Stephen C West

Stephen C West

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GEN1 Endonuclease: Purification and Nuclease Assays.

Methods Enzymol 2018 9;600:527-542. Epub 2018 Jan 9.

The Francis Crick Institute, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.11.020DOI Listing
March 2019

Preparation and Resolution of Holliday Junction DNA Recombination Intermediates.

Methods Enzymol 2018 9;600:569-590. Epub 2018 Jan 9.

The Francis Crick Institute, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.11.022DOI Listing
March 2019

A new class of ultrafine anaphase bridges generated by homologous recombination.

Cell Cycle 2018 25;17(17):2101-2109. Epub 2018 Sep 25.

a Department of DNA Recombination and Repair , The Francis Crick Institute , London , UK.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2018.1
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http://dx.doi.org/10.1080/15384101.2018.1515555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226235PMC
September 2018

Analysis of Structure-Selective Endonuclease Activities From Yeast and Human Extracts.

Methods Enzymol 2017 14;591:271-286. Epub 2017 Apr 14.

The Francis Crick Institute, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.03.005DOI Listing
April 2018

Resolution of Recombination Intermediates: Mechanisms and Regulation.

Cold Spring Harb Symp Quant Biol 2015 14;80:103-9. Epub 2015 Sep 14.

The Francis Crick Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1101/sqb.2015.80.027649DOI Listing
January 2018

Genome Instability as a Consequence of Defects in the Resolution of Recombination Intermediates.

Cold Spring Harb Symp Quant Biol 2017 18;82:207-212. Epub 2018 Jan 18.

The Francis Crick Institute, London NW1 1AT, United Kingdom.

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http://dx.doi.org/10.1101/sqb.2017.82.034256DOI Listing
January 2018

SMX makes the cut in genome stability.

Oncotarget 2017 Nov 13;8(61):102765-102766. Epub 2017 Nov 13.

Haley D.M. Wyatt: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.22420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732687PMC
November 2017

The SMX DNA Repair Tri-nuclease.

Mol Cell 2017 Mar;65(5):848-860.e11

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765173008
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http://dx.doi.org/10.1016/j.molcel.2017.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344696PMC
March 2017

Resolution of single and double Holliday junction recombination intermediates by GEN1.

Proc Natl Acad Sci U S A 2017 01 3;114(3):443-450. Epub 2017 Jan 3.

DNA Recombination and Repair Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom

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http://dx.doi.org/10.1073/pnas.1619790114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255610PMC
January 2017

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.

Cell Rep 2016 12;17(10):2672-2686

Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK; Boehringer Ingelheim RCV, Dr.-Boehringer-Gasse 5-11, 1121 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177604PMC
December 2016

Keeping homologous recombination in check.

Cell Res 2016 Apr 23;26(4):397-8. Epub 2016 Feb 23.

The Francis Crick Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.

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http://dx.doi.org/10.1038/cr.2016.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822126PMC
April 2016

Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.

Cell Rep 2015 Mar 5;10(9):1467-1476. Epub 2015 Mar 5.

Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 4 Księcia Trojdena Street, 02-109 Warsaw, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407285PMC
March 2015

Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.

Nat Struct Mol Biol 2014 Nov 5;21(11):962-968. Epub 2014 Oct 5.

Centre for Structural Biology, Imperial College, London, U.K.

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http://dx.doi.org/10.1038/nsmb.2899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222816PMC
November 2014

Holliday junction processing enzymes as guardians of genome stability.

Trends Biochem Sci 2014 Sep 14;39(9):409-19. Epub 2014 Aug 14.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2014.07.003DOI Listing
September 2014

Holliday junction resolvases.

Cold Spring Harb Perspect Biol 2014 Sep 2;6(9):a023192. Epub 2014 Sep 2.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a023192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142969PMC
September 2014

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.

Nat Commun 2014 Sep 11;5:4844. Epub 2014 Sep 11.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/ncomms5844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172962PMC
September 2014

Holliday junction resolution: regulation in space and time.

DNA Repair (Amst) 2014 Jul 24;19:176-81. Epub 2014 Apr 24.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065333PMC
July 2014

MUS81-EME2 promotes replication fork restart.

Cell Rep 2014 May 9;7(4):1048-55. Epub 2014 May 9.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092538PMC
May 2014

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.

