Stephen H Hughes

Stephen H Hughes

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Stephen H Hughes

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Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans.

PLoS Pathog 2019 07 10;15(7):e1007869. Epub 2019 Jul 10.

HIV Dynamics and Replication Program, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619828PMC
July 2019

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs.

J Virol 2019 Jun 15;93(11). Epub 2019 May 15.

Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00224-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532099PMC
June 2019

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants.

Antimicrob Agents Chemother 2018 09 27;62(9). Epub 2018 Aug 27.

HIV Dynamics and Replication Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01035-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125528PMC
September 2018

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Cell Host Microbe 2018 09 30;24(3):392-404.e8. Epub 2018 Aug 30.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368089PMC
September 2018

Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.

J Virol 2018 07 13;92(13). Epub 2018 Jun 13.

HIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA

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http://dx.doi.org/10.1128/JVI.02203-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002700PMC
July 2018

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.

Retrovirology 2018 05 16;15(1):37. Epub 2018 May 16.

HIV Dynamics and Replication Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1186/s12977-018-0420-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956922PMC
May 2018

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.

J Med Chem 2017 09 10;60(17):7315-7332. Epub 2017 Aug 10.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601359PMC
September 2017

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.

PLoS Pathog 2017 03 22;13(3):e1006283. Epub 2017 Mar 22.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378418PMC
March 2017

Drug resistant integrase mutants cause aberrant HIV integrations.

Retrovirology 2016 Sep 29;13(1):71. Epub 2016 Sep 29.

HIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute-Frederick, 1050 Boyles Street, Bldg. 539, Room 130A, Frederick, MD, 21702, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041404PMC
http://dx.doi.org/10.1186/s12977-016-0305-6DOI Listing
September 2016

Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.

J Acquir Immune Defic Syndr 2016 08;72(5):485-91

*HIV Dynamics and Replication Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD; †Chemical Biology Laboratory, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD; ‡Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; and §Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/QAI.0000000000001031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942337PMC
August 2016

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.

Nucleic Acids Res 2016 08 1;44(14):6896-906. Epub 2016 Jul 1.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1093/nar/gkw592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001616PMC
August 2016

What Integration Sites Tell Us about HIV Persistence.

Cell Host Microbe 2016 May;19(5):588-98

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.chom.2016.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900157PMC
May 2016

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.

ACS Chem Biol 2016 Apr 5;11(4):1074-81. Epub 2016 Feb 5.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acschembio.5b00948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836387PMC
April 2016

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.

Retrovirology 2016 Feb 16;13:11. Epub 2016 Feb 16.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1186/s12977-016-0244-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833PMC
February 2016

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.

Antimicrob Agents Chemother 2015 Dec 31;59(12):7184-96. Epub 2015 Aug 31.

HIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA

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http://dx.doi.org/10.1128/AAC.05069-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649230PMC
December 2015

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.

Genes Dev 2015 Nov;29(21):2287-97

Section on Eukaryotic Transposable Elements, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA;

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http://dx.doi.org/10.1101/gad.267609.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647561PMC
November 2015

Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients.

Virology 2015 Oct 18;484:127-35. Epub 2015 Jun 18.

HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887144PMC
October 2015

A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.

PLoS One 2014 10;9(10):e108926. Epub 2014 Oct 10.

Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193875PMC
June 2015

Reverse Transcription of Retroviruses and LTR Retrotransposons.

Authors:
Stephen H Hughes

Microbiol Spectr 2015 Apr;3(2):MDNA3-0027-2014

HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles St., Building 539 Rm. 130A, Frederick, MD 21702.

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http://dx.doi.org/10.1128/microbiolspec.MDNA3-0027-2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775776PMC
April 2015

The Integrator complex controls the termination of transcription at diverse classes of gene targets.

Cell Res 2015 Mar 13;25(3):288-305. Epub 2015 Feb 13.

1] Department of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA [2] Howard Hughes Medical Institute, 522 First Avenue New York, NY 10016, USA.

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http://dx.doi.org/10.1038/cr.2015.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349240PMC
March 2015

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.

J Virol 2014 Jul 23;88(13):7589-601. Epub 2014 Apr 23.

HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00302-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054409PMC
July 2014

4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.

J Med Chem 2014 Jun 16;57(12):5190-202. Epub 2014 Jun 16.

Chemical Biology Laboratory, and ‡HIV Drug Resistance Program, Center for Cancer Research, NCI at Frederick, National Institutes of Health , Building 376, Boyles Street, P.O. Box B, Frederick, Maryland 21702, United States.

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http://dx.doi.org/10.1021/jm5001908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216207PMC
June 2014

Discovery of novel inhibitors of HIV-1 reverse transcriptase through virtual screening of experimental and theoretical ensembles.

Chem Biol Drug Des 2014 May 24;83(5):521-31. Epub 2014 Mar 24.

Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093-0365, USA.

