Stephen F Traynelis

Stephen F Traynelis

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Stephen F Traynelis

Stephen F Traynelis

Publications by authors named "Stephen F Traynelis"

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Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors.

J Physiol 2019 Sep 21. Epub 2019 Sep 21.

Department of Biomedical and Pharmaceutical Sciences and Center for Structural and Functional Neuroscience, University of Montana, Missoula, MT, 59812.

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http://dx.doi.org/10.1113/JP278168DOI Listing
September 2019

Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([F]N2B-0518) for GluN2B Subunit in the Brain.

ACS Chem Neurosci 2019 May 27;10(5):2263-2275. Epub 2019 Feb 27.

Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727982PMC
May 2019

AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.

Neurochem Res 2019 Mar 23;44(3):539-548. Epub 2018 Feb 23.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/s11064-018-2491-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533624PMC
March 2019

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.

ACS Med Chem Lett 2019 Mar 14;10(3):226. Epub 2019 Mar 14.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421527PMC
March 2019

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.

Nat Commun 2019 01 18;10(1):321. Epub 2019 Jan 18.

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.

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http://dx.doi.org/10.1038/s41467-019-08291-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338780PMC
January 2019

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors.

J Exp Neurosci 2018 19;12:1179069518810423. Epub 2018 Nov 19.

Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1177/1179069518810423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247487PMC
November 2018

A structurally derived model of subunit-dependent NMDA receptor function.

J Physiol 2018 09 1;596(17):4057-4089. Epub 2018 Aug 1.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1113/JP276093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117563PMC
September 2018

Structure, function, and allosteric modulation of NMDA receptors.

J Gen Physiol 2018 08 23;150(8):1081-1105. Epub 2018 Jul 23.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA

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http://dx.doi.org/10.1085/jgp.201812032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080888PMC
August 2018

Synaptic Receptor Diversity Revealed Across Space and Time.

Trends Neurosci 2018 08;41(8):486-488

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2018.06.001DOI Listing
August 2018

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder.

Mov Disord 2018 Jul 11;33(6):992-999. Epub 2018 Apr 11.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1002/mds.27315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105539PMC
July 2018

NMDA Receptors in the Central Nervous System.

Methods Mol Biol 2017 ;1677:1-80

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7321-7_1DOI Listing
June 2018

Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.

Methods Mol Biol 2017 ;1677:145-162

Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.

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http://dx.doi.org/10.1007/978-1-4939-7321-7_7DOI Listing
June 2018

Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.

Neuron 2018 05 12;98(3):521-529.e3. Epub 2018 Apr 12.

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963293PMC
May 2018

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.

ACS Med Chem Lett 2018 May 10;9(5):398-399. Epub 2018 May 10.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949834PMC
May 2018

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.

Mol Pharmacol 2018 02 14;93(2):141-156. Epub 2017 Dec 14.

Department of Chemistry, Emory University, Atlanta, Georgia (T.M.K., S.A.K., M.P.E., K.L.S., E.J.M., B.D.C., D.S.M., D.C.L., P.B.B.); and Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (H.K., G.S., S.B., S.F.T.)

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http://dx.doi.org/10.1124/mol.117.110940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767683PMC
February 2018

Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.

Cell Rep 2018 01 28;22(4):941-952. Epub 2018 Jan 28.

Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798888PMC
January 2018

encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

J Med Genet 2017 07 4;54(7):460-470. Epub 2017 Apr 4.

Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2016-104509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656050PMC
July 2017

Functional Evaluation of a De Novo Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.

Mol Pharmacol 2017 04 26;91(4):317-330. Epub 2017 Jan 26.

Department of Pharmacology, Rollins Research Center, School of Medicine, Emory University, Atlanta, Georgia (W.C., A.T., H.K., S.F.T., H.Y.); Department of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China (W.C.); Department of Chemistry, Emory University, Atlanta, Georgia (P.B.B.); Center for Functional Evaluation of Rare Variants (CFERV), Rollins Research Center, School of Medicine, Emory University, Atlanta, Georgia (S.F.T., H.Y.)