Genes Dev 2014 May;28(10):1124-36

Clare Hall Laboratories, Cancer Research UK, London Research Institute, Herts EN6 3LD, United Kingdom;

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http://dx.doi.org/10.1101/gad.238303.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035540PMC
May 2014

Substrate specificity of the MUS81-EME2 structure selective endonuclease.

Nucleic Acids Res 2014 Apr 25;42(6):3833-45. Epub 2013 Dec 25.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1093/nar/gkt1333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973302PMC
April 2014

Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.

Mol Cell 2014 Apr 13;54(1):94-106. Epub 2014 Mar 13.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988869PMC
April 2014

Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.

Mol Cell 2013 Oct 26;52(2):234-47. Epub 2013 Sep 26.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.molcel.2013.08.035DOI Listing
October 2013

DNA-dependent SUMO modification of PARP-1.

DNA Repair (Amst) 2013 Sep 18;12(9):761-73. Epub 2013 Jul 18.

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/j.dnarep.2013.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744807PMC
September 2013

Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.

Structure 2013 Sep 8;21(9):1648-58. Epub 2013 Aug 8.

Structural Biology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

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http://dx.doi.org/10.1016/j.str.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763369PMC
September 2013

Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.

Cell Rep 2013 Jul 27;4(1):76-86. Epub 2013 Jun 27.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.celrep.2013.05.039DOI Listing
July 2013

Pulmonary-renal syndrome: a life threatening but treatable condition.

Postgrad Med J 2013 May 24;89(1051):274-83. Epub 2013 Jan 24.

Renal Section, Department of Medicine, Hammersmith Hospital, 5th Floor Commonwealth Building, Ducane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1136/postgradmedj-2012-131416DOI Listing
May 2013

Risk factors for persistent problems following acute whiplash injury: update of a systematic review and meta-analysis.

J Orthop Sports Phys Ther 2013 Feb 14;43(2):31-43. Epub 2013 Jan 14.

School of Physical Therapy, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.2519/jospt.2013.4507DOI Listing
February 2013

Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

Mol Cell Biol 2013 Jan 12;33(2):406-17. Epub 2012 Nov 12.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

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http://mcb.asm.org/content/33/2/406.full.pdf
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http://mcb.asm.org/cgi/doi/10.1128/MCB.01195-12
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http://dx.doi.org/10.1128/MCB.01195-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554130PMC
January 2013

The DNA translocase activity of FANCM protects stalled replication forks.

Hum Mol Genet 2012 May 24;21(9):2005-16. Epub 2012 Jan 24.

Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1093/hmg/dds013DOI Listing
May 2012

Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis.

Cell 2011 Sep;147(1):158-72

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.cell.2011.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560330PMC
September 2011

DNA interstrand crosslink repair and cancer.

Nat Rev Cancer 2011 Jun 24;11(7):467-80. Epub 2011 Jun 24.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms EN63LD, UK.

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http://dx.doi.org/10.1038/nrc3088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560328PMC
June 2011

Aberrant chromosome morphology in human cells defective for Holliday junction resolution.

Nature 2011 Mar 13;471(7340):642-6. Epub 2011 Mar 13.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature09790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560329PMC
March 2011

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Nat Struct Mol Biol 2010 Oct 22;17(10):1263-5. Epub 2010 Aug 22.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.

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http://www.nature.com/articles/nsmb.1905
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http://dx.doi.org/10.1038/nsmb.1905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041013PMC
October 2010

InTERTpreting telomerase structure and function.

Nucleic Acids Res 2010 Sep 11;38(17):5609-22. Epub 2010 May 11.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, EN6 3LD, UK .

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http://dx.doi.org/10.1093/nar/gkq370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943602PMC
September 2010

Mechanism of Holliday junction resolution by the human GEN1 protein.

Genes Dev 2010 Jul;24(14):1559-69

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

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http://dx.doi.org/10.1101/gad.585310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904945PMC
July 2010

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.

Nucleic Acids Res 2010 Apr 29;38(6):1866-73. Epub 2009 Dec 29.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://dx.doi.org/10.1093/nar/gkp1179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847240PMC
April 2010

Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae.

DNA Repair (Amst) 2010 Apr 27;9(4):394-402. Epub 2010 Jan 27.

London Research Institute, Cancer Research UK, South Mimms, Herts, UK.

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http://dx.doi.org/10.1016/j.dnarep.2009.12.017DOI Listing
April 2010

RTEL-1 enforces meiotic crossover interference and homeostasis.

Science 2010 Mar;327(5970):1254-8

DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK.

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http://dx.doi.org/10.1126/science.1183112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770885PMC
March 2010

FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.

