Publications by authors named "Stephen J Tucker"

68Publications

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions.

Authors:
Shanlin Rao Gianni Klesse Charlotte I Lynch Stephen J Tucker Mark S P Sansom

J Phys Chem B 2021 Jan 13. Epub 2021 Jan 13.

Department of Biochemistry, University of Oxford, Oxford, U.K.

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January 2021

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT Receptor Channel.

Authors:
Gianni Klesse Stephen J Tucker Mark S P Sansom

ACS Nano 2020 08 23;14(8):10480-10491. Epub 2020 Jul 23.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

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August 2020

A lower X-gate in TASK channels traps inhibitors within the vestibule.

Authors:
Karin E J Rödström Aytuğ K Kiper Wei Zhang Susanne Rinné Ashley C W Pike Matthias Goldstein Linus J Conrad Martina Delbeck Michael G Hahn Heinrich Meier Magdalena Platzk Andrew Quigley David Speedman Leela Shrestha Shubhashish M M Mukhopadhyay Nicola A Burgess-Brown Stephen J Tucker Thomas Müller Niels Decher Elisabeth P Carpenter

Nature 2020 06 29;582(7812):443-447. Epub 2020 Apr 29.

Structural Genomics Consortium, University of Oxford, Oxford, UK.

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June 2020

Altered functional properties of a missense variant in the TRESK K channel (KCNK18) associated with migraine and intellectual disability.

Authors:
Paola Imbrici Ehsan Nematian-Ardestani Sonia Hasan Mauro Pessia Stephen J Tucker Maria Cristina D'Adamo

Pflugers Arch 2020 07 12;472(7):923-930. Epub 2020 May 12.

Department of Physiology & Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD, Msida, 2080, Malta.

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July 2020

Induced Polarization in Molecular Dynamics Simulations of the 5-HT Receptor Channel.

Authors:
Gianni Klesse Shanlin Rao Stephen J Tucker Mark S P Sansom

J Am Chem Soc 2020 05 8;142(20):9415-9427. Epub 2020 May 8.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K.

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May 2020

Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins.

Authors:
Johanna L Syrjanen Kevin Michalski Tsung-Han Chou Timothy Grant Shanlin Rao Noriko Simorowski Stephen J Tucker Nikolaus Grigorieff Hiro Furukawa

Nat Struct Mol Biol 2020 03;27(3):305

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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March 2020

Structure and assembly of calcium homeostasis modulator proteins.

Authors:
Johanna L Syrjanen Kevin Michalski Tsung-Han Chou Timothy Grant Shanlin Rao Noriko Simorowski Stephen J Tucker Nikolaus Grigorieff Hiro Furukawa

Nat Struct Mol Biol 2020 02 27;27(2):150-159. Epub 2020 Jan 27.

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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February 2020

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K channel.

Authors:
Ehsan Nematian-Ardestani Firdaus Abd-Wahab Franck C Chatelain Han Sun Marcus Schewe Thomas Baukrowitz Stephen J Tucker

J Biol Chem 2020 01 5;295(2):610-618. Epub 2019 Dec 5.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdom

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January 2020

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates.

Authors:
Shanlin Rao Gianni Klesse Phillip J Stansfeld Stephen J Tucker Mark S P Sansom

Proc Natl Acad Sci U S A 2019 07 24;116(28):13989-13995. Epub 2019 Jun 24.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom;

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July 2019

CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores.

Authors:
Gianni Klesse Shanlin Rao Mark S P Sansom Stephen J Tucker

J Mol Biol 2019 08 17;431(17):3353-3365. Epub 2019 Jun 17.

Clarendon Laboratory, Department of Physics, University of Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, UK. Electronic address:

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August 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K channels.

Authors:
Marcus Schewe Han Sun Ümit Mert Alexandra Mackenzie Ashley C W Pike Friederike Schulz Cristina Constantin Kirsty S Vowinkel Linus J Conrad Aytug K Kiper Wendy Gonzalez Marianne Musinszki Marie Tegtmeier David C Pryde Hassane Belabed Marc Nazare Bert L de Groot Niels Decher Bernd Fakler Elisabeth P Carpenter Stephen J Tucker Thomas Baukrowitz

Science 2019 02;363(6429):875-880

Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.

