Stephen A Ward

Stephen A Ward

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Stephen A Ward

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A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 14;234:118257. Epub 2020 Mar 14.

MOE Joint International Research Laboratory of Synthesis Biology and Medicine, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2020.118257DOI Listing
March 2020

Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis.

Antimicrob Agents Chemother 2019 12 20;64(1). Epub 2019 Dec 20.

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom

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http://dx.doi.org/10.1128/AAC.00989-19DOI Listing
December 2019

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Nat Commun 2019 07 19;10(1):3226. Epub 2019 Jul 19.

Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1038/s41467-019-11239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642103PMC
July 2019

Intracellular PD Modelling () for the Prediction of Clinical Activity of Increased Rifampicin Dosing.

Pharmaceutics 2019 Jun 13;11(6). Epub 2019 Jun 13.

Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.3390/pharmaceutics11060278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630509PMC
June 2019

Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid.

J Antimicrob Chemother 2019 02;74(2):416-424

TB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1093/jac/dky444DOI Listing
February 2019

Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients.

Infect Genet Evol 2018 11 23;65:414-424. Epub 2018 Aug 23.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1016/j.meegid.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219893PMC
November 2018

Exploring pancreatic pathology in Plasmodium falciparum malaria patients.

Sci Rep 2018 Jul 11;8(1):10456. Epub 2018 Jul 11.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand.

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http://dx.doi.org/10.1038/s41598-018-28797-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041343PMC
July 2018

Identification and prioritization of novel anti- chemotypes from screening a 10,000-compound diversity library.

Sci Adv 2017 09 27;3(9):eaao1551. Epub 2017 Sep 27.

Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1126/sciadv.aao1551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617373PMC
September 2017

Influence of the Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of .

Am J Trop Med Hyg 2017 03 6;96(3):624-629. Epub 2017 Apr 6.

Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://dx.doi.org/10.4269/ajtmh.16-0668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361536PMC
March 2017

OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.

Malar J 2016 07 7;15(1):344. Epub 2016 Jul 7.

Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1186/s12936-016-1401-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936002PMC
July 2016

A simple breath test for tuberculosis using ion mobility: A pilot study.

Tuberculosis (Edinb) 2016 07 29;99:143-6. Epub 2016 May 29.

School of Engineering, University of Warwick, Coventry, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2016.05.005DOI Listing
July 2016

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2080-5. Epub 2016 Feb 8.

Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1600459113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776496PMC
February 2016

A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.

Angew Chem Int Ed Engl 2015 Nov 1;54(46):13504-6. Epub 2015 Oct 1.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA (UK).

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http://dx.doi.org/10.1002/anie.201507264DOI Listing
November 2015

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.

Proc Natl Acad Sci U S A 2015 Jan 6;112(3):755-60. Epub 2015 Jan 6.

Molecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1416611112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311836PMC
January 2015

Effects of dosage, comorbidities, and food on isoniazid pharmacokinetics in Peruvian tuberculosis patients.

Antimicrob Agents Chemother 2014 Dec 15;58(12):7164-70. Epub 2014 Sep 15.

Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru TB Centre and Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1128/AAC.03258-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249529PMC
December 2014

Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.

Exp Parasitol 2014 Oct 4;145:80-6. Epub 2014 Aug 4.

Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumtani 12121, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2014.07.013DOI Listing
October 2014

Reprint of "Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin".

Comput Methods Programs Biomed 2014 May 20;114(3):e14-28. Epub 2014 Jan 20.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1016/j.cmpb.2013.12.001DOI Listing
May 2014

The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development.

Trends Parasitol 2014 Apr 11;30(4):170-5. Epub 2014 Mar 11.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714922140002
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http://dx.doi.org/10.1016/j.pt.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989997PMC
April 2014

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis.

Parasitology 2014 Jan 18;141(1):119-27. Epub 2013 Jul 18.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1017/S0031182013001108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884836PMC
January 2014

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

Bioorg Med Chem 2013 Dec 1;21(23):7392-7. Epub 2013 Oct 1.

Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.09.047DOI Listing
December 2013

Plasma and cerebrospinal proteomes from children with cerebral malaria differ from those of children with other encephalopathies.

J Infect Dis 2013 Nov 25;208(9):1494-503. Epub 2013 Jul 25.

Centre for Geographic Medicine-Coast, KEMRI-Wellcome Trust Research Programme, Kilifi.

