Stephen D Hursting

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, USA. Electronic address:

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June 2020

Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy.

Authors:

Michael F Coleman Alyssa J Cozzo Alexander J Pfeil Suhas K Etigunta Stephen D Hursting

Cancers (Basel) 2020 Apr 1;12(4). Epub 2020 Apr 1.

Department of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USA.

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April 2020

The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions.

Authors:

Steven K Clinton Edward L Giovannucci Stephen D Hursting

J Nutr 2020 04;150(4):663-671

Department of Nutrition, Nutrition Research Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

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April 2020

A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.

Mol Cancer Res 2019 12 19;17(12):2492-2507. Epub 2019 Sep 19.

Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montréal, Québec, Canada.

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December 2019

Zoledronic Acid-containing Nanoparticles With Minimum Premature Release Show Enhanced Activity Against Extraskeletal Tumor.

Authors:

Xu Li Solange A Valdes Riyad F Alzhrani Stephanie Hufnagel Stephen D Hursting Zhengrong Cui

ACS Appl Mater Interfaces 2019 Feb 11;11(7):7311-7319. Epub 2019 Feb 11.

College of Pharmacy, Division of Molecular Pharmaceutics and Drug Delivery , The University of Texas at Austin , Austin , Texas 78723 , United States.

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February 2019

The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.

Authors:

Laura W Bowers Claire G Lineberger Nikki A Ford Emily L Rossi Arunima Punjala Kristina K Camp Bruce K Kimler Carol J Fabian Stephen D Hursting

Breast Cancer Res Treat 2019 Feb 26;173(3):545-557. Epub 2018 Oct 26.

Department of Nutrition, University of North Carolina, 135 Dauer Drive, CB #7461, Chapel Hill, NC, 27599, USA.

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February 2019

Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study.

Cancer Epidemiol Biomarkers Prev 2019 01 17;28(1):76-82. Epub 2018 Oct 17.

Huntsman Cancer Institute, Salt Lake City, Utah.

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January 2019

Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms.

Authors:

Cornelia M Ulrich Caroline Himbert Andreana N Holowatyj Stephen D Hursting

Nat Rev Gastroenterol Hepatol 2018 11;15(11):683-698

Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.

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November 2018

Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models.

Authors:

Laura W Bowers Emily L Rossi Shannon B McDonell Steven S Doerstling Subreen A Khatib Claire G Lineberger Jody E Albright Xiaohu Tang Linda A deGraffenried Stephen D Hursting

Mol Cancer Res 2018 05 16;16(5):869-879. Epub 2018 Feb 16.

Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina.

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May 2018

Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention.

Authors:

Somdat Mahabir Walter C Willett Christine M Friedenreich Gabriel Y Lai Carol J Boushey Charles E Matthews Rashmi Sinha Graham A Colditz Joseph A Rothwell Jill Reedy Alpa V Patel Michael F Leitzmann Gary E Fraser Sharon Ross Stephen D Hursting Christian C Abnet Lawrence H Kushi Philip R Taylor Ross L Prentice

Cancer Epidemiol Biomarkers Prev 2018 03 18;27(3):233-244. Epub 2017 Dec 18.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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March 2018

Resveratrol inhibits obesity-associated adipose tissue dysfunction and tumor growth in a mouse model of postmenopausal claudin-low breast cancer.

Authors:

Emily L Rossi Subreen A Khatib Steven S Doerstling Laura W Bowers Melissa Pruski Nikki A Ford Randolph D Glickman Mengmeng Niu Peiying Yang Zhengrong Cui John DiGiovanni Stephen D Hursting

Mol Carcinog 2018 03 1;57(3):393-407. Epub 2017 Dec 1.

Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina.

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March 2018

Translating Mechanism-Based Strategies to Break the Obesity-Cancer Link: A Narrative Review.

Authors:

Laura A Smith Ciara H O'Flanagan Laura W Bowers Emma H Allott Stephen D Hursting

J Acad Nutr Diet 2018 04;118(4):652-667

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April 2018

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.

Authors:

Steven S Doerstling Ciara H O'Flanagan Stephen D Hursting

Front Oncol 2017 14;7:216. Epub 2017 Sep 14.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

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September 2017

Early Exposure to a High Fat/High Sugar Diet Increases the Mammary Stem Cell Compartment and Mammary Tumor Risk in Female Mice.

Authors:

Isabel U Lambertz Linjie Luo Thomas R Berton Scott L Schwartz Stephen D Hursting Claudio J Conti Robin Fuchs-Young

Cancer Prev Res (Phila) 2017 Oct 13;10(10):553-562. Epub 2017 Sep 13.

Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, Texas.

