Stephanie Padilla

Stephanie Padilla

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Stephanie Padilla

Stephanie Padilla

Publications by authors named "Stephanie Padilla"

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Characterizing sources of variability in zebrafish embryo screening protocols.

ALTEX 2019 10;36(1):103-120. Epub 2018 Nov 10.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

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https://www.altex.org/index.php/altex/article/view/997
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http://dx.doi.org/10.14573/altex.1804162DOI Listing
April 2019

Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.

Curr Biol 2019 02 7;29(4):592-604.e4. Epub 2019 Feb 7.

Department of Biology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.01.022DOI Listing
February 2019

NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice.

Elife 2018 12 19;7. Epub 2018 Dec 19.

Department of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, United States.

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http://dx.doi.org/10.7554/eLife.40476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300354PMC
December 2018

A Neural Circuit Underlying the Generation of Hot Flushes.

Cell Rep 2018 07;24(2):271-277

Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Departments of Biochemistry and Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094949PMC
July 2018

Evaluating the zebrafish embryo toxicity test for pesticide hazard screening.

Environ Toxicol Chem 2017 05 11;36(5):1221-1226. Epub 2016 Nov 11.

Gulf Ecology Division, US Environmental Protection Agency, Gulf Breeze, Florida, USA.

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http://dx.doi.org/10.1002/etc.3641DOI Listing
May 2017

AgRP to Kiss1 neuron signaling links nutritional state and fertility.

Proc Natl Acad Sci U S A 2017 02 14;114(9):2413-2418. Epub 2017 Feb 14.

Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;

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http://dx.doi.org/10.1073/pnas.1621065114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338482PMC
February 2017

Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.

Neurotoxicol Teratol 2015 Nov-Dec;52(Pt B):194-209. Epub 2015 Sep 5.

Integrated Systems Toxicology Division, NHEERL, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2015.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768762PMC
October 2016

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity.

Neurotoxicol Teratol 2015 Nov-Dec;52(Pt B):181-93. Epub 2015 Sep 18.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.ntt.2015.09.003DOI Listing
October 2016

Expanding the test set: Chemicals with potential to disrupt mammalian brain development.

Neurotoxicol Teratol 2015 Nov-Dec;52(Pt A):25-35. Epub 2015 Oct 22.

National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.ntt.2015.10.001DOI Listing
October 2016

Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis.

J Appl Toxicol 2016 09 29;36(9):1214-22. Epub 2016 Feb 29.

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1002/jat.3290DOI Listing
September 2016

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons.

Elife 2016 08 23;5. Epub 2016 Aug 23.

Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, United States.

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http://dx.doi.org/10.7554/eLife.16246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995096PMC
August 2016

Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice.

Mol Endocrinol 2016 Jun 19;30(6):630-44. Epub 2016 Apr 19.

Department of Physiology and Pharmacology (C.CN., J.Q., C.Z., M.A.B., S.A.A., O.K.R., M.J.K.) and Anesthesiology and Perioperative Medicine and Knight Cardiovascular Institute (W.F.), Oregon Health & Science University, Portland, Oregon 97239; Division of Neuroscience (O.K.R., M.J.K.), Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006; and Howard Hughes Medical Institute (S.L.P., R.D.P.), University of Washington, Seattle, Washington 98195.

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http://dx.doi.org/10.1210/me.2016-1026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884339PMC
June 2016

Esterase detoxication of acetylcholinesterase inhibitors using human liver samples in vitro.

Toxicology 2016 Apr 27;353-354:11-20. Epub 2016 Apr 27.

Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.tox.2016.04.006DOI Listing
April 2016

Palatability Can Drive Feeding Independent of AgRP Neurons.

Cell Metab 2015 Oct 13;22(4):646-57. Epub 2015 Aug 13.

Unité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024566PMC
October 2015

Developmental exposure to organophosphate flame retardants elicits overt toxicity and alters behavior in early life stage zebrafish (Danio rerio).

Toxicol Sci 2014 Dec 19;142(2):445-54. Epub 2014 Sep 19.

*Nicholas School of the Environment, Duke University, Durham, North Carolina 27708 and Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfu194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250848PMC
December 2014

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation.

ALTEX 2012 ;29(2):202-15

Validation of Alternative Methods Unit, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra (VA), Italy.

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http://dx.doi.org/10.14573/altex.2012.2.202DOI Listing
January 2013

Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult rats.

Toxicol Sci 2012 Sep 30;129(1):126-34. Epub 2012 May 30.

Toxicity Assessment Division, US EPA, Research Triangle Park, North Carolina 27711, USA.

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https://academic.oup.com/toxsci/article/1629122/Impact
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http://dx.doi.org/10.1093/toxsci/kfs190DOI Listing
September 2012

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

Chem Res Toxicol 2012 Jul 15;25(7):1287-302. Epub 2012 May 15.

National Center for Computational Toxicology, Office of Research and Development, U. S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://dx.doi.org/10.1021/tx3000939DOI Listing
July 2012

Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition.

Neurotoxicol Teratol 2011 Nov-Dec;33(6):708-14. Epub 2011 Feb 22.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ntt.2011.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112298PMC
May 2012

Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos.

