Stephen J Lye

Stephen J Lye

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Stephen J Lye

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Uterine artery and umbilical vein blood flow are unaffected by moderate habitual physical activity during pregnancy.

Prenat Diagn 2019 Oct 29;39(11):976-985. Epub 2019 Jul 29.

Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pd.5517DOI Listing
October 2019

MicroRNA-transcriptome networks in whole blood and monocytes of women undergoing preterm labour.

J Cell Mol Med 2019 Oct 24;23(10):6835-6845. Epub 2019 Jul 24.

Program in Development and Fetal Health, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jcmm.14567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787570PMC
October 2019

Environmental, Social, and Structural Constraints for Health Behavior: Perceptions of Young Urban Black Women During the Preconception Period-A Healthy Life Trajectories Initiative.

J Nutr Educ Behav 2019 Sep 15;51(8):946-957. Epub 2019 May 15.

MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.jneb.2019.04.009DOI Listing
September 2019

Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction.

Front Endocrinol (Lausanne) 2019 20;10:160. Epub 2019 Mar 20.

Research Centre for Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fendo.2019.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436182PMC
March 2019

Decidual leucocytes infiltrating human spiral arterioles are rich source of matrix metalloproteinases and degrade extracellular matrix in vitro and in situ.

Am J Reprod Immunol 2019 01 29;81(1):e13054. Epub 2018 Sep 29.

Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/aji.13054DOI Listing
January 2019

TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia.

EBioMedicine 2019 Jan 19;39:531-539. Epub 2018 Dec 19.

Research Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto M5T 3H7, Canada; Department of Obstetrics & Gynecology, University of Toronto, Toronto M5G 1L4, Canada; Department of Physiology, University of Toronto, Toronto M5G 1L4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183059
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http://dx.doi.org/10.1016/j.ebiom.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355656PMC
January 2019

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling.

Mol Ther 2018 09 12;26(9):2189-2205. Epub 2018 Jul 12.

Department of Biology, York University, Toronto, ON M3J 1P3, Canada; Centre for Research in Biomolecular Interactions, York University, Toronto, ON M3J 1P3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127878PMC
September 2018

Analysis of S1P Receptor Expression by Uterine Immune Cells Using Standardized Multi-parametric Flow Cytometry.

Methods Mol Biol 2018 ;1697:83-97

Research Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, Canada, M5T 3H7.

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http://dx.doi.org/10.1007/7651_2017_24DOI Listing
July 2018

Reply.

Am J Obstet Gynecol 2018 07 28;219(1):123-124. Epub 2018 Mar 28.

Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2018.03.022DOI Listing
July 2018

Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta.

J Cell Mol Med 2018 07 24;22(7):3652-3660. Epub 2018 Apr 24.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jcmm.13646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010777PMC
July 2018

Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy.

J Am Heart Assoc 2018 07 14;7(14). Epub 2018 Jul 14.

The Centre for Women's and Infant's Health at the Lunenfeld-Tanenbaum Research Institute Sinai Health System, Toronto, Canada

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http://dx.doi.org/10.1161/JAHA.118.009595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064839PMC
July 2018

Parental ethnicity and placental maternal vascular malperfusion pathology in healthy nulliparous women.

Placenta 2018 06 16;66:40-46. Epub 2018 May 16.

The Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada; Faculty of Medicine - University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology (Maternal Fetal Medicine), University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2018.04.014DOI Listing
June 2018

Maternal metabolic, immune, and microbial systems in late pregnancy vary with malnutrition in mice.

Biol Reprod 2018 04;98(4):579-592

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/biolre/ioy002DOI Listing
April 2018

Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor.

Am J Obstet Gynecol 2018 03 2;218(3):345.e1-345.e30. Epub 2018 Jan 2.

Program in Development and Fetal Health, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2017.12.234DOI Listing
March 2018

Nurturing Care for Young Children under Conditions of Fragility and Conflict.

New Dir Child Adolesc Dev 2018 Mar;2018(159):13-26

Lunenfeld-Tanenbaum Research Institute.

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http://dx.doi.org/10.1002/cad.20232DOI Listing
March 2018

Generation and Use of Trophoblast Stem Cells and Uterine Myocytes to Study the Role of Connexins for Pregnancy and Labor.

Methods Mol Biol 2016 ;1437:83-95

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, ON, Canada, M5T 3H7.

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http://dx.doi.org/10.1007/978-1-4939-3664-9_6DOI Listing
December 2017

Maternal Vascular Malperfusion and Adverse Perinatal Outcomes in Low-Risk Nulliparous Women.