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February 2019

Water and hydrophobic gates in ion channels and nanopores.

Authors:
Shanlin Rao Charlotte I Lynch Gianni Klesse Georgia E Oakley Phillip J Stansfeld Stephen J Tucker Mark S P Sansom

Faraday Discuss 2018 09;209(0):231-247

Department of Biochemistry, University of Oxford, UK.

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September 2018

Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.

Authors:
Iulia Blesneac Andreas C Themistocleous Carl Fratter Linus J Conrad Juan D Ramirez James J Cox Solomon Tesfaye Pallai R Shillo Andrew S C Rice Stephen J Tucker David L H Bennett

Pain 2018 03;159(3):469-480

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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March 2018

Asymmetric mechanosensitivity in a eukaryotic ion channel.

Authors:
Michael V Clausen Viwan Jarerattanachat Elisabeth P Carpenter Mark S P Sansom Stephen J Tucker

Proc Natl Acad Sci U S A 2017 10 18;114(40):E8343-E8351. Epub 2017 Sep 18.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom;

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October 2017

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K channel.

Authors:
Ehsan Nematian-Ardestani Viwan Jarerattanachat Prafulla Aryal Mark S P Sansom Stephen J Tucker

Channels (Austin) 2017 Sep 19;11(5):482-486. Epub 2017 Jul 19.

a Clarendon Laboratory, Department of Physics and OXION Initiative in Ion Channels and Disease , University of Oxford , Oxford , UK.

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September 2017

Dynamic role of the tether helix in PIP-dependent gating of a G protein-gated potassium channel.

Authors:
Emre Lacin Prafulla Aryal Ian W Glaaser Karthik Bodhinathan Eric Tsai Nidaa Marsh Stephen J Tucker Mark S P Sansom Paul A Slesinger

J Gen Physiol 2017 08 7;149(8):799-811. Epub 2017 Aug 7.

Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY

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August 2017

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Authors:
Prafulla Aryal Viwan Jarerattanachat Michael V Clausen Marcus Schewe Conor McClenaghan Liam Argent Linus J Conrad Yin Y Dong Ashley C W Pike Elisabeth P Carpenter Thomas Baukrowitz Mark S P Sansom Stephen J Tucker

Structure 2017 05 6;25(5):708-718.e2. Epub 2017 Apr 6.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK. Electronic address:

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May 2017

A BEST example of channel structure annotation by molecular simulation.

Authors:
Shanlin Rao Gianni Klesse Phillip J Stansfeld Stephen J Tucker Mark S P Sansom

Channels (Austin) 2017 Jul 20;11(4):347-353. Epub 2017 Mar 20.

a Department of Biochemistry , University of Oxford , Oxford , UK.

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July 2017

Functional Annotation of Ion Channel Structures by Molecular Simulation.

Authors:
Jemma L Trick Sivapalan Chelvaniththilan Gianni Klesse Prafulla Aryal E Jayne Wallace Stephen J Tucker Mark S P Sansom

Structure 2016 12 17;24(12):2207-2216. Epub 2016 Nov 17.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. Electronic address:

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December 2016

Correction: Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.

Authors:
Alan P Reed Giovanna Bucci Firdaus Abd-Wahab Stephen J Tucker

PLoS One 2016;11(7):e0160114. Epub 2016 Jul 21.

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July 2016

Solution-Based Single-Molecule FRET Studies of K(+) Channel Gating in a Lipid Bilayer.

Authors:
Emma E Sadler Achillefs N Kapanidis Stephen J Tucker

Biophys J 2016 Jun;110(12):2663-2670

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom. Electronic address:

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June 2016

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Authors:
Conor McClenaghan Marcus Schewe Prafulla Aryal Elisabeth P Carpenter Thomas Baukrowitz Stephen J Tucker

J Gen Physiol 2016 06;147(6):497-505

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, England, UK OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PU, England, UK

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June 2016

Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.

Authors:
Alan P Reed Giovanna Bucci Firdaus Abd-Wahab Stephen J Tucker

PLoS One 2016 26;11(5):e0156456. Epub 2016 May 26.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom.