Mol Cell 2009 Dec;36(6):943-53

London Research Institute, Cancer Research UK, South Mimms, UK.

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http://dx.doi.org/10.1016/j.molcel.2009.12.006DOI Listing
December 2009

The search for a human Holliday junction resolvase.

Authors:
Stephen C West

Biochem Soc Trans 2009 Jun;37(Pt 3):519-26

London Research Institute, Clare Hall Laboratories, Cancer Research UK, South Mimms, Hertfordshire, UK.

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http://www.biochemsoctrans.org/cgi/doi/10.1042/BST0370519
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http://dx.doi.org/10.1042/BST0370519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120095PMC
June 2009

Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin.

J Biol Chem 2008 Dec 3;283(49):33994-4001. Epub 2008 Oct 3.

London Research Institute, Clare Hall Laboratories, Cancer Research UK, South Mimms, Herts EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M807124200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662222PMC
December 2008

Identification of Holliday junction resolvases from humans and yeast.

Nature 2008 Nov;456(7220):357-61

Genetic Recombination Laboratory, Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature07470DOI Listing
November 2008

More complexity to the Bloom's syndrome complex.

Genes Dev 2008 Oct;22(20):2737-42

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1101/gad.1732808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751278PMC
October 2008

Structural and functional relationships of the XPF/MUS81 family of proteins.

Annu Rev Biochem 2008 ;77:259-87

London Research Institute, Cancer Research UK, Clare Hall Laboratories, Hertfordshire, United Kingdom.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.77.
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http://dx.doi.org/10.1146/annurev.biochem.77.070306.102408DOI Listing
September 2008

DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair.

Mol Cell 2008 Feb;29(4):510-6

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.11.037DOI Listing
February 2008

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.

Nature 2008 Jan;451(7174):81-5

Genetic Recombination and, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature06420DOI Listing
January 2008

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.

Proc Natl Acad Sci U S A 2007 Oct 16;104(43):16910-5. Epub 2007 Oct 16.

Cancer Research UK, Institute for Cancer Studies, Birmingham University, Vincent Drive, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0708408104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040433PMC
October 2007

Defective DNA repair and neurodegenerative disease.

Cell 2007 Sep;130(6):991-1004

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.cell.2007.08.043DOI Listing
September 2007

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

Nat Struct Mol Biol 2007 Jun 21;14(6):468-74. Epub 2007 May 21.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/nsmb1245DOI Listing
June 2007

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.

EMBO J 2007 Jun 31;26(12):2915-22. Epub 2007 May 31.

Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms, Herts, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894777PMC
June 2007

Actions of aprataxin in multiple DNA repair pathways.

J Biol Chem 2007 Mar 2;282(13):9469-74. Epub 2007 Feb 2.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://www.jbc.org/content/282/13/9469.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M611489200
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http://dx.doi.org/10.1074/jbc.M611489200DOI Listing
March 2007

Synthetic junctions as tools to identify and characterize Holliday junction resolvases.

Methods Enzymol 2006 ;408:485-501

Cancer Research United Kingdom, London Research Institutem Clare Hall Laboratories, South Mimms, Hertfordshire.

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http://dx.doi.org/10.1016/S0076-6879(06)08030-XDOI Listing
February 2007

Role of RAD51C and XRCC3 in genetic recombination and DNA repair.

J Biol Chem 2007 Jan 17;282(3):1973-9. Epub 2006 Nov 17.

Clare Hall Laboratories, London Research Institute, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M609066200DOI Listing
January 2007

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.

Nature 2006 Oct 10;443(7112):713-6. Epub 2006 Sep 10.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature05164DOI Listing
October 2006

Interplay between human DNA repair proteins at a unique double-strand break in vivo.

EMBO J 2006 Jan 5;25(1):222-31. Epub 2006 Jan 5.

Genome Stability Laboratory, Laval University Cancer Research Center, Québec City, Québec, Canada.

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http://dx.doi.org/10.1038/sj.emboj.7600914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356357PMC
January 2006

Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination.

Mol Cell 2005 Dec;20(5):783-92

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/j.molcel.2005.10.001DOI Listing
December 2005

BRCA2 BRC motifs bind RAD51-DNA filaments.

Proc Natl Acad Sci U S A 2005 Jun 3;102(24):8537-42. Epub 2005 Jun 3.

Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA 22908-0733, USA.