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http://dx.doi.org/10.1111/cbdd.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999242PMC
May 2014

Enhancers are major targets for murine leukemia virus vector integration.

J Virol 2014 Apr 5;88(8):4504-13. Epub 2014 Feb 5.

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.00011-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993722PMC
April 2014

Rapid screening of HIV reverse transcriptase and integrase inhibitors.

J Vis Exp 2014 Apr 9(86). Epub 2014 Apr 9.

HIV Drug Resistance Program, National Cancer Institute;

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http://dx.doi.org/10.3791/51400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165338PMC
April 2014

Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.

Virology 2013 Sep 11;444(1-2):241-9. Epub 2013 Jul 11.

HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, PO Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.virol.2013.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804327PMC
September 2013

Treatment with suboptimal doses of raltegravir leads to aberrant HIV-1 integrations.

Proc Natl Acad Sci U S A 2013 Sep 19;110(36):14747-52. Epub 2013 Aug 19.

HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.1305066110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767498PMC
September 2013

A homology model of HIV-1 integrase and analysis of mutations designed to test the model.

J Mol Biol 2013 Jun 27;425(12):2133-46. Epub 2013 Mar 27.

HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, P.O. Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775779PMC
June 2013

H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.

Cell 2013 Feb;152(5):1021-36

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2013.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588593PMC
February 2013

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

ACS Chem Biol 2013 Jan 24;8(1):209-17. Epub 2012 Dec 24.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , 37 Convent Drive, Bethesda, Maryland 20892, United States.

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http://pubs.acs.org/doi/10.1021/cb300471n
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http://dx.doi.org/10.1021/cb300471nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548936PMC
January 2013

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Bioorg Med Chem Lett 2012 Dec 27;22(24):7309-13. Epub 2012 Oct 27.

Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523327PMC
December 2012

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase.

Virol J 2012 Dec 11;9:305. Epub 2012 Dec 11.

The Salk Institute for Biological Studies, Nomis Center for Immunobiology and Microbial Pathogenesis, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/1743-422X-9-305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560175PMC
December 2012

HIV-1 reverse transcription.

Cold Spring Harb Perspect Med 2012 Oct 1;2(10). Epub 2012 Oct 1.

Viral Recombination Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702-1201, USA.

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http://dx.doi.org/10.1101/cshperspect.a006882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475395PMC
October 2012

HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.

J Virol 2012 May 21;86(10):5885-94. Epub 2012 Mar 21.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.06597-11
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http://dx.doi.org/10.1128/JVI.06597-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347278PMC
May 2012

Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.

J Biol Chem 2012 Feb 21;287(6):4066-75. Epub 2011 Nov 21.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1074/jbc.M111.314781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281700PMC
February 2012

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Chem Biol Drug Des 2012 Feb 22;79(2):157-65. Epub 2011 Dec 22.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2011.01270.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385889PMC
February 2012

Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.

Antimicrob Agents Chemother 2012 Jan 28;56(1):411-9. Epub 2011 Oct 28.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.05292-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256025PMC
January 2012

The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC.

Virology 2011 Oct 9;419(2):64-71. Epub 2011 Sep 9.

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.virol.2011.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262452PMC
October 2011

Protein delivery using engineered virus-like particles.

Proc Natl Acad Sci U S A 2011 Oct 26;108(41):16998-7003. Epub 2011 Sep 26.

Protein Expression Laboratory, Advanced Technology Program, Science Applications International Corporation-Frederick, Inc, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.1101874108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193192PMC
October 2011

4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replication.

Antimicrob Agents Chemother 2011 May 22;55(5):2379-89. Epub 2011 Feb 22.

HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Building 539, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1128/AAC.01290-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088259PMC
May 2011

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Bioorg Med Chem Lett 2011 May 21;21(10):2986-90. Epub 2011 Mar 21.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085635PMC
May 2011

Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.

J Virol 2011 Feb 1;85(4):1655-61. Epub 2010 Dec 1.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01873-09
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http://dx.doi.org/10.1128/JVI.01873-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028899PMC
February 2011

Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.

Nucleic Acids Symp Ser (Oxf) 2008 (52):623-4

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nass/nrn315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727548PMC
November 2010

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.

J Virol 2010 Oct 21;84(19):9864-78. Epub 2010 Jul 21.

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1128/JVI.00915-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937799PMC
October 2010

Structural basis of HIV-1 resistance to AZT by excision.

Nat Struct Mol Biol 2010 Oct 19;17(10):1202-9. Epub 2010 Sep 19.

Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA.

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http://dx.doi.org/10.1038/nsmb.1908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987654PMC
October 2010

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.

Proc Natl Acad Sci U S A 2010 Feb 1;107(7):3135-40. Epub 2010 Feb 1.

HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.0914142107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840313PMC
February 2010

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Structure 2009 Dec;17(12):1625-1635

Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8021, USA. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S096921260900417
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http://dx.doi.org/10.1016/j.str.2009.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365588PMC
December 2009

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.