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July 2017

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

Authors:
Marcus Schewe Ehsan Nematian-Ardestani Han Sun Marianne Musinszki Sönke Cordeiro Giovanna Bucci Bert L de Groot Stephen J Tucker Markus Rapedius Thomas Baukrowitz

Cell 2016 Feb;164(5):937-49

Institute of Physiology, Christian-Albrechts University, 24118 Kiel, Germany. Electronic address:

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February 2016

Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels.

Authors:
Lejla Zubcevic Shizhen Wang Vassiliy N Bavro Sun-Joo Lee Colin G Nichols Stephen J Tucker

Sci Rep 2015 Oct 16;5:15305. Epub 2015 Oct 16.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom.

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October 2015

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.

Authors:
John H Beale Joanne L Parker Firdaus Samsudin Anne L Barrett Anish Senan Louise E Bird David Scott Raymond J Owens Mark S P Sansom Stephen J Tucker David Meredith Philip W Fowler Simon Newstead

Structure 2015 Oct 27;23(10):1889-1899. Epub 2015 Aug 27.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; OXION Initiative in Ion Channels and Membrane Transport, University of Oxford OX1 3PU, UK. Electronic address:

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October 2015

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

Authors:
Ricardo Parolin Schnekenberg Emma M Perkins Jack W Miller Wayne I L Davies Maria Cristina D'Adamo Mauro Pessia Katherine A Fawcett David Sims Elodie Gillard Karl Hudspith Paul Skehel Jonathan Williams Mary O'Regan Sandeep Jayawant Rosalind Jefferson Sarah Hughes Andrea Lustenberger Jiannis Ragoussis Mandy Jackson Stephen J Tucker Andrea H Németh

Brain 2015 Jul 16;138(Pt 7):1817-32. Epub 2015 May 16.

4 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK 16 Department of Clinical Genetics, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK

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July 2015

Molecular simulation studies of hydrophobic gating in nanopores and ion channels.

Authors:
Jemma L Trick Prafulla Aryal Stephen J Tucker Mark S P Sansom

Biochem Soc Trans 2015 Apr;43(2):146-50

*Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

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April 2015

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Authors:
Yin Yao Dong Ashley C W Pike Alexandra Mackenzie Conor McClenaghan Prafulla Aryal Liang Dong Andrew Quigley Mariana Grieben Solenne Goubin Shubhashish Mukhopadhyay Gian Filippo Ruda Michael V Clausen Lishuang Cao Paul E Brennan Nicola A Burgess-Brown Mark S P Sansom Stephen J Tucker Elisabeth P Carpenter

Science 2015 Mar;347(6227):1256-9

Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.

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March 2015

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene.

Authors:
Maria C D'Adamo Constanze Gallenmüller Ilenio Servettini Elisabeth Hartl Stephen J Tucker Larissa Arning Saskia Biskup Alessandro Grottesi Luca Guglielmi Paola Imbrici Pia Bernasconi Giuseppe Di Giovanni Fabio Franciolini Luigi Catacuzzeno Mauro Pessia Thomas Klopstock

Front Physiol 2014 15;5:525. Epub 2015 Jan 15.

Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University Munich, Germany ; German Network for Mitochondrial Disorders (mitoNET) Ludwigshafen, Germany ; DZNE - German Center for Neurodegenerative Diseases Munich, Germany ; German Center for Vertigo and Balance Disorders Munich, Germany.

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February 2015

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.

Authors:
Prafulla Aryal Firdaus Abd-Wahab Giovanna Bucci Mark S P Sansom Stephen J Tucker

Channels (Austin) 2015 ;9(1):44-9

a Clarendon Laboratory, Department of Physics; University of Oxford ; Oxford , UK.

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December 2015

Insights into the structural nature of the transition state in the Kir channel gating pathway.

Authors:
Philip W Fowler Murali K Bollepalli Markus Rapedius Ehsan Nematian-Ardestani Lijun Shang Mark Sp Sansom Stephen J Tucker Thomas Baukrowitz

Channels (Austin) 2014 ;8(6):551-5

a Department of Biochemistry ; University of Oxford , Oxford , UK.

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September 2015

Hydrophobic gating in ion channels.

