Stephen Fowler

Stephen Fowler

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Stephen Fowler

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Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT receptor activation.

Neuropharmacology 2019 Nov 1;159:107513. Epub 2019 Feb 1.

Dept. of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA; Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA), University of Kansas, Lawrence, KS, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.01.028DOI Listing
November 2019

Circadian rhythm of exhaled biomarkers in health and asthma.

Eur Respir J 2019 Oct 17;54(4). Epub 2019 Oct 17.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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http://dx.doi.org/10.1183/13993003.01068-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796150PMC
October 2019

Allopregnanolone is required for prepulse inhibition deficits induced by D dopamine receptor activation.

Psychoneuroendocrinology 2019 Oct 14;108:53-61. Epub 2019 Jun 14.

Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City UT United States. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773911PMC
October 2019

-Derived Volatile Sulfur Compounds Promote Distal Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.

Front Microbiol 2019 9;10:2311. Epub 2019 Oct 9.

Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.3389/fmicb.2019.02311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794476PMC
October 2019

Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma.

J Allergy Clin Immunol 2019 Sep 17;144(3):788-795.e1. Epub 2019 Jan 17.

Division of Infection, Immunity and Respiratory Medicine, University of Manchester, and the Manchester Academic Health Science Centre, Manchester, United Kingdom; NHS Foundation Trust, University of Manchester, Manchester, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193003
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http://dx.doi.org/10.1016/j.jaci.2018.11.050DOI Listing
September 2019

Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes.

J Clin Pharmacol 2019 Sep;59 Suppl 1:S42-S55

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/jcph.1493DOI Listing
September 2019

Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma.

Eur Respir J 2019 Sep 12. Epub 2019 Sep 12.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.

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http://dx.doi.org/10.1183/13993003.00544-2019DOI Listing
September 2019

Breath biomarkers in asthma: we're getting answers, but what are the important questions?

Eur Respir J 2019 Sep 29;54(3). Epub 2019 Sep 29.

Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01411-2019DOI Listing
September 2019

Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools.

SLAS Discov 2019 06 28;24(5):523-536. Epub 2019 Feb 28.

1 Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/2472555219831407DOI Listing
June 2019

The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review.

J Breath Res 2019 Jun 24;13(3):036015. Epub 2019 Jun 24.

Norwich Medical School, University of East Anglia, Norwich, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/ab1284DOI Listing
June 2019

Investigating the safety of capsaicin cough challenge in severe asthma.

Clin Exp Allergy 2019 Jun 16;49(6):932-934. Epub 2019 Apr 16.

Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13392
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http://dx.doi.org/10.1111/cea.13392DOI Listing
June 2019

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies.

AAPS J 2019 Jun 18;21(5):77. Epub 2019 Jun 18.

Department of Pharmacy, Uppsala University, Box 580, SE-751 23, Uppsala, Sweden.

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http://link.springer.com/10.1208/s12248-019-0344-8
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http://dx.doi.org/10.1208/s12248-019-0344-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581936PMC
June 2019

Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study.

Am J Physiol Lung Cell Mol Physiol 2019 May 13;316(5):L751-L756. Epub 2019 Feb 13.

Department of Intensive Care, Amsterdam University Medical Center-Academic Medical Centre , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00449.2018DOI Listing
May 2019

Burden of fungal asthma in Africa: A systematic review and meta-analysis.

PLoS One 2019 16;14(5):e0216568. Epub 2019 May 16.

The National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521988PMC
May 2019

Heliox for inducible laryngeal obstruction (vocal cord dysfunction): A systematic literature review.

Laryngoscope Investig Otolaryngol 2019 Apr 8;4(2):255-258. Epub 2019 Feb 8.

Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester and University Hospital of South Manchester, NHS Foundation Trust Manchester United Kingdom.

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http://dx.doi.org/10.1002/lio2.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476266PMC
April 2019

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.

Sci Rep 2019 Mar 11;9(1):4074. Epub 2019 Mar 11.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstr. 124, CH-4070, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41598-019-40542-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411889PMC
March 2019

Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice.

