Stephen Durham

Stephen Durham

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Stephen Durham

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Immunologic mechanisms of a short-course of Lolium perenne peptide immunotherapy: A randomized, double-blind, placebo-controlled trial.

J Allergy Clin Immunol 2019 Sep 5;144(3):738-749. Epub 2019 Mar 5.

Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair & Development, Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.02.023DOI Listing
September 2019

Duration of allergen immunotherapy for inhalant allergy.

Curr Opin Allergy Clin Immunol 2019 Aug 28. Epub 2019 Aug 28.

Allergy and Clinical Immunology, Division of Respiratory Science, Imperial College London and National Heart and Lung Institute, Royal Brompton Hospital. Dovehouse Street, London, United Kingdom.

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http://dx.doi.org/10.1097/ACI.0000000000000585DOI Listing
August 2019

Hymenoptera Venom Allergy: How Does Venom Immunotherapy Prevent Anaphylaxis From Bee and Wasp Stings?

Front Immunol 2019 21;10:1959. Epub 2019 Aug 21.

Immunomodulation and Tolerance Group, Allergy and Clinical Immunology Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712168PMC
August 2019

The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study.

J Allergy Clin Immunol 2019 Jul 15. Epub 2019 Jul 15.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; Department of Allergy, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1016/j.jaci.2019.06.038DOI Listing
July 2019

Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses.

J Allergy Clin Immunol 2019 Jun 11;143(6):2086-2094.e2. Epub 2019 Feb 11.

Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2019.02.001DOI Listing
June 2019

2019 ARIA Care pathways for allergen immunotherapy.

Authors:
Jean Bousquet Oliver Pfaar Alkis Togias Holger J Schünemann Ignacio Ansotegui Nikolaos G Papadopoulos Ioanna Tsiligianni Ioana Agache Josep M Anto Claus Bachert Anna Bedbrook Karl-Christian Bergmann Sinthia Bosnic-Anticevich Isabelle Bosse Jan Brozek Moises A Calderon Giorgio W Canonica Luigi Caraballo Victoria Cardona Thomas Casale Lorenzo Cecchi Derek Chu Elisio Costa Alvaro A Cruz Wienczyslawa Czarlewski Stephen R Durham George Du Toit Mark Dykewicz Motohiro Ebisawa Jean Luc Fauquert Montserrat Fernandez-Rivas Wytske J Fokkens João Fonseca Jean-François Fontaine Roy Gerth van Wijk Tari Haahtela Susanne Halken Peter W Hellings Despo Ierodiakonou Tomohisa Iinuma Juan Carlos Ivancevich Lars Jacobsen Marek Jutel Igor Kaidashev Musa Khaitov Omer Kalayci Jörg Kleine Tebbe Ludger Klimek Marek L Kowalski Piotr Kuna Violeta Kvedariene Stefania La Grutta Désirée Larenas-Linemann Susanne Lau Daniel Laune Lan Le Karin Lodrup Carlsen Olga Lourenço Hans-Jørgen Malling Gert Marien Enrica Menditto Gregoire Mercier Joaquim Mullol Antonella Muraro Robyn O'Hehir Yoshitaka Okamoto Giovanni B Pajno Hae-Sim Park Petr Panzner Giovanni Passalacqua Nhan Pham-Thi Graham Roberts Ruby Pawankar Christine Rolland Nelson Rosario Dermot Ryan Bolesław Samolinski Mario Sanchez-Borges Glenis Scadding Mohamed H Shamji Aziz Sheikh Gunter J Sturm Ana Todo Bom Sanna Toppila-Salmi Maryline Valentin-Rostan Arunas Valiulis Erkka Valovirta Maria-Teresa Ventura Ulrich Wahn Samantha Walker Dana Wallace Susan Waserman Arzu Yorgancioglu Torsten Zuberbier

Allergy 2019 Apr 7. Epub 2019 Apr 7.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Comprehensive Allergy Centre, Member of GA2LEN, Humboldt-Uniersität zu Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/all.13805DOI Listing
April 2019

The allergen-specificity of allergen immunotherapy - doubt no more.

