Stephen C Blacklow

Stephen C Blacklow

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Stephen C Blacklow

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Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.

J Exp Med 2020 May;217(5)

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1084/jem.20190888DOI Listing
May 2020

MAML1-dependent Notch responsive genes exhibit differing co-factor requirements for transcriptional activation.

Mol Cell Biol 2020 Mar 16. Epub 2020 Mar 16.

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1128/MCB.00014-20DOI Listing
March 2020

Domain integration of ADAM family proteins: Emerging themes from structural studies.

Exp Biol Med (Maywood) 2019 Dec 23;244(17):1510-1519. Epub 2019 Jul 23.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1177/1535370219865901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920674PMC
December 2019

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Sci Signal 2019 11 5;12(606). Epub 2019 Nov 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aay2369DOI Listing
November 2019

A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis.

Biochemistry 2019 May 12;58(20):2509-2518. Epub 2019 Apr 12.

Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.9b00106
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http://dx.doi.org/10.1021/acs.biochem.9b00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607913PMC
May 2019

Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.

Mol Cell 2019 04 27;74(2):245-253.e6. Epub 2019 Feb 27.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA; Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474805PMC
April 2019

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193000
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http://dx.doi.org/10.1016/j.molcel.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485942PMC
March 2019

The Molecular Mechanism of Notch Activation.

Adv Exp Med Biol 2018 ;1066:47-58

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-3-319-89512-3_3DOI Listing
February 2019

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

Bioorg Med Chem 2017 12 20;25(24):6479-6485. Epub 2017 Oct 20.

Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173139
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http://dx.doi.org/10.1016/j.bmc.2017.10.025DOI Listing
December 2017

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Cell 2017 Dec 7;171(7):1638-1648.e7. Epub 2017 Dec 7.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773094PMC
December 2017

Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.

Am J Surg Pathol 2017 Nov;41(11):1473-1482

*Department of Pathology, Massachusetts General Hospital ¶Department of Surgery, Massachusetts General Hospital ‡Department of Pathology, Brigham and Women's Hospital §Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School ∥Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA #Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN †Northern Institute for Cancer Research, University of Newcastle, Newcastle on Tyne, UK.

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http://Insights.ovid.com/crossref?an=00000478-201711000-0000
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http://dx.doi.org/10.1097/PAS.0000000000000945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657508PMC
November 2017

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

PLoS One 2017 12;12(10):e0185762. Epub 2017 Oct 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296PMC
October 2017

Signal Transduction: Notch catches a Jagged edge.

Nat Chem Biol 2017 05;13(6):570-571

Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553272PMC
May 2017

Structural Basis for Regulation of ESCRT-III Complexes by Lgd.

Cell Rep 2017 05;19(9):1750-1757

Institute of Genetics, Heinrich-Heine-University, Dusseldorf 40225, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528166PMC
May 2017

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

Structure 2017 02 12;25(2):287-294. Epub 2017 Jan 12.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299031PMC
February 2017

The Varied Roles of Notch in Cancer.

Annu Rev Pathol 2017 Jan 5;12:245-275. Epub 2016 Dec 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1146/annurev-pathol-052016-100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933931PMC
January 2017

Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction.

Curr Opin Struct Biol 2016 12 7;41:38-45. Epub 2016 Jun 7.

Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, MA 02115, United States; Dana Farber Cancer Institute, Department of Cancer Biology, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143217PMC
December 2016

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

Cell 2016 11 27;167(4):1041-1051.e11. Epub 2016 Oct 27.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127602PMC
November 2016

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.

Cell Rep 2016 08 21;16(5):1211-1217. Epub 2016 Jul 21.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163086
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http://dx.doi.org/10.1016/j.celrep.2016.06.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985235PMC
August 2016

Structural Basis for Substrate Selectivity of the E3 Ligase COP1.

Structure 2016 05 31;24(5):687-696. Epub 2016 Mar 31.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856590PMC
May 2016

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

Biochemistry 2016 Apr 11;55(15):2269-77. Epub 2016 Apr 11.

Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b01287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900891PMC
April 2016

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.

Structure 2015 Jul 4;23(7):1227-35. Epub 2015 Jun 4.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497832PMC
July 2015

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

J Biol Chem 2015 Jun 27;290(23):14705-16. Epub 2015 Apr 27.

