Publications by authors named "Stephen B Helliwell"

18Publications

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide.

Authors:
Nathan A Snyder Adam Kim Louis Kester Andrew N Gale Christian Studer Dominic Hoepfner Silvio Roggo Stephen B Helliwell Kyle W Cunningham

G3 (Bethesda) 2019 03 7;9(3):829-840. Epub 2019 Mar 7.

Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218

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March 2019

Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in .

Authors:
Clélia Bourgoint Delphine Rispal Marina Berti Ireos Filipuzzi Stephen B Helliwell Manoël Prouteau Robbie Loewith

J Biol Chem 2018 08 12;293(31):12043-12053. Epub 2018 Jun 12.

From the Department of Molecular Biology and Institute of Genetics and Genomics of Geneva (iGE3), National Center for Competence in Research in Chemical Biology, University of Geneva, 1211 Geneva, Switzerland and

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August 2018

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo.

Authors:
Oliver M Russell Isabelle Fruh Pavandeep K Rai David Marcellin Thierry Doll Amy Reeve Mitchel Germain Julie Bastien Karolina A Rygiel Raffaele Cerino Andreas W Sailer Majlinda Lako Robert W Taylor Matthias Mueller Robert N Lightowlers Doug M Turnbull Stephen B Helliwell

Sci Rep 2018 01 29;8(1):1799. Epub 2018 Jan 29.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

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January 2018

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.

Authors:
Christoph Potting Christophe Crochemore Francesca Moretti Florian Nigsch Isabel Schmidt Carole Manneville Walter Carbone Judith Knehr Rowena DeJesus Alicia Lindeman Rob Maher Carsten Russ Gregory McAllister John S Reece-Hoyes Gregory R Hoffman Guglielmo Roma Matthias Müller Andreas W Sailer Stephen B Helliwell

Proc Natl Acad Sci U S A 2018 01 21;115(2):E180-E189. Epub 2017 Dec 21.

Novartis Institutes for BioMedical Research, Basel CH 4002, Switzerland;

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January 2018

Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.

Authors:
Ireos Filipuzzi Janos Steffen Mitchel Germain Laetitia Goepfert Michael A Conti Christoph Potting Raffaele Cerino Martin Pfeifer Philipp Krastel Dominic Hoepfner Julie Bastien Carla M Koehler Stephen B Helliwell

Nat Chem Biol 2017 Dec 9;13(12):1239-1244. Epub 2017 Oct 9.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2017

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

Authors:
Katarina Petrovic Martin Pfeifer Christian N Parker Sven Schuierer John Tallarico Dominic Hoepfner N Rao Movva Gunther Scheel Stephen B Helliwell

Microbiol Res 2017 Jun 21;199:10-18. Epub 2017 Feb 21.

Novartis Institutes for Biomedical Research, Novartis AG, Basel, Switzerland. Electronic address:

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June 2017

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.

Authors:
Ireos Filipuzzi Simona Cotesta Francesca Perruccio Britta Knapp Yue Fu Christian Studer Verena Pries Ralph Riedl Stephen B Helliwell Katarina T Petrovic N Rao Movva Dominique Sanglard Jianshi Tao Dominic Hoepfner

PLoS Genet 2016 Nov 17;12(11):e1006374. Epub 2016 Nov 17.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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November 2016

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Authors:
Stephen B Helliwell Shantanu Karkare Marc Bergdoll Alain Rahier Juliet R Leighton-Davis Celine Fioretto Thomas Aust Ireos Filipuzzi Mathias Frederiksen John Gounarides Dominic Hoepfner Andreas Hofmann Pierre-Eloi Imbert Rolf Jeker Richard Knochenmuss Philipp Krastel Anais Margerit Klaus Memmert Charlotte V Miault N Rao Movva Alban Muller Hans-Ulrich Naegeli Lukas Oberer Vivian Prindle Ralph Riedl Sven Schuierer Jessica A Sexton Jianshi Tao Trixie Wagner Hong Yin Juan Zhang Silvio Roggo Stefan Reinker Christian N Parker

Nat Commun 2015 Oct 12;6:8613. Epub 2015 Oct 12.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

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October 2015

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.

Authors:
Delphine Rispal Sandra Eltschinger Michael Stahl Stefania Vaga Bernd Bodenmiller Yann Abraham Ireos Filipuzzi N Rao Movva Ruedi Aebersold Stephen B Helliwell Robbie Loewith

J Biol Chem 2015 Jun 16;290(24):14963-78. Epub 2015 Apr 16.