Sci Rep 2019 Mar 13;9(1):4379. Epub 2019 Mar 13.

Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41598-019-40714-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416404PMC
March 2019

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.

Clin Pharmacokinet 2019 Feb;58(2):189-211

Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.

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http://dx.doi.org/10.1007/s40262-018-0681-2DOI Listing
February 2019

Exhaled breath testing - A tool for the clinician and researcher.

Paediatr Respir Rev 2019 Feb 17;29:37-41. Epub 2018 May 17.

VCU Health, Department of Emergency Medicine, Adult Emergency Department, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2018.05.002DOI Listing
February 2019

Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.

Drug Metab Dispos 2019 02 26;47(2):124-134. Epub 2018 Nov 26.

Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, University of Florida at Lake Nona, Orlando, Florida (J.B., S.S.); Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Centre Basel, Basel, Switzerland (N.Q., N.P., S.F.); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (A.C.C.).

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0843
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http://dx.doi.org/10.1124/dmd.118.084301DOI Listing
February 2019

Sex and intimacy in people with severe asthma: a qualitative study.

BMJ Open Respir Res 2019 12;6(1):e000382. Epub 2019 Feb 12.

Respiratory Medicine, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1136/bmjresp-2018-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424302PMC
February 2019

Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review.

Respir Res 2019 Jan 11;20(1). Epub 2019 Jan 11.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0971-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329167PMC
January 2019

Two pathways, one patient; UK asthma guidelines.

Thorax 2018 09 3;73(9):797-798. Epub 2018 May 3.

Respiratory Research Unit, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211703DOI Listing
September 2018

Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa.

Analyst 2018 Jul 7;143(13):3148-3155. Epub 2018 Jun 7.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. and Manchester Academic Health Science Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1039/c8an00759dDOI Listing
July 2018

Clinical presentation, assessment, and management of inducible laryngeal obstruction.

Curr Opin Otolaryngol Head Neck Surg 2018 Jun;26(3):174-179

Department of Respiratory Medicine, North West Lung Centre, Wythenshawe Hospital, Manchester University National Health Service Foundation Trust, Manchester.

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http://Insights.ovid.com/crossref?an=00020840-900000000-9927
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http://dx.doi.org/10.1097/MOO.0000000000000452DOI Listing
June 2018

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

J Pharmacol Exp Ther 2018 05 16;365(2):237-248. Epub 2018 Feb 16.

Pharmaceutical Sciences (N.A.K., M.B.M., F.K., A.E., B.M., I.W., P.-A.G., C.A.T., A.D., M.M., R.J., M.U., F.B., N.J.P., S.F.) and Inflammation, Immunology, and Infectious Diseases Therapeutic Areas (M.T., B.L., D.T., J.S.), Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland; and Pharmaceutical Sciences, Roche Innovation Center Shanghai, Roche R&D Center (China) Ltd., Pudong, Shanghai, China (G.O., Y.Y.)

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http://dx.doi.org/10.1124/jpet.117.245712DOI Listing
May 2018

Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.

Psychoneuroendocrinology 2018 05 16;91:95-104. Epub 2018 Feb 16.

Dept of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901899PMC
May 2018

Reclassification of Bronchodilator Reversibility in the U-BIOPRED Adult Asthma Cohort Using z Scores.

Chest 2018 04;153(4):1070-1072

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183025
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http://dx.doi.org/10.1016/j.chest.2017.10.051DOI Listing
April 2018

TD/GC-MS analysis of volatile markers emitted from mono- and co-cultures of and in artificial sputum.

Metabolomics 2018 26;14(5):66. Epub 2018 Apr 26.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://link.springer.com/10.1007/s11306-018-1357-5
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http://dx.doi.org/10.1007/s11306-018-1357-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920131PMC
April 2018

Peripheral Interventions for Painful Stump Neuromas of the Lower Limb: A Systematic Review.

Clin J Pain 2018 03;34(3):285-295

Manchester Institute of Biotechnology, Faculty of Science and Engineering.

