Stephen J Fowler

Stephen J Fowler

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Stephen J Fowler

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Circadian rhythm of exhaled biomarkers in health and asthma.

Eur Respir J 2019 Oct 17;54(4). Epub 2019 Oct 17.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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http://dx.doi.org/10.1183/13993003.01068-2019DOI Listing
October 2019

Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma.

J Allergy Clin Immunol 2019 Sep 17;144(3):788-795.e1. Epub 2019 Jan 17.

Division of Infection, Immunity and Respiratory Medicine, University of Manchester, and the Manchester Academic Health Science Centre, Manchester, United Kingdom; NHS Foundation Trust, University of Manchester, Manchester, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193003
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http://dx.doi.org/10.1016/j.jaci.2018.11.050DOI Listing
September 2019

Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma.

Eur Respir J 2019 Sep 12. Epub 2019 Sep 12.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.

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http://dx.doi.org/10.1183/13993003.00544-2019DOI Listing
September 2019

Breath biomarkers in asthma: we're getting answers, but what are the important questions?

Eur Respir J 2019 Sep 29;54(3). Epub 2019 Sep 29.

Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01411-2019DOI Listing
September 2019

The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review.

J Breath Res 2019 Jun 24;13(3):036015. Epub 2019 Jun 24.

Norwich Medical School, University of East Anglia, Norwich, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/ab1284DOI Listing
June 2019

Investigating the safety of capsaicin cough challenge in severe asthma.

Clin Exp Allergy 2019 Jun 16;49(6):932-934. Epub 2019 Apr 16.

Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13392
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http://dx.doi.org/10.1111/cea.13392DOI Listing
June 2019

Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study.

Am J Physiol Lung Cell Mol Physiol 2019 May 13;316(5):L751-L756. Epub 2019 Feb 13.

Department of Intensive Care, Amsterdam University Medical Center-Academic Medical Centre , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00449.2018DOI Listing
May 2019

Burden of fungal asthma in Africa: A systematic review and meta-analysis.

PLoS One 2019 16;14(5):e0216568. Epub 2019 May 16.

The National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521988PMC
May 2019

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives.

Am J Respir Crit Care Med 2019 Apr;199(7):823-829

2 Allergy, Pulmonary, and Critical Care Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

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http://dx.doi.org/10.1164/rccm.201809-1817PPDOI Listing
April 2019

Heliox for inducible laryngeal obstruction (vocal cord dysfunction): A systematic literature review.

Laryngoscope Investig Otolaryngol 2019 Apr 8;4(2):255-258. Epub 2019 Feb 8.

Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester and University Hospital of South Manchester, NHS Foundation Trust Manchester United Kingdom.

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http://dx.doi.org/10.1002/lio2.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476266PMC
April 2019

Exhaled breath testing - A tool for the clinician and researcher.

Paediatr Respir Rev 2019 Feb 17;29:37-41. Epub 2018 May 17.

VCU Health, Department of Emergency Medicine, Adult Emergency Department, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.05.002DOI Listing
February 2019

Sex and intimacy in people with severe asthma: a qualitative study.

BMJ Open Respir Res 2019 12;6(1):e000382. Epub 2019 Feb 12.

Respiratory Medicine, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1136/bmjresp-2018-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424302PMC
February 2019

Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review.

Respir Res 2019 Jan 11;20(1). Epub 2019 Jan 11.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0971-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329167PMC
January 2019

Two pathways, one patient; UK asthma guidelines.

Thorax 2018 09 3;73(9):797-798. Epub 2018 May 3.

Respiratory Research Unit, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211703DOI Listing
September 2018

Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa.

Analyst 2018 Jul 7;143(13):3148-3155. Epub 2018 Jun 7.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. and Manchester Academic Health Science Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1039/c8an00759dDOI Listing
July 2018

Clinical presentation, assessment, and management of inducible laryngeal obstruction.

Curr Opin Otolaryngol Head Neck Surg 2018 Jun;26(3):174-179

Department of Respiratory Medicine, North West Lung Centre, Wythenshawe Hospital, Manchester University National Health Service Foundation Trust, Manchester.

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http://Insights.ovid.com/crossref?an=00020840-900000000-9927
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http://dx.doi.org/10.1097/MOO.0000000000000452DOI Listing
June 2018

Reclassification of Bronchodilator Reversibility in the U-BIOPRED Adult Asthma Cohort Using z Scores.

Chest 2018 04;153(4):1070-1072

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183025
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http://dx.doi.org/10.1016/j.chest.2017.10.051DOI Listing
April 2018

TD/GC-MS analysis of volatile markers emitted from mono- and co-cultures of and in artificial sputum.

Metabolomics 2018 26;14(5):66. Epub 2018 Apr 26.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://link.springer.com/10.1007/s11306-018-1357-5
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http://dx.doi.org/10.1007/s11306-018-1357-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920131PMC
April 2018

The potential role of exhaled breath analysis in the diagnostic process of pneumonia-a systematic review.

