Publications by authors named "Stephen A Goutman"

38Publications

Untargeted metabolomics yields insight into ALS disease mechanisms.

J Neurol Neurosurg Psychiatry 2020 Sep 14. Epub 2020 Sep 14.

Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1136/jnnp-2020-323611DOI Listing
September 2020

The NEALS primary lateral sclerosis registry.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Sep 11:1-8. Epub 2020 Sep 11.

Department of Neurology, Sean M. Healey & AMG Center for ALS at Mass General, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1080/21678421.2020.1804591DOI Listing
September 2020

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.

N Engl J Med 2020 09;383(10):919-930

From the Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School (S.P., J.D.B., S.B., M.C., D.D., M.M., J.O., L.P., A.V.S., E.T., P.V., J. Walker, H.Y., R.E.T., M.E.C.), the Biostatistics Center, Massachusetts General Hospital, Harvard Medical School (E.A.M., J. Chan, D.S.), and Spaulding Rehabilitation Hospital, Harvard Medical School (S.P.), Boston, the University of Massachusetts Memorial Medical Center, Worcester (M.A.O.), and Amylyx Pharmaceuticals (J. Cohen, J. Klee, K.L., P.D.Y.) and Harvard University (W.G.), Cambridge - all in Massachusetts; Pentara, Millcreek, UT (S.H., S.P.D., N.E., K.H.); Swedish Neuroscience Institute, Seattle (M.A.E.); Hennepin Healthcare, Minneapolis (S.M.); the Department of Neurology, Oregon Health and Science University, Portland (C.K.); the Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC (J.B.C.); the Department of Neurology, Ohio State University College of Medicine, Columbus (A.Q.); the Department of Neurology, University of Florida College of Medicine, Gainesville (J. Wymer); the Department of Neurology, University of Michigan, Ann Arbor (S.A.G.); Texas Neurology, Dallas (D.H.); the Department of Neurology, Lewis Katz School of Medicine, Temple University (T.H.-P.), and the Department of Neurology, University of Pennsylvania Perelman School of Medicine (C.Q.) - both in Philadelphia; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Disease, University of Texas Health Science Center at San Antonio, San Antonio (C.E.J.); the Brain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore (J.D.R.); the Department of Neurology, University of Kentucky College of Medicine, Lexington (E.J.K.); California Pacific Medical Center and Forbes Norris MDA-ALS Research and Treatment Center, San Francisco (J. Katz, L.J.); Barrow Neurological Institute, Phoenix, AZ (S.L., M.H., G.K., R.R., J.M.S.); the Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis (T.M.M.); the Department of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York (S.N.S.); the Department of Neurology, University of South Florida Morsani College of Medicine, Tampa (T.H.V.); the Departments of Neurology and Pathology, Emory University School of Medicine, Atlanta (C.N.F., J.D.G.); Ochsner Health System, New Orleans (K.M.J.); the Department of Neurology, University of Iowa Carver College of Medicine, Iowa City (A.S.); the Department of Neurology, University of California, Irvine, School of Medicine, Irvine (N.A.G.); Neurology Associates, Lincoln, NB (G.L.P.); independent consultant, Nobleboro, ME (P.L.A.); and Statistics Collaborative, Washington, DC (J. Wittes).

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http://dx.doi.org/10.1056/NEJMoa1916945DOI Listing
September 2020

A 2020 centenary perspective on neuromuscular disorders.

J Neurol Neurosurg Psychiatry 2020 Aug 14;91(8):791-792. Epub 2020 Jul 14.

Neurology, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1136/jnnp-2020-324327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402453PMC
August 2020

Early life metal dysregulation in amyotrophic lateral sclerosis.

Ann Clin Transl Neurol 2020 06 21;7(6):872-882. Epub 2020 May 21.

Department of Environmental Medicine and Public Health, and Senator Frank Lautenberg Laboratory for Environmental Health Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1002/acn3.51006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318091PMC
June 2020

Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis.

PLoS Comput Biol 2020 04 15;16(4):e1007773. Epub 2020 Apr 15.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1007773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159190PMC
April 2020

Voicing the Need for Amyotrophic Lateral Sclerosis Environmental Research.