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http://dx.doi.org/10.1097/AJP.0000000000000533DOI Listing
March 2018

Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy.

ACS Chem Neurosci 2018 02 9;9(2):381-390. Epub 2017 Nov 9.

Department of Pharmacology and Toxicology and ‡Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821551PMC
February 2018

The potential role of exhaled breath analysis in the diagnostic process of pneumonia-a systematic review.

J Breath Res 2018 02 6;12(2):024001. Epub 2018 Feb 6.

Department of Intensive Care, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1088/1752-7163/aaa499DOI Listing
February 2018

Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses.

Proc Natl Acad Sci U S A 2018 02 8;115(9):2234-2239. Epub 2018 Feb 8.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1719012115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834710PMC
February 2018

Headspace volatile organic compounds from bacteria implicated in ventilator-associated pneumonia analysed by TD-GC/MS.

J Breath Res 2018 01 3;12(2):026002. Epub 2018 Jan 3.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. Philips Research, Royal Philips B.V., Eindhoven, The Netherlands. School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/aa8efcDOI Listing
January 2018

Breath analysis for label-free characterisation of airways disease.

Authors:
Stephen J Fowler

Eur Respir J 2018 01 11;51(1). Epub 2018 Jan 11.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02586
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http://dx.doi.org/10.1183/13993003.02586-2017DOI Listing
January 2018

Assessment of gait and sensorimotor deficits in the D1CT-7 mouse model of Tourette syndrome.

J Neurosci Methods 2017 Dec 15;292:37-44. Epub 2017 Jan 15.

Dept. of Pharmacology and Toxicology, College of Pharmacy; University of Utah, Salt Lake City UT, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511586PMC
December 2017

The interaction between bronchoconstriction and cough in asthma.

Thorax 2017 12 24;72(12):1144-1146. Epub 2017 Feb 24.

Division of Infection, Immunity and Respiratory Medicine, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2016-209625DOI Listing
December 2017

Exhaled Volatile Organic Compounds of Infection: A Systematic Review.

ACS Infect Dis 2017 10 13;3(10):695-710. Epub 2017 Sep 13.

Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, The University of Manchester , Oxford Road, Manchester, M13 9PL, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00088DOI Listing
October 2017

An airway traffic jam: a plastic traffic cone masquerading as bronchial carcinoma.

BMJ Case Rep 2017 Sep 21;2017. Epub 2017 Sep 21.

Department of Respiratory Medicine, Royal Preston Hospital, Preston, UK.

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http://dx.doi.org/10.1136/bcr-2017-220514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747653PMC
September 2017

Exhaled breath analysis: a review of 'breath-taking' methods for off-line analysis.

Metabolomics 2017 19;13(10):110. Epub 2017 Aug 19.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s11306-017-1241-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563344PMC
August 2017

Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation.

Neurobiol Dis 2017 Jul 19;103:174-183. Epub 2017 Apr 19.

Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA; Department of Psychiatry, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine ARC 517, Philadelphia, PA 19104-5127, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703052PMC
July 2017

Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models.

Sci Rep 2017 06 13;7(1):3348. Epub 2017 Jun 13.

Dept. of Pharmacology and Toxicology, College of Pharmacy; University of Utah, Salt Lake City (UT), USA.

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http://dx.doi.org/10.1038/s41598-017-03649-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469807PMC
June 2017

Perspectives of patients and healthcare professionals on mHealth for asthma self-management.

Eur Respir J 2017 05 1;49(5). Epub 2017 May 1.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1183/13993003.01966-2016DOI Listing
May 2017

Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.

J Allergy Clin Immunol 2017 Mar 15;139(3):771-779.e10. Epub 2016 Jun 15.

Centre for Respiratory Medicine and Allergy, University of Manchester and Manchester Academic Health Science Centre, Manchester, United Kingdom; University Hospital of South Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.04.045DOI Listing
March 2017

Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.

Arch Toxicol 2017 Mar 2;91(3):1187-1197. Epub 2016 Aug 2.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Singapore, 138673, Singapore.