Authors:
Prafulla Aryal Mark S P Sansom Stephen J Tucker

J Mol Biol 2015 Jan 12;427(1):121-30. Epub 2014 Aug 12.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 2JD, UK. Electronic address:

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January 2015

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

Authors:
Prafulla Aryal Firdaus Abd-Wahab Giovanna Bucci Mark S P Sansom Stephen J Tucker

Nat Commun 2014 Jul 8;5:4377. Epub 2014 Jul 8.

1] Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK [2] OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.

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July 2014

State-dependent network connectivity determines gating in a K+ channel.

Authors:
Murali K Bollepalli Philip W Fowler Markus Rapedius Lijun Shang Mark S P Sansom Stephen J Tucker Thomas Baukrowitz

Structure 2014 Jul 26;22(7):1037-46. Epub 2014 Jun 26.

Physiological Institute, Christian-Albrechts University, 24118 Kiel, Germany. Electronic address:

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July 2014

Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels.

Authors:
Emma L Veale Ehab Al-Moubarak Naina Bajaria Kiyoyuki Omoto Lishuang Cao Stephen J Tucker Edward B Stevens Alistair Mathie

Mol Pharmacol 2014 May 7;85(5):671-81. Epub 2014 Feb 7.

Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, United Kingdom (E.L.V., E.A.-M., N.B., A.M.); Pfizer Neusentis, Great Abington, Cambridge, United Kingdom (K.O., L.C., E.B.S.); and Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom (S.J.T.).

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May 2014

Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.

Authors:
Lejla Zubcevic Vassiliy N Bavro Joao R C Muniz Matthias R Schmidt Shizhen Wang Rita De Zorzi Catherine Venien-Bryan Mark S P Sansom Colin G Nichols Stephen J Tucker

J Biol Chem 2014 Jan 20;289(1):143-51. Epub 2013 Nov 20.

From the Biological Physics Group, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU, United Kingdom.

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January 2014

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.

Authors:
Matthias R Schmidt Phillip J Stansfeld Stephen J Tucker Mark S P Sansom

Biochemistry 2013 Jan 28;52(2):279-81. Epub 2012 Dec 28.

Department of Biochemistry, University of Oxford , Oxford OX1 3QU, United Kingdom.

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January 2013

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

Authors:
Markus Rapedius Matthias R Schmidt Chetan Sharma Phillip J Stansfeld Mark S P Sansom Thomas Baukrowitz Stephen J Tucker

Channels (Austin) 2012 Nov-Dec;6(6):473-8. Epub 2012 Sep 18.

Physiological Institute, Christian-Albrechts University, Kiel, Germany.

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July 2013

Functional analysis of missense variants in the TRESK (KCNK18) K channel.

Authors:
Isabelle Andres-Enguix Lijun Shang Phillip J Stansfeld Julia M Morahan Mark S P Sansom Ronald G Lafrenière Bishakha Roy Lyn R Griffiths Guy A Rouleau George C Ebers Zameel M Cader Stephen J Tucker

Sci Rep 2012 27;2:237. Epub 2012 Jan 27.

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September 2012

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.

Authors:
Vassiliy N Bavro Rita De Zorzi Matthias R Schmidt João R C Muniz Lejla Zubcevic Mark S P Sansom Catherine Vénien-Bryan Stephen J Tucker

Nat Struct Mol Biol 2012 Jan 8;19(2):158-63. Epub 2012 Jan 8.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.

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January 2012

The pore structure and gating mechanism of K2P channels.

Authors:
Paula L Piechotta Markus Rapedius Phillip J Stansfeld Murali K Bollepalli Gunter Ehrlich Gunter Erhlich Isabelle Andres-Enguix Hariolf Fritzenschaft Niels Decher Mark S P Sansom Stephen J Tucker Thomas Baukrowitz

EMBO J 2011 Aug 5;30(17):3607-19. Epub 2011 Aug 5.

Universitätsklinikum Jena, Institute of Physiology II, Jena, Germany.

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August 2011

Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.

Authors:
Marc Paulais May Bloch-Faure Nicolas Picard Thibaut Jacques Suresh Krishna Ramakrishnan Mathilde Keck Fabien Sohet Dominique Eladari Pascal Houillier Stéphane Lourdel Jacques Teulon Stephen J Tucker

Proc Natl Acad Sci U S A 2011 Jun 1;108(25):10361-6. Epub 2011 Jun 1.

