Publications by authors named "Stephen Lessnick"

88Publications

Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein.

Epigenetics 2020 Aug 25:1-20. Epub 2020 Aug 25.

Center for Childhood Cancer and Blood Diseases, The Abigail Wexner Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.

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http://dx.doi.org/10.1080/15592294.2020.1805678DOI Listing
August 2020

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.

J Vis Exp 2020 06 27(160). Epub 2020 Jun 27.

Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital; Department of Pediatrics, The Ohio State University;

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http://dx.doi.org/10.3791/61564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484955PMC
June 2020

Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma.

iScience 2020 Jul 20;23(7):101293. Epub 2020 Jun 20.

Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44106, USA; Systems Biology and Bioinformatics Department, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA; Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.101293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334607PMC
July 2020

Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.

Cancer Med 2019 12 31;8(18):7924-7930. Epub 2019 Oct 31.

Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1002/cam4.2575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912049PMC
December 2019

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma.

Oncotarget 2019 Jun 11;10(39):3865-3878. Epub 2019 Jun 11.

The Division of Pediatric Hematology, Oncology & Blood and Marrow Transplant, Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.26988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570473PMC
June 2019

Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.

Genes Cancer 2019 Feb;10(1-2):21-38

Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.18632/genesandcancer.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420793PMC
February 2019

Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.

Oncotarget 2018 Nov 23;9(92):36413-36429. Epub 2018 Nov 23.

Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.26326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284858PMC
November 2018

Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.

PLoS One 2017 1;12(11):e0186275. Epub 2017 Nov 1.

The Medical Scientist Training Program and the Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186275PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665490PMC
December 2017

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.

Mol Cancer Res 2017 11 18;15(11):1517-1530. Epub 2017 Jul 18.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668171PMC
November 2017

Recent advances in targeted therapy for Ewing sarcoma.

F1000Res 2016 25;5. Epub 2016 Aug 25.

Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.12688/f1000research.8631.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007751PMC
September 2016

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Clin Cancer Res 2016 Aug 15;22(16):4105-18. Epub 2016 Mar 15.

Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee. Van Andel Research Institute, Grand Rapids, Michigan. Helen De Vos Children's Hospital, Grand Rapids, Michigan. Department of Pediatrics, Michigan State University School of Medicine, East Lansing, Michigan.

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http://clincancerres.aacrjournals.org/content/early/2016/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987166PMC
August 2016

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.

Oncotarget 2016 Apr;7(14):17616-30

Center for Childhood Cancer and Blood Disorders, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.18632/oncotarget.7124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951237PMC
April 2016

EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.

Genes Cancer 2015 Mar;6(3-4):129-43

Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah, USA ; Department of Oncological Sciences, School of Medicine, University of Utah, Salt Lake City, Utah, USA ; Center for Children's Cancer Research, School of Medicine, University of Utah, Salt Lake City, Utah, USA ; Division of Pediatric Hematology and Oncology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426950PMC
http://dx.doi.org/10.18632/genesandcancer.57DOI Listing
March 2015

Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group.

Pediatr Blood Cancer 2015 May 2;62(5):759-65. Epub 2014 Dec 2.

Department of Orthopedics, University of Utah, Salt Lake City, Utah; Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

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http://dx.doi.org/10.1002/pbc.25340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376595PMC
May 2015

Targeting Glutathione S-transferase M4 in Ewing sarcoma.

Front Pediatr 2014 6;2:83. Epub 2014 Aug 6.

Department of Pediatrics, New York Medical College , Valhalla, NY , USA ; Department of Pathology, New York Medical College , Valhalla, NY , USA.

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http://dx.doi.org/10.3389/fped.2014.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123608PMC
August 2014

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

PLoS One 2014 5;9(8):e104378. Epub 2014 Aug 5.

Sarcoma Services, Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, United States of America; Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America; Division of Pediatric Hematology/Oncology, University of Utah, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104378PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122435PMC
November 2015

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Mol Biol Cell 2014 Sep 23;25(18):2695-709. Epub 2014 Jul 23.