Obstet Gynecol 2017 11;130(5):1112-1120

Department of Obstetrics & Gynaecology, Maternal-Fetal Medicine Division, the Lunenfeld-Tanenbaum Research Institute, the Maternal-Infant Care Research Centre, the Department of Pediatrics, and the Department of Pathology and Laboratory Medicine at Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/AOG.0000000000002264DOI Listing
November 2017

Immunophenotyping and activation status of maternal peripheral blood leukocytes during pregnancy and labour, both term and preterm.

J Cell Mol Med 2017 10 21;21(10):2386-2402. Epub 2017 Apr 21.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jcmm.13160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618694PMC
October 2017

Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition.

Am J Reprod Immunol 2017 06 10;77(6). Epub 2017 Feb 10.

Department of Obstetrics and Gynecology, University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/aji.12643DOI Listing
June 2017

The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study.

BMC Pregnancy Childbirth 2017 Jun 29;17(1):207. Epub 2017 Jun 29.

School of Women's and Infants' Health, The University of Western Australia at King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA, 6008, Australia.

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http://dx.doi.org/10.1186/s12884-017-1391-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492127PMC
June 2017

Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall.

J Immunol 2017 05 10;198(10):4115-4128. Epub 2017 Apr 10.

Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9WL, United Kingdom.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1601175
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http://dx.doi.org/10.4049/jimmunol.1601175DOI Listing
May 2017

Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy.

Cell Mol Immunol 2017 Feb 17;14(2):203-213. Epub 2015 Aug 17.

Research Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.

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http://dx.doi.org/10.1038/cmi.2015.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301153PMC
February 2017

Improving customized fetal biometry by longitudinal modelling.

J Matern Fetal Neonatal Med 2016 18;29(12):1888-94. Epub 2015 Aug 18.

a School of Women's and Infants' Health, The University of Western Australia , Perth , Western Australia , Australia .

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http://www.tandfonline.com/doi/full/10.3109/14767058.2015.10
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http://dx.doi.org/10.3109/14767058.2015.1070139DOI Listing
January 2017

Nurturing care: promoting early childhood development.

Lancet 2017 01 4;389(10064):91-102. Epub 2016 Oct 4.

Center of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan; Center for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736163139
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http://dx.doi.org/10.1016/S0140-6736(16)31390-3DOI Listing
January 2017

Characterization and novel analyses of acute stress response patterns in a population-based cohort of young adults: influence of gender, smoking, and BMI.

Stress 2016 3;19(2):139-50. Epub 2016 Mar 3.

a School of Women's and Infants' Health, The University of Western Australia , Perth , WA , Australia .

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http://dx.doi.org/10.3109/10253890.2016.1146672DOI Listing
December 2016

Elevated mRNA expression of PGF2α receptor splice variant 2(FP-V2) in human decidua is associated with incomplete mifepristone-misoprostol-induced early medical abortion by regulation of interleukin-8.

J Matern Fetal Neonatal Med 2016 Nov 10;29(21):3472-7. Epub 2016 Feb 10.

a Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Liaoning Province Research Institute of Family Planning , Shenyang , China and.

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http://dx.doi.org/10.3109/14767058.2015.1132692DOI Listing
November 2016

Longitudinal Trajectories of Television Watching Across Childhood and Adolescence Predict Bone Mass at Age 20 Years in the Raine Study.

J Bone Miner Res 2016 11 4;31(11):2032-2040. Epub 2016 Jul 4.

School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia.

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http://dx.doi.org/10.1002/jbmr.2890DOI Listing
November 2016

Quantitative large scale gene expression profiling from human stem cell culture micro samples using multiplex pre-amplification.

Syst Biol Reprod Med 2016 3;62(1):84-91. Epub 2015 Aug 3.

e Gene Expression Division , Life Science Group, Bio-Rad Laboratories , Mississauga , Ontario , Canada.

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http://dx.doi.org/10.3109/19396368.2015.1062578DOI Listing
October 2016

P-glycoprotein expression and localization in the rat uterus throughout gestation and labor.

Reproduction 2016 09 22;152(3):195-204. Epub 2016 Jun 22.

Lunenfeld-Tanenbaum Research InstituteMount Sinai Hospital, Toronto, Ontario, Canada Department of Obstetrics & GynecologyUniversity of Toronto, Toronto, Ontario, Canada Department of PhysiologyUniversity of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1530/REP-16-0161DOI Listing
September 2016

Matrix Metalloproteinase Expression in the Rat Myometrium During Pregnancy, Term Labor, and Postpartum.