Université Pierre et Marie Curie Paris 6, Université Paris 5, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche en Santé 872, 75006 Paris, France.

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June 2011

In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers.

Authors:
Sebastian Leptihn James R Thompson J Clive Ellory Stephen J Tucker Mark I Wallace

J Am Chem Soc 2011 Jun 27;133(24):9370-5. Epub 2011 May 27.

Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.

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June 2011

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).

Authors:
Stefan Trapp Stephen J Tucker Alexander V Gourine

Exp Physiol 2011 Apr 14;96(4):451-9. Epub 2011 Jan 14.

Department of Surgery and Cancer, Biophysics Section, Imperial College London, London, UK.

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April 2011

Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.

Authors:
M Cristina D'Adamo Lijun Shang Paola Imbrici Steve D M Brown Mauro Pessia Stephen J Tucker

J Biol Chem 2011 Jan 3;286(1):192-8. Epub 2010 Nov 3.

Section of Human Physiology, University of Perugia School of Medicine, Perugia 06100, Italy.

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January 2011

Ion mobility mass spectrometry of two tetrameric membrane protein complexes reveals compact structures and differences in stability and packing.

Authors:
Sheila C Wang Argyris Politis Natalie Di Bartolo Vassiliy N Bavro Stephen J Tucker Paula J Booth Nelson P Barrera Carol V Robinson

J Am Chem Soc 2010 Nov;132(44):15468-70

Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.

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November 2010

Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.

Authors:
Jennifer J Paynter Isabelle Andres-Enguix Philip W Fowler Stephen Tottey Wayland Cheng Decha Enkvetchakul Vassiliy N Bavro Yoshio Kusakabe Mark S P Sansom Nigel J Robinson Colin G Nichols Stephen J Tucker

J Biol Chem 2010 Dec 28;285(52):40754-61. Epub 2010 Sep 28.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PU, United Kingdom.

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December 2010

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Authors:
Ronald G Lafrenière M Zameel Cader Jean-François Poulin Isabelle Andres-Enguix Maryse Simoneau Namrata Gupta Karine Boisvert François Lafrenière Shannon McLaughlan Marie-Pierre Dubé Martin M Marcinkiewicz Sreeram Ramagopalan Olaf Ansorge Bernard Brais Jorge Sequeiros Jose Maria Pereira-Monteiro Lyn R Griffiths Stephen J Tucker George Ebers Guy A Rouleau

Nat Med 2010 Oct 26;16(10):1157-60. Epub 2010 Sep 26.

Centre of Excellence in Neuromics and Department of Medicine, Université de Montréal, Centre Hospitalier de l'Université de Montréal, Research Centre, Notre-Dame Hospital, Montreal, Quebec, Canada.

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October 2010

Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.

Authors:
Jennifer J Paynter Lijun Shang Murali K Bollepalli Thomas Baukrowitz Stephen J Tucker

Channels (Austin) 2010 Sep-Oct;4(5):390-7. Epub 2010 Sep 1.

Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

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May 2011

Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry.

Authors:
Sayan Gupta Vassiliy N Bavro Rhijuta D'Mello Stephen J Tucker Catherine Vénien-Bryan Mark R Chance

Structure 2010 Jul;18(7):839-46

Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44022, USA.

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July 2010

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.

Authors:
Lijun Shang Sarah V Ranson Stephen J Tucker

Biochem Biophys Res Commun 2009 Oct 8;388(3):501-5. Epub 2009 Aug 8.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdom.

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October 2009

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Authors:
Paola Imbrici Alessandro Grottesi Maria Cristina D'Adamo Roberta Mannucci Stephen J Tucker Mauro Pessia

Channels (Austin) 2009 Jan-Feb;3(1):39-45. Epub 2009 Jan 3.

Section of Human Physiology, Department of Internal Medicine, University of Perugia School of Medicine, Perugia, Italy.

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May 2009

Genetic selection of activatory mutations in KcsA.

Authors:
Jennifer J Paynter Peter Sarkies Isabelle Andres-Enguix Stephen J Tucker

Channels (Austin) 2008 Nov-Dec;2(6):413-8. Epub 2008 Nov 27.

Oxford Centre for Gene Function, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.