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112 Department of Biology, University of Utah, Salt Lake City, UT 84112

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http://dx.doi.org/10.1091/mbc.E14-01-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161506PMC
September 2014

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

Clin Cancer Res 2014 Sep 24;20(17):4584-97. Epub 2014 Jun 24.

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah. Center for Children's Cancer Research at Huntsman Cancer Institute, Salt Lake City, Utah. Division of Pediatric Hematology/Oncology, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155010PMC
September 2014

ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma.

Genes Cancer 2013 Nov;4(11-12):486-500

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA ; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA ; Center for Children's Cancer Research, University of Utah, Salt Lake City, UT, USA ; Division of Pediatric Hematology/Oncology, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1177/1947601913506115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877663PMC
November 2013

BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.

PLoS One 2013 19;8(3):e59369. Epub 2013 Mar 19.

Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059369PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601955PMC
September 2013

Microsatellite instability in sarcoma: fact or fiction?

ISRN Oncol 2012 18;2012:473146. Epub 2012 Jul 18.

Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.5402/2012/473146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564276PMC
February 2013

Children's Oncology Group's 2013 blueprint for research: bone tumors.

Pediatr Blood Cancer 2013 Jun 19;60(6):1009-15. Epub 2012 Dec 19.

The Department of Pediatrics and Molecular Pharmacology, The Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10467, USA.

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http://dx.doi.org/10.1002/pbc.24429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610028PMC
June 2013

The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.

Genes Cancer 2012 Feb;3(2):102-16

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA ; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1177/1947601912457024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463921PMC
February 2012

The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm.

Front Oncol 2012 16;2. Epub 2012 Jan 16.

Division of Pediatric Hematology-Oncology, Primary Children's Medical Center, University of Utah Salt Lake City, UT, USA.

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http://dx.doi.org/10.3389/fonc.2012.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355929PMC
August 2012

At-risk populations for osteosarcoma: the syndromes and beyond.

Sarcoma 2012 12;2012:152382. Epub 2012 Mar 12.

Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1155/2012/152382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329649PMC
August 2012

Antibody detection of translocations in Ewing sarcoma.

EMBO Mol Med 2012 Jun 15;4(6):453-61. Epub 2012 Mar 15.

The Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1002/emmm.201200225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443953PMC
June 2012

Microsatellites with macro-influence in ewing sarcoma.

Genes (Basel) 2012 Jul 23;3(3):444-60. Epub 2012 Jul 23.

Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.3390/genes3030444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899989PMC
July 2012

Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas.

Sarcoma 2011 1;2011:847409. Epub 2011 Nov 1.

Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1155/2011/847409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206362PMC
August 2012

Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.

Annu Rev Pathol 2012 19;7:145-59. Epub 2011 Sep 19.

Center for Children's Cancer Research at Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.1146/annurev-pathol-011110-130237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555146PMC
April 2013

Promiscuous partnerships in Ewing's sarcoma.

Cancer Genet 2011 Jul;204(7):351-65

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1016/j.cancergen.2011.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164520PMC
July 2011

The molecular basis of sarcoma.

Sarcoma 2011 7;2011:864130. Epub 2011 Jun 7.

Huntsman Cancer Institute, Center for Children's Cancer Research, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1155/2011/864130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137959PMC
November 2011

Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes.

Cancer Epidemiol Biomarkers Prev 2011 May 17;20(5):751-7. Epub 2011 Jan 17.

Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-10-1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085094PMC
May 2011

Glutathione s-transferases in pediatric cancer.

Front Oncol 2011 24;1:39. Epub 2011 Oct 24.

The Department of Oncological Sciences, University of Utah School of Medicine Salt Lake City, UT, USA.

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http://dx.doi.org/10.3389/fonc.2011.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356086PMC
August 2012

Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis.

Sarcoma 2011 1;2011:598704. Epub 2010 Nov 1.

Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1155/2011/598704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968116PMC
July 2011

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma.