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http://dx.doi.org/10.1007/s00204-016-1789-5DOI Listing
March 2017

A pilot study to investigate the use of serum inhaled corticosteroid concentration as a potential marker of treatment adherence in severe asthma.

J Allergy Clin Immunol 2017 03 11;139(3):1037-1039.e1. Epub 2016 Oct 11.

University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749163112
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http://dx.doi.org/10.1016/j.jaci.2016.08.037DOI Listing
March 2017

Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.

Neuropharmacology 2017 03 23;114:77-87. Epub 2016 Nov 23.

Dept. of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United States; Problem Gambling Research Studies (ProGResS) Network, University of Kansas, Lawrence, KS, United States; Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241163PMC
March 2017

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate.

J Breath Res 2017 02 10;11(1):016011. Epub 2017 Feb 10.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom.

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http://dx.doi.org/10.1088/1752-7163/aa5a8aDOI Listing
February 2017

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

Curr Pharmacol Rep 2017 1;3(1):36-49. Epub 2017 Feb 1.

Pharmaceutical Reseach and Early Development, Roche Innovation Center New York, F. Hoffmann-La Roche Ltd., 430 East 29th Street, New York City, NY USA.

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http://dx.doi.org/10.1007/s40495-017-0082-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315728PMC
February 2017

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

J Pharmacol Exp Ther 2017 Jan 7;360(1):164-173. Epub 2016 Nov 7.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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http://dx.doi.org/10.1124/jpet.116.237214DOI Listing
January 2017

Shedding light on minipig drug metabolism - elevated amide hydrolysis in vitro.

Xenobiotica 2016 25;46(6):483-94. Epub 2015 Sep 25.

a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.

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http://dx.doi.org/10.3109/00498254.2015.1089452DOI Listing
December 2016

Laryngeal Dysfunction: Assessment and Management for the Clinician.

Am J Respir Crit Care Med 2016 11;194(9):1062-1072

6 Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester, United Kingdom; and.

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http://dx.doi.org/10.1164/rccm.201606-1249CIDOI Listing
November 2016

Breathomics in the setting of asthma and chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2016 10 31;138(4):970-976. Epub 2016 Aug 31.

Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.08.004DOI Listing
October 2016

Fungal sensitisation in severe asthma is associated with the identification of Aspergillus fumigatus in sputum.

J Asthma 2016 09 6;53(7):732-5. Epub 2016 Apr 6.

a Severe Asthma Department , University Hospital of South Manchester , Manchester , UK.

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http://dx.doi.org/10.3109/02770903.2016.1154073DOI Listing
September 2016

Dysfunctional breathing: a review of the literature and proposal for classification.

Eur Respir Rev 2016 Sep;25(141):287-94

Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK

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http://dx.doi.org/10.1183/16000617.0088-2015DOI Listing
September 2016

The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement.

Br J Pharmacol 2016 07 10;173(13):2111-21. Epub 2015 Aug 10.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA.

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http://dx.doi.org/10.1111/bph.13243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908200PMC
July 2016

Reduction in peripheral blood eosinophil counts after bronchial thermoplasty.

J Allergy Clin Immunol 2016 07 4;138(1):308-310.e2. Epub 2016 Mar 4.

University Hospital of South Manchester, NHS Foundation Trust, Manchester, United Kingdom; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester and University Hospital of South Manchester, NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.11.044DOI Listing
July 2016

Objective Cough Frequency, Airway Inflammation, and Disease Control in Asthma.

Chest 2016 06 10;149(6):1460-6. Epub 2016 Mar 10.

Centre for Respiratory Medicine and Allergy, University of Manchester, and Manchester Academic Health Science Centre, Manchester, England; University Hospital of South Manchester NHS Foundation Trust, Manchester, England. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.02.676DOI Listing
June 2016

Effects of Morphine on Behavioral Task Performance in SIV-Infected Rhesus Macaques.

J Neuroimmune Pharmacol 2016 06 2;11(2):348-57. Epub 2016 Apr 2.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.1007/s11481-016-9667-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848131PMC
June 2016

Electronic cigarette exposure triggers neutrophil inflammatory responses.