Biol Reprod 2016 07 1;95(1):24. Epub 2016 Jun 1.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada Department of Physiology, University of Toronto, Canada Department of Obstetrics and Gynecology, University of Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029434PMC
http://dx.doi.org/10.1095/biolreprod.115.138248DOI Listing
July 2016

Preeclampsia is associated with low placental transthyretin levels.

Taiwan J Obstet Gynecol 2016 Jun;55(3):385-9

Beijing Chaoyang Hospital Affiliated Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2016.04.014DOI Listing
June 2016

Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy.

Histol Histopathol 2016 May 25;31(5):557-71. Epub 2015 Nov 25.

Maternal and Fetal Health Research Centre (MFHRC), Institute of Human Development, University of Manchester, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK and Manchester Pharmacy School, Stopford Building, Manchester, UK.

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http://dx.doi.org/10.14670/HH-11-696DOI Listing
May 2016

Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents.

Psychoneuroendocrinology 2016 Apr 9;66:118-24. Epub 2016 Jan 9.

School of Medicine and Pharmacology, University of Western Australia, Australia.

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http://dx.doi.org/10.1016/j.psyneuen.2016.01.002DOI Listing
April 2016

Impact of maternal physical activity on fetal breathing and body movement--A review.

Early Hum Dev 2016 Mar 23;94:53-6. Epub 2016 Jan 23.

Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON M5S 2C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2016.01.006DOI Listing
March 2016

Introductory editorial: Effects of maternal physical activity on the fetus.

Early Hum Dev 2016 Mar 2;94:31. Epub 2016 Feb 2.

Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON, M5S 2C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2016.01.003DOI Listing
March 2016

Summary and synthesis of current knowledge.

Early Hum Dev 2016 Mar 3;94:63-4. Epub 2016 Feb 3.

Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON M5S 2C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2016.01.009DOI Listing
March 2016

To serve and to protect: the role of decidual innate immune cells on human pregnancy.

Cell Tissue Res 2016 Jan 14;363(1):249-265. Epub 2015 Nov 14.

Research Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde St., Toronto, ON, M5T 3H7, Canada.

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http://dx.doi.org/10.1007/s00441-015-2315-4DOI Listing
January 2016

HoxA13 Regulates Phenotype Regionalization of Human Pregnant Myometrium.

J Clin Endocrinol Metab 2015 Dec 20;100(12):E1512-22. Epub 2015 Oct 20.

Vancouver Prostate Centre (L.L., H.L., X.D.), Department of Urologic Sciences, University of British Columbia, Vancouver V6H 3Z6, Canada; BC Cancer Agency (D.D., S.J.M.J.), Genome Sciences Center, Vancouver V5Z 4S6, Canada; Department of Molecular Biology and Biochemistry (D.D., S.J.M.J.), Simon Fraser University, Burnaby V5A 1S6, Canada; Department of Obstetrics and Gynaecology (O.S., S.J.L., X.D.), University of Toronto, Toronto M5G 1E2, Canada; Department of Physiology & Pharmacology (D.S.), University of Calgary, Calgary T2N 4N1, Canada; and Department of Medical Genetics (S.J.M.J), University of British Columbia, Vancouver V6T 1Z3, Canada.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2015-2815DOI Listing
December 2015

Impact of bacterial and viral challenge on multidrug resistance in first- and third-trimester human placenta.

Am J Pathol 2015 Jun 8;185(6):1666-75. Epub 2015 May 8.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.02.013DOI Listing
June 2015

Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation.

Cell Mol Immunol 2015 Mar 2;12(2):231-42. Epub 2014 Jun 2.

1] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada [2] Department of Physiology, University of Toronto, Toronto, Canada [3] Department of Obstetrics & Gynecology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1038/cmi.2014.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654292PMC
March 2015

Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor.

J Proteome Res 2015 Jan 9;14(1):457-66. Epub 2014 Oct 9.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , 25 Orde Street, 6-1001, Toronto, ON M5T 3H7, Canada.

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http://dx.doi.org/10.1021/pr500852pDOI Listing
January 2015

Association of a body mass index genetic risk score with growth throughout childhood and adolescence.

PLoS One 2013 11;8(11):e79547. Epub 2013 Nov 11.

School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia ; Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823612PMC
November 2014

Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development.

Stem Cells Dev 2014 Nov 9;23(21):2649-60. Epub 2014 Jul 9.

1 Lunenfeld-Tanenbaum Research Institute , Mount Sinai Hospital, Toronto, Canada .

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https://www.liebertpub.com/doi/10.1089/scd.2014.0013
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http://dx.doi.org/10.1089/scd.2014.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201296PMC
November 2014

Leukocyte driven-decidual angiogenesis in early pregnancy.