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http://dx.doi.org/10.1093/infdis/jit334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789566PMC
November 2013

Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin.

Comput Methods Programs Biomed 2013 Oct 18;112(1):1-15. Epub 2013 Jul 18.

Departments of Mathematics and Statistics, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmpb.2013.05.010DOI Listing
October 2013

Glutathione transport: a new role for PfCRT in chloroquine resistance.

Antioxid Redox Signal 2013 Sep 20;19(7):683-95. Epub 2012 Dec 20.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1089/ars.2012.4625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739961PMC
September 2013

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.

ChemMedChem 2013 Sep 12;8(9):1528-36. Epub 2013 Jul 12.

iMed.UL and Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon 1649-003, Portugal.

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http://dx.doi.org/10.1002/cmdc.201300202DOI Listing
September 2013

Antimalarial pharmacology and therapeutics of atovaquone.

J Antimicrob Chemother 2013 May 4;68(5):977-85. Epub 2013 Jan 4.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1093/jac/dks504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344550PMC
May 2013

Antitubercular pharmacodynamics of phenothiazines.

J Antimicrob Chemother 2013 Apr 9;68(4):869-80. Epub 2012 Dec 9.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1093/jac/dks483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594496PMC
April 2013

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Mol Med 2012 Sep 25;18:1045-55. Epub 2012 Sep 25.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, The University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool, United Kingdom.

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http://dx.doi.org/10.2119/molmed.2012.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474437PMC
September 2012

Pharmacokinetics of rifampin in Peruvian tuberculosis patients with and without comorbid diabetes or HIV.

Antimicrob Agents Chemother 2012 May 13;56(5):2357-63. Epub 2012 Feb 13.

Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.

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http://dx.doi.org/10.1128/AAC.06059-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346648PMC
May 2012

The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.

J Biol Chem 2011 Dec 13;286(52):44659-68. Epub 2011 Oct 13.

Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.286054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247980PMC
December 2011

Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.

ChemMedChem 2011 Nov 8;6(11):2094-108. Epub 2011 Sep 8.

Department of Chemistry, University of Liverpool, Crown street, Liverpool, L69 3BX UK.

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http://dx.doi.org/10.1002/cmdc.201100265DOI Listing
November 2011

Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation.

Toxicology 2010 Oct 3;276(2):128-34. Epub 2010 Aug 3.

Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.tox.2010.07.016DOI Listing
October 2010

Inhibiting Plasmodium cytochrome bc1: a complex issue.

Curr Opin Chem Biol 2010 Aug;14(4):440-6

Department of Chemistry, University of Liverpool, Oxford Street, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.1016/j.cbpa.2010.05.005DOI Listing
August 2010

The molecular mechanism of action of artemisinin--the debate continues.

Molecules 2010 Mar 12;15(3):1705-21. Epub 2010 Mar 12.

Department of Chemistry, University of Liverpool, Oxford Street, Liverpool L697ZD, UK.

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http://www.mdpi.com/1420-3049/15/3/1705
Publisher Site
http://dx.doi.org/10.3390/molecules15031705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257357PMC
March 2010

Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

Eur J Clin Pharmacol 2009 Oct 11;65(10):977-87. Epub 2009 Jun 11.

Clinical PK Modelling & Simulation, Quantitative Sciences, GlaxoSmithKline, Mailcode UW2350, King of Prussia, PA, 19406, USA.

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http://dx.doi.org/10.1007/s00228-009-0672-1DOI Listing
October 2009

Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

Methods Enzymol 2009 ;456:303-20

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(08)04417-0DOI Listing
June 2009

Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.

Antimicrob Agents Chemother 2009 Apr 2;53(4):1362-6. Epub 2009 Feb 2.

Molecular and Biochemical Parasitology Group, Centre for Tropical and Infectious Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.01656-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663099PMC
April 2009

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

Bioorg Med Chem Lett 2009 Apr 11;19(7):2033-7. Epub 2009 Feb 11.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.028DOI Listing
April 2009

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

Bioorg Med Chem Lett 2009 Apr 8;19(7):2038-43. Epub 2009 Feb 8.

Centro de Ciências do Mar and Departamento de Química e Bioquímica, F.C.T, Campus de Gambelas, Universidade do Algarve, 8005-039 Faro, Portugal.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.013DOI Listing
April 2009