Stephen Brimijoin

Stephen Brimijoin

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Stephen Brimijoin

Publications by authors named "Stephen Brimijoin"

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A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior.

Prog Neuropsychopharmacol Biol Psychiatry 2020 May 6;102:109961. Epub 2020 May 6.

School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA; Center of Immunotherapy, Vaccines, and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ 85287-4501, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2020.109961DOI Listing
May 2020

Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice.

Hum Gene Ther 2020 Jan 19;31(1-2):70-79. Epub 2019 Dec 19.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1089/hum.2019.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985763PMC
January 2020

localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's disease.

J Biol Chem 2019 04 20;294(16):6253-6272. Epub 2019 Feb 20.

From the Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom and

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http://dx.doi.org/10.1074/jbc.RA118.006230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484111PMC
April 2019

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Sci Rep 2018 10 10;8(1):15077. Epub 2018 Oct 10.

Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41598-018-33475-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180112PMC
October 2018

Cholinesterases and the fine line between poison and remedy.

Biochem Pharmacol 2018 07 31;153:205-216. Epub 2018 Jan 31.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55902, USA.

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http://dx.doi.org/10.1016/j.bcp.2018.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959757PMC
July 2018

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.

Front Pharmacol 2018 27;9:112. Epub 2018 Feb 27.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.

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http://journal.frontiersin.org/article/10.3389/fphar.2018.00
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http://dx.doi.org/10.3389/fphar.2018.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835039PMC
February 2018

Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling.

Proc Natl Acad Sci U S A 2017 10 25;114(41):10960-10965. Epub 2017 Sep 25.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905

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http://dx.doi.org/10.1073/pnas.1706517114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642694PMC
October 2017

Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat.

Chem Biol Interact 2017 Sep 27;275:86-94. Epub 2017 Jul 27.

Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2017.07.019DOI Listing
September 2017

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity.

Sci Rep 2017 09 5;7(1):10419. Epub 2017 Sep 5.

School of Life Sciences and Center for Immunotherapy, Vaccines, and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ, 85287-4501, USA.

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http://dx.doi.org/10.1038/s41598-017-10571-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585256PMC
September 2017

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice.

Molecules 2017 Jul 8;22(7). Epub 2017 Jul 8.

Department of Molecular Pharmacology and Experimental Therapeutics, Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.3390/molecules22071145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963683PMC
July 2017

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.

Chem Biol Interact 2016 Nov 23;259(Pt B):271-275. Epub 2016 Feb 23.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995144PMC
November 2016

Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.

Endocrinology 2016 08 14;157(8):3086-95. Epub 2016 Jun 14.

Department of Molecular Pharmacology and Experimental Therapeutics, Kogod Center on Aging, Mayo Clinic, and Minnesota Nutrition and Obesity Center, Rochester, Minnesota 55905.

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http://dx.doi.org/10.1210/en.2016-1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967128PMC
August 2016

Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.

J Pharmacol Exp Ther 2016 May 11;357(2):375-81. Epub 2016 Mar 11.

Research Fellow, Pharmaco-Neuro-Immunology Training Program (J.R.S.) and Department of Biological Science (A.G.), University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry, University of Minnesota Medical School (N.S., M.E.C.), Minneapolis, Minnesota; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota (S.B., Y.G.); Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (R.J.P.).

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.116.23250
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http://dx.doi.org/10.1124/jpet.116.232504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851322PMC
May 2016

Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in Mice.

J Pharmacol Exp Ther 2016 Mar 15;356(3):720-5. Epub 2015 Dec 15.

Department of Molecular Pharmacology and Experimental Therapeutics, Robert and Arlene Kogod Center on Aging (V.M., L.G., Y.G., S.B.), and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases (S.R.), Mayo Clinic, Rochester, Minnesota.

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http://jpet.aspetjournals.org/content/early/2015/12/15/jpet.
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22882
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http://dx.doi.org/10.1124/jpet.115.228825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767396PMC
March 2016

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma.

Chem Biol Interact 2016 Jan 14;243:82-90. Epub 2015 Nov 14.

Eppley Institute, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097833PMC
January 2016

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin.

Gen Comp Endocrinol 2015 Dec 12;224:61-8. Epub 2015 Jun 12.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygcen.2015.05.017DOI Listing
December 2015

In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase.

Biochem Pharmacol 2015 Dec 8;98(3):531-9. Epub 2015 Oct 8.

Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.10.005DOI Listing
December 2015

Radiometric assay of ghrelin hydrolase activity and 3H-ghrelin distribution into mouse tissues.