Authors:
Stephen R Durham

Allergy 2019 Apr 20. Epub 2019 Apr 20.

National Heart and Lung Institute, Imperial College London, Dovehouse Street, London.

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http://dx.doi.org/10.1111/all.13826DOI Listing
April 2019

Role of IL-35 in sublingual allergen immunotherapy.

J Allergy Clin Immunol 2019 Mar 25;143(3):1131-1142.e4. Epub 2018 Jul 25.

Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2018.06.041DOI Listing
March 2019

Nasal allergen-neutralizing IgG antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy.

J Allergy Clin Immunol 2019 Mar 14;143(3):1067-1076. Epub 2018 Nov 14.

Allergy and Clinical Immunology, Immunomodulation and Tolerance Group, National Heart and Lung Institute, Inflammation Repair and Development, Imperial College, London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183159
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http://dx.doi.org/10.1016/j.jaci.2018.09.039DOI Listing
March 2019

Allergen Immunotherapy for a Teenager with Seasonal Allergic Rhinitis Due to Grass Pollen: Subcutaneous or Sublingual Route?

J Allergy Clin Immunol Pract 2017 Jan - Feb;5(1):52-57

Allergy and Clinical Immunology, Division of Respiratory Science, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2016.10.012DOI Listing
December 2018

UK Immunotherapy Study: Reanalysis by a combined symptom and medication score.

J Allergy Clin Immunol 2018 12 24;142(6):1998-1999.e3. Epub 2018 Aug 24.

Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.07.034DOI Listing
December 2018

New approaches to allergen immunotherapy.

Ann Allergy Asthma Immunol 2018 09 17;121(3):293-305. Epub 2018 Jul 17.

Imperial College London, London, United Kingdom; Royal Brompton and Harefield Hospitals, NHS Foundation Trust, London, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10811206183057
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http://dx.doi.org/10.1016/j.anai.2018.07.014DOI Listing
September 2018

Antiapoptotic serine protease inhibitors contribute to survival of allergenic T2 cells.

J Allergy Clin Immunol 2018 08 26;142(2):569-581.e5. Epub 2017 Oct 26.

Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749173164
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http://dx.doi.org/10.1016/j.jaci.2017.07.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920800PMC
August 2018

Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis.

Curr Treat Options Allergy 2018 31;5(3):275-290. Epub 2018 Aug 31.

Allergy and Clinical Immunology, Division of Respiratory Science, National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital Imperial College London, Dovehouse Street, London, SW3 6LY UK.

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http://dx.doi.org/10.1007/s40521-018-0176-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132438PMC
August 2018

Synchronous immune alterations mirror clinical response during allergen immunotherapy.

J Allergy Clin Immunol 2018 05 9;141(5):1750-1760.e1. Epub 2017 Nov 9.

Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Section of Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London, United Kingdom; MRC and Asthma UK, Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938141PMC
May 2018

A Recombinant Fragment of Human Surfactant Protein D Suppresses Basophil Activation and T-Helper Type 2 and B-Cell Responses in Grass Pollen-induced Allergic Inflammation.

Am J Respir Crit Care Med 2017 12;196(12):1526-1534

1 Allergy and Clinical Immunology, Inflammation, Repair and Development, and Immune Modulation and Tolerance Group, National Heart and Lung Institute, Imperial College London, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom; and.

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http://www.atsjournals.org/doi/10.1164/rccm.201701-0225OC
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http://dx.doi.org/10.1164/rccm.201701-0225OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754441PMC
December 2017

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers.

J Allergy Clin Immunol 2017 Dec;140(6):1485-1498

Immunomodulation and Tolerance Group; Allergy and Clinical Immunology; Section of Inflammation, Repair and Development; National Heart and Lung Institute; Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.010DOI Listing
December 2017

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial.

J Allergy Clin Immunol 2017 Oct 4;140(4):1024-1031.e14. Epub 2017 Jul 4.

Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2017.05.044DOI Listing
October 2017

Intradermal grass pollen immunotherapy increases T2 and IgE responses and worsens respiratory allergic symptoms.

J Allergy Clin Immunol 2017 Jun 20;139(6):1830-1839.e13. Epub 2016 Oct 20.

Division of Asthma, Allergy and Lung Biology, King's College London, School of Medicine, Guy's Hospital, London, United Kingdom; MRC-Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457129PMC
June 2017

Applications and mechanisms of immunotherapy in allergic rhinitis and asthma.

Ther Adv Respir Dis 2017 01 27;11(1):73-86. Epub 2016 Sep 27.

Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1177/1753465816669662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941975PMC
January 2017

Omalizumab reduces bronchial mucosal IgE and improves lung function in non-atopic asthma.

Eur Respir J 2016 12 20;48(6):1593-1601. Epub 2016 Oct 20.

Dept of Respiratory Medicine and Allergy, and Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.

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http://dx.doi.org/10.1183/13993003.01501-2015DOI Listing
December 2016

Geohistorical records indicate no impact of the Deepwater Horizon oil spill on oyster body size.

R Soc Open Sci 2016 Nov 30;3(11):160763. Epub 2016 Nov 30.

Department of Earth and Atmospheric Sciences , Cornell University , Ithaca, NY 14853 , USA.

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http://dx.doi.org/10.1098/rsos.160763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180161PMC
November 2016

Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses.

J Allergy Clin Immunol 2016 10 15;138(4):1081-1088.e4. Epub 2016 Jul 15.

Merck & Co, Kenilworth, NJ. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.04.061DOI Listing
October 2016

IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa.

J Allergy Clin Immunol 2016 05 10;137(5):1514-24. Epub 2015 Dec 10.

Division of Asthma, Allergy and Lung Biology, Guy's Hospital, King's College London, London, United Kingdom; Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852988PMC
May 2016

Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial.

J Allergy Clin Immunol 2016 Feb 31;137(2):452-461.e9. Epub 2015 Oct 31.

Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, London, United Kingdom; Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Center Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.046DOI Listing
February 2016

Sublingual or subcutaneous immunotherapy for allergic rhinitis?

J Allergy Clin Immunol 2016 Feb;137(2):339-349.e10

Allergy and Clinical Immunology, Division of Respiratory Science, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.12.1298DOI Listing
February 2016

Specific allergen immunotherapy for the treatment of atopic eczema.

Cochrane Database Syst Rev 2016 Feb 12;2:CD008774. Epub 2016 Feb 12.

Section of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, Wright Fleming Building, Norfolk Place, London, UK, W2 1PG.

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http://dx.doi.org/10.1002/14651858.CD008774.pub2DOI Listing
February 2016

Asthma phenotypes and IgE responses.

Eur Respir J 2016 Jan 17;47(1):304-19. Epub 2015 Dec 17.

Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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http://erj.ersjournals.com/content/erj/47/1/304.full.pdf
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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01824
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http://dx.doi.org/10.1183/13993003.01824-2014DOI Listing
January 2016

Severe Persistent Allergic Rhinitis. Inflammation but No Histologic Features of Structural Upper Airway Remodeling.

Am J Respir Crit Care Med 2015 Dec;192(12):1431-9

Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201502-0339OCDOI Listing
December 2015

Basophil activation test using recombinant allergens: highly specific diagnostic method complementing routine tests in wasp venom allergy.

PLoS One 2014 17;9(10):e108619. Epub 2014 Oct 17.

Department of Dermatology and Allergy, Biederstein, Technische Universität München, Munich, Germany; Molecular Immunology, Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom; Christine Kuhne-center for Allergy Research and Education (CK-CARE), Davos, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201461PMC
July 2015

IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens.

J Allergy Clin Immunol 2015 May 7;135(5):1249-56. Epub 2015 Feb 7.

Department of Pediatric Allergy, Division of Asthma, Allergy & Lung Biology, King's College London, London, United Kingdom; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418748PMC
May 2015

Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.