Cell Mol Immunol 2014 Nov 28;11(6):522-37. Epub 2014 Jul 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1038/cmi.2014.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220841PMC
November 2014

Identification of a novel neutrophil population: proangiogenic granulocytes in second-trimester human decidua.

J Immunol 2014 Sep 18;193(6):3070-9. Epub 2014 Aug 18.

Research Centre for Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3H7, Canada; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1E2, Canada; and

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http://dx.doi.org/10.4049/jimmunol.1303117DOI Listing
September 2014

Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration.

Hum Reprod 2013 Nov 3;28(11):3026-37. Epub 2013 Sep 3.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada M5T 3H7.

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http://dx.doi.org/10.1093/humrep/det339DOI Listing
November 2013

DREAM mediated regulation of GCM1 in the human placental trophoblast.

PLoS One 2013 3;8(1):e51837. Epub 2013 Jan 3.

Research Centre for Women's and Infants' Health at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051837PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536794PMC
August 2013

Development and validation of primary human myometrial cell culture models to study pregnancy and labour.

BMC Pregnancy Childbirth 2013 31;13 Suppl 1:S7. Epub 2013 Jan 31.

Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1186/1471-2393-13-S1-S7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561148PMC
August 2013

Modelling BMI trajectories in children for genetic association studies.

PLoS One 2013 17;8(1):e53897. Epub 2013 Jan 17.

School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547961PMC
July 2013

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

Hum Mol Genet 2013 Jul 27;22(13):2735-47. Epub 2013 Feb 27.

Institute for Molecular Medicine, and Department of Public Health, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/hmg/ddt104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674797PMC
July 2013

Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals.

Reprod Sci 2013 Feb 21;20(2):154-67. Epub 2012 May 21.

Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1177/1933719112446084DOI Listing
February 2013

Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice.

J Cell Mol Med 2013 Jan 4;17(1):90-102. Epub 2012 Dec 4.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1111/j.1582-4934.2012.01650.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823139PMC
January 2013

A standardized template for clinical studies in preterm birth.

Reprod Sci 2012 May 16;19(5):474-82. Epub 2012 Feb 16.

Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229-3900, USA.

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http://journals.sagepub.com/doi/10.1177/1933719111426602
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http://dx.doi.org/10.1177/1933719111426602DOI Listing
May 2012

Common variants at 12q15 and 12q24 are associated with infant head circumference.

Nat Genet 2012 Apr 15;44(5):532-538. Epub 2012 Apr 15.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng.2238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773913PMC
April 2012

Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor.

Biol Reprod 2012 Feb 14;86(2):39. Epub 2012 Feb 14.

Maternal and Fetal Health Research Centre, University of Manchester, United Kingdom.

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http://dx.doi.org/10.1095/biolreprod.111.095505DOI Listing
February 2012

Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.

Mol Endocrinol 2011 Jul 12;25(7):1197-210. Epub 2011 May 12.

Vancouver Prostate Center, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1210/me.2010-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417251PMC
July 2011

Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters.

J Clin Endocrinol Metab 2011 May 9;96(5):E810-5. Epub 2011 Feb 9.

The Generation R Study Group and Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2010-2316DOI Listing
May 2011

Human embryonic fibroblasts support single cell enzymatic expansion of human embryonic stem cells in xeno-free cultures.

Stem Cell Res 2011 Jan 27;6(1):70-82. Epub 2010 Aug 27.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5T 3H7, Canada.

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http://dx.doi.org/10.1016/j.scr.2010.08.002DOI Listing
January 2011

Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro.

Am J Pathol 2010 Aug 17;177(2):1017-30. Epub 2010 Jun 17.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2353/ajpath.2010.091105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913364PMC
August 2010

The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.

Hum Mol Genet 2010 Jul 16;19(13):2658-67. Epub 2010 Apr 16.

Department of Clinical Chemistry, VU University Medical Center, Amsterdam the Netherlands.

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http://dx.doi.org/10.1093/hmg/ddq152DOI Listing
July 2010

Stretch-induced uterine myocyte differentiation during rat pregnancy: involvement of caspase activation.

Biol Reprod 2010 Jun 24;82(6):1248-55. Epub 2010 Feb 24.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.109.081158DOI Listing
June 2010

Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.

Endocrinology 2010 Jun 17;151(6):2835-45. Epub 2010 Mar 17.

Department of Molecular Biology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.

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http://dx.doi.org/10.1210/en.2009-1195DOI Listing
June 2010

Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy.