Biochem Pharmacol 2015 Dec 26;98(4):732-9. Epub 2015 Oct 26.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA; Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669970PMC
December 2015

Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.

Cell Mol Neurobiol 2015 Aug 27;35(6):819-26. Epub 2015 Mar 27.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA,

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http://dx.doi.org/10.1007/s10571-015-0175-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617233PMC
August 2015

Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.

Biochem J 2015 Mar;466(2):243-51

*Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, U.S.A.

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http://dx.doi.org/10.1042/BJ20141266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367957PMC
March 2015

Plasma butyrylcholinesterase regulates ghrelin to control aggression.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2251-6. Epub 2015 Feb 2.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905; Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905; and

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http://dx.doi.org/10.1073/pnas.1421536112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343161PMC
February 2015

The future potential for cocaine vaccines.

Expert Opin Biol Ther 2014 Sep 16;14(9):1271-83. Epub 2014 May 16.

Center for Translational Research in Inflammatory Diseases, Baylor College of Medicine, Department of Medicine , Bldg. 109, Rm. 234, 2002 Holcombe Blvd, Houston, TX 77030 , USA +1 713 794 7960 ; +1 713 794 7938 ;

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http://www.tandfonline.com/doi/full/10.1517/14712598.2014.92
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http://dx.doi.org/10.1517/14712598.2014.920319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154474PMC
September 2014

Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.

Vaccine 2014 Jul 2;32(33):4155-62. Epub 2014 Jun 2.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.vaccine.2014.05.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077905PMC
July 2014

Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity.

Neuropsychopharmacology 2014 May 10;39(6):1538-46. Epub 2014 Jan 10.

Deprtment of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.

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http://dx.doi.org/10.1038/npp.2014.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988560PMC
May 2014

Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.

Chem Biol Interact 2013 Mar 23;203(1):208-11. Epub 2012 Aug 23.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.cbi.2012.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537841PMC
March 2013

Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.

Chem Biol Interact 2013 Mar 20;203(1):217-20. Epub 2012 Sep 20.

School of Life Sciences and The Biodesign Institute, PO Box 874501, Arizona State University, Tempe, AZ 85287-4501, USA.

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http://dx.doi.org/10.1016/j.cbi.2012.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552022PMC
March 2013

Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.

Expert Rev Vaccines 2013 Mar;12(3):323-32

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1586/erv.13.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738206PMC
March 2013

Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months.

Biol Psychiatry 2012 Apr 30;71(8):700-5. Epub 2011 Dec 30.

Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314110PMC
April 2012

Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.

Curr Drug Targets 2012 Apr;13(4):471-82

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343382PMC
http://dx.doi.org/10.2174/138945012799499703DOI Listing
April 2012

Cocaine hydrolase gene therapy for cocaine abuse.

Future Med Chem 2012 Feb;4(2):151-62

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.4155/fmc.11.183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730835PMC
February 2012

Interception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users.

CNS Neurol Disord Drug Targets 2011 Dec;10(8):880-91

Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738214PMC
http://dx.doi.org/10.2174/187152711799219398DOI Listing
December 2011

Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats.

Psychopharmacology (Berl) 2011 Feb 23;213(4):817-29. Epub 2010 Oct 23.

Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1007/s00213-010-2040-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631565PMC
February 2011

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle.

Chem Biol Interact 2010 Sep 28;187(1-3):142-7. Epub 2010 Jan 28.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S000927971000060
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http://dx.doi.org/10.1016/j.cbi.2010.01.036DOI Listing
September 2010

The concept of pharmacologic cocaine interception as a treatment for drug abuse.

Chem Biol Interact 2010 Sep 26;187(1-3):421-4. Epub 2010 Feb 26.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895017PMC
September 2010

Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach.

J Pharmacol Exp Ther 2009 Aug 28;330(2):449-57. Epub 2009 May 28.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1124/jpet.109.152231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713082PMC
August 2009

Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.

PLoS One 2009 4;4(2):e4349. Epub 2009 Feb 4.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632757PMC
April 2009

Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves.

Neuropeptides 2009 Apr 23;43(2):81-92. Epub 2009 Feb 23.

Department of Molecular Pharmacology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.npep.2009.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703811PMC
April 2009

Amyloid-beta alters trafficking of internalized acetylcholinesterase and dextran.

Int J Physiol Pathophysiol Pharmacol 2009 Jan 1;1(1):15-24. Epub 2009 Jan 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040938PMC
January 2009

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

Neuropsychopharmacology 2008 Oct 16;33(11):2715-25. Epub 2008 Jan 16.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/sj.npp.1301666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562914PMC
October 2008

Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage.

