Stephen Hanessian

Stephen Hanessian

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Stephen Hanessian

Stephen Hanessian

Publications by authors named "Stephen Hanessian"

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Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras.

J Org Chem 2020 Mar 5;85(6):4237-4247. Epub 2020 Mar 5.

Department of Chemistry, Université de Montréal, Station Centre-Ville, C.P. 6128, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/acs.joc.9b03413DOI Listing
March 2020

Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.

Bioorg Med Chem Lett 2019 Sep 19;29(18):2681-2685. Epub 2019 Jul 19.

Department of Developmental and Cell Biology, University of California, Irvine, 2128 Natural Sciences 1, CA 92697-2300, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.07.023DOI Listing
September 2019

Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs.

Nucleosides Nucleotides Nucleic Acids 2019 Aug 5:1-23. Epub 2019 Aug 5.

a Department of Chemistry, Université de Montréal , Downtown Station , Montréal , P.O. Box 6128 , Canada QC H3C 3J7.

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http://dx.doi.org/10.1080/15257770.2019.1646916DOI Listing
August 2019

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines.

Org Lett 2019 Jun 26. Epub 2019 Jun 26.

Department of Chemistry , Université de Montréal , P.O. Box 6128, Succ., Centre-ville, Montréal , Québec , Canada H3C 3J7.

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http://dx.doi.org/10.1021/acs.orglett.9b01842DOI Listing
June 2019

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.

Mol Cell Proteomics 2019 03 27;18(3):408-422. Epub 2018 Nov 27.

From the ‡Institute for Research in Immunology and Cancer, Université de Montréal, C.P. 6128, Succursale centre-ville, Montréal, Québec, H3C 3J7, Canada;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA118.001053
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http://dx.doi.org/10.1074/mcp.RA118.001053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398214PMC
March 2019

Synthesis of 1',2'-methano-2',3'-dideoxynucleosides as potential antivirals.

Bioorg Med Chem Lett 2019 02 24;29(4):597-600. Epub 2018 Dec 24.

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.12.054DOI Listing
February 2019

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.

Eur J Med Chem 2018 Nov 21;159:217-242. Epub 2018 Sep 21.

Department of Developmental and Cell Biology, University of California, Irvine, 2128 Natural Sciences 1, CA, 92697-2300, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183081
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http://dx.doi.org/10.1016/j.ejmech.2018.09.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217821PMC
November 2018

Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs.

Org Lett 2018 09 27;20(17):5296-5299. Epub 2018 Aug 27.

Department of Chemistry , Université de Montréal , P.O. Box 6128, Downtown Station , Montréal , QC H3C 3J7 , Canada.

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http://dx.doi.org/10.1021/acs.orglett.8b02233DOI Listing
September 2018

Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.

ChemMedChem 2018 08 4;13(15):1541-1548. Epub 2018 Jul 4.

Graduate School of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554, Tokyo, Japan.

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http://dx.doi.org/10.1002/cmdc.201800166DOI Listing
August 2018

Design and synthesis of bridged piperidine and piperazine isosteres.

Bioorg Med Chem Lett 2018 08 19;28(15):2627-2630. Epub 2018 Jun 19.

Department of Chemistry, Université de Montréal, Station Centre-Ville, C.P. 6128 Montréal, QC H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.06.038DOI Listing
August 2018

Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma.

Bioorg Med Chem Lett 2018 08 1;28(15):2652-2654. Epub 2018 Jun 1.

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.06.002DOI Listing
August 2018

Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2.

Org Lett 2018 07 5;20(14):4277-4280. Epub 2018 Jul 5.

Department of Chemistry , Université de Montréal , P.O. Box 6128, Succ., Centre-ville, Montréal , Québec , Canada , H3C 3J7.

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http://pubs.acs.org/doi/10.1021/acs.orglett.8b01701
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http://dx.doi.org/10.1021/acs.orglett.8b01701DOI Listing
July 2018

Recent Progress in the Chemistry of Daphniphyllum Alkaloids †.

