Stephen D Nimer

Stephen D Nimer

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Stephen D Nimer

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Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Leukemia 2019 07 12;33(7):1822-1827. Epub 2019 Feb 12.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/s41375-019-0398-8DOI Listing
July 2019

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes.

Leukemia 2019 Jul 22. Epub 2019 Jul 22.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1038/s41375-019-0518-5DOI Listing
July 2019

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.

Leukemia 2019 05 16;33(5):1287-1291. Epub 2019 Jan 16.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://www.nature.com/articles/s41375-018-0347-y
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http://dx.doi.org/10.1038/s41375-018-0347-yDOI Listing
May 2019

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.

Proc Natl Acad Sci U S A 2019 01 28;116(3):890-899. Epub 2018 Dec 28.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;

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http://dx.doi.org/10.1073/pnas.1809327116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338862PMC
January 2019

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

J Clin Invest 2018 12 29;128(12):5383-5398. Epub 2018 Oct 29.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1172/JCI121366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264643PMC
December 2018

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes.

Cell Rep 2018 09;24(10):2643-2657

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322662PMC
September 2018

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.

Leukemia 2018 08 2;32(8):1834-1837. Epub 2018 Apr 2.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41375-018-0126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168429PMC
August 2018

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.

Cancer Cell 2018 06;33(6):1111-1127.e5

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191185PMC
June 2018

p300 suppresses leukemia development in NUP98-HOXD13 driven myelodysplastic syndrome.

Oncotarget 2018 Jun 1;9(42):26603-26604. Epub 2018 Jun 1.

Sylvester Comprehensive Cancer Center and The Department of Biochemistry and Molecular Biology, Miller School of Medicine University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.23402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003552PMC
June 2018

Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma.

Neuro Oncol 2017 Oct;19(10):1380-1390

Memorial Sloan Kettering Cancer Center, New York, New York,USA; Northwestern Memorial Hospital, Chicago, Illinois, USA; NorthShore University, Evanston, Illinois,USA; University of Calgary, Calgary, Alberta, Canada; Massachusetts General Hospital, Boston, Massachusetts, USA; MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1093/neuonc/nox086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596171PMC
October 2017

Covalent Modifications of RUNX Proteins: Structure Affects Function.

Adv Exp Med Biol 2017 ;962:33-44

Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/978-981-10-3233-2_3DOI Listing
September 2017

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

Proc Natl Acad Sci U S A 2017 06 22;114(23):6016-6021. Epub 2017 May 22.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;

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http://dx.doi.org/10.1073/pnas.1700328114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468650PMC
June 2017

Loss of Asxl2 leads to myeloid malignancies in mice.

Nat Commun 2017 06 8;8:15456. Epub 2017 Jun 8.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 417, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/ncomms15456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472177PMC
June 2017

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.

Sci Adv 2017 Jan 20;3(1):e1601602. Epub 2017 Jan 20.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1126/sciadv.1601602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249256PMC
January 2017

Arginine methyltransferases in normal and malignant hematopoiesis.

Exp Hematol 2016 06 26;44(6):435-41. Epub 2016 Mar 26.

Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.03.009DOI Listing
June 2016

Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape.

Nat Rev Cancer 2016 06;16(6):359-72

Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1038/nrc.2016.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548460PMC
June 2016

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.

Blood 2016 05 4;127(19):2322-6. Epub 2016 Mar 4.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

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http://dx.doi.org/10.1182/blood-2015-11-677708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865589PMC
May 2016

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.

Cancer Res 2016 04 26;76(7):1814-24. Epub 2016 Feb 26.

Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Strategic Basic Research Program, Japan Science and Technology Agency, Saitama, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3816DOI Listing
April 2016

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.

Nat Commun 2016 Feb 22;7:10739. Epub 2016 Feb 22.

Molecular Pharmacology and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms10739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764878PMC
February 2016

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

J Exp Med 2016 Jan 14;213(1):25-34. Epub 2015 Dec 14.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136 Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136 Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136

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http://dx.doi.org/10.1084/jem.20150524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710200PMC
January 2016

PARP inhibitors: a treatment option for AML?

Nat Med 2015 Dec;21(12):1393-4

Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1038/nm.4007DOI Listing
December 2015

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.

Cell Rep 2015 Nov 12;13(8):1692-704. Epub 2015 Nov 12.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL 33136, USA; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764044PMC
November 2015

Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

Br J Haematol 2015 Sep 26;170(6):859-73. Epub 2015 May 26.

Department of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.

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http://dx.doi.org/10.1111/bjh.13499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996932PMC
September 2015

Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.

Blood 2015 Jul 17;126(5):640-50. Epub 2015 Jun 17.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, and Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

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http://dx.doi.org/10.1182/blood-2015-03-635532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520879PMC
July 2015

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.

Nat Biotechnol 2015 Jun 23;33(6):646-55. Epub 2015 Mar 23.

1] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [4] Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, USA. [5] Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA. [6] Department of Pathology, University of Washington, Seattle, Washington, USA. [7] Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.3178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464949PMC
June 2015

The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.

Front Oncol 2015 26;5:108. Epub 2015 May 26.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL , USA ; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL , USA.

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http://www.frontiersin.org/Cancer_Endocrinology/10.3389/fonc
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http://dx.doi.org/10.3389/fonc.2015.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443728PMC
June 2015

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.

Cancer Cell 2015 Apr;27(4):502-15

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518555PMC
April 2015

PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.

Cell Rep 2013 Dec 12;5(6):1625-38. Epub 2013 Dec 12.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073674PMC
December 2013

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia.

Haematologica 2013 Jun 24;98(6):908-12. Epub 2013 Jan 24.

Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.3324/haematol.2012.076729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669447PMC
June 2013

Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.

Int J Hematol 2013 Feb 4;97(2):198-209. Epub 2013 Jan 4.

Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/s12185-012-1247-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555405PMC
February 2013

Efficacy of hypomethylating agents in therapy-related myelodysplastic syndromes.

Leuk Res 2012 Sep 17;36(9):1093-7. Epub 2012 May 17.

Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.leukres.2012.04.025DOI Listing
September 2012

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.

Front Med 2012 Sep 9;6(3):248-62. Epub 2012 Aug 9.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s11684-012-0206-6DOI Listing
September 2012

The checkpoint kinase inhibitor AZD7762 potentiates chemotherapy-induced apoptosis of p53-mutated multiple myeloma cells.

Mol Cancer Ther 2012 Aug 31;11(8):1781-8. Epub 2012 May 31.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0949DOI Listing
August 2012

Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia.

Leuk Res 2012 May 9;36(5):570-4. Epub 2011 Dec 9.

Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.leukres.2011.10.023DOI Listing
May 2012

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Blood 2011 Dec 19;118(25):6544-52. Epub 2011 Oct 19.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1182/blood-2010-11-317909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242717PMC
December 2011

L3MBTL1 deficiency directs the differentiation of human embryonic stem cells toward trophectoderm.

Stem Cells Dev 2011 Nov 3;20(11):1889-900. Epub 2011 Apr 3.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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https://www.liebertpub.com/doi/10.1089/scd.2010.0437
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http://dx.doi.org/10.1089/scd.2010.0437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202892PMC
November 2011

The p53 tumor suppressor protein regulates hematopoietic stem cell fate.

J Cell Physiol 2011 Sep;226(9):2215-21

Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1002/jcp.22561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081536PMC
September 2011

The mef/elf4 transcription factor fine tunes the DNA damage response.

Cancer Res 2011 Jul 26;71(14):4857-65. Epub 2011 May 26.

Molecular Pharmacology and Chemistry Program of the Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073677PMC
July 2011

An update on the molecular pathogenesis of myelodysplastic syndromes.

Authors:
Stephen D Nimer

Biol Blood Marrow Transplant 2011 Jan;17(1 Suppl):S11-4

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bbmt.2010.10.012DOI Listing
January 2011

L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.

Proc Natl Acad Sci U S A 2010 Dec 13;107(52):22552-7. Epub 2010 Dec 13.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1017092108
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http://dx.doi.org/10.1073/pnas.1017092108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012470PMC
December 2010

The oncogenic role of the ETS transcription factors MEF and ERG.

Cell Cycle 2010 Sep 13;9(17):3457-9. Epub 2010 Sep 13.

Molecular Pharmacology and Chemistry Program of the Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230474PMC
http://dx.doi.org/10.4161/cc.9.17.13000DOI Listing
September 2010

Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.

Stem Cells 2010 Feb;28(2):308-17

Molecular Pharmacology and Chemistry Program and Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1002/stem.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144254PMC
February 2010

Myelodysplasia: battle in the bone marrow.

Nat Med 2010 Jan;16(1):30-2

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http://dx.doi.org/10.1038/nm0110-30DOI Listing
January 2010

The role of p53 in limiting somatic cell reprogramming.

Cell Res 2009 Nov 2;19(11):1227-8. Epub 2009 Nov 2.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/cr.2009.121DOI Listing
November 2009

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.

Cell Cycle 2009 Oct;8(19):3120-4

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637974PMC
http://dx.doi.org/10.4161/cc.8.19.9627DOI Listing
October 2009

Post-translational modifications of Runx1 regulate its activity in the cell.

Blood Cells Mol Dis 2009 Jul-Aug;43(1):30-4. Epub 2009 Apr 21.

Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bcmd.2009.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743917PMC
September 2009

MDS: a stem cell disorder--but what exactly is wrong with the primitive hematopoietic cells in this disease?

Authors:
Stephen D Nimer

Hematology Am Soc Hematol Educ Program 2008 :43-51

Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering Institute, New York, NY 10021, USA.

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http://dx.doi.org/10.1182/asheducation-2008.1.43DOI Listing
July 2009

p53 regulates hematopoietic stem cell quiescence.

Cell Stem Cell 2009 Jan;4(1):37-48

Molecular Phamacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.stem.2008.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839936PMC
January 2009

Myelodysplastic syndromes: diagnosis and staging.

Cancer Control 2008 Oct;15 Suppl:4-13

Department of Hematology, University of Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1177/107327480801504s02DOI Listing
October 2008

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.

J Exp Med 2008 Jun 12;205(6):1395-408. Epub 2008 May 12.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1084/jem.20080277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413036PMC
June 2008

Myelodysplastic syndromes.

Authors:
Stephen D Nimer

Blood 2008 May;111(10):4841-51

Division of Hematologic Oncology and Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2007-08-078139DOI Listing
May 2008

DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.

Cancer Res 2008 Apr;68(7):2186-93

Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996041PMC
April 2008

Is it important to decipher the heterogeneity of "normal karyotype AML"?

Authors:
Stephen D Nimer

Best Pract Res Clin Haematol 2008 Mar;21(1):43-52

Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, NY 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.beha.2007.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654590PMC
March 2008

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Nat Genet 2008 Jan 11;40(1):51-60. Epub 2007 Nov 11.

Hematology/Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng.2007.7DOI Listing
January 2008

Id1 restrains p21 expression to control endothelial progenitor cell formation.

PLoS One 2007 Dec 19;2(12):e1338. Epub 2007 Dec 19.

Program of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129121PMC
December 2007