From the Department of Radiotherapy (MaastRO)/GROW, School for Developmental Biology & Oncology, Maastricht University, 6200 MD Maastricht, The Netherlands,

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http://dx.doi.org/10.1074/jbc.M115.643676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505536PMC
June 2015

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

Dev Cell 2015 Jun 4;33(6):729-36. Epub 2015 Jun 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Dana Farber Cancer Institute, Boston, MA 02215, USA; Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481192PMC
June 2015

Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay.

Methods Mol Biol 2014 ;1187:231-45

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck St., Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410701PMC
March 2015

A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.

Mol Cell 2015 Mar;57(5):912-924

Harvard Medical School, Boston, MA 02115, USA; Dana Farber Cancer Institute, Boston, MA 02215 USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355479PMC
March 2015

Biased multicomponent reactions to develop novel bromodomain inhibitors.

J Med Chem 2014 Nov 31;57(21):9019-27. Epub 2014 Oct 31.

Department of Medical Oncology, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/jm501120zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234447PMC
November 2014

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):705-10. Epub 2013 Dec 27.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1315023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896193PMC
January 2014

Refining a Jagged edge.

Structure 2013 Dec;21(12):2100-1

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck Street, Boston, MA 02115, USA; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892149PMC
December 2013

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

J Mol Biol 2013 Sep 6;425(17):3192-204. Epub 2013 Jun 6.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jmb.2013.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751422PMC
September 2013

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

J Biol Chem 2013 Aug 9;288(35):25477-89. Epub 2013 Jul 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M113.454850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757209PMC
August 2013

Targeting the Notch pathway: twists and turns on the road to rational therapeutics.

J Clin Oncol 2012 Jul 14;30(19):2418-20. Epub 2012 May 14.

Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2012.42.0992DOI Listing
July 2012

A grid-enabled web service for low-resolution crystal structure refinement.

Acta Crystallogr D Biol Crystallogr 2012 Mar 14;68(Pt 3):261-7. Epub 2012 Feb 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1107/S0907444912001163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282622PMC
March 2012

Conformational locking upon cooperative assembly of notch transcription complexes.

Structure 2012 Feb;20(2):340-9

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.str.2011.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285698PMC
February 2012

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

Proc Natl Acad Sci U S A 2011 Dec 22;108(50):20060-5. Epub 2011 Nov 22.

Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1110230108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250146PMC
December 2011

Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth.

Virology 2011 May 26;414(1):19-25. Epub 2011 Mar 26.

Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.virol.2011.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104408PMC
May 2011

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

J Pathol 2011 Jan 21;223(2):262-73. Epub 2010 Oct 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/path.2789
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http://dx.doi.org/10.1002/path.2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996483PMC
January 2011

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood 2010 Dec 30;116(23):4948-57. Epub 2010 Aug 30.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2009-10-247361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012589PMC
December 2010

Mechanistic insights into Notch receptor signaling from structural and biochemical studies.

Curr Top Dev Biol 2010 ;92:31-71

Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/S0070-2153(10)92002-4DOI Listing
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Nat Struct Mol Biol 2010 Nov 24;17(11):1312-7. Epub 2010 Oct 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.1938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024583PMC
November 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood 2010 Aug 21;116(8):1321-8. Epub 2010 Apr 21.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine & Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-07-229450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938240PMC
August 2010

Direct inhibition of the NOTCH transcription factor complex.

Nature 2009 Nov;462(7270):182-8

Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature08543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951323PMC
November 2009

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

Genes Dev 2009 Jul;23(14):1665-76

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://genesdev.cshlp.org/content/23/14/1665.full.pdf
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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1793709
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http://dx.doi.org/10.1101/gad.1793709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714710PMC
July 2009

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.

Blood 2009 Apr 15;113(18):4381-90. Epub 2008 Dec 15.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2008-08-174748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676092PMC
April 2009

The molecular logic of Notch signaling--a structural and biochemical perspective.

J Cell Sci 2008 Oct;121(Pt 19):3109-19

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/jcs.035683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696053PMC
October 2008

Notch signaling in leukemia.

Annu Rev Pathol 2008 ;3:587-613

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.154300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934586PMC
May 2008

Mutational and energetic studies of Notch 1 transcription complexes.

J Mol Biol 2008 Feb 28;376(1):131-40. Epub 2007 Nov 28.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.11.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766816PMC
February 2008

Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes.