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October 2017

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

Authors:

Amy Lyons Michael Coleman Sarah Riis Cedric Favre Ciara H O'Flanagan Alexander V Zhdanov Dmitri B Papkovsky Stephen D Hursting Rosemary O'Connor

J Biol Chem 2017 10 18;292(41):16983-16998. Epub 2017 Aug 18.

From the Cell Biology Laboratory and

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October 2017

Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer.

Authors:

Ciara H O'Flanagan Emily L Rossi Shannon B McDonell Xuewen Chen Yi-Hsuan Tsai Joel S Parker Jerry Usary Charles M Perou Stephen D Hursting

NPJ Breast Cancer 2017 17;3:26. Epub 2017 Jul 17.

Department of Nutrition, University of North Carolina, Chapel Hill, NC 27517 USA.

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July 2017

When less may be more: calorie restriction and response to cancer therapy.

Authors:

Ciara H O'Flanagan Laura A Smith Shannon B McDonell Stephen D Hursting

BMC Med 2017 05 24;15(1):106. Epub 2017 May 24.

Department of Nutrition, University of North Carolina, Chapel Hill, NC, 27517, USA.

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May 2017

Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice.

Authors:

Emily L Rossi Sarah M Dunlap Laura W Bowers Subreen A Khatib Steven S Doerstling Laura A Smith Nikki A Ford Darcy Holley Powel H Brown Marcos R Estecio Donna F Kusewitt Linda A deGraffenried Scott J Bultman Stephen D Hursting

Cancer Res 2017 05 3;77(9):2500-2511. Epub 2017 Apr 3.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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May 2017

Energy balance and obesity: what are the main drivers?

Cancer Causes Control 2017 03 17;28(3):247-258. Epub 2017 Feb 17.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.

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March 2017

Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype.

Authors:

Zahra Ashkavand Ciara O'Flanagan Mirko Hennig Xiuxia Du Stephen D Hursting Sergey A Krupenko

Mol Cancer Res 2017 02;15(2):189-200

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina.

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February 2017

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors.

Authors:

Laura M Lashinger Ciara H O'Flanagan Sarah M Dunlap Audrey J Rasmussen Shannon Sweeney Jessie Yangxiang Guo Alessia Lodi Stefano Tiziani Eileen White Stephen D Hursting

Cancer Metab 2016 16;4:18. Epub 2016 Sep 16.

Department of Nutritional Sciences, University of Texas at Austin, Austin, TX 78723 USA.

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September 2016

Reducing the burden of obesity-associated cancers with anti-inflammatory long-chain omega-3 polyunsaturated fatty acids.

Authors:

Subreen A Khatib Emily L Rossi Laura W Bowers Stephen D Hursting

Prostaglandins Other Lipid Mediat 2016 09 19;125:100-7. Epub 2016 Jul 19.

Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address:

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September 2016

Stage-Specific MicroRNAs and Their Role in the Anticancer Effects of Calorie Restriction in a Rat Model of ER-Positive Luminal Breast Cancer.

Authors:

Kaylyn L Devlin Tiffany Sanford Lauren M Harrison Paul LeBourgeois Laura M Lashinger Elizabeth Mambo Stephen D Hursting

PLoS One 2016 19;11(7):e0159686. Epub 2016 Jul 19.

Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, United States of America.

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July 2017

Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer.

Authors:

Mengmeng Niu Solange Valdes Youssef W Naguib Stephen D Hursting Zhengrong Cui

Mol Pharm 2016 06 26;13(6):1833-42. Epub 2016 Apr 26.

The University of Texas at Austin , College of Pharmacy, Pharmaceutics Division, Austin, Texas 78712, United States.

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June 2016

Obesity-Associated Alterations in Inflammation, Epigenetics, and Mammary Tumor Growth Persist in Formerly Obese Mice.

Authors:

Emily L Rossi Rebecca E de Angel Laura W Bowers Subreen A Khatib Laura A Smith Eric Van Buren Priya Bhardwaj Dilip Giri Marcos R Estecio Melissa A Troester Brionna Y Hair Erin L Kirk Ting Gong Jianjun Shen Andrew J Dannenberg Stephen D Hursting

Cancer Prev Res (Phila) 2016 05 11;9(5):339-48. Epub 2016 Feb 11.

Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina. Department of Nutritional Sciences, University of Texas, Austin, Texas.

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May 2016

Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2', 2'-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity.

Authors:

Youssef W Naguib Dharmika Lansakara-P Laura M Lashinger B Leticia Rodriguez Solange Valdes Mengmeng Niu Abdulaziz M Aldayel Lan Peng Stephen D Hursting Zhengrong Cui

Neoplasia 2016 Jan;18(1):33-48

Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712. Electronic address:

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January 2016

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