From the Department of Molecular Biology and Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, 1211 Geneva, the National Centre for Competence in Research Chemical Biology, 1211 Geneva, Switzerland

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June 2015

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Authors:
William E Dowdle Beat Nyfeler Jane Nagel Robert A Elling Shanming Liu Ellen Triantafellow Suchithra Menon Zuncai Wang Ayako Honda Gwynn Pardee John Cantwell Catherine Luu Ivan Cornella-Taracido Edmund Harrington Peter Fekkes Hong Lei Qing Fang Mary Ellen Digan Debra Burdick Andrew F Powers Stephen B Helliwell Simon D'Aquin Julie Bastien Henry Wang Dmitri Wiederschain Jenny Kuerth Philip Bergman David Schwalb Jason Thomas Savuth Ugwonali Fred Harbinski John Tallarico Christopher J Wilson Vic E Myer Jeffery A Porter Dirksen E Bussiere Peter M Finan Mark A Labow Xiaohong Mao Lawrence G Hamann Brendan D Manning Reginald A Valdez Thomas Nicholson Markus Schirle Mark S Knapp Erin P Keaney Leon O Murphy

Nat Cell Biol 2014 Nov 19;16(11):1069-79. Epub 2014 Oct 19.

Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2014

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Authors:
Dominic Hoepfner Stephen B Helliwell Heather Sadlish Sven Schuierer Ireos Filipuzzi Sophie Brachat Bhupinder Bhullar Uwe Plikat Yann Abraham Marc Altorfer Thomas Aust Lukas Baeriswyl Raffaele Cerino Lena Chang David Estoppey Juerg Eichenberger Mathias Frederiksen Nicole Hartmann Annika Hohendahl Britta Knapp Philipp Krastel Nicolas Melin Florian Nigsch Edward J Oakeley Virginie Petitjean Frank Petersen Ralph Riedl Esther K Schmitt Frank Staedtler Christian Studer John A Tallarico Stefan Wetzel Mark C Fishman Jeffrey A Porter N Rao Movva

Microbiol Res 2014 Feb-Mar;169(2-3):107-20. Epub 2013 Dec 1.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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September 2014

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

Authors:
Kenji Shimada Ireos Filipuzzi Michael Stahl Stephen B Helliwell Christian Studer Dominic Hoepfner Andrew Seeber Robbie Loewith N Rao Movva Susan M Gasser

Mol Cell 2013 Sep 12;51(6):829-39. Epub 2013 Sep 12.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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September 2013

Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.

Authors:
Heather Sadlish Gabriela Galicia-Vazquez C Gregory Paris Thomas Aust Bhupinder Bhullar Lena Chang Stephen B Helliwell Dominic Hoepfner Britta Knapp Ralph Riedl Silvio Roggo Sven Schuierer Christian Studer John A Porco Jerry Pelletier N Rao Movva

ACS Chem Biol 2013 Jul 7;8(7):1519-27. Epub 2013 May 7.

Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.

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July 2013

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Authors:
Dominic Hoepfner Shantanu Karkare Stephen B Helliwell Martin Pfeifer Markus Trunzer Sophie De Bonnechose Alfred Zimmerlin Jianshi Tao Daryl Richie Andreas Hofmann Stefan Reinker Mathias Frederiksen N Rao Movva Jeffrey A Porter Neil S Ryder Christian N Parker

Antimicrob Agents Chemother 2012 Aug 21;56(8):4233-40. Epub 2012 May 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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August 2012

Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast.

Authors:
Gina Devasahayam Danilo Ritz Stephen B Helliwell Daniel J Burke Thomas W Sturgill

Proc Natl Acad Sci U S A 2006 Nov 9;103(47):17840-5. Epub 2006 Nov 9.

Departments of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

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November 2006

NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.

Authors:
José L Crespo Stephen B Helliwell Christa Wiederkehr Philippe Demougin Brian Fowler Michael Primig Michael N Hall

J Biol Chem 2004 Sep 9;279(36):37512-7. Epub 2004 Jul 9.

Division of Biochemistry, University of Basel, Basel, Switzerland.

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September 2004

Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Authors:
Katherine Bowers Jillian Lottridge Stephen B Helliwell Lisa M Goldthwaite J Paul Luzio Tom H Stevens

Traffic 2004 Mar;5(3):194-210

Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK.

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March 2004

Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.

Authors:
Tobias Schmelzle Stephen B Helliwell Michael N Hall

Mol Cell Biol 2002 Mar;22(5):1329-39

Department of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

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March 2002