Chem Rev 2017 Mar 16;117(5):4104-4146. Epub 2017 Feb 16.

Department of Chemistry, Université de Montréal , Post Office Box 6128, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/acs.chemrev.6b00412DOI Listing
March 2017

Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT receptor ligands with significant selectivity for D over D receptors.

Bioorg Med Chem 2017 01 12;25(1):38-52. Epub 2016 Oct 12.

Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montréal, Que. H3C 3J7, Canada.

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http://dx.doi.org/10.1016/j.bmc.2016.10.010DOI Listing
January 2017

Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex.

Org Lett 2016 07 15;18(13):3106-9. Epub 2016 Jun 15.

Department of Chemistry, Université de Montréal , P.O. Box 6128, Succ., Centre-ville, Montréal, Québec, Canada , H3C 3J7.

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http://dx.doi.org/10.1021/acs.orglett.6b01263DOI Listing
July 2016

Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs.

Bioorg Med Chem 2016 06 29;24(11):2397-409. Epub 2016 Mar 29.

Department of Chemistry, Université de Montréal, PO Box 6128, Succ., Centre-ville, Montréal, Québec H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.03.047DOI Listing
June 2016

Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis.

J Org Chem 2016 06 2;81(12):5074-86. Epub 2016 Jun 2.

Department of Chemistry, Université de Montréal , Station Centre Ville, C.P. 6128, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/acs.joc.6b00638DOI Listing
June 2016

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

Angew Chem Int Ed Engl 2016 Mar 2;55(13):4156-86. Epub 2016 Feb 2.

Department of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA.

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http://dx.doi.org/10.1002/anie.201507549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865016PMC
March 2016

Synthesis of a Model Tetracyclic Core Structure of Calyciphylline B-Type Alkaloids.

J Org Chem 2016 Mar 15;81(5):2182-8. Epub 2016 Feb 15.

Department of Chemistry, Université de Montréal , Station Centre Ville, C.P. 6128, Montreal, QC, H3C 3J7, Canada.

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http://pubs.acs.org/doi/10.1021/acs.joc.5b02875
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http://dx.doi.org/10.1021/acs.joc.5b02875DOI Listing
March 2016

Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA.

Org Biomol Chem 2016 Feb;14(6):2034-40

Department of Chemistry, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1039/c5ob02576aDOI Listing
February 2016

Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum.

Angew Chem Int Ed Engl 2016 Feb 14;55(7):2577-81. Epub 2016 Jan 14.

Department of Chemistry, Université de Montréal, Station Centre Ville, C.P. 6128, Montréal, Qc, H3C 3J7, Canada.

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http://dx.doi.org/10.1002/anie.201510861DOI Listing
February 2016

Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes.

ACS Med Chem Lett 2016 Jan 22;7(1):6-9. Epub 2015 Dec 22.

Department of Chemistry, Université de Montréal, Pavillon R. Gaudry, FAS-Chimie , CP 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716587PMC
January 2016

Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer.

Angew Chem Int Ed Engl 2015 Nov 8;54(45):13268-72. Epub 2015 Sep 8.

Department of Chemistry, Université de Montréal, Station Centre-Ville, C.P. 6128, Montreal, QC, H3C 3J7 (Canada).

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http://dx.doi.org/10.1002/anie.201506208DOI Listing
November 2015

Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods.

Chem Commun (Camb) 2015 Nov;51(92):16437-49

Department of Chemistry, Université de Montréal, Station Centre Ville, C.P. 6128, Montreal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1039/c5cc05891kDOI Listing
November 2015

Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis.

Chem Commun (Camb) 2015 Nov;51(92):16450-67

Department of Chemistry, Université de Montréal, Station Centre Ville, C. P. 6128, Montréal, Qc H3C 3J7, Canada.

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http://dx.doi.org/10.1039/c5cc05892aDOI Listing
November 2015

Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences.

J Org Chem 2014 Dec 17;79(23):11651-60. Epub 2014 Nov 17.