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April 2009

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

Authors:
Markus Rapedius Jennifer J Paynter Philip W Fowler Lijun Shang Mark S P Sansom Stephen J Tucker Thomas Baukrowitz

Channels (Austin) 2007 Sep-Oct;1(5):327-30. Epub 2007 Oct 15.

Institute of Physiology II, Friedrich Schiller University, Jena, Germany.

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November 2008

Peptide backbone mutagenesis of putative gating hinges in a potassium ion channel.

Authors:
Yasuo Nagaoka Lijun Shang Arijit Banerjee Hagan Bayley Stephen J Tucker

Chembiochem 2008 Jul;9(11):1725-8

Oxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX13PT, UK.

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July 2008

How highly charged anionic lipids bind and regulate ion channels.

Authors:
Stephen J Tucker Thomas Baukrowitz

J Gen Physiol 2008 May 14;131(5):431-8. Epub 2008 Apr 14.

Oxford Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.

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May 2008

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

Authors:
Markus Rapedius Philip W Fowler Lijun Shang Mark S P Sansom Stephen J Tucker Thomas Baukrowitz

Neuron 2007 Aug;55(4):602-14

Institute of Physiology II, Friedrich Schiller University, D-07743 Jena, Germany.

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August 2007

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.

Authors:
Lijun Shang Stephen J Tucker

Eur Biophys J 2008 Feb 27;37(2):165-71. Epub 2007 Jul 27.

Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.

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February 2008

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.

Authors:
Shozeb Haider Syma Khalid Stephen J Tucker Frances M Ashcroft Mark S P Sansom

Biochemistry 2007 Mar 28;46(12):3643-52. Epub 2007 Feb 28.

Department of Biochemistry, University of Oxford, UK.

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March 2007

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

Authors:
Markus Rapedius Shozeb Haider Katharine F Browne Lijun Shang Mark S P Sansom Thomas Baukrowitz Stephen J Tucker

EMBO Rep 2006 Jun 21;7(6):611-6. Epub 2006 Apr 21.

Institute of Physiology II, Friedrich Schiller University, Jena, Germany.

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June 2006

Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels.

Authors:
Si Sun Jo Han Gan Jennifer J Paynter Stephen J Tucker

Physiol Genomics 2006 Jun 4;26(1):1-7. Epub 2006 Apr 4.

Oxford Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.

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June 2006

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.

Authors:
Markus Rapedius Malle Soom Ekaterina Shumilina Dirk Schulze Roland Schönherr Cornelia Kirsch Florian Lang Stephen J Tucker Thomas Baukrowitz

J Biol Chem 2005 Sep 24;280(35):30760-7. Epub 2005 Jun 24.

Institute of Physiology II, Friedrich Schiller University Jena, Teichgraben 8, 07743 Jena, Germany.

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September 2005

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

Authors:
Lijun Shang Christopher J Lucchese Shozeb Haider Stephen J Tucker

Brain Res Mol Brain Res 2005 Sep;139(1):178-83

Oxford Centre for Gene Function, University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK.

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September 2005

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.

Authors:
Maria Casamassima M Cristina D'Adamo Mauro Pessia Stephen J Tucker

J Biol Chem 2003 Oct 15;278(44):43533-40. Epub 2003 Aug 15.

Istituto di Ricerche Farmacologiche "Mario Negri," Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Chieti), Italy.

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October 2003

Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.

Authors:
Angelos-Aristeidis Konstas Christoph Korbmacher Stephen J Tucker

Am J Physiol Cell Physiol 2003 Apr 27;284(4):C910-7. Epub 2002 Nov 27.

University Laboratory of Physiology, Oxford, OX1 3PT, United Kingdom.

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April 2003

Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel.

Authors:
Angelos-Aristeidis Konstas Jan-Peter Koch Stephen J Tucker Christoph Korbmacher

J Biol Chem 2002 Jul 6;277(28):25377-84. Epub 2002 May 6.

University Laboratory of Physiology, University of Oxford, Parks Road, United Kingdom.

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July 2002

Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.

Authors:
Angelos-Aristeidis Konstas Michael Dabrowski Christoph Korbmacher Stephen J Tucker

J Biol Chem 2002 Jun 1;277(24):21346-51. Epub 2002 Apr 1.

University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, United Kingdom.

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June 2002