J Allergy Clin Immunol 2015 Apr 22;135(4):913-21.e9. Epub 2014 Nov 22.

Allergy and Clinical Immunology Section, Department of Leukocyte Biology, Division of National Heart and Lung Institute, Imperial College London, and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.09.049DOI Listing
April 2015

Reply: To PMID 25457150.

J Allergy Clin Immunol 2015 Apr 25;135(4):1089-90. Epub 2015 Feb 25.

Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1944DOI Listing
April 2015

Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy.

J Allergy Clin Immunol 2014 Nov 8;134(5):1193-5.e4. Epub 2014 Sep 8.

Allergy and Clinical Immunology, Section Leukocyte Biology, National Heart and Lung Institute, Imperial College London, London, and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.07.029DOI Listing
November 2014

Silk contact anaphylaxis.

Contact Dermatitis 2014 Nov;71(5):314-5

Allergy Department, Royal Brompton and Harefield NHS Foundation Trust, Fulham Road SW3 6NP, London, UK.

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http://dx.doi.org/10.1111/cod.12289DOI Listing
November 2014

Grass pollen immunotherapy for treatment of allergic rhinitis.

BMJ 2014 Nov 17;349:g6586. Epub 2014 Nov 17.

Division of Asthma, Allergy and Lung Biology, King's College London, School of Medicine, Guy's Hospital, London SE1 9RT, UK Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK

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http://dx.doi.org/10.1136/bmj.g6586DOI Listing
November 2014

Biomarkers of tolerance in response to allergen immunotherapy.

Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess 2013 ;97:75-81

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September 2014

Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis.

J Allergy Clin Immunol 2014 Sep;134(3):604-12

Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom; Medical Research Council and Asthma UK Centre, Allergic Mechanisms in Asthma, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2014.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151999PMC
September 2014

Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients.

J Allergy Clin Immunol 2014 Jun 1;133(6):1770-2.e11. Epub 2014 May 1.

Department of Asthma, Allergy and Respiratory Science and Randall Division of Cell and Molecular Biophysics, King's College London, London.

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https://www.researchgate.net/profile/Sun_Ying3/publication/2
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http://dx.doi.org/10.1016/j.jaci.2014.03.027DOI Listing
June 2014

Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner.

J Allergy Clin Immunol 2014 Mar 25;133(3):872-9.e7. Epub 2013 Dec 25.

Benaroya Research Institute at Virginia Mason, Seattle, Wash; Department of Medicine, University of Washington, Seattle, Wash. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961577PMC
March 2014

Allergen immunotherapy and tolerance.

Allergol Int 2013 Dec;62(4):403-13

Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Imperial College London, London, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S132389301530159
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http://dx.doi.org/10.2332/allergolint.13-RAI-0650DOI Listing
December 2013

Children must be protected from the tobacco industry's marketing tactics.

