floor James S Fraser John D Gross Andrej Sali Bryan L Roth Davide Ruggero Jack Taunton Tanja Kortemme Pedro Beltrao Marco Vignuzzi Adolfo García-Sastre Kevan M Shokat Brian K Shoichet Nevan J Krogan

Nature 2020 07 30;583(7816):459-468. Epub 2020 Apr 30.

QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-020-2286-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030PMC
July 2020

mRNA isoforms and regulation of their translation.

RNA 2019 10 1;25(10):1324-1336. Epub 2019 Jul 1.

Graduate Study in Comparative Biochemistry, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1261/rna.070193.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800477PMC
October 2019

Move Over, Genomes: Here Comes Transcriptome Engineering.

CRISPR J 2018 04;1:126-127

1 Department of Cell and Tissue Biology, University of California , San Francisco, San Francisco, California.

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http://dx.doi.org/10.1089/crispr.2018.29010.stfDOI Listing
April 2018

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

Nat Genet 2018 08 27;50(8):1132-1139. Epub 2018 Jul 27.

Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.

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http://www.nature.com/articles/s41588-018-0174-0
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http://dx.doi.org/10.1038/s41588-018-0174-0DOI Listing
August 2018

The Traffic Jam: Polyamine Prevalence Pauses Protein Production.

Mol Cell 2018 04;70(2):191-192

Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.005DOI Listing
April 2018

Widespread Translational Remodeling during Human Neuronal Differentiation.

Cell Rep 2017 Nov;21(7):2005-2016

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759054PMC
November 2017

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Nature 2016 06 15;534(7608):558-61. Epub 2016 Jun 15.

Department of Molecular and Cell Biology, Center for RNA Systems Biology, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nature17978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946961PMC
June 2016

Tunable protein synthesis by transcript isoforms in human cells.

Elife 2016 Jan 6;5. Epub 2016 Jan 6.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.

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http://dx.doi.org/10.7554/eLife.10921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764583PMC
January 2016

Analog sensitive chemical inhibition of the DEAD-box protein DDX3.

Protein Sci 2016 Mar 26;25(3):638-49. Epub 2015 Dec 26.

Department of Molecular and Cell Biology, University of California, Berkeley, California.

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http://dx.doi.org/10.1002/pro.2857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815421PMC
March 2016

Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome.

Mol Cell 2015 Dec;60(5):712-714

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, CA 94720, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.11.014DOI Listing
December 2015

Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.

J Biol Chem 2016 Jan 23;291(5):2412-21. Epub 2015 Nov 23.

From the Department of Molecular and Cell Biology, Howard Hughes Medical Institute, Department of Chemistry, and Innovative Genomics Initiative, University of California, Berkeley, California 94720, the Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, and

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http://dx.doi.org/10.1074/jbc.M115.700625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732223PMC
January 2016

Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2.

Structure 2013 Sep 1;21(9):1571-80. Epub 2013 Aug 1.

Program in Chemistry and Chemical Biology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.str.2013.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769517PMC
September 2013

Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.

Proc Natl Acad Sci U S A 2012 Feb 9;109(8):2872-7. Epub 2012 Feb 9.

Graduate Group in Biophysics, University of California, San Francisco, CA 94158, USA.

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http://www.pnas.org/content/109/8/2872.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1113620109
Publisher Site
http://dx.doi.org/10.1073/pnas.1113620109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286934PMC
February 2012

A split active site couples cap recognition by Dcp2 to activation.

Nat Struct Mol Biol 2010 Sep 15;17(9):1096-101. Epub 2010 Aug 15.

Graduate Group in Biophysics, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nsmb.1879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933276PMC
September 2010

SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction.

Nat Struct Mol Biol 2008 Sep;15(9):916-23

Howard Hughes Medical Institute, University of California at San Francisco, 600 16th Street, San Francisco, California 94158, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767265PMC
http://dx.doi.org/10.1038/nsmb.1467DOI Listing
September 2008

Control of mRNA decapping by Dcp2: An open and shut case?

RNA Biol 2008 Oct-Dec;5(4):189-92. Epub 2008 Oct 26.

Graduate Group in Biophysics, University of California, San Francisco, California 94158-2517, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699264PMC
http://dx.doi.org/10.4161/rna.6859DOI Listing
March 2009

mRNA decapping is promoted by an RNA-binding channel in Dcp2.

Mol Cell 2008 Feb;29(3):324-36

Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, CA 94107, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.11.027DOI Listing
February 2008