Department of Chemistry, Université de Montréal , Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo502320yDOI Listing
December 2014

Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren.

J Org Chem 2014 Oct 6;79(20):9531-45. Epub 2014 Oct 6.

Department of Chemistry, Université de Montréal , CP6128 Succursale A, Centre-ville, Montréal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo5015195DOI Listing
October 2014

Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs.

ACS Chem Biol 2014 Sep 14;9(9):2067-73. Epub 2014 Jul 14.

Department of Chemistry, Université de Montréal , CP 6128 Succ. Centre-Ville, Montréal, Québec H3C3J7, Canada.

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http://dx.doi.org/10.1021/cb5003416DOI Listing
September 2014

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules.

Beilstein J Org Chem 2014 13;10:1848-77. Epub 2014 Aug 13.

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.3762/bjoc.10.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168934PMC
September 2014

Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes.

Org Lett 2014 May 7;16(10):2668-71. Epub 2014 May 7.

Department of Chemistry, Université de Montréal , C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol500902pDOI Listing
May 2014

Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists.

ACS Med Chem Lett 2014 May 13;5(5):550-5. Epub 2014 Feb 13.

Neuroscience Chemistry Research Unit, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.

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http://dx.doi.org/10.1021/ml400528yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027792PMC
May 2014

Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products.

Org Lett 2014 Jan 16;16(1):232-5. Epub 2013 Dec 16.

Department of Chemistry, Université de Montréal , Station Centre Ville, C.P. 6128, Montreal, Quebec, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol403229qDOI Listing
January 2014

Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.

Bioorg Med Chem Lett 2014 Jan 15;24(2):510-4. Epub 2013 Dec 15.

Neuroscience Chemistry Research Unit, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.

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http://dx.doi.org/10.1016/j.bmcl.2013.12.033DOI Listing
January 2014

Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).

ACS Med Chem Lett 2013 Oct;4(10)

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-Ville, Montréal, Que., H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ml4002425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834958PMC
October 2013

Studies toward the generation of functionalized quaternary carbon centers relying on Wittig and Wittig-Still allylic ether anionic transpositions.

J Org Chem 2013 Sep 20;78(17):8915-21. Epub 2013 Aug 20.

Department of Chemistry, Université de Montréal, Station Centre-Ville, C.P. 6128, Montreal, Qc, H3C 3J7, Canada.

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http://pubs.acs.org/doi/10.1021/jo401488y
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http://dx.doi.org/10.1021/jo401488yDOI Listing
September 2013

A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability.

J Org Chem 2013 Sep 4;78(18):9064-75. Epub 2013 Sep 4.

Department of Chemistry, Université de Montréal , Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo401170yDOI Listing
September 2013

Synthesis of cis- and trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides.

J Org Chem 2013 Sep 4;78(18):9051-63. Epub 2013 Sep 4.

Department of Chemistry, Université de Montréal , Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo401166qDOI Listing
September 2013

Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C.

Org Lett 2013 Aug 26;15(16):4134-7. Epub 2013 Jul 26.

Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville, Montreal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol4018112DOI Listing
August 2013

Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites.

ChemMedChem 2013 May 21;8(5):733-9. Epub 2013 Feb 21.

Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan.

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http://dx.doi.org/10.1002/cmdc.201200579DOI Listing
May 2013

Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.

Bioorg Med Chem 2013 Apr 31;21(7):1775-86. Epub 2013 Jan 31.

Department of Chemistry, Université de Montréal, Station Centre Ville, CP 6128, Montréal, Qc, Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmc.2013.01.037DOI Listing
April 2013

Total synthesis of pactamycin and pactamycate: a detailed account.

J Org Chem 2012 Nov 19;77(21):9458-72. Epub 2012 Oct 19.

Department of Chemistry, Université de Montréal, Montreal, Quebec, Canada H3C 3J7.

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http://dx.doi.org/10.1021/jo301638zDOI Listing
November 2012

The enterprise of synthesis: from concept to practice.

