Stephen J Haggarty

Stephen J Haggarty

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Stephen J Haggarty

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Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.

Ann N Y Acad Sci 2019 Mar 15. Epub 2019 Mar 15.

Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.14012DOI Listing
March 2019

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.

ACS Chem Neurosci 2018 Sep 22;9(9):2262-2273. Epub 2018 Jun 22.

Chemical Neurobiology Laboratory, Center for Genomic Medicine , Massachusetts General Hospital , 185 Cambridge Street , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00116DOI Listing
September 2018

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.

Nat Commun 2017 11 21;8(1):1659. Epub 2017 Nov 21.

Chemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-017-01750-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698418PMC
November 2017

HDAC6 Brain Mapping with [F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination.

ACS Cent Sci 2017 Sep 6;3(9):1006-1014. Epub 2017 Sep 6.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/acscentsci.7b00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620987PMC
September 2017

Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.

ACS Chem Biol 2017 08 10;12(8):2139-2148. Epub 2017 Jul 10.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Harvard Medical School and Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acschembio.6b01014DOI Listing
August 2017

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

Cell Chem Biol 2017 Jul 14;24(7):892-906.e5. Epub 2017 Jul 14.

Chemical Neurobiology Laboratory, Departments of Neurology & Psychiatry, Massachusetts General Hospital, Center for Genomic Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695697PMC
July 2017

Classics in Chemical Neuroscience: Ketamine.

ACS Chem Neurosci 2017 06 21;8(6):1122-1134. Epub 2017 Apr 21.

Chemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Chemical Biology Program, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00074DOI Listing
June 2017

Correction to "Classics in Chemical Neuroscience: Haloperidol".

ACS Chem Neurosci 2017 06 16;8(6):1429. Epub 2017 May 16.

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http://dx.doi.org/10.1021/acschemneuro.7b00172DOI Listing
June 2017

Classics in Chemical Neuroscience: Haloperidol.

ACS Chem Neurosci 2017 03 15;8(3):444-453. Epub 2017 Feb 15.

Chemical Neurobiology Laboratory, Center for Genomic Medicine, Chemical Biology Program, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.7b00018
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http://dx.doi.org/10.1021/acschemneuro.7b00018DOI Listing
March 2017

Development of [F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

ACS Med Chem Lett 2017 Mar 2;8(3):287-292. Epub 2017 Feb 2.

Department of Chemistry, and Institute of Chemical Biology and Drug Discovery, Stony Brook University , Stony Brook, New York 11794-3400, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346984PMC
March 2017

Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.

Prog Neuropsychopharmacol Biol Psychiatry 2017 02 9;73:87-103. Epub 2016 Apr 9.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2016.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292013PMC
February 2017

Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening.

Curr Protoc Hum Genet 2017 01 11;92:21.8.1-21.8.21. Epub 2017 Jan 11.

Chemical Neurobiology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cphg.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293008PMC
January 2017

Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

Psychiatry Clin Neurosci 2016 Dec 7;70(12):536-550. Epub 2016 Sep 7.

Departments of Neurology & Psychiatry, Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1111/pcn.12426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764164PMC
December 2016

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch.

J Biol Chem 2016 Nov 15;291(47):24756-24767. Epub 2016 Sep 15.

the Chemical Neurobiology Laboratory, Center for Human Genetic Research, Departments of Neurology & Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

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http://dx.doi.org/10.1074/jbc.M116.734426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114423PMC
November 2016

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Stem Cell Reports 2016 09 1;7(3):325-340. Epub 2016 Sep 1.

Department of Neurology, Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032560PMC
September 2016

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

ACS Med Chem Lett 2016 Sep 14;7(9):852-6. Epub 2016 Jul 14.

Chemical Biology Program, The Broad Institute of Harvard and MIT , 415 Main Street, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018862PMC
September 2016

Insights into neuroepigenetics through human histone deacetylase PET imaging.