Authors:
Nicholas Hopkinson Colin Wallis Bernard Higgins Stephen Gaduzo Rebecca Sherrington Sarah Keilty Myra Stern John Britton Andrew Bush John Moxham Karl Sylvester Valerie Griffiths Tim Sutherland Iain Crossingham Raghu Raju Charlotte Spencer Shahideh Safavi Paul Deegan John Seymour Katherine Hickman John Hughes Jason Wieboldt Fizah Shaheen Clive Peedell Nesta Mackenzie David Nicholl Caroline Jolley Gillian Crooks Gillian Crooks Claire Dow Pete Deveson Oliver Bintcliffe Barry Gray Sanjay Kumar Sarah Haney Marianne Docherty Angela Thomas Felix Chua Akshay Dwarakanath Geoffrey Summers Keith Prowse Stephen Lytton Yee Ean Ong Jennifer Graves Tushar Banerjee Peter English Andrew Leonard Martin Brunet Nauman Chaudhry Robert Ian Ketchell Natalie Cummings Jenny Lebus Charles Sharp Chris Meadows Amelie Harle Tara Stewart Diane Parry Suzanne Templeton-Wright John Moore-Gillon James Stratford- Martin Sarvesh Saini Simon Matusiewicz Simon Merritt Lee Dowson Karnan Satkunam Luke Hodgson Eui-Sik Suh Hannah Durrington Emma Browne Nicola Walters Joerg Steier Simon Barry Mark Griffiths Nicholas Hart Marko Nikolic Matthew Berry Ajit Thomas Joy Miller Diarmuid McNicholl Paul Marsden Geoffrey Warwick Laura Barr David Adeboyeku Mohd Shahrin Mohd Noh Paul Griffiths Lisa Davies Jennifer Quint Rebecca Lyall Jonathan Shribman Andrea Collins Jon Goldman Susannah Bloch Alison Gill William Man Anne Christopher Razouqi Yasso Ashwin Rajhan Dinesh Shrikrishna Caroline Moore Gareth Absalom Richard Booton Robert William Fowler Carolyn Mackinlay Elizabeth Sapey Sara Lock Paul Walker Akhilesh Jha Imran Satia Bethia Bradley Naveed Mustfa Raana Haqqee Matt Thomas Anant Patel Anthony Redington Anilkumar Pillai Niall Keaney Stephen Fowler Lesley Lowe Amanda Brennan Douglas Morrison Clare Murray Jenny Hankinson P Dutta Matthew Maddocks Martino Pengo Katrina Curtis Gerrard Rafferty John Hutchinson Ruth Whitfield Steve Turner Ronan Breen Shams-un-nisa Naveed Chris Goode Georgina Esterbrook Liju Ahmed Woolf Walker David Ford Gary Connett Philip Davidson Will Elston Andrew Stanton David Morgan James Myerson David Maxwell Ann Harrris Sonia Parmar Catherine Houghton Robert Winter Zudin Puthucheary Fiona Thomson Sharon Sturney John Harvey Patricia L Haslam Irem Patel David Jennings Simon Range Brendan Mallia-Milanes Anne Collett Paul Tate Richard Russell Johanna Feary Ronan O'Driscoll James Eaden Jonathan Round Emma Sharkey Mary Montgomery Sophie Vaughan Kate Scheele Anna Lithgow Samuel Partridge Richard Chavasse Louise Restrick Sanjay Agrawal Said Abdallah Amruta Lacy-Colson Nick Adams Sally Mitchell Helmy Haja Mydin Ann Ward Sarah Denniston Mark Steel Dipansu Ghosh Stephen Connellan Lucy Rigge Ruth Williams Alison Grove Sadia Anwar Lee Dobson Harold Hosker David Stableforth Neil Greening Tim Howell Georgina Casswell Sarah Davies Georgia Tunnicliffe Philip Mitchelmore Elpida Phitidis Louise Robinson Keith Prowse Mona Bafadhel Grace Robinson Alison Boland Marc Lipman Stephen Bourke Sundeep Kaul Calvin Cowie Ian Forrest Elizabeth Starren Hannah Burke John Furness Angshu Bhowmik Caroline Everett Douglas