J Breath Res 2018 02 6;12(2):024001. Epub 2018 Feb 6.

Department of Intensive Care, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1088/1752-7163/aaa499DOI Listing
February 2018

Headspace volatile organic compounds from bacteria implicated in ventilator-associated pneumonia analysed by TD-GC/MS.

J Breath Res 2018 01 3;12(2):026002. Epub 2018 Jan 3.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. Philips Research, Royal Philips B.V., Eindhoven, The Netherlands. School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/aa8efcDOI Listing
January 2018

Breath analysis for label-free characterisation of airways disease.

Authors:
Stephen J Fowler

Eur Respir J 2018 01 11;51(1). Epub 2018 Jan 11.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02586
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http://dx.doi.org/10.1183/13993003.02586-2017DOI Listing
January 2018

The interaction between bronchoconstriction and cough in asthma.

Thorax 2017 12 24;72(12):1144-1146. Epub 2017 Feb 24.

Division of Infection, Immunity and Respiratory Medicine, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2016-209625DOI Listing
December 2017

Exhaled Volatile Organic Compounds of Infection: A Systematic Review.

ACS Infect Dis 2017 10 13;3(10):695-710. Epub 2017 Sep 13.

Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, The University of Manchester , Oxford Road, Manchester, M13 9PL, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00088DOI Listing
October 2017

Exhaled breath analysis: a review of 'breath-taking' methods for off-line analysis.

Metabolomics 2017 19;13(10):110. Epub 2017 Aug 19.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s11306-017-1241-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563344PMC
August 2017

Perspectives of patients and healthcare professionals on mHealth for asthma self-management.

Eur Respir J 2017 05 1;49(5). Epub 2017 May 1.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1183/13993003.01966-2016DOI Listing
May 2017

Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.

J Allergy Clin Immunol 2017 Mar 15;139(3):771-779.e10. Epub 2016 Jun 15.

Centre for Respiratory Medicine and Allergy, University of Manchester and Manchester Academic Health Science Centre, Manchester, United Kingdom; University Hospital of South Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.04.045DOI Listing
March 2017

A pilot study to investigate the use of serum inhaled corticosteroid concentration as a potential marker of treatment adherence in severe asthma.

J Allergy Clin Immunol 2017 03 11;139(3):1037-1039.e1. Epub 2016 Oct 11.

University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749163112
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http://dx.doi.org/10.1016/j.jaci.2016.08.037DOI Listing
March 2017

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate.

J Breath Res 2017 02 10;11(1):016011. Epub 2017 Feb 10.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/aa5a8aDOI Listing
February 2017

Laryngeal Dysfunction: Assessment and Management for the Clinician.

Am J Respir Crit Care Med 2016 11;194(9):1062-1072

6 Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester, United Kingdom; and.

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http://dx.doi.org/10.1164/rccm.201606-1249CIDOI Listing
November 2016

Breathomics in the setting of asthma and chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2016 10 31;138(4):970-976. Epub 2016 Aug 31.

Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.08.004DOI Listing
October 2016

Dysfunctional breathing: a review of the literature and proposal for classification.

Eur Respir Rev 2016 Sep;25(141):287-94

Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK

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http://dx.doi.org/10.1183/16000617.0088-2015DOI Listing
September 2016

Reduction in peripheral blood eosinophil counts after bronchial thermoplasty.

J Allergy Clin Immunol 2016 07 4;138(1):308-310.e2. Epub 2016 Mar 4.

University Hospital of South Manchester, NHS Foundation Trust, Manchester, United Kingdom; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester and University Hospital of South Manchester, NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.11.044DOI Listing
July 2016

Objective Cough Frequency, Airway Inflammation, and Disease Control in Asthma.

Chest 2016 06 10;149(6):1460-6. Epub 2016 Mar 10.

Centre for Respiratory Medicine and Allergy, University of Manchester, and Manchester Academic Health Science Centre, Manchester, England; University Hospital of South Manchester NHS Foundation Trust, Manchester, England. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.02.676DOI Listing
June 2016

Electronic cigarette exposure triggers neutrophil inflammatory responses.

Respir Res 2016 05 17;17(1):56. Epub 2016 May 17.

Manchester Academic Health and Science Centre, University Hospital of South Manchester Foundation Trust, Centre for Respiratory and Allergy Medicine, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-016-0368-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869345PMC
May 2016

Detecting laryngopharyngeal reflux in patients with upper airways symptoms: Symptoms, signs or salivary pepsin?

Respir Med 2015 Aug 22;109(8):963-9. Epub 2015 May 22.

Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK; The University of Manchester, Manchester Academic Health Science Centre, NIHR South Manchester Respiratory and Allergy Clinical Research Facility, University Hospital of South Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2015.05.019DOI Listing
August 2015

Interventions for bronchiectasis: an overview of Cochrane systematic reviews.