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http://dx.doi.org/10.1124/mol.116.106781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363715PMC
April 2017

Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121].

J Pharmacol Sci 2017 04 12;133(4):280. Epub 2017 Apr 12.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2017.04.001DOI Listing
April 2017

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity.

Mol Pharmacol 2016 Dec 13;90(6):689-702. Epub 2016 Sep 13.

Departments of Pharmacology (R.E.P., J.O.D., K.K.O., A.K., S.F.T.), Chemistry (J.O.D., K.L.S., D.C.L.), Neurology (Y.S.), Yerkes National Primate Research Center (Y.S.), and Morris K. Udall Center of Excellence for Parkinson's Disease Research (Y.S.), Emory University, Atlanta, Georgia; Departments of Pharmacology and Anaesthesiology (C.-M.L.), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development (G.A.V., K.A.P., L.T., C.J.M.), National Institutes of Health, Bethesda, Maryland

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http://dx.doi.org/10.1124/mol.116.105130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118640PMC
December 2016

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.

Am J Hum Genet 2016 Dec 10;99(6):1261-1280. Epub 2016 Nov 10.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142120PMC
December 2016

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.

J Med Chem 2016 12 6;59(24):11110-11119. Epub 2016 Dec 6.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School , Baltimore, Maryland 21287, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484777PMC
http://dx.doi.org/10.1021/acs.jmedchem.6b01344DOI Listing
December 2016

Human GRIN2B variants in neurodevelopmental disorders.

J Pharmacol Sci 2016 Oct 19;132(2):115-121. Epub 2016 Oct 19.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125235PMC
October 2016

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use.

Pharmacol Ther 2016 08 29;164:170-82. Epub 2016 Apr 29.

College of Pharmacy, Touro University California, Vallejo, CA, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2016.04.010DOI Listing
August 2016

Altered motility of plaque-associated microglia in a model of Alzheimer's disease.

Neuroscience 2016 08 7;330:410-20. Epub 2016 Jun 7.

Department of Pharmacology, Emory University, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.05.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927418PMC
August 2016

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Mol Pharmacol 2016 Feb 10;89(2):253-62. Epub 2015 Dec 10.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (A.S.K., K.B.H., N.L.K., S.M.D., S.F.T.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (A.S.K., P.N., L.O., T.K., J.P., R.P.C., M.G., J.S.K.); and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (K.B.H., F.Y.)

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http://dx.doi.org/10.1124/mol.115.100909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746485PMC
February 2016

A novel class of negative allosteric modulators of NMDA receptor function.

Bioorg Med Chem Lett 2015 Dec 19;25(23):5583-8. Epub 2015 Oct 19.

Department of Chemistry, Emory University, 1521 Dickey Drive, Atlanta, GA 30322, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.10.046DOI Listing
December 2015

Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke.

Rehabil Res Pract 2015 26;2015:534239. Epub 2015 Oct 26.

Atlanta Veterans Affairs Medical Center, Rehabilitation Research and Development Center of Excellence for Visual and Neurocognitive Rehabilitation, Decatur, GA 30033, USA ; Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, USA.

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http://dx.doi.org/10.1155/2015/534239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637506PMC
November 2015

The genetics of neuropsychiatric diseases: looking in and beyond the exome.

Annu Rev Neurosci 2015 Jul 2;38:47-68. Epub 2015 Apr 2.

Institute for Genomic Medicine.

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http://dx.doi.org/10.1146/annurev-neuro-071714-034136DOI Listing
July 2015

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.

Mol Pharmacol 2015 Jul 22;88(1):203-17. Epub 2015 Apr 22.

Departments of Pharmacology (H.Y., A.J., S.F.T.) and Anesthesiology (O.A.M., A.J.), Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia; and Departments of Pharmacology and Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore Graduate School for Integrative Sciences and Engineering, and Neurobiology/Ageing Programme, National University of Singapore, Singapore (C.-M.L.)