Reproduction 2010 Jan;139(1):247-53

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Room 6-1019, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1530/REP-09-0260DOI Listing
January 2010

Developmental regulation of cardiovascular function is dependent on both genotype and environment.

Am J Physiol Heart Circ Physiol 2009 Dec 25;297(6):H2234-41. Epub 2009 Sep 25.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Physiology, University of Toronto, 25 Orde St. Ste. 6-1004, Toronto, ON, M5T 3H7, Canada.

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http://dx.doi.org/10.1152/ajpheart.01338.2008DOI Listing
December 2009

Expression and organization of basement membranes and focal adhesion proteins in pregnant myometrium is regulated by uterine stretch.

Reprod Sci 2009 Oct 14;16(10):960-9. Epub 2009 Jul 14.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5T 3H7.

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http://dx.doi.org/10.1177/1933719109338220DOI Listing
October 2009

p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1).

Mol Endocrinol 2009 Aug 7;23(8):1147-60. Epub 2009 May 7.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1210/me.2008-0357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419194PMC
August 2009

Early life origins of obesity.

Obstet Gynecol Clin North Am 2009 Jun;36(2):227-44, xii

School of Women's and Infants' Health, The University of Western Australia, 374 Bagot Road, Subiaco, Perth, Western Australia 6008, Australia.

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http://dx.doi.org/10.1016/j.ogc.2009.03.004DOI Listing
June 2009

Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour.

Eur J Obstet Gynecol Reprod Biol 2009 May 18;144 Suppl 1:S2-10. Epub 2009 Mar 18.

Centre for Women's and Infant's Health Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto M5G1X5, Canada.

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http://dx.doi.org/10.1016/j.ejogrb.2009.02.044DOI Listing
May 2009

Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor.

J Immunol 2008 Jul;181(2):1470-9

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.181.2.1470DOI Listing
July 2008

Characterization of connexin31.1-deficient mice reveals impaired placental development.

Dev Biol 2007 Dec 26;312(1):258-71. Epub 2007 Sep 26.

Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, D-53117 Bonn, Germany.

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http://dx.doi.org/10.1016/j.ydbio.2007.09.025DOI Listing
December 2007

Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats.

Biol Reprod 2007 Nov 22;77(5):880-8. Epub 2007 Aug 22.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.107.062356DOI Listing
November 2007

The expression of transforming growth factor beta in pregnant rat myometrium is hormone and stretch dependent.

Reproduction 2007 Sep;134(3):503-11

Samuel Lunenfeld Research Institute at Mount Sinai, Mount Sinai Hospital, 600 University Avenue, Suite 870, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1530/REP-07-0004DOI Listing
September 2007

Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.

Mol Cell Biol 2007 Jul 23;27(13):4863-75. Epub 2007 Apr 23.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Canada.

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http://dx.doi.org/10.1128/MCB.02144-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951499PMC
July 2007

The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy.

J Physiol 2007 Jun 8;581(Pt 2):873-81. Epub 2007 Mar 8.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1113/jphysiol.2006.126573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075185PMC
June 2007

Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat.

Biol Reprod 2007 Apr 22;76(4):571-8. Epub 2006 Nov 22.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.106.056929DOI Listing
April 2007

Genetic epidemiologic studies of preterm birth: guidelines for research.

Am J Obstet Gynecol 2007 Feb;196(2):107-18

School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1016/j.ajog.2006.03.109DOI Listing
February 2007

Strain differences in the impact of dietary restriction on fetal growth and pregnancy in mice.

Reprod Sci 2007 Jan;14(1):81-90

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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January 2007

Meloxicam effectively inhibits preterm labor uterine contractions in a chronically catheterized pregnant sheep model: impact on fetal blood flow and fetal-maternal physiologic parameters.

Am J Obstet Gynecol 2006 Aug 19;195(2):528-34. Epub 2006 Apr 19.

Research Centre for Women's and Infant's Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajog.2006.02.011DOI Listing
August 2006

Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia.

Mol Hum Reprod 2006 Jun 4;12(6):389-99. Epub 2006 May 4.

Institute of Anatomy and Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1093/molehr/gal044DOI Listing
June 2006

Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation.

Biol Reprod 2006 May 11;74(5):839-49. Epub 2006 Jan 11.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1095/biolreprod.105.048124DOI Listing
May 2006

Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition.

J Cell Sci 2006 May 4;119(Pt 9):1715-22. Epub 2006 Apr 4.

Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, Römerstr. 164, 53117 Bonn, Germany.

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http://dx.doi.org/10.1242/jcs.02892DOI Listing
May 2006