J Org Chem 2012 Aug 11;77(16):6657-88. Epub 2012 Jul 11.

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo300902mDOI Listing
August 2012

A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones.

Org Lett 2012 Jun 5;14(12):3222-5. Epub 2012 Jun 5.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://pubs.acs.org/doi/10.1021/ol301332f
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http://dx.doi.org/10.1021/ol301332fDOI Listing
June 2012

Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation.

Org Lett 2011 Dec 15;13(24):6476-9. Epub 2011 Nov 15.

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, Canada, H3C 3J7.

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http://dx.doi.org/10.1021/ol2027703DOI Listing
December 2011

Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.

ChemMedChem 2011 Nov 8;6(11):1961-6. Epub 2011 Sep 8.

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1002/cmdc.201100346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179253PMC
November 2011

Total synthesis of pactamycin.

Angew Chem Int Ed Engl 2011 Apr 2;50(15):3497-500. Epub 2011 Mar 2.

Department of Chemistry, Université de Montréal, Station Centre Ville, C.P. 6128, Montreal, Qc, H3C 3J7, Canada.

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http://dx.doi.org/10.1002/anie.201008079DOI Listing
April 2011

Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors.

Org Lett 2011 Mar 27;13(5):840-3. Epub 2011 Jan 27.

Department of Chemistry, Université de Montréal, Montreal, QC, Canada.

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http://dx.doi.org/10.1021/ol102795gDOI Listing
March 2011

Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791.

Org Lett 2011 Mar 27;13(5):1048-51. Epub 2011 Jan 27.

Department of Chemistry, Université de Montréal, Montreal, QC, Canada.

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http://dx.doi.org/10.1021/ol103094jDOI Listing
March 2011

Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa.

Bioorg Med Chem Lett 2010 Dec 8;20(23):6925-8. Epub 2010 Oct 8.

Department of Chemistry, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.141DOI Listing
December 2010

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

J Med Chem 2010 Dec 12;53(23):8387-99. Epub 2010 Nov 12.

Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville, Montréal, QC, H3C 3J7 Canada.

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http://dx.doi.org/10.1021/jm101092uDOI Listing
December 2010

Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit.

J Org Chem 2010 Aug;75(16):5601-18

Department of Chemistry, Université de Montréal, Canada H3C 3J7.

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http://dx.doi.org/10.1021/jo100956vDOI Listing
August 2010

Total synthesis of jerangolid A.

Org Lett 2010 Jul;12(14):3172-5

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol101103qDOI Listing
July 2010

Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics.

J Org Chem 2010 May;75(9):2861-76

Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo100017tDOI Listing
May 2010

Vorinostat-like molecules as structural, stereochemical, and pharmacological tools.

ACS Med Chem Lett 2010 May 11;1(2):70-4. Epub 2010 Mar 11.

Sigma-Tau Research & Development, Via Pontina Km 30.400, I-00040 Pomezia, Roma, Italy.

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http://dx.doi.org/10.1021/ml100028gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007911PMC
May 2010

Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension.

Org Lett 2010 Apr;12(8):1816-9

Department of Chemistry, Universite de Montreal, C.P. 6128, Succ. Centre-Ville, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol100427vDOI Listing
April 2010

Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.

Bioorg Med Chem Lett 2010 Mar 2;20(6):1924-7. Epub 2010 Feb 2.

Department of Chemistry, Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.139DOI Listing
March 2010

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin.

Chem Commun (Camb) 2010 Mar 15;46(12):2013-5. Epub 2010 Feb 15.

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, Canada H3C 3J7.

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http://dx.doi.org/10.1039/b925668gDOI Listing
March 2010

Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F.

Org Lett 2009 Oct;11(20):4640-3

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol901896cDOI Listing
October 2009

From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.

Bioorg Med Chem Lett 2009 Sep 26;19(18):5429-32. Epub 2009 Jul 26.

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, P. Q., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.107DOI Listing
September 2009

Total synthesis and structural revision of the presumed aeruginosins 205A and B.