JAMA Neurol 2020 May;77(5):543-544

Department of Neurology, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1001/jamaneurol.2020.0051DOI Listing
May 2020

ALS/SURV: a modification of the CAFS statistic.

Amyotroph Lateral Scler Frontotemporal Degener 2019 11 23;20(7-8):576-583. Epub 2019 Jul 23.

Department of Neurology, University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/21678421.2019.1643375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768708PMC
November 2019

Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials.

Expert Opin Investig Drugs 2019 06 12;28(6):525-543. Epub 2019 Jun 12.

a Department of Neurology , University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/13543784.2019.1627324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697143PMC
June 2019

Lack of consensus in ALS genetic testing practices and divergent views between ALS clinicians and patients.

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 1;20(3-4):216-221. Epub 2019 Apr 1.

a Division of Human Genetics , The Ohio State University Medical Center , Columbus , OH , USA.

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http://dx.doi.org/10.1080/21678421.2019.1582670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085941PMC
May 2019

Variable reporting of and a high rate of uncertain results in ALS genetic testing.

Neurol Genet 2019 Feb 7;5(1):e301. Epub 2019 Jan 7.

Department of Neurology (H.K.), Indiana University Medical Center, Indianapolis; Department of Neurology (S.A.G.), University of Michigan Medical Center, Ann Arbor; Department of Neurology (A.Q., S.J.K., J.R.) and Department of Biological Chemistry & Pharmacy (S.J.K.), The Ohio State University Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1212/NXG.0000000000000301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340336PMC
February 2019

Model-Based and Model-Free Techniques for Amyotrophic Lateral Sclerosis Diagnostic Prediction and Patient Clustering.

Neuroinformatics 2019 07;17(3):407-421

Statistics Online Computational Resource, Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s12021-018-9406-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527505PMC
July 2019

Amyotrophic lateral sclerosis-specific quality of life-short form (ALSSQOL-SF): A brief, reliable, and valid version of the ALSSQOL-R.

Muscle Nerve 2018 11 19;58(5):646-654. Epub 2018 Oct 19.

Department of Neurology, Penn State Hershey Medical Center, Department of Neurology, EC 037, P.O. Box 859, Hershey, Pennsylvania, 17033, USA.

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http://doi.wiley.com/10.1002/mus.26203
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http://dx.doi.org/10.1002/mus.26203DOI Listing
November 2018

Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS.

Ann Clin Transl Neurol 2018 Jun 2;5(6):730-740. Epub 2018 May 2.

Department of Neurology University of Michigan 109 Zina Pitcher Place 5017 AAT-BSRB Ann Arbor Michigan 48109.

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http://doi.wiley.com/10.1002/acn3.567
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http://dx.doi.org/10.1002/acn3.567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989736PMC
June 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Emerging understanding of the genotype-phenotype relationship in amyotrophic lateral sclerosis.

Handb Clin Neurol 2018 ;148:603-623

Department of Neurology, University of Michigan, Ann Arbor, MI, United States.

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https://linkinghub.elsevier.com/retrieve/pii/B97804446407650
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http://dx.doi.org/10.1016/B978-0-444-64076-5.00039-9DOI Listing
August 2018

Complete hazard ranking to analyze right-censored data: An ALS survival study.

PLoS Comput Biol 2017 12 18;13(12):e1005887. Epub 2017 Dec 18.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749893PMC
December 2017

Diagnosis and Clinical Management of Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders.

Continuum (Minneap Minn) 2017 10;23(5, Peripheral Nerve and Motor Neuron Disorders):1332-1359

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http://dx.doi.org/10.1212/CON.0000000000000535DOI Listing
October 2017

Symptom management in amyotrophic lateral sclerosis: We can do better.

Muscle Nerve 2018 01 30;57(1):1-3. Epub 2017 Aug 30.

Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mus.25740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749258PMC
January 2018

Use of Angle-Independent M-Mode Sonography for Assessment of Diaphragm Displacement.

J Ultrasound Med 2017 06;36(6):1285

Department of Radiology , University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/jum.14204DOI Listing
June 2017

Speckle tracking as a method to measure hemidiaphragm excursion.

Muscle Nerve 2017 01 22;55(1):125-127. Epub 2016 Aug 22.