Genes Cancer 2010 Feb;1(2):177-187

Department of Oncological Sciences, University of Utah School of Medicine, and Center for Children's Cancer Research, Huntsman Cancer Institute, Salt Lake City, Utah.

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http://dx.doi.org/10.1177/1947601910361495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935179PMC
February 2010

CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.

J Clin Invest 2010 Mar 8;120(3):668-80. Epub 2010 Feb 8.

Laboratory of Experimental Oncology, CRS Development of Biomolecular Therapies, SSN Emilia Romagna Istituti Ortopedici Rizzoli IRCCS, Bologna, Italy.

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http://dx.doi.org/10.1172/JCI36667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827943PMC
March 2010

EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma.

Cancer Res 2009 Dec 17;69(23):9047-55. Epub 2009 Nov 17.

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789197PMC
December 2009

Small round cell sarcomas.

Semin Oncol 2009 Aug;36(4):338-46

Huntsman Cancer Institute, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2009.06.006DOI Listing
August 2009

Pediatric malignancies: update on sarcomas and leukemia development in children.

Curr Opin Genet Dev 2009 Feb 29;19(1):92-6. Epub 2009 Jan 29.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California, San Francisco, CA 94143, United States.

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http://dx.doi.org/10.1016/j.gde.2008.12.005DOI Listing
February 2009

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.

Cell Cycle 2008 Oct 2;7(20):3127-32. Epub 2008 Oct 2.

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.4161/cc.7.20.6892DOI Listing
October 2008

Microsatellites as EWS/FLI response elements in Ewing's sarcoma.

Proc Natl Acad Sci U S A 2008 Jul 14;105(29):10149-54. Epub 2008 Jul 14.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1073/pnas.0801073105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481306PMC
July 2008

Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee.

Pediatr Blood Cancer 2008 Aug;51(2):163-70

Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/pbc.21596DOI Listing
August 2008

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.

PLoS One 2008 Apr 16;3(4):e1965. Epub 2008 Apr 16.

Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001965PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291578PMC
April 2008

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature.

Cell Cycle 2008 Jan 30;7(2):250-6. Epub 2007 Oct 30.

The Division of Pediatric Hematology/Oncology and The Center for Children, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.4161/cc.7.2.5229DOI Listing
January 2008

EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.

Cancer Res 2007 Jul;67(14):6675-84

Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4140DOI Listing
July 2007

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

PLoS Med 2007 Apr;4(4):e122

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.0040122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851624PMC
April 2007

A conditional mouse model of synovial sarcoma: insights into a myogenic origin.

Cancer Cell 2007 Apr;11(4):375-88

Department of Human Genetics, The Center for Children, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.01.016DOI Listing
April 2007

Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma.

Cell Cycle 2006 Dec 1;5(23):2753-9. Epub 2006 Dec 1.

The Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.4161/cc.5.23.3505DOI Listing
December 2006

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.

Mol Cancer Res 2006 Nov;4(11):851-9

The Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0090DOI Listing
November 2006

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.

Cell Cycle 2006 Sep 15;5(18):2049-53. Epub 2006 Sep 15.

The Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.4161/cc.5.18.3213DOI Listing
September 2006

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.

Cancer Cell 2006 May;9(5):405-16

The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.04.004DOI Listing
May 2006

The potential for molecular therapeutic targets in Ewing's sarcoma.

Curr Treat Options Oncol 2005 Nov;6(6):461-71

Huntsman Cancer Institute, Room 4242, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1007/s11864-005-0025-yDOI Listing
November 2005

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.

Cancer Cell 2003 Mar;3(3):285-96

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/s1535-6108(03)00050-3DOI Listing
March 2003

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor.

J Cell Biol 2002 Sep 16;158(6):1079-87. Epub 2002 Sep 16.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200202049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173224PMC
September 2002

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.

Cancer Cell 2002 May;1(4):393-401

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00056-9DOI Listing
May 2002