Seaton Steve Holmes Simon Doe Samuel Parker Annika Graham Ian Paterson Usman Maqsood Chandra Ohri Peter Iles Samuel Kemp Ahsan Iftikhar Chris Carlin Tim Fletcher Peter Emerson Victoria Beasley Michelle Ramsay Robert Buttery Sarah Mungall Stephen Crooks John Ridyard David Ross Alison Guadagno Emma Holden Ian Coutts Kathy Cullen Sally O'Connor Jack Barker Katherine Sloper John Watson Peter Smith Paul Anderson Louise Brown Cyril Nyman Heather Milburn Amelia Clive Matthew Serlin Charlotte Bolton Jonathan Fuld Helen Powell Mark Dayer Ian Woolhouse Adamantia Georgiadi Helen Leonard James Dodd Ian Campbell Gary Ruiz Andrew Zurek James Y Paton Adam Malin Fraser Wood Gareth Hynes David Connell David Spencer Sarah Brown David Smith David Cooper Cecilia O'Kane Alex Hicks Ben Creagh-Brown James Lordan Annabel Nickol Robert Primhak Louise Fleming Duncan Powrie Joanna Brown Zaid Zoumot Sarah Elkin Joanna Szram Anthony Scaffardi Robert Marshall Ian Macdonald Darren Lightbody Ray Farmer Iain Wheatley Paul Radnan Ian Lane Andrew Booth Sean Tilbrook Toby Capstick Lee Hewitt Martin McHugh Christopher Nelson Patrick Wilson Vijay Padmanaban John White John Davison Una O'Callaghan Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Rosalind Backham Kim Randall Tracey Mathieson Alex Long Marilyn Parkes Sarah Clarke Bev Allen Carol Connelly Georgia Forster Jacky Hoadley Katharine Martin Kate Barnham Katie Khan Maureen Munday Catherine Edwards Doreen O'Hara Sally Turner Sue Pieri-Davies Kate Ford Tracey Daniels Joanne Wright Rebecca Towns Karen Fern Jane Butcher Karen Burgin Barbara Winter Debbie Freeman Sandra Olive Linda Gray Kathy Pye Debbie Roots Nicola Cox Carol-Anne Davies Jacquelyne Wicker Kay Hilton Jananee Lloyd Vicky MacBean Marion Wood Julia Kowal Janis Downs Helen Ryan Fran Guyatt Debby Nicoll Elizabeth Lyons Divya Narasimhan Anne Rodman Sandy Walmsley Alison Newey Maria Buxton Maria Dewar Angela Cooper Jacqui Reilly Julie Lloyd Alison Bennett Macmillan Debbie Roots Amy Olley Nia Voase Sarah Martin Iona McCarvill Anne Christensen Rowan Agate Karen Heslop Amber Timlett Karen Hailes Claire Davey Barbara Pawulska Amber Lane Shona Ioakim Alexandra Hough Jo Treharne Helen Jones Alice Winter-Burke Lauren Miller Bronwen Connolly Lyn Bingham Una Fraser Julia Bott Carol Johnston Alison Graham Denise Curry Helen Sumner Carol Ann Costello Charlotte Bartoszewicz Ros Badman Kathryn Williamson Amy Taylor Helen Purcell Emma Barnett Alanna Molloy Laura Crawfurd Nicola Collins Valerie Monaghan Misbah Mir Victoria Lord Janet Stocks Adrian Edwards Trish Greenhalgh Warren Lenney Martin McKee Danny McAuley Azeem Majeed John Cookson Emma Baker Sam Janes Wisia Wedzicha David Lomas Dean Brian Harrison Tony Davison Peter Calverley Robert Wilson Robert Stockley Jon Ayres John Gibson John Simpson Sherwood Burge John Warner Warren Lenney Neil Thomson Peter Davies Ashley Woodcock Mark Woodhead Stephen Spiro Lawrence Ormerod Graham Bothamley Martyn Partridge Michael Shields Hugh Montgomery Anita Simonds Peter Barnes Stephen Durham Sarah Malone Gilda Arabnia Sharon Olivier Karen Gardiner Sheila Edwards