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/mus.25380DOI Listing
January 2017

Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.

Neurology 2016 Jul 29;87(4):392-400. Epub 2016 Jun 29.

From the Departments of Neurology (J.D.G., M.P., J.B., C.F.) and Neurosurgery (N.M.B., J.R., T.F.), Emory University School of Medicine, Atlanta; Center for Nursing Data Science (V.S.H.), Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA; Neuralstem, Inc. (K.J., T.H.), Germantown, MD; Department of Neurology, Neurological Clinical Research Institute (M.C., N.A.), and Department of Neurosurgery (L.F.B.), Massachusetts General Hospital, Boston; Department of Neurology (S.B.R.), Beth Israel Hospital, Boston, MA; and Departments of Neurosurgery (P.G.P.) and Neurology (J.D., P.G.P., S.A.G., E.L.F.), University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1212/WNL.0000000000002889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977116PMC
July 2016

Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 1;3(4):e242. Epub 2016 Jun 1.

Department of Neurology (B.J.M., D.E.B., S.R.K., C.F.-R., C.B., B.C.C., S.A.G., E.L.F.) and A. Alfred Taubman Medical Research Institute (E.L.F.), University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1212/NXI.0000000000000242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897983PMC
August 2016

Screening for novel hexanucleotide repeat expansions at ALS- and FTD-associated loci.

Neurol Genet 2016 Jun 11;2(3):e71. Epub 2016 May 11.

Department of Neurology (F.H., C.F.-R., B.C.C., E.L.F., S.A.G., P.K.T.) and Department of Human Genetics (J.M.J., M.H.M.), University of Michigan, Ann Arbor; Veteran Association Health System (B.C.C., P.K.T.), Ann Arbor; and National Center for Biotechnology Information (D.Z.), National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1212/NXG.0000000000000071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865132PMC
June 2016

Association of Environmental Toxins With Amyotrophic Lateral Sclerosis.

JAMA Neurol 2016 07;73(7):803-11

Department of Neurology, University of Michigan, Ann Arbor4A. Alfred Taubman Medical Research Institute, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1001/jamaneurol.2016.0594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032145PMC
July 2016

Clinical Trials of Therapies for Amyotrophic Lateral Sclerosis: One Size Does Not Fit All.

JAMA Neurol 2015 Jul;72(7):743-4

Department of Neurology, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1001/jamaneurol.2014.4275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499507PMC
July 2015

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era.

Nat Rev Neurol 2015 May 21;11(5):266-79. Epub 2015 Apr 21.

Department of Neurology, University of Michigan, 1500 East Medical Centre Drive, 1914 Taubman Centre SPC 5316, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1038/nrneurol.2015.57DOI Listing
May 2015

Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis.

Neurotherapeutics 2015 Apr;12(2):428-48

Department of Neurology, University of Michigan, F2647 UH South, SPC 5223, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5036, USA,

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http://link.springer.com/10.1007/s13311-015-0339-9
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http://dx.doi.org/10.1007/s13311-015-0339-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404436PMC
April 2015

Minorities, men, and unmarried amyotrophic lateral sclerosis patients are more likely to die in an acute care facility.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Sep 12;15(5-6):440-3. Epub 2014 Jun 12.

Department of Neurology, University of Michigan , Ann Arbor, Michigan , USA.

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http://dx.doi.org/10.3109/21678421.2014.924143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681497PMC
September 2014

Painful diabetic neuropathy.

BMJ 2014 May 6;348:g1799. Epub 2014 May 6.

Department of Neurology, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1136/bmj.g1799DOI Listing
May 2014

Role of repeat skeletal muscle biopsy: how useful is it?

Muscle Nerve 2013 Jun 21;47(6):835-9. Epub 2013 Apr 21.

Neuromuscular Center, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1002/mus.23697DOI Listing
June 2013

Transcranial Doppler with bubble study as a method to detect extracardiac right-to-left shunts in patients with ischemic stroke.

J Neuroimaging 2013 Oct 28;23(4):523-5. Epub 2012 Aug 28.

Cerebrovascular Center, Cleveland Clinic Foundation, OH.

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http://dx.doi.org/10.1111/j.1552-6569.2012.00738.xDOI Listing
October 2013