Stephen B Baylin

Stephen B Baylin

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Stephen B Baylin

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The emerging role of epigenetic therapeutics in immuno-oncology.

Nat Rev Clin Oncol 2019 Sep 23. Epub 2019 Sep 23.

Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA.

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http://www.nature.com/articles/s41571-019-0266-5
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http://dx.doi.org/10.1038/s41571-019-0266-5DOI Listing
September 2019

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.

Cancer Cell 2019 Apr 4;35(4):633-648.e7. Epub 2019 Apr 4.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521721PMC
April 2019

DNA methylation in senescence, aging and cancer.

Oncoscience 2019 Jan 31;6(1-2):291-293. Epub 2019 Jan 31.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.18632/oncoscience.476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382259PMC
January 2019

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.

Cancer Res 2018 03 27;78(5):1127-1139. Epub 2017 Dec 27.

Department of Oncology, the Sidney Kimmel Comprehensive Cancer Research Center at Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935520PMC
March 2018

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.

ACS Chem Biol 2018 03 8;13(3):772-781. Epub 2018 Feb 8.

Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.

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http://dx.doi.org/10.1021/acschembio.7b00890DOI Listing
March 2018

Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells.

PLoS One 2017 16;12(6):e0179501. Epub 2017 Jun 16.

Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179501PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473589PMC
September 2017

Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma.

PLoS One 2016 19;11(9):e0162929. Epub 2016 Sep 19.

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162929PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028050PMC
August 2017

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.

Cancer Cell 2017 05;31(5):653-668.e7

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587180PMC
May 2017

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.

Genome Res 2017 04 23;27(4):533-544. Epub 2017 Feb 23.

Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1101/gr.208108.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378172PMC
April 2017

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.

Mol Cell 2017 Jan;65(2):323-335

Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260804PMC
January 2017

Epigenetic Therapeutics: A New Weapon in the War Against Cancer.

Annu Rev Med 2016 ;67:73-89

Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; email:

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http://dx.doi.org/10.1146/annurev-med-111314-035900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937439PMC
October 2016

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.

Cancer Cell 2016 10;30(4):637-650

Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201166PMC
October 2016

Interview with Stephen B Baylin.

Authors:
Stephen B Baylin

Epigenomics 2015 29;7(6):881-3. Epub 2015 Sep 29.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.2217/epi.15.61DOI Listing
September 2016

Epigenetic Determinants of Cancer.

Cold Spring Harb Perspect Biol 2016 Sep 1;8(9). Epub 2016 Sep 1.

Van Andel Research Institute, Grand Rapids, Michigan 49503.

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http://dx.doi.org/10.1101/cshperspect.a019505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008069PMC
September 2016

Genome-wide positioning of bivalent mononucleosomes.

BMC Med Genomics 2016 09 15;9(1):60. Epub 2016 Sep 15.

CRB1, Room 530, Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.

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http://dx.doi.org/10.1186/s12920-016-0221-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025636PMC
September 2016

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.

J Mol Cell Biol 2016 06 17;8(3):244-54. Epub 2015 Jul 17.

Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA

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http://dx.doi.org/10.1093/jmcb/mjv050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937888PMC
June 2016

Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors.

Oncoimmunology 2016 May 29;5(5):e1122160. Epub 2015 Dec 29.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1122160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910697PMC
May 2016

Combining Epigenetic and Immunotherapy to Combat Cancer.

Cancer Res 2016 Apr 17;76(7):1683-9. Epub 2016 Mar 17.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873370PMC
April 2016

Jacob, Monod, the Lac Operon, and the PaJaMa Experiment-Gene Expression Circuitry Changing the Face of Cancer Research.

Authors:
Stephen B Baylin

Cancer Res 2016 Apr;76(8):2060-2

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0865DOI Listing
April 2016

IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers.

Ann Surg 2016 Feb;263(2):337-44

*Department of Gastrointestinal Surgery, Daping Hospital, Third Military Medical University, Chongqing, China †Department of Surgery ‡Department of Oncology, The Sydney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology and David Rubenstein Pancreatic Cancer Research Center, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/SLA.0000000000001204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648704PMC
February 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

Epigenetic therapy for solid tumors: from bench science to clinical trials.

Epigenomics 2015 ;7(2):215-35

Department of Surgery, George Washington University Medical Center, 2150 Pennsylvania Ave. NW, Suite 6B, Washington, DC 20037, USA.

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http://dx.doi.org/10.2217/epi.14.73DOI Listing
September 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair.

Curr Opin Genet Dev 2014 Oct 14;28:43-9. Epub 2014 Oct 14.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262610PMC
October 2014

Epigenetic biomarkers.

Curr Top Microbiol Immunol 2012 ;355:189-216

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/82_2011_165DOI Listing
August 2014

A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.