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http://dx.doi.org/10.1124/mol.115.097998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468639PMC
July 2015

The First 50 Years of Molecular Pharmacology.

Mol Pharmacol 2015 Jul 5;88(1):139-40. Epub 2015 May 5.

Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.)

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http://dx.doi.org/10.1124/mol.115.099564DOI Listing
July 2015

Binding of ArgTX-636 in the NMDA receptor ion channel.

J Mol Biol 2015 Jan 24;427(1):176-89. Epub 2014 May 24.

Department of Drug Design and Pharmacology, University of Copenhagen, 2100 København, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864154PMC
January 2015

NMDA receptor modulators: an updated patent review (2013-2014).

Expert Opin Ther Pat 2014 Dec 29;24(12):1349-66. Epub 2014 Oct 29.

Emory University, Department of Chemistry , 1521 Dickey Drive, Atlanta, GA 30322 , USA

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http://dx.doi.org/10.1517/13543776.2014.972938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860953PMC
December 2014

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Mol Pharmacol 2014 Nov 9;86(5):548-60. Epub 2014 Sep 9.

Pharmacology Department (A.K., S.A.S., S.F.T.) and Chemistry Department (S.Z., P.B.B., D.C.L., J.P.S.), Emory University, Atlanta, Georgia; Department of Biomedical and Pharmaceutical Sciences, and Center for Biomolecular Structure and Dynamics (K.B.H.), University of Montana, Missoula, Montana; and Cold Spring Harbor Laboratories (E.K., H.F.), Cold Spring Harbor, New York

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http://dx.doi.org/10.1124/mol.114.094516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201136PMC
November 2014

Glutamate receptors: mechanistic twists and turns.

Nat Chem Biol 2014 Sep;10(9):698-9

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http://dx.doi.org/10.1038/nchembio.1614DOI Listing
September 2014

Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840.

Mol Pharmacol 2014 Apr 22;85(4):618-29. Epub 2014 Jan 22.

Department of Pharmacology (M.A.J., A.J., S.F.T.) and Department of Anesthesiology (A.J.), School of Medicine, and Department of Chemistry (G.W., J.P.S.), Emory University, Atlanta, Georgia; Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland (J.B., R.L.H.); and Department of Molecular Medicine, Cornell University, Ithaca, New York (R.E.O.).

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.113.09
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http://dx.doi.org/10.1124/mol.113.091488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014661PMC
April 2014

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

Neuron 2014 Mar;81(5):1084-1096

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.neuron.2014.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957490PMC
March 2014

mutation and early-onset epileptic encephalopathy: personalized therapy with memantine.

Ann Clin Transl Neurol 2014 Mar;1(3):190-198

NIH Undiagnosed Diseases Program, NIH Office of Rare Diseases Research and NHGRI, Bethesda, MD, USA ; Division of Neurology, Children's Hospital of Philadelphia and Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/acn3.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019449PMC
March 2014

Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice.

Neuropsychopharmacology 2014 Feb 6;39(3):625-37. Epub 2013 Sep 6.

1] Department of Anatomy and Neurobiology [2] Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1038/npp.2013.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895240PMC
February 2014

Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.

Neuropharmacology 2013 Dec 22;75:324-36. Epub 2013 Aug 22.

Dept. of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865070PMC
December 2013

Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.

J Biol Chem 2013 Nov 26;288(46):33124-35. Epub 2013 Sep 26.

From the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M113.480210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829161PMC
November 2013

PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance.

Channels (Austin) 2012 Jan-Feb;6(1):60-4. Epub 2012 Jan 1.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.4161/chan.18648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367675PMC
September 2013

Modal gating of GluN1/GluN2D NMDA receptors.

Neuropharmacology 2013 Aug 8;71:184-90. Epub 2013 Apr 8.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2013.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690137PMC
August 2013

Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.