Biochemistry 2008 Feb 5;47(6):1532-9. Epub 2008 Jan 5.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi702076yDOI Listing
February 2008

Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers.

Curr Opin Struct Biol 2007 Aug 17;17(4):419-26. Epub 2007 Sep 17.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.sbi.2007.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766800PMC
August 2007

Notch directly regulates Gata3 expression during T helper 2 cell differentiation.

Immunity 2007 Jul 19;27(1):100-10. Epub 2007 Jul 19.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613070033
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http://dx.doi.org/10.1016/j.immuni.2007.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801546PMC
July 2007

Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.

Biochemistry 2007 Jun 9;46(22):6570-7. Epub 2007 May 9.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi700049gDOI Listing
June 2007

Structural basis for autoinhibition of Notch.

Nat Struct Mol Biol 2007 Apr 1;14(4):295-300. Epub 2007 Apr 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Ave. Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nsmb1227DOI Listing
April 2007

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

Proc Natl Acad Sci U S A 2007 Feb 6;104(7):2103-8. Epub 2007 Feb 6.

Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0611092104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892977PMC
February 2007

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

Mol Cell Biol 2006 Aug;26(16):6261-71

Department of Hematology/Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02478-05
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http://dx.doi.org/10.1128/MCB.02478-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592797PMC
August 2006

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors.

Mol Cell 2006 Apr;22(2):277-83

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.02.021DOI Listing
April 2006

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Cell 2006 Mar;124(5):973-83

Biological and Biomedical Sciences Graduate Program in the Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.12.037DOI Listing
March 2006

A new niche for Notch on Deltex?

Structure 2005 Nov;13(11):1579-80

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http://dx.doi.org/10.1016/j.str.2005.10.001DOI Listing
November 2005

Structure and physiologic function of the low-density lipoprotein receptor.

Annu Rev Biochem 2005 ;74:535-62

Life Sciences Division, Korea Institute of Science and Technology, Seoul 136-791, Korea.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.74.
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http://dx.doi.org/10.1146/annurev.biochem.74.082803.133354DOI Listing
September 2005

De novo genetic codes and pure translation display.

Methods 2005 Jul;36(3):279-90

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

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http://dx.doi.org/10.1016/j.ymeth.2005.04.011DOI Listing
July 2005

The LDL receptor: how acid pulls the trigger.

Trends Biochem Sci 2005 Jun;30(6):309-17

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.tibs.2005.03.007DOI Listing
June 2005

Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions.

Biochemistry 2005 Apr;44(13):5075-85

Department of Pathology, Harvard Medical School and Brigham & Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi047575jDOI Listing
April 2005

Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction.

J Biol Chem 2005 Mar 4;280(10):9671-7. Epub 2005 Jan 4.

Department of Pathology, Harvard Medical School, Brigham and Womens' Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M413356200DOI Listing
March 2005

Pure translation display.

Anal Biochem 2004 Oct;333(2):358-64

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ab.2004.06.028DOI Listing
October 2004

Amino acid backbone specificity of the Escherichia coli translation machinery.

J Am Chem Soc 2004 Oct;126(40):12752-3

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

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http://dx.doi.org/10.1021/ja0472174DOI Listing
October 2004

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Science 2004 Oct;306(5694):269-71

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1102160DOI Listing
October 2004

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor.

Mol Cell 2004 Oct;16(2):281-92

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.09.038DOI Listing
October 2004

The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands.

Biochemistry 2004 Aug;43(34):10979-87

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi049092lDOI Listing
August 2004

Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair.

J Biol Chem 2004 Jul 20;279(29):30611-21. Epub 2004 Apr 20.

Department of Biochemistry, Division of Structural Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M401412200DOI Listing
July 2004

Catching the common cold.

Nat Struct Mol Biol 2004 May;11(5):388-90

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http://dx.doi.org/10.1038/nsmb0504-388DOI Listing
May 2004

The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection.

J Virol 2004 Feb;78(3):1403-10

Department of Medicine. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321377PMC
http://dx.doi.org/10.1128/jvi.78.3.1403-1410.2004DOI Listing
February 2004

A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands.

Biochemistry 2004 Feb;43(4):1037-44

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi035529yDOI Listing
February 2004

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

Science 2003 Sep;301(5640):1725-8

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1085643DOI Listing
September 2003

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.

Biochemistry 2003 Jun;42(23):7061-7

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi034156yDOI Listing
June 2003