Sci Transl Med 2016 08;8(351):351ra106

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf7551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784409PMC
August 2016

Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.

Mol Cell Neurosci 2016 06 28;73:104-15. Epub 2016 Jan 28.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States; Center for Experimental Drugs & Diagnostics, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.mcn.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292010PMC
June 2016

Stem cell models of neuropsychiatric disorders.

Mol Cell Neurosci 2016 06 21;73:1-2. Epub 2016 Mar 21.

Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United States; Center for Experimental Drugs & Diagnostics, Departments of Psychiatry & Neurology, Massachusetts General Hospital, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.mcn.2016.03.007DOI Listing
June 2016

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.

Bioorg Med Chem Lett 2016 Feb 11;26(4):1265-1271. Epub 2016 Jan 11.

Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753070PMC
February 2016

Epigenetic diagnostics for neuropsychiatric disorders: Above the genome.

Neurology 2015 Apr 25;84(16):1618-9. Epub 2015 Mar 25.

From the Departments of Neurology & Psychiatry and the Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital & Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000001505DOI Listing
April 2015

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells.

ACS Chem Biol 2015 Mar 8;10(3):883-90. Epub 2015 Jan 8.

†Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/cb500838rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372110PMC
March 2015

In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.

J Med Chem 2014 Oct 18;57(19):7999-8009. Epub 2014 Sep 18.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , 73 High Street, Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/jm500872pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191584PMC
October 2014

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.

Proc Natl Acad Sci U S A 2014 Oct 7;111(42):E4468-77. Epub 2014 Oct 7.

Molecular Neurogenetics Unit and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114; Departments of Neurology and Broad Institute of M.I.T. and Harvard, Cambridge, MA 02142

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http://dx.doi.org/10.1073/pnas.1405266111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210312PMC
October 2014

β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.

Proc Natl Acad Sci U S A 2014 Jul 23;111(27):9947-52. Epub 2014 Jun 23.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139; and

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http://dx.doi.org/10.1073/pnas.1309426111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103343PMC
July 2014

Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models.

Biol Psychiatry 2014 Jun 19;75(12):952-60. Epub 2013 Jul 19.

Center for Human Genetic Research; Center for Experimental Drugs and Diagnostics (SJH, RHP),; Departments of Psychiatry.

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http://dx.doi.org/10.1016/j.biopsych.2013.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815991PMC
June 2014

A polygenic burden of rare disruptive mutations in schizophrenia.

Nature 2014 Feb 22;506(7487):185-90. Epub 2014 Jan 22.

1] Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [3] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature12975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136494PMC
February 2014

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

Cell 2014 Jan;156(1-2):261-76

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986862PMC
January 2014

Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.

Am J Nucl Med Mol Imaging 2013 15;4(1):29-38. Epub 2013 Dec 15.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867727PMC
December 2013

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.

Neurosci Lett 2013 Aug 25;550:119-24. Epub 2013 Jun 25.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neulet.2013.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750730PMC
August 2013

Class I HDAC imaging using [ (3)H]CI-994 autoradiography.

Epigenetics 2013 Jul 11;8(7):756-64. Epub 2013 Jun 11.

Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.4161/epi.25202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781195PMC
July 2013

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation.

Nat Neurosci 2013 Apr 10;16(4):434-40. Epub 2013 Mar 10.

Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.3354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609040PMC
April 2013

Regulation of primitive hematopoiesis by class I histone deacetylases.

Dev Dyn 2013 Feb;242(2):108-21

Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/dvdy.23906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553261PMC
February 2013

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors.

J Biomol Screen 2012 Oct 24;17(9):1252-63. Epub 2012 Aug 24.

Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1177/1087057112456876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903585PMC
October 2012

PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation.

J Cell Sci 2012 May 17;125(Pt 9):2276-87. Epub 2012 Feb 17.

Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1242/jcs.099192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367942PMC
May 2012

Brain-penetrant LSD1 inhibitors can block memory consolidation.