BMJ 2013 Dec 9;347:f7358. Epub 2013 Dec 9.

British Thoracic Society Chronic Obstructive Pulmonary Disease Specialist Advisory Group, National Heart and Lung Institute, Imperial College, London SW3 6NP, UK.

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http://dx.doi.org/10.1136/bmj.f7358DOI Listing
December 2013

Allergen immunotherapy for house dust mite: clinical efficacy and immunological mechanisms in allergic rhinitis and asthma.

Expert Opin Biol Ther 2013 Nov 8;13(11):1543-56. Epub 2013 Oct 8.

Imperial College London, Allergy and Clinical Immunology , NHLI, London, SW7 2AZ , UK

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http://www.tandfonline.com/doi/full/10.1517/14712598.2013.84
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http://dx.doi.org/10.1517/14712598.2013.844226DOI Listing
November 2013

Cell-free detection of allergen-IgE cross-linking with immobilized phase CD23: inhibition by blocking antibody responses after immunotherapy.

J Allergy Clin Immunol 2013 Oct 1;132(4):1003-5.e1-4. Epub 2013 Jul 1.

Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom; Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2013.05.025DOI Listing
October 2013

Beta₂-agonists for exercise-induced asthma.

Cochrane Database Syst Rev 2013 Oct 2(10):CD003564. Epub 2013 Oct 2.

Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.1002/14651858.CD003564.pub3DOI Listing
October 2013

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.

J Allergy Clin Immunol 2013 Aug 18;132(2):446-54.e5. Epub 2013 May 18.

Allergy and Clinical Immunology, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2013.03.050DOI Listing
August 2013

A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype.

J Immunol 2013 Apr 25;190(7):3068-78. Epub 2013 Feb 25.

Christian Doppler Laboratory of Allergy Research, Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology, and Immunology, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.4049/jimmunol.1202441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148560PMC
April 2013

IL-22 suppresses IFN-γ-mediated lung inflammation in asthmatic patients.

J Allergy Clin Immunol 2013 Feb 19;131(2):562-70. Epub 2012 Nov 19.

ZAUM-Center of Allergy and Environment, Technische Universität and Helmholtz Center Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.jaci.2012.09.036DOI Listing
February 2013

Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes.

J Immunol Methods 2012 Oct 30;384(1-2):25-32. Epub 2012 Jun 30.

Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK.

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http://dx.doi.org/10.1016/j.jim.2012.06.013DOI Listing
October 2012

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses.

J Allergy Clin Immunol 2012 Oct 9;130(4):918-24.e1. Epub 2012 Sep 9.

Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2012.06.052DOI Listing
October 2012

Allergen immunotherapy for allergic respiratory diseases.

Hum Vaccin Immunother 2012 Oct 1;8(10):1499-512. Epub 2012 Oct 1.

Section Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.4161/hv.21629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660772PMC
October 2012

Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

J Allergy Clin Immunol 2012 Sep 13;130(3):663-670.e3. Epub 2012 May 13.

Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2012.04.006DOI Listing
September 2012

Local allergic rhinitis: concept, pathophysiology, and management.

J Allergy Clin Immunol 2012 Jun 18;129(6):1460-7. Epub 2012 Apr 18.

Allergy Service, Carlos Haya Hospital, Málaga, Spain.

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http://dx.doi.org/10.1016/j.jaci.2012.02.032DOI Listing
June 2012

SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial.

J Allergy Clin Immunol 2012 Mar 29;129(3):717-725.e5. Epub 2012 Jan 29.

Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2011.12.973DOI Listing
March 2012

Long-term clinical and immunological effects of allergen immunotherapy.

Curr Opin Allergy Clin Immunol 2011 Dec;11(6):586-93

Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1097/ACI.0b013e32834cb994DOI Listing
December 2011

Sublingual immunotherapy for treating allergic conjunctivitis.

Cochrane Database Syst Rev 2011 Jul 6(7):CD007685. Epub 2011 Jul 6.

Department of Allergy and Respiratory Medicine, Royal Brompton Hospital, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK, SW3 6LY.

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http://dx.doi.org/10.1002/14651858.CD007685.pub2DOI Listing
July 2011

Systematic reviews of sublingual immunotherapy (SLIT).

Allergy 2011 Jun 28;66(6):740-52. Epub 2011 Mar 28.

Paediatric Allergy, King's College, London, UK.

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http://dx.doi.org/10.1111/j.1398-9995.2011.02583.xDOI Listing
June 2011

Allergen immunotherapy: a centenary celebration.

World Allergy Organ J 2011 Jun;4(6):104-6

From the 1Royal Brompton National Heart & Lung Institute, London; and 2National Jewish Health, Denver, CO.

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http://dx.doi.org/10.1097/WOX.0b013e3182218920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651049PMC
June 2011

Mechanisms of sublingual immunotherapy.