Bioorg Med Chem Lett 2009 May 28;19(10):2714-7. Epub 2009 Mar 28.

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, MD 21702, United States.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747502PMC
May 2009

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

J Mol Biol 2009 Jan 3;385(3):693-713. Epub 2008 Nov 3.

Christopher Bond Life Sciences Center, Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, MO 65211, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.10.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881421PMC
January 2009

Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.

J Virol 2008 Nov 3;82(22):11480-3. Epub 2008 Sep 3.

HIV Drug Resistance Program, NCI at Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01353-08
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http://dx.doi.org/10.1128/JVI.01353-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573277PMC
November 2008

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.

Mol Ther 2008 Sep 24;16(9):1617-23. Epub 2008 Jun 24.

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, Blood Institute, National Institute of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2008.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561952PMC
September 2008

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.

Nucleic Acids Res 2008 Sep 1;36(15):5083-92. Epub 2008 Aug 1.

Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA.

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http://dx.doi.org/10.1093/nar/gkn464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528191PMC
September 2008

HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision.

Proc Natl Acad Sci U S A 2008 Aug 30;105(31):10943-8. Epub 2008 Jul 30.

Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0804660105
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http://dx.doi.org/10.1073/pnas.0804660105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491488PMC
August 2008

D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.

ChemMedChem 2008 Jul;3(7):1129-34

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Building 376, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cmdc.200800027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727455PMC
July 2008

Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc.

Biologicals 2008 May 22;36(3):184-97. Epub 2008 Jan 22.

Division of Viral Products, OVRR, CBER, FDA, Building 29A, Room 3D08, 29 Lincoln Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.biologicals.2007.11.003DOI Listing
May 2008

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1466-71. Epub 2008 Jan 29.

Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1073/pnas.0711209105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234167PMC
February 2008

Rous sarcoma virus (RSV) integration in vivo: a CA dinucleotide is not required in U3, and RSV linear DNA does not autointegrate.

J Virol 2008 Jan 24;82(1):503-12. Epub 2007 Oct 24.

HIV Drug Resistance Program, NCI at Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01441-07
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http://dx.doi.org/10.1128/JVI.01441-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224354PMC
January 2008

Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo.

J Virol 2008 Jan 7;82(2):719-27. Epub 2007 Nov 7.

HIV Drug Resistance Program, NCI at Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1128/JVI.02611-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224596PMC
January 2008

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.

J Med Chem 2008 Jan 21;51(2):251-9. Epub 2007 Dec 21.

Laboratory of Medicinal Chemistry and HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1021/jm070715dDOI Listing
January 2008

Targeting to the endoplasmic reticulum improves the folding of recombinant human telomerase reverse transcriptase.

Protein Expr Purif 2007 Nov 12;56(1):8-19. Epub 2007 Jun 12.

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.pep.2007.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790190PMC
November 2007

In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.

Virology 2007 Oct 12;367(2):253-64. Epub 2007 Jul 12.

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.virol.2007.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720797PMC
October 2007

The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.

J Mol Biol 2007 Aug 18;371(4):873-82. Epub 2007 May 18.

HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.05.043DOI Listing
August 2007

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.

Hum Gene Ther 2007 Aug;18(8):691-700

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.liebertpub.com/doi/10.1089/hum.2006.175
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August 2007

Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses.

J Virol 2007 Jun 4;81(12):6731-41. Epub 2007 Apr 4.

HIV Drug Resistance Program, Laboratory of Molecular Technology, SAIC-Frederick, Inc., NCI-Frederick, 915 Toll House Avenue, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1128/JVI.02752-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900082PMC
June 2007

In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity.

Virology 2007 Apr 21;360(2):341-9. Epub 2006 Nov 21.

HIV Drug Resistance Program, NCI Frederick, PO Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.virol.2006.10.008DOI Listing
April 2007

Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication.

J Mol Biol 2007 Feb 10;365(5):1368-78. Epub 2006 Nov 10.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.10.089DOI Listing
February 2007

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

J Mol Biol 2007 Jan 15;365(1):77-89. Epub 2006 Sep 15.

Center for Advanced Biotechnology and Medicine, Rutgers University, Department of Chemistry and Chemical Biology, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.08.097DOI Listing
January 2007

Alternate polypurine tracts affect rous sarcoma virus integration in vivo.

J Virol 2006 Oct;80(20):10281-4

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00361-06
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http://dx.doi.org/10.1128/JVI.00361-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617299PMC
October 2006

Alternate polypurine tracts affect rous sarcoma virus integration in vivo.

J Virol 2006 Oct;80(20):10281-4

HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00361-06
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http://dx.doi.org/10.1128/JVI.00361-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617299PMC
October 2006

The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent.

Antiviral Res 2006 Sep 6;71(2-3):268-75. Epub 2006 May 6.

Laboratory of Medicinal Chemistry, National Cancer Institute at Frederick, P.O. Box B, Building 539, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.antiviral.2006.04.012DOI Listing
September 2006