Org Lett 2009 Sep;11(18):4232-5

Department of Chemistry, Universite de Montreal, C. P. 6128, Succ. Centre-Ville, Montreal, P. Q., Canada H3C 3J7.

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http://dx.doi.org/10.1021/ol901702kDOI Listing
September 2009

Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin.

ChemMedChem 2009 Jun;4(6):988-97

Centre Hospitalier Universitaire Vaudois and University of Lausanne, University Institute of Pathology, Rue du Bugnon 25, CH-1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1002/cmdc.200800424DOI Listing
June 2009

Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans.

Org Lett 2009 Jan;11(2):429-32

Department of Chemistry, Universite de Montreal, C. P. 6128, Succ. Centre-Ville, Montreal, P.Q., Canada, H3C 3J7.

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http://dx.doi.org/10.1021/ol802421dDOI Listing
January 2009

The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids.

Acc Chem Res 2008 Oct 23;41(10):1241-51. Epub 2008 Jul 23.

Department of Chemistry, Universite de Montreal, P.O. Box 6128, Station Centre-ville, Montreal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ar8000052DOI Listing
October 2008

Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles.

Org Lett 2008 Apr 4;10(7):1381-4. Epub 2008 Mar 4.

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol703071cDOI Listing
April 2008

Chemistry and biology of the aeruginosin family of serine protease inhibitors.

Angew Chem Int Ed Engl 2008 ;47(7):1202-23

Department of Chemistry, Université de Montréal, C.P. 6128, Station Centre-ville, Montréal, PQ, H3C 3J7, Canada.

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http://dx.doi.org/10.1002/anie.200605219DOI Listing
March 2008

Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs.

Bioorg Med Chem 2008 Mar 31;16(6):2921-31. Epub 2007 Dec 31.

Université de Montréal, Department of Chemistry, PO Box 6128, Station, Centre-ville, Montreal, Que., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmc.2007.12.051DOI Listing
March 2008

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

Bioorg Med Chem Lett 2008 Mar 7;18(6):1972-6. Epub 2008 Feb 7.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Que., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.122DOI Listing
March 2008

Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure.

J Org Chem 2008 Feb 7;73(4):1181-91. Epub 2007 Dec 7.

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo701621cDOI Listing
February 2008

Targeting ACE and ECE with dual acting inhibitors.

Bioorg Med Chem Lett 2008 Feb 10;18(3):1058-62. Epub 2007 Dec 10.

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-Ville, Montréal, QB, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2007.12.013DOI Listing
February 2008

Alternative and expedient asymmetric syntheses of L-(+)-noviose.

Org Lett 2008 Jan 15;10(2):261-4. Epub 2007 Dec 15.

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, QC, H3C 3J7 Canada.

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http://pubs.acs.org/doi/abs/10.1021/ol702655c
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January 2008

Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.

ChemMedChem 2007 Nov;2(11):1631-8

Architecture et Réactivité de l'ARN, Université Louis Pasteur, Institut de Biologie Moléculaire et Cellulaire, CNRS, 15 rue René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1002/cmdc.200700113DOI Listing
November 2007

Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

Bioorg Med Chem Lett 2007 Nov 8;17(22):6261-5. Epub 2007 Sep 8.

Department of Chemistry, Université de Montréal, Station Centre-ville, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.014DOI Listing
November 2007

Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants.

J Org Chem 2007 Aug 21;72(17):6353-63. Epub 2007 Jul 21.

Syngenta, Crop Protection Research, Schwarzwaldallee 215, CH-4002 Basel, Switzerland.

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http://pubs.acs.org/doi/abs/10.1021/jo070520d
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August 2007

6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase.

Bioorg Med Chem Lett 2007 Jun 12;17(11):3221-5. Epub 2007 Mar 12.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, P.Q., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2007.03.014DOI Listing
June 2007

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin.

Bioorg Med Chem Lett 2007 Jun 27;17(12):3480-5. Epub 2007 Mar 27.