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http://dx.doi.org/10.1073/pnas.0407266102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150802PMC
June 2005

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation.

Cell Cycle 2005 May 25;4(5):672-4. Epub 2005 May 25.

Cancer Research UK, London Research Institute, South Mimms, Herts, UK.

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http://dx.doi.org/10.4161/cc.4.5.1689DOI Listing
May 2005

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.

Nature 2005 Mar;434(7033):598-604

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1038/nature03404DOI Listing
March 2005

Happy Hollidays: 40th anniversary of the Holliday junction.

Nat Rev Mol Cell Biol 2004 11;5(11):937-44

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1038/nrm1502DOI Listing
November 2004

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide.

EMBO J 2004 Jul 8;23(14):2882-91. Epub 2004 Jul 8.

Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600301
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http://dx.doi.org/10.1038/sj.emboj.7600301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514958PMC
July 2004

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.

Hum Mol Genet 2004 Jun 28;13(12):1241-8. Epub 2004 Apr 28.

Division of Genetics and Development, Guy's, King's and St Thomas's School of Medicine, King's College London, UK.

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http://dx.doi.org/10.1093/hmg/ddh135DOI Listing
June 2004

Molecular cross-talk among chromosome fragility syndromes.

Genes Dev 2004 Jun;18(12):1359-70

Group of Mutagenesis, Department of Genetics and Microbiology, Universitat Autonòma de Barcelona, 08193-Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1101/gad.1216304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423188PMC
June 2004

Conformational changes modulate the activity of human RAD51 protein.

J Mol Biol 2004 Apr;337(4):817-27

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.02.022DOI Listing
April 2004

Telomere maintenance requires the RAD51D recombination/repair protein.

Cell 2004 Apr;117(3):337-47

Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire, EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/s0092-8674(04)00337-xDOI Listing
April 2004

Holliday junction branch migration and resolution assays.

Methods Mol Biol 2004 ;262:239-53

Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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http://dx.doi.org/10.1385/1-59259-761-0:239DOI Listing
March 2004

RAD51C is required for Holliday junction processing in mammalian cells.

Science 2004 Jan;303(5655):243-6

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1126/science.1093037DOI Listing
January 2004

RAD51 localization and activation following DNA damage.

Philos Trans R Soc Lond B Biol Sci 2004 Jan;359(1441):87-93

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.

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http://dx.doi.org/10.1098/rstb.2003.1368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693300PMC
January 2004

Identification and characterization of the human mus81-eme1 endonuclease.

J Biol Chem 2003 Jul 29;278(27):25172-8. Epub 2003 Apr 29.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M302882200DOI Listing
July 2003

Molecular views of recombination proteins and their control.

Authors:
Stephen C West

Nat Rev Mol Cell Biol 2003 Jun;4(6):435-45

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1038/nrm1127DOI Listing
June 2003

XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes.

Mol Cell 2003 Apr;11(4):1109-17

School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(03)00132-1DOI Listing
April 2003

Cross-links between Fanconi anaemia and BRCA2.

Authors:
Stephen C West

DNA Repair (Amst) 2003 Feb;2(2):231-4

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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February 2003

BRCA2-dependent and independent formation of RAD51 nuclear foci.

Oncogene 2003 Feb;22(8):1115-23

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1038/sj.onc.1206263DOI Listing
February 2003

Distinct functions of BRCA1 and BRCA2 in double-strand break repair.

Breast Cancer Res 2002 20;4(1):9-13. Epub 2001 Nov 20.

Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138716PMC
December 2002

Structure of the single-strand annealing domain of human RAD52 protein.

Proc Natl Acad Sci U S A 2002 Oct 7;99(21):13492-7. Epub 2002 Oct 7.

Cancer Research U.K., London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1073/pnas.212449899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129701PMC
October 2002

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities.

EMBO J 2002 Oct;21(20):5577-85

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://emboj.embopress.org/cgi/doi/10.1093/emboj/cdf554
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129086PMC
http://dx.doi.org/10.1093/emboj/cdf554DOI Listing
October 2002

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining.

EMBO J 2002 Jun;21(11):2827-32

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1093/emboj/21.11.2827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126026PMC
June 2002

Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.

J Biol Chem 2002 May 23;277(22):19322-30. Epub 2002 Mar 23.

Medical Research Council, Radiation & Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M201402200DOI Listing
May 2002

Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK.

EMBO J 2002 Apr;21(8):2038-44

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1093/emboj/21.8.2038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125973PMC
April 2002