Stephen Mack

Stephen Mack

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Stephen Mack

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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.

Cancer Discov 2019 Aug 27. Epub 2019 Aug 27.

Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California, San Diego, California.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0215DOI Listing
August 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 Jul;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Pediatric ependymoma: current treatment and newer therapeutic insights.

Future Oncol 2018 Dec 12;14(30):3175-3186. Epub 2018 Nov 12.

Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0502
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http://dx.doi.org/10.2217/fon-2018-0502DOI Listing
December 2018

A functional genomics approach to identify pathways of drug resistance in medulloblastoma.

Acta Neuropathol Commun 2018 12 27;6(1):146. Epub 2018 Dec 27.

Department of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1186/s40478-018-0652-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307130PMC
December 2018

N-methyladenine DNA Modification in Glioblastoma.

Cell 2018 11 1;175(5):1228-1243.e20. Epub 2018 Nov 1.

Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183131
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http://dx.doi.org/10.1016/j.cell.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433469PMC
November 2018

Childhood Medulloblastoma: Current Therapies, Emerging Molecular Landscape and Newer Therapeutic Insights.

Curr Neuropharmacol 2018 ;16(7):1045-1058

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, The University of Texas Health Science Center at Houston, Pediatrics Houston, Texas, United States.

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http://dx.doi.org/10.2174/1570159X15666171129111324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120114PMC
October 2018

Identification of compounds acting as negative allosteric modulators of the LPA receptor.

Eur J Pharmacol 2018 Aug 26;833:8-15. Epub 2018 May 26.

Takeda Cambridge Ltd., 418 Cambridge Science Park, Cambridge, Cambridgeshire CB4 0PZ, UK; Heptares Therapeutics Ltd., BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.05.040DOI Listing
August 2018

miR miR on the wall, who's the most malignant medulloblastoma miR of them all?

Neuro Oncol 2018 02;20(3):313-323

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817951PMC
February 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Put away your microscopes: the ependymoma molecular era has begun.

Curr Opin Oncol 2017 Nov;29(6):443-447

aDepartment of Pediatrics, Baylor College of Medicine bDepartment of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA cDivision of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/CCO.0000000000000411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003664PMC
November 2017

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.

Nat Med 2017 Nov 9;23(11):1352-1361. Epub 2017 Oct 9.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nm.4415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679732PMC
November 2017

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.

Childs Nerv Syst 2017 Jul 16;33(7):1047-1051. Epub 2017 Jun 16.

Division of Haematology/Oncology, Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-017-3481-3DOI Listing
July 2017

Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream.

J Clin Oncol 2017 Jul 22;35(21):2346-2354. Epub 2017 Jun 22.

Stephen C. Mack, Cleveland Clinic, Cleveland, OH; and Paul A. Northcott, St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2017.72.9921DOI Listing
July 2017

Transposase-driven rearrangements in human tumors.

Nat Genet 2017 Jun;49(7):975-977

The Hospital for Sick Children, Department of Neurosurgery, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3908DOI Listing
June 2017

Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

JCI Insight 2017 May 18;2(10). Epub 2017 May 18.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.90019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436539PMC
May 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

An epigenetic gateway to brain tumor cell identity.

Nat Neurosci 2016 Jan;19(1):10-9

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nn.4190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568053PMC
January 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
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http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.

Cancer Discov 2015 Oct;5(10):1018-20

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608252PMC
October 2015

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

Clin Cancer Res 2015 Aug 8;21(16):3750-8. Epub 2015 May 8.

Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537825PMC
August 2015

Optimal and human eye movements to clustered low value cues to increase decision rewards during search.

Vision Res 2015 Aug 17;113(Pt B):137-54. Epub 2015 Jun 17.

Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, United States.

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http://dx.doi.org/10.1016/j.visres.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020051PMC
August 2015

Cancer stem cells in glioblastoma.

Genes Dev 2015 Jun;29(12):1203-17

Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.261982.115
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http://dx.doi.org/10.1101/gad.261982.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495393PMC
June 2015

CDC20 maintains tumor initiating cells.

Oncotarget 2015 May;6(15):13241-54

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537011PMC
http://dx.doi.org/10.18632/oncotarget.3676DOI Listing
May 2015

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Cancer Res 2015 Jan 12;75(1):134-46. Epub 2014 Nov 12.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada. Division of Neurosurgery, Hospital for Sick Children, Toronto, Canada. Department of Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3629DOI Listing
January 2015

Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.

Pain 2014 Oct 30;155(10):2097-107. Epub 2014 Jul 30.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

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http://dx.doi.org/10.1016/j.pain.2014.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220012PMC
October 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Rethinking human visual attention: spatial cueing effects and optimality of decisions by honeybees, monkeys and humans.

Vision Res 2013 Jun 5;85:5-19. Epub 2013 Jan 5.

Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.

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http://dx.doi.org/10.1016/j.visres.2012.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968950PMC
June 2013

Emerging insights into the ependymoma epigenome.

Brain Pathol 2013 Mar;23(2):206-9

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bpa.12020DOI Listing
March 2013

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

The epigenetics of brain tumors.

Methods Mol Biol 2012 ;863:139-53

Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-612-8_8DOI Listing
June 2012

Molecular genetics of ependymoma.

Chin J Cancer 2011 Oct;30(10):669-81

Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.5732/cjc.011.10129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012267PMC
October 2011

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

Childs Nerv Syst 2011 Aug 20;27(8):1243-9. Epub 2011 May 20.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, M4N 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-011-1486-xDOI Listing
August 2011

Object co-occurrence serves as a contextual cue to guide and facilitate visual search in a natural viewing environment.

J Vis 2011 Aug 19;11(9):1-16. Epub 2011 Aug 19.

Vision & Image Understanding Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1167/11.9.9DOI Listing
August 2011

The genetics of pediatric brain tumors.

Curr Neurol Neurosci Rep 2010 May;10(3):215-23

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.

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