Cochrane Database Syst Rev 2015 Jul 14(7):CD010337. Epub 2015 Jul 14.

Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

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http://dx.doi.org/10.1002/14651858.CD010337.pub2DOI Listing
July 2015

Surveillance for lower airway pathogens in mechanically ventilated patients by metabolomic analysis of exhaled breath: a case-control study.

Thorax 2015 Apr 6;70(4):320-5. Epub 2015 Feb 6.

Manchester Academic Health Science Centre, and NIHR Respiratory and Allergy Clinical Research Facility, University of Manchester, University Hospital of South Manchester, Manchester, UK Salford Royal Hospitals NHS Foundation Trust, Salford, UK.

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http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2014-206273
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http://dx.doi.org/10.1136/thoraxjnl-2014-206273DOI Listing
April 2015

High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

J Allergy Clin Immunol 2015 Mar 30;135(3):822-4.e2. Epub 2014 Oct 30.

University of Manchester, Manchester Academic Health Science Centre, and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.09.034DOI Listing
March 2015

Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

Chron Respir Dis 2015 Feb 9;12(1):69-77. Epub 2014 Dec 9.

Manchester Academic Health Science Centre, University Hospital of South Manchester, University of Manchester, Southmoor Road, Manchester, UK.

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http://dx.doi.org/10.1177/1479972314562210DOI Listing
February 2015

Taking your breath away: metabolomics breathes life in to personalized medicine.

Trends Biotechnol 2014 Oct 29;32(10):538-48. Epub 2014 Aug 29.

University of Manchester, Manchester Academic Health Science Centre, NIHR Respiratory and Allergy Clinical Research Facility, University Hospital of South Manchester, Manchester, UK; Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2014.08.003DOI Listing
October 2014

Inhaled hyperosmolar agents for bronchiectasis.

Cochrane Database Syst Rev 2014 May 12(5):CD002996. Epub 2014 May 12.

Lancaster Medical School, Clinical Research Hub, Lancaster University, Lancaster, Lancashire, UK, LA1 4TB.

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http://dx.doi.org/10.1002/14651858.CD002996.pub3DOI Listing
May 2014

Exhaled volatile organic compounds for phenotyping chronic obstructive pulmonary disease: a cross-sectional study.

Respir Res 2012 Aug 23;13:72. Epub 2012 Aug 23.

Respiratory Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Southmoor Road, Manchester M23 9LT, UK.

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http://dx.doi.org/10.1186/1465-9921-13-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514190PMC
August 2012

Non-invasive phenotyping using exhaled volatile organic compounds in asthma.

Thorax 2011 Sep 11;66(9):804-9. Epub 2011 Jul 11.

Respiratory Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/thx.2010.156695DOI Listing
September 2011

Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers.

Analyst 2010 Feb 5;135(2):315-20. Epub 2010 Jan 5.

Respiratory Research Group, Manchester Academic Health Science Centre, University of Manchester, Wythenshawe Hospital, Manchester, UK.

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http://dx.doi.org/10.1039/b916374cDOI Listing
February 2010

Long-term effects of allergen sensitization and exposure in adult asthma: a prospective study.

World Allergy Organ J 2009 May;2(5):83-90

From the 1University of Manchester, Manchester, United Kingdom; and 2Lancashire Teaching Hospitals NHS Trust, Preston, United Kingdom.

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http://dx.doi.org/10.1097/WOX.0b013e3181a45f96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651019PMC
May 2009

Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma.

Am J Respir Med 2003 ;2(5):433-8

Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

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March 2004

A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics.

Br J Clin Pharmacol 2003 Jun;55(6):609-15

Asthma & Allergy Research Group, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884256PMC
http://dx.doi.org/10.1046/j.1365-2125.2003.01813.xDOI Listing
June 2003

Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis.

Ann Allergy Asthma Immunol 2003 Feb;90(2):194-8

Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/S1081-1206(10)62140-0DOI Listing
February 2003

Relationship of skin-prick reactivity to aeroallergens and hyperresponsiveness to challenges with methacholine and adenosine monophosphate.

Allergy 2003 Jan;58(1):46-52

Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Scotland.

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http://dx.doi.org/10.1034/j.1398-9995.2003.23779.xDOI Listing
January 2003

Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate.

Chest 2002 Aug;122(2):618-23

Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1378/chest.122.2.618DOI Listing
August 2002

Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma.

Chest 2002 Jul;122(1):151-9

Asthma and Allergy Research Group, Section of Vascular Medicine & Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1378/chest.122.1.151DOI Listing
July 2002

Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone.

J Allergy Clin Immunol 2002 Jun;109(6):929-35

Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutic, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

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http://dx.doi.org/10.1067/mai.2002.123869DOI Listing
June 2002

5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists.

Eur J Clin Pharmacol 2002 Jun 17;58(3):187-90. Epub 2002 May 17.

Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00228-002-0458-1DOI Listing
June 2002