Immunol Allergy Clin North Am 2011 May;31(2):191-209, viii

Department of Allergy and Clinical Immunology, Imperial College, Exhibition Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.iac.2011.02.005DOI Listing
May 2011

Serum immunologic markers for monitoring allergen-specific immunotherapy.

Immunol Allergy Clin North Am 2011 May;31(2):311-23, x

Allergy and Clinical Immunology Section, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S08898561110001
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http://dx.doi.org/10.1016/j.iac.2011.03.005DOI Listing
May 2011

Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.

J Allergy Clin Immunol 2011 Feb;127(2):509-516.e1-5

Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK.

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http://dx.doi.org/10.1016/j.jaci.2010.12.1080DOI Listing
February 2011

Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond.

J Allergy Clin Immunol 2011 Jan 20;127(1):30-8. Epub 2010 Oct 20.

Section of Allergy and Clinical Immunology, Imperial College, NHLI, Royal Brompton Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.08.024DOI Listing
January 2011

One hundred years of allergen immunotherapy: time to ring the changes.

J Allergy Clin Immunol 2011 Jan;127(1):3-7

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http://dx.doi.org/10.1016/j.jaci.2010.11.032DOI Listing
January 2011

Sublingual immunotherapy for allergic rhinitis.

Cochrane Database Syst Rev 2010 Dec 8(12):CD002893. Epub 2010 Dec 8.

LEAP Study Team, Paediatric Allergy Research Department, St. Thomas' Hospital, Lambeth Palace Road, London, UK, SE1 7EH.

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http://dx.doi.org/10.1002/14651858.CD002893DOI Listing
December 2010

SQ-standardised grass tablet sublingual immunotherapy: persistent clinical benefit and progressive immunological changes during three years treatment.

Authors:
Stephen R Durham

Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess 2009 ;96:121-7; discussion 127-31

Imperial College London, National Heart & Lung Institute, UK-London SW3 6LY.

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October 2010

Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet.

J Allergy Clin Immunol 2010 Jan;125(1):131-8.e1-7

Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Guy Scadding Building, Royal Brompton Campus, Dovehouse St, SW3 6LY London, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167490901583
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http://dx.doi.org/10.1016/j.jaci.2009.10.035DOI Listing
January 2010

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling.

J Clin Invest 2009 Dec 16;119(12):3573-85. Epub 2009 Nov 16.

Molecular Immunology, Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1172/JCI40202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786807PMC
December 2009

Postnasal drip and chronic cough: An open interventional study.

Respir Med 2009 Nov 29;103(11):1700-5. Epub 2009 May 29.

Royal Brompton Hospital, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.rmed.2009.05.005DOI Listing
November 2009

Clinical efficacy and immune regulation with peanut oral immunotherapy.

J Allergy Clin Immunol 2009 Aug 3;124(2):292-300, 300.e1-97. Epub 2009 Jul 3.

Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725434PMC
August 2009

Mechanisms of sublingual immunotherapy.

J Asthma 2009 May;46(4):322-34

Allergy and Clinical Immunology, Imperial College, London, UK.

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http://dx.doi.org/10.1080/02770900902785729DOI Listing
May 2009

Sublingual immunotherapy for allergic Rhinoconjunctivitis, allergic asthma, and prevention of allergic diseases.

Clin Allergy Immunol 2008 ;21:359-75

Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK.

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January 2009

Sublingual immunotherapy: what have we learnt from the 'big trials'?

Authors:
Stephen R Durham

Curr Opin Allergy Clin Immunol 2008 Dec;8(6):577-84

Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1097/ACI.0b013e3283196764DOI Listing
December 2008

Regulatory T cells and allergic disease.

Inflamm Allergy Drug Targets 2008 Dec;7(4):237-52

Department of Allergy & Clinical Immunology, National Heart & Lung Institute at Imperial College London, Exhibition Road, London, UK.

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December 2008

Mechanisms of immunotherapy.

Authors:
Stephen R Durham

Drugs Today (Barc) 2008 Dec;44 Suppl B:93-4

Allergy and Clinical Immunology, Imperial College and Royal Brompton Hospital, London, UK.

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December 2008