Cancer Res 2014 Jul 29;74(14):3834-43. Epub 2014 May 29.

Authors' Affiliations: Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103012PMC
July 2014

Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.

Mol Cell 2014 Jun;54(5):716-27

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103691PMC
June 2014

CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas.

Epigenetics 2014 May 11;9(5):738-46. Epub 2014 Feb 11.

Department of Surgery; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Urology; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Gastrointestinal Surgery; Daping Hospital; Third Military Medical University; Chongqing, PR China.

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http://dx.doi.org/10.4161/epi.28082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063833PMC
May 2014

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.

Clin Cancer Res 2014 Apr 31;20(7):1856-64. Epub 2014 Jan 31.

Authors' Affiliations: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; MDxHealth Inc, Irvine, California; Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan; and Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019442PMC
April 2014

Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer.

PLoS One 2013 3;8(7):e68630. Epub 2013 Jul 3.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701071PMC
February 2014

Targeting epigenetic regulators for cancer therapy.

Ann N Y Acad Sci 2014 Feb;1309:30-6

Bristol Myers Squibb Company, Princeton, New Jersey.

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http://dx.doi.org/10.1111/nyas.12356DOI Listing
February 2014

The future of epigenetic therapy in solid tumours--lessons from the past.

Nat Rev Clin Oncol 2013 May 2;10(5):256-66. Epub 2013 Apr 2.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1038/nrclinonc.2013.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730253PMC
May 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

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http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

Functional DNA demethylation is accompanied by chromatin accessibility.

Nucleic Acids Res 2013 Apr 13;41(7):3973-85. Epub 2013 Feb 13.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.

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http://dx.doi.org/10.1093/nar/gkt077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627572PMC
April 2013

Epigenetic abnormalities in cancer find a "home on the range".

Cancer Cell 2013 Jan;23(1):1-3

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586528PMC
January 2013

Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.

Clin Cancer Res 2012 Jun 17;18(12):3387-95. Epub 2012 Apr 17.

Lung Cancer Program, Lovelace Respiratory Research Institute, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87108, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483793PMC
June 2012

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.

Nucleic Acids Res 2012 May 25;40(10):4334-46. Epub 2012 Jan 25.

Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1093/nar/gks031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378872PMC
May 2012

The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications.

Authors:
Stephen B Baylin

Proc Am Thorac Soc 2012 May;9(2):64-5

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1513/pats.201201-001MSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359110PMC
May 2012

Biomarkers for EGFR-antagonist response: in the genes and on the genes!

Clin Cancer Res 2012 Apr 27;18(8):2121-3. Epub 2012 Feb 27.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586523PMC
April 2012

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

Cancer Cell 2011 Nov;20(5):606-19

Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220885PMC
November 2011

A decade of exploring the cancer epigenome - biological and translational implications.

Nat Rev Cancer 2011 Sep 23;11(10):726-34. Epub 2011 Sep 23.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://www.nature.com/articles/nrc3130
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http://dx.doi.org/10.1038/nrc3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307543PMC
September 2011

Cancer epigenetics: linking basic biology to clinical medicine.

Cell Res 2011 Mar 15;21(3):502-17. Epub 2011 Feb 15.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting-Blaustein Cancer Research Building, Suite 541, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://search.proquest.com/openview/e8fd536b36059d1a0709740a
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http://www.nature.com/doifinder/10.1038/cr.2011.24
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http://dx.doi.org/10.1038/cr.2011.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193419PMC
March 2011

Resistance, epigenetics and the cancer ecosystem.

Authors:
Stephen B Baylin

Nat Med 2011 Mar;17(3):288-9

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March 2011

Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

Nat Rev Genet 2010 Nov 5;11(11):806-12. Epub 2010 Oct 5.

The Sidney Kimmel Cancer Research Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Suite 544, Baltimore, Maryland 21231-1000, USA.

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http://dx.doi.org/10.1038/nrg2881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148009PMC
November 2010

Linking cell signaling and the epigenetic machinery.

Nat Biotechnol 2010 Oct;28(10):1033-8

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nbt1010-1033DOI Listing
October 2010

Epigenetic networks and miRNAs in stem cells and cancer.

Mol Cell 2010 Sep;39(5):661-3

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical, Institutions, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.08.036DOI Listing
September 2010

Mapping networks of protein-mediated physical interactions between chromatin elements.

Curr Protoc Mol Biol 2010 Jan;Chapter 21:Unit 21.16.1-13

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1002/0471142727.mb2116s89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857687PMC
January 2010

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Clin Cancer Res 2009 Dec 24;15(23):7217-28. Epub 2009 Nov 24.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927136PMC
December 2009

Combined 3C-ChIP-cloning (6C) assay: a tool to unravel protein-mediated genome architecture.

Cold Spring Harb Protoc 2009 Mar;2009(3):pdb.prot5168

Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586525PMC
March 2009