Stephen L Sturley

Stephen L Sturley

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Stephen L Sturley

Stephen L Sturley

Publications by authors named "Stephen L Sturley"

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The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 17;1864(8):1109-1123. Epub 2019 Apr 17.

Department of Biology, Barnard College-Columbia University, New York, NY 10027, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.04.002DOI Listing
April 2019

Exacerbating and reversing lysosomal storage diseases: from yeast to humans.

Microb Cell 2017 Aug 25;4(9):278-293. Epub 2017 Aug 25.

Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032.

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http://dx.doi.org/10.15698/mic2017.09.588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597791PMC
August 2017

ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification.

FASEB J 2015 Nov 28;29(11):4682-94. Epub 2015 Jul 28.

*Institute of Human Nutrition, Department of Neurology, **Department of Genetics and Development, and Department of Pediatrics, Columbia University Medical Center, New York, New York, USA; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, New York, USA; Donnelly Center for Cellular and Biomolecular Research, Toronto, Ontario, Canada; Institute of Molecular Biosciences, BioTechMed Graz, University of Graz, Graz, Austria; Department of Biology, Providence College, Providence, Rhode Island, USA; and Marine Biological Laboratory, Woods Hole, Massachusetts, USA

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http://dx.doi.org/10.1096/fj.14-264796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608909PMC
November 2015

Making, baking, and breaking: the synthesis, storage, and hydrolysis of neutral lipids.

Annu Rev Nutr 2013 22;33:413-51. Epub 2013 May 22.

Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1146/annurev-nutr-071812-161254DOI Listing
February 2014

Lipid droplet formation on opposing sides of the endoplasmic reticulum.

J Lipid Res 2012 Sep 14;53(9):1800-10. Epub 2012 Jun 14.

Institute of Human Nutrition and Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1194/jlr.R028290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413221PMC
September 2012

Sterols and sphingolipids: dynamic duo or partners in crime?

Prog Lipid Res 2010 Oct 1;49(4):353-65. Epub 2010 Apr 1.

Institute of Human Nutrition, Columbia University Medical Center, 630 W. 168th St., New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.plipres.2010.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938828PMC
October 2010

Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism.

J Biol Chem 2010 Oct 27;285(44):33632-41. Epub 2010 Jul 27.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M110.165761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962461PMC
October 2010

Niemann-Pick type C pathogenesis and treatment: from statins to sugars.

Clin Lipidol 2010 Jun;5(3):387-395

Department of Pediatrics, Columbia University Medical Center, 630 West 168th St, NY 10032, USA.

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http://dx.doi.org/10.2217/clp.10.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050622PMC
June 2010

The genetics of neutral lipid biosynthesis: an evolutionary perspective.

Am J Physiol Endocrinol Metab 2009 Jul 30;297(1):E19-27. Epub 2008 Dec 30.

Department of Pediatrics, Columbia University Medical Center, 630 W. 168th St., New York, NY, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.90898.2008
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http://dx.doi.org/10.1152/ajpendo.90898.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711666PMC
July 2009

Spreading the wealth: Niemann-Pick type C proteins bind and transport cholesterol.

Cell Metab 2009 Jul;10(1):3-4

Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.06.007DOI Listing
July 2009

Saturated with fat: new perspectives on lipotoxicity.

Curr Opin Clin Nutr Metab Care 2009 Mar;12(2):110-6

Institute of Human Nutrition, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1097/MCO.0b013e32832182eeDOI Listing
March 2009

Unraveling the sterol-trafficking defect in Niemann-Pick C disease.

Proc Natl Acad Sci U S A 2009 Feb 11;106(7):2093-4. Epub 2009 Feb 11.

Department of Pediatrics and Institute of Human Nutrition, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0812934106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650112PMC
February 2009

Niemann-Pick type C disease proteins: orphan transporters or membrane rheostats?

Future Lipidol 2007 Jun;2(3):357-367

Columbia University Medical Center, Department of Pediatrics; Institute of Human Nutrition, 630 West 168th Street, New York, NY 10032, USA,

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http://dx.doi.org/10.2217/17460875.2.3.357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704495PMC
June 2007

Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".

Am J Physiol Gastrointest Liver Physiol 2007 Apr 9;292(4):G953-7. Epub 2006 Nov 9.

Department of Pediatrics, Columbia University Medical Center, 650 W. 168th St., New York, NY 10032, USA.

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http://www.physiology.org/doi/10.1152/ajpgi.00509.2006
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http://dx.doi.org/10.1152/ajpgi.00509.2006DOI Listing
April 2007

Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae.

Semin Cell Dev Biol 2005 Apr;16(2):155-61

Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.semcdb.2005.01.006DOI Listing
April 2005

Acyl-coenzymeA (CoA):cholesterol acyltransferase inhibition in rat and human aortic smooth muscle cells is nontoxic and retards foam cell formation.

Arterioscler Thromb Vasc Biol 2005 Jan 21;25(1):122-7. Epub 2004 Oct 21.

Marc and Ruti Bell Vascular Biology Research Program of the Leon H. Charney Division of Cardiology, Department of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1161/01.ATV.0000148202.49842.3bDOI Listing
January 2005

Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport.

Biochim Biophys Acta 2004 Oct;1685(1-3):22-7

Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810400131
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http://dx.doi.org/10.1016/j.bbalip.2004.08.008DOI Listing
October 2004

Metazoan and microbial models of Niemann-Pick Type C disease.

Biochim Biophys Acta 2004 Oct;1685(1-3):38-47

The Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, 630 W168th St. New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.bbalip.2004.08.010DOI Listing
October 2004

The pathophysiology and mechanisms of NP-C disease.

Biochim Biophys Acta 2004 Oct;1685(1-3):83-7

Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.bbalip.2004.08.014DOI Listing
October 2004

A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism.

Lipids 2004 Aug;39(8):747-52

Biology Department, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.

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August 2004

Nutritional genomics in yeast models.

Nutrition 2004 Jan;20(1):166-72

Institute of Human Nutrition, Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, New York 10032, USA.

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January 2004

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

J Biol Chem 2002 Dec 28;277(52):50876-84. Epub 2002 Oct 28.

Department of Medicine, Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M207353200DOI Listing
December 2002

Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells.

J Lipid Res 2002 Oct;43(10):1708-17

Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1194/jlr.m200179-jlr200DOI Listing
October 2002

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.

J Biol Chem 2002 Sep 20;277(36):32466-72. Epub 2002 Jun 20.

Institute of Human Nutrition and Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M204707200DOI Listing
September 2002

Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.

J Biol Chem 2002 Sep 26;277(39):36152-60. Epub 2002 Jul 26.

Department of Biochemistry, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA.

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http://dx.doi.org/10.1074/jbc.M206624200DOI Listing
September 2002

The DGA1 gene determines a second triglyceride synthetic pathway in yeast.

J Biol Chem 2002 Mar 18;277(11):8877-81. Epub 2001 Dec 18.

Institute of Human Nutrition and the Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M111646200DOI Listing
March 2002