ACS Chem Neurosci 2012 Feb 18;3(2):120-128. Epub 2011 Oct 18.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.

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http://pubs.acs.org/doi/10.1021/cn200104y
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http://dx.doi.org/10.1021/cn200104yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382965PMC
February 2012

Emerging roles of epigenetic mechanisms in Parkinson's disease.

Funct Integr Genomics 2011 Dec 4;11(4):523-37. Epub 2011 Sep 4.

Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics and Center of Excellence in Biomathematics, University of Tehran, Tehran, Iran.

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http://dx.doi.org/10.1007/s10142-011-0246-zDOI Listing
December 2011

Synapse microarray identification of small molecules that enhance synaptogenesis.

Nat Commun 2011 Oct 25;2:510. Epub 2011 Oct 25.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/ncomms1518
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http://dx.doi.org/10.1038/ncomms1518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544154PMC
October 2011

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity.

Neurobiol Learn Mem 2011 Jul 27;96(1):41-52. Epub 2011 Apr 27.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.nlm.2011.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188418PMC
July 2011

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

Hum Mol Genet 2011 Jun 29;20(12):2344-55. Epub 2011 Mar 29.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddr127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098733PMC
June 2011

Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma.

Chem Biol 2010 Nov;17(11):1177-82

Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.chembiol.2010.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044442PMC
November 2010

Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.

Proc Natl Acad Sci U S A 2010 Oct 11;107(43):18342-7. Epub 2010 Oct 11.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1005372107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972960PMC
October 2010

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

Neuropsychopharmacology 2010 Mar 9;35(4):870-80. Epub 2009 Dec 9.

Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1038/npp.2009.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055373PMC
March 2010

Rapid behavior-based identification of neuroactive small molecules in the zebrafish.

Nat Chem Biol 2010 Mar 17;6(3):231-237. Epub 2010 Jan 17.

[1] Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. [2] Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834185PMC
March 2010

Chemical phylogenetics of histone deacetylases.

Nat Chem Biol 2010 Mar 7;6(3):238-243. Epub 2010 Feb 7.

[1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Chemical Biology Program, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822059PMC
March 2010

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.

ACS Chem Neurosci 2010 Jan;1(4):325-342

Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1021/cn900046aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873204PMC
January 2010

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.

Neuron 2008 Dec;60(5):803-17

Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2008.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912147PMC
December 2008

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

Neuron 2007 Nov;56(3):517-29

Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.09.032DOI Listing
November 2007

Detecting binding interactions using microarrays of natural product extracts.

J Am Chem Soc 2007 Sep 24;129(37):11346-7. Epub 2007 Aug 24.

Department of Biological Chemistry, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ja073965sDOI Listing
September 2007

Revealing complex traits with small molecules and naturally recombinant yeast strains.

Chem Biol 2006 Mar;13(3):319-27

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210600045
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http://dx.doi.org/10.1016/j.chembiol.2006.01.010DOI Listing
March 2006

SpectralNET--an application for spectral graph analysis and visualization.

BMC Bioinformatics 2005 Oct 19;6:260. Epub 2005 Oct 19.

The Broad Institute of MIT & Harvard University, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.1186/1471-2105-6-260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276787PMC
October 2005

The principle of complementarity: chemical versus biological space.

Curr Opin Chem Biol 2005 Jun;9(3):296-303

Eli & Edythe L Broad Institute, 320 Charles Street, Cambridge, MA 02141, USA.

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http://dx.doi.org/10.1016/j.cbpa.2005.04.006DOI Listing
June 2005

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.

Proc Natl Acad Sci U S A 2004 Nov 11;101(47):16594-9. Epub 2004 Nov 11.

Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0407117101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC527135PMC
November 2004

Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.

Comb Chem High Throughput Screen 2004 Nov;7(7):669-76

The Eli and Edythe L. Broad Institute, Massachusetts Institute of Technology and Harvard University, 320 Charles Street, Cambridge, MA 02141, USA.

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November 2004