Department of Chemistry, Université de Montréal, PO Box 6128, Station, Centre-Ville, Montréal, QC, Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2007.03.075DOI Listing
June 2007

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.

Bioorg Med Chem Lett 2007 Jan 10;17(2):491-4. Epub 2006 Oct 10.

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, Que., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2006.10.014DOI Listing
January 2007

Structure-based organic synthesis of drug prototypes: a personal odyssey.

ChemMedChem 2006 Dec;1(12):1301-30

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, QC, H3C3J7, Canada.

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http://dx.doi.org/10.1002/cmdc.200600203DOI Listing
December 2006

Structure-based organic synthesis of a tricyclic N-malayamycin analogue.

J Org Chem 2006 Dec;71(26):9807-17

Department of Chemistry, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo061904rDOI Listing
December 2006

Total synthesis and stereochemical confirmation of manassantin A, B, and B1.

Org Lett 2006 Nov;8(24):5477-80

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol0621710DOI Listing
November 2006

Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst.

Org Lett 2006 Nov;8(24):5481-4

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/ol062167oDOI Listing
November 2006

A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors.

J Med Chem 2006 Oct;49(20):5885-94

Department of Chemistry, McGill University, 801 Sherbrooke Street W, Montréal, Québec H3A 2K6, Canada.

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http://dx.doi.org/10.1021/jm050138yDOI Listing
October 2006

Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline.

Org Lett 2006 Oct;8(21):4787-90

Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville, Montréal, QC H3C 3J7, Canada.

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http://pubs.acs.org/doi/abs/10.1021/ol0618407
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October 2006

Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.

Glia 2006 Sep;54(4):272-84

Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, CNRS UMR 6184. Université de la Méditerranée, Faculté de Médecine de Marseille, IFR Jean Roche, Pierre Dramard 13916, Marseille cedex 20, France.

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http://doi.wiley.com/10.1002/glia.20349
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http://dx.doi.org/10.1002/glia.20349DOI Listing
September 2006

Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA.

Bioorg Med Chem Lett 2006 Sep 25;16(18):4784-7. Epub 2006 Jul 25.

Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, Que., Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2006.06.090DOI Listing
September 2006

Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design.

J Org Chem 2006 Sep;71(19):7403-11

Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville Montréal, P.Q. H3C 3J7.

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http://dx.doi.org/10.1021/jo061098oDOI Listing
September 2006

Total synthesis and structural confirmation of chlorodysinosin A.

J Am Chem Soc 2006 Aug;128(32):10491-5

Department of Chemistry, Université de Montréal, C.P. 6128, Station Centre-ville, Montréal, P.Q., H3C 3J7 Canada.

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http://dx.doi.org/10.1021/ja0625834DOI Listing
August 2006

Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A.

Org Lett 2006 Aug;8(18):4047-9

Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7 Canada.

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http://pubs.acs.org/doi/abs/10.1021/ol0615230
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August 2006

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE).

J Med Chem 2006 Jul;49(15):4544-67

Department of Chemistry, Université de Montréal, C. P. 6128, Station Centre-ville, Montréal, Quebec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jm060154aDOI Listing
July 2006

Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme.

J Org Chem 2006 Mar;71(7):2760-78

Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, P. Q., Canada H3C 3J7.

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http://dx.doi.org/10.1021/jo052649yDOI Listing
March 2006

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.

Bioorg Med Chem Lett 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, PQ, Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.082DOI Listing
February 2006

Docking of aminoglycosides to hydrated and flexible RNA.

J Med Chem 2006 Feb;49(3):1023-33

Department of Chemistry, McGill University, 801 Sherbrooke Street W, Montréal, Québec H3A 2K6, Canada.

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http://dx.doi.org/10.1021/jm0508437DOI Listing
February 2006

Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates.

Curr Opin Drug Discov Devel 2005 Nov;8(6):798-819

Université de Montréal, Department of Chemistry, CP 6128, Succursale Centre-ville, Montréal, Canada.

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November 2005