Respir Res 2016 05 17;17(1):56. Epub 2016 May 17.

Manchester Academic Health and Science Centre, University Hospital of South Manchester Foundation Trust, Centre for Respiratory and Allergy Medicine, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-016-0368-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869345PMC
May 2016

Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.

Clin Pharmacokinet 2016 Feb;55(2):237-47

Clinical Pharmacology, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Hochstrasse 16, 4070, Basel, Switzerland.

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http://dx.doi.org/10.1007/s40262-015-0312-0DOI Listing
February 2016

Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's disease model mice.

Behav Brain Res 2015 Nov 22;294:7-16. Epub 2015 Jul 22.

Department of Pharmacology and Toxicology, Pharmacy School, University of Kansas, Lawrence, KS 66045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564309PMC
November 2015

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Eur Respir J 2015 Nov 24;46(5):1322-33. Epub 2015 Sep 24.

NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK

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http://www.copsac.com/userfiles/2015_Flemming-Eur%20resp%20J
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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00780
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http://dx.doi.org/10.1183/13993003.00780-2015DOI Listing
November 2015

Detecting laryngopharyngeal reflux in patients with upper airways symptoms: Symptoms, signs or salivary pepsin?

Respir Med 2015 Aug 22;109(8):963-9. Epub 2015 May 22.

Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK; The University of Manchester, Manchester Academic Health Science Centre, NIHR South Manchester Respiratory and Allergy Clinical Research Facility, University Hospital of South Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2015.05.019DOI Listing
August 2015

Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers.

Sci Rep 2015 Aug 4;5:12752. Epub 2015 Aug 4.

1] Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA [2] The Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/srep12752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523849PMC
August 2015

Interventions for bronchiectasis: an overview of Cochrane systematic reviews.

Cochrane Database Syst Rev 2015 Jul 14(7):CD010337. Epub 2015 Jul 14.

Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

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http://dx.doi.org/10.1002/14651858.CD010337.pub2DOI Listing
July 2015

Surveillance for lower airway pathogens in mechanically ventilated patients by metabolomic analysis of exhaled breath: a case-control study.

Thorax 2015 Apr 6;70(4):320-5. Epub 2015 Feb 6.

Manchester Academic Health Science Centre, and NIHR Respiratory and Allergy Clinical Research Facility, University of Manchester, University Hospital of South Manchester, Manchester, UK Salford Royal Hospitals NHS Foundation Trust, Salford, UK.

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http://thorax.bmj.com/cgi/doi/10.1136/thoraxjnl-2014-206273
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http://dx.doi.org/10.1136/thoraxjnl-2014-206273DOI Listing
April 2015

High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

J Allergy Clin Immunol 2015 Mar 30;135(3):822-4.e2. Epub 2014 Oct 30.

University of Manchester, Manchester Academic Health Science Centre, and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.09.034DOI Listing
March 2015

Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits.

Pediatr Res 2015 Mar 17;77(3):434-9. Epub 2014 Dec 17.

1] Department of Neurology, Children's Mercy Hospital, Kansas City, Missouri [2] Departments of Neurology and Pediatrics, University of Kansas Medical Center, Kansas City, Kansas [3] Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri.

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http://dx.doi.org/10.1038/pr.2014.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346430PMC
March 2015

Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

Chron Respir Dis 2015 Feb 9;12(1):69-77. Epub 2014 Dec 9.

Manchester Academic Health Science Centre, University Hospital of South Manchester, University of Manchester, Southmoor Road, Manchester, UK.

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http://dx.doi.org/10.1177/1479972314562210DOI Listing
February 2015

A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.

J Pharmacol Exp Ther 2015 Feb 12;352(2):358-67. Epub 2014 Dec 12.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland (S.F., H.K., P.S., D.T., R.D.N., M.C.H., O.S., V.A.I.); and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F., N.M.)

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http://dx.doi.org/10.1124/jpet.114.220194DOI Listing
February 2015