Publications by authors named "Stephen B Baylin"

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A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.
Cancer Res 2018 Mar 27;78(5):1127-1139. Epub 2017 Dec 27.
Department of Oncology, the Sidney Kimmel Comprehensive Cancer Research Center at Johns Hopkins University, Baltimore, Maryland.

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS Chem Biol 2018 Mar 8;13(3):772-781. Epub 2018 Feb 8.
Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.
Cancer Cell 2018 Feb;33(2):309-321.e5
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:



Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.
Cancer Cell 2017 Sep;32(3):360-376.e6
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:


Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.
Mol Cell 2017 Jan;65(2):323-335
Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:


IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers.
Ann Surg 2016 Feb;263(2):337-44
*Department of Gastrointestinal Surgery, Daping Hospital, Third Military Medical University, Chongqing, China †Department of Surgery ‡Department of Oncology, The Sydney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology and David Rubenstein Pancreatic Cancer Research Center, Memorial Sloan Kettering Cancer Center, New York, NY.


Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
N Engl J Med 2016 Jan 4;374(2):135-45. Epub 2015 Nov 4.


Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
N Engl J Med 2015 Jun 10;372(26):2481-98. Epub 2015 Jun 10.

Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood.
Cancer Prev Res (Phila) 2015 Feb 23;8(2):157-64. Epub 2014 Dec 23.
Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.

Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair.
Curr Opin Genet Dev 2014 Oct 14;28:43-9. Epub 2014 Oct 14.
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205, USA. Electronic address:

CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas.
Epigenetics 2014 May 11;9(5):738-46. Epub 2014 Feb 11.
Department of Surgery; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Oncology; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Urology; The Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Gastrointestinal Surgery; Daping Hospital; Third Military Medical University; Chongqing, PR China.

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.
Clin Cancer Res 2014 Apr 31;20(7):1856-64. Epub 2014 Jan 31.
Authors' Affiliations: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; MDxHealth Inc, Irvine, California; Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan; and Lovelace Respiratory Research Institute, Albuquerque, New Mexico.








Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.
Clin Cancer Res 2012 Jun 17;18(12):3387-95. Epub 2012 Apr 17.
Lung Cancer Program, Lovelace Respiratory Research Institute, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87108, USA.

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.
Nucleic Acids Res 2012 May 25;40(10):4334-46. Epub 2012 Jan 25.
Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.
Genome Res 2012 May 5;22(5):837-49. Epub 2012 Mar 5.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Johns Hopkins Medical Institutions, Baltimore, MD 21117, USA.



Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Cancer Cell 2011 Nov;20(5):606-19
Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.








Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
Clin Cancer Res 2009 Dec 24;15(23):7217-28. Epub 2009 Nov 24.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.



Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.


Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Cancer Cell 2016 10;30(4):637-650
Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD 21201, USA. Electronic address:

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum.
Clin Cancer Res 2017 04 11;23(8):1998-2005. Epub 2016 Oct 11.
Sidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.



Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.
Genome Res 2017 04 23;27(4):533-544. Epub 2017 Feb 23.
Department of Oncology, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.



CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.
Cancer Cell 2017 05;31(5):653-668.e7
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells.
PLoS One 2017 16;12(6):e0179501. Epub 2017 Jun 16.
Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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