Neurol Res 2008 Sep 21;30(7):751-60. Epub 2008 May 21.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Foundation, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1179/174313208X298020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682715PMC
September 2008

An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.

Chem Biol Interact 2008 Sep 1;175(1-3):83-7. Epub 2008 May 1.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.cbi.2008.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536750PMC
September 2008

Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos.

Neurotoxicol Teratol 2008 Mar-Apr;30(2):125-30. Epub 2007 Nov 6.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ntt.2007.10.004DOI Listing
May 2008

Neuroscience in China.

Cell Mol Neurobiol 2008 Jan 14;28(1):1-2. Epub 2007 Nov 14.

Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1007/s10571-007-9232-3DOI Listing
January 2008

Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease.

J Neurochem 2007 Jun 26;101(6):1701-11. Epub 2007 Feb 26.

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Sant Joan d'Alacant, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04461.xDOI Listing
June 2007

Viral transduction of cocaine hydrolase in brain reward centers.

Cell Mol Neurobiol 2006 Jul-Aug;26(4-6):357-63. Epub 2006 May 18.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1007/s10571-006-9050-zDOI Listing
April 2007

A method to determine precise benchmark doses for carbamate anticholinesterases.

Toxicol Sci 2007 Mar 11;96(1):154-61. Epub 2006 Dec 11.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1093/toxsci/kfl183DOI Listing
March 2007

Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats.

Chem Biol Interact 2005 Dec 21;157-158:97-103. Epub 2005 Oct 21.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester MN 55905, USA.

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http://dx.doi.org/10.1016/j.cbi.2005.10.011DOI Listing
December 2005

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

Curr Alzheimer Res 2005 Jul;2(3):291-300

Department of Molecular Pharmacology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.2174/1567205054367847DOI Listing
July 2005

Can cholinesterase inhibitors affect neural development?

Environ Toxicol Pharmacol 2005 May 12;19(3):429-32. Epub 2005 Feb 12.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street, S.W., Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.etap.2004.12.004DOI Listing
May 2005

Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.

Mol Pharmacol 2005 Jan 1;67(1):204-11. Epub 2004 Oct 1.

Department of Molecular Pharmacology, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, USA.

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http://dx.doi.org/10.1124/mol.104.006924DOI Listing
January 2005

An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats.

J Pharmacol Exp Ther 2004 Sep 20;310(3):1046-52. Epub 2004 Apr 20.

Department of Molecular Pharmacology, Mayo Clinic, 200 First Street S.W., Rochester MN 55905, USA.

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http://dx.doi.org/10.1124/jpet.104.068122DOI Listing
September 2004

Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors.

Neurobiol Dis 2004 Feb;15(1):106-14

Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.nbd.2003.09.009DOI Listing
February 2004

Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.

Acta Pharmacol Sin 2003 Sep;24(9):853-8

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.

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September 2003

Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation.

J Neurochem 2003 Jul;86(2):470-8

Department of Molecular Pharmacology, Mayo Medical School, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01855.xDOI Listing
July 2003

Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.

Chem Biol 2003 Jun;10(6):491-502

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Foundation for Medical Education and Research, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/s1074-5521(03)00126-1DOI Listing
June 2003

Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles.

Brain Res Mol Brain Res 2003 Mar;111(1-2):104-10

Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim 7, Mayo Clinic 200 First Street Southwest, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00693-9DOI Listing
March 2003

The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease.

Drugs Today (Barc) 2003 Jan;39(1):75-83

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Guggenheim 7, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1358/dot.2003.39.1.740206DOI Listing
January 2003

Radiometric solvent-partitioning assay for screening cocaine hydrolases and measuring cocaine levels in milligram tissue samples.

Anal Biochem 2002 Oct;309(2):200-5

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation for Medical Research, 200 First St. SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/s0003-2697(02)00238-5DOI Listing
October 2002

Death of preganglionic sympathetic neurons after surgical or immunologic lesion of peripheral processes.

Exp Neurol 2002 Sep;177(1):105-14

Department of Molecular Pharmacology and Experimental Therapeutics, Guggenheim-7, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1006/exnr.2002.7974DOI Listing
September 2002

Re-engineering butyrylcholinesterase as a cocaine hydrolase.

Mol Pharmacol 2002 Aug;62(2):220-4

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic & Foundation for Medical Education and Research, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1124/mol.62.2.220DOI Listing
August 2002

Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.

J Pharmacol Exp Ther 2002 Aug;302(2):710-6

Molecular Neuroscience Program, Mayo Foundation for Medical Education and Research, 200 First Street Southwest, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1124/jpet.302.2.710DOI Listing
August 2002