Mol Pharmacol 2013 Jul 26;84(1):114-27. Epub 2013 Apr 26.

Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Rollins Research Center, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1124/mol.113.085803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684824PMC
July 2013

Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors.

Mol Pharmacol 2013 May 1;83(5):1045-56. Epub 2013 Mar 1.

Department of Pharmacology, Emory University, 1510 Clifton Rd., Room 5062, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1124/mol.113.085209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629829PMC
May 2013

Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors.

J Biol Chem 2013 May 2;288(21):15291-302. Epub 2013 Apr 2.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M113.458901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663549PMC
May 2013

Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists.

J Med Chem 2013 May 9;56(10):4071-81. Epub 2013 May 9.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/jm400346aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689883PMC
May 2013

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.

Proc Natl Acad Sci U S A 2013 Jan 31;110(3):1077-82. Epub 2012 Dec 31.

Solomon H Snyder Department of Neuroscience and Departments of Psychiatry and Behavioral Sciences, Pharmacology and Molecular Sciences, and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1221295110
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http://dx.doi.org/10.1073/pnas.1221295110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549090PMC
January 2013

Molecular pharmacology of human NMDA receptors.

Neurochem Int 2012 Sep 17;61(4):601-9. Epub 2011 Dec 17.

Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Rollins Research Center, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.neuint.2011.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335988PMC
September 2012

Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.

Mol Pharmacol 2012 Aug 17;82(2):344-59. Epub 2012 May 17.

Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1124/mol.112.078568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400845PMC
August 2012

GluN1 splice variant control of GluN1/GluN2D NMDA receptors.

J Physiol 2012 Aug 28;590(16):3857-75. Epub 2012 May 28.

S. F. Traynelis: Department of Pharmacology, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://dx.doi.org/10.1113/jphysiol.2012.234062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476637PMC
August 2012

Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

J Neurosci 2012 May;32(18):6197-208

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5757-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355950PMC
May 2012

NMDA receptor permeation: a light in the tunnel.

Nat Neurosci 2012 Feb 24;15(3):343-4. Epub 2012 Feb 24.

Centre for Integrative Physiology at the University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nn.3058DOI Listing
February 2012

New advances in NMDA receptor pharmacology.

Trends Pharmacol Sci 2011 Dec 11;32(12):726-33. Epub 2011 Oct 11.

Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.tips.2011.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223280PMC
December 2011

L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking.

J Bone Miner Metab 2011 Sep 19;29(5):515-25. Epub 2011 Jan 19.

Department of Pharmacology, School of Pharmacy, Fudan University, Pudong New District, Shanghai, China.

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http://dx.doi.org/10.1007/s00774-010-0252-6DOI Listing
September 2011

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.

Nat Commun 2011 ;2:294

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, Georgia 30322-3090, USA.

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http://dx.doi.org/10.1038/ncomms1295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302728PMC
August 2011

How glutamate receptor subunits mix and match: details uncovered.

Neuron 2011 Jul;71(2):198-200

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.07.008DOI Listing
July 2011

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating.

Nat Neurosci 2011 Jun 24;14(6):727-35. Epub 2011 Apr 24.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1038/nn.2804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102786PMC
June 2011

Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors.

J Neurosci 2011 Mar;31(10):3650-61

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5565-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063124PMC
March 2011

Control of assembly and function of glutamate receptors by the amino-terminal domain.

Mol Pharmacol 2010 Oct 21;78(4):535-49. Epub 2010 Jul 21.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.110.06
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http://dx.doi.org/10.1124/mol.110.067157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981397PMC
October 2010

Glutamate receptor ion channels: structure, regulation, and function.

Pharmacol Rev 2010 Sep;62(3):405-96

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.109.002
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http://dx.doi.org/10.1124/pr.109.002451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964903PMC
September 2010

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.

Mol Pharmacol 2010 Jun 9;77(6):1005-15. Epub 2010 Mar 9.

Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1124/mol.109.062018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879918PMC
June 2010