Reprod Toxicol 2012 Apr 5;33(2):165-73. Epub 2012 Jan 5.

Integrated Systems Toxicology Division United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08906238110052
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http://dx.doi.org/10.1016/j.reprotox.2011.11.111DOI Listing
April 2012

Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.

Endocrinology 2012 Mar 13;153(3):1219-31. Epub 2011 Dec 13.

Institute of Human Nutrition, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1210/en.2011-1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281533PMC
March 2012

Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies.

Toxicol Sci 2011 Oct 12;123(2):349-58. Epub 2011 Jul 12.

Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA.

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https://academic.oup.com/toxsci/article/1687401/Adverse
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http://dx.doi.org/10.1093/toxsci/kfr185DOI Listing
October 2011

Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening.

Aquat Toxicol 2011 Sep 6;105(1-2):127-35. Epub 2011 Jun 6.

Integrated Systems Toxicology and Toxicity Assessment Divisions, National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, NC 27711, USA.

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http://dx.doi.org/10.1016/j.aquatox.2011.05.017DOI Listing
September 2011

Zebrafish: as an integrative model for twenty-first century toxicity testing.

Birth Defects Res C Embryo Today 2011 Sep;93(3):256-67

National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1002/bdrc.20214DOI Listing
September 2011

The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany.

Reprod Toxicol 2011 May;31(4):585-8

UFZ – Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, Permoserstr. 15, 04318 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.reprotox.2011.02.010DOI Listing
May 2011

Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

Environ Health Perspect 2010 Oct 8;118(10):1395-9. Epub 2010 Jun 8.

Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1289/ehp.0901764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957918PMC
October 2010

Relationship between brain and plasma carbaryl levels and cholinesterase inhibition.

Toxicology 2010 Oct 11;276(3):172-83. Epub 2010 Aug 11.

Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Research Triangle Park, NC 27711, United States.

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http://dx.doi.org/10.1016/j.tox.2010.08.001DOI Listing
October 2010

Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening.

Neurotoxicol Teratol 2010 Jan-Feb;32(1):91-8. Epub 2009 May 19.

Cellular and Molecular Toxicology Branch, Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://dx.doi.org/10.1016/j.ntt.2009.04.065DOI Listing
April 2010

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits.

Nat Med 2010 Apr 28;16(4):403-5. Epub 2010 Mar 28.

Institute of Human Nutrition, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.2126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854504PMC
April 2010

Use of medaka in toxicity testing.

Curr Protoc Toxicol 2009 Feb;Chapter 1:Unit1.10

United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://doi.wiley.com/10.1002/0471140856.tx0110s39
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http://dx.doi.org/10.1002/0471140856.tx0110s39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300524PMC
February 2009

Regulation of Fto/Ftm gene expression in mice and humans.

Am J Physiol Regul Integr Comp Physiol 2008 Apr 6;294(4):R1185-96. Epub 2008 Feb 6.

Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1152/ajpregu.00839.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808712PMC
April 2008

Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat.

Toxicol Sci 2007 Aug 15;98(2):552-60. Epub 2007 May 15.

Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfm114DOI Listing
August 2007

Re: age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon.

Toxicol Sci 2007 Aug 6;98(2):604; author reply 605-6. Epub 2007 Jun 6.

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http://dx.doi.org/10.1093/toxsci/kfm116DOI Listing
August 2007

Vulnerable windows for developmental ethanol toxicity in the Japanese medaka fish (Oryzias latipes).

Aquat Toxicol 2006 Dec 27;80(4):396-404. Epub 2006 Nov 27.

Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

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http://dx.doi.org/10.1016/j.aquatox.2006.10.007DOI Listing
December 2006

Measuring cholinesterase activity in human saliva.

J Toxicol Environ Health A 2006 Oct;69(19):1805-18

U.S. Environmental Protection Agency, Neurotoxicology Division and Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1080/15287390600631458DOI Listing
October 2006

Adapting the medaka embryo assay to a high-throughput approach for developmental toxicity testing.

Neurotoxicology 2006 Sep 18;27(5):840-5. Epub 2006 Apr 18.

Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.neuro.2006.02.009DOI Listing
September 2006

Characterization of deltamethrin metabolism by rat plasma and liver microsomes.

Toxicol Appl Pharmacol 2006 Apr 16;212(2):156-66. Epub 2005 Sep 16.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1016/j.taap.2005.07.021DOI Listing
April 2006

Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity.

Drug Metab Dispos 2006 Mar 2;34(3):389-97. Epub 2005 Dec 2.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1124/dmd.105.007807DOI Listing
March 2006

Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats.

Toxicol Sci 2005 Nov 4;88(1):161-71. Epub 2005 Aug 4.

Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://academic.oup.com/toxsci/article/88/1/161/1662786/Neur
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http://dx.doi.org/10.1093/toxsci/kfi274DOI Listing
November 2005

A dried blood spot method to evaluate cholinesterase activity in young children.

Arch Environ Health 2004 Sep;59(9):467-70

National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1080/00039890409603427DOI Listing
September 2004

Automated measurement of acetylcholinesterase activity in rat peripheral tissues.

Toxicology 2003 Apr;186(3):241-53

Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27516, USA.

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http://dx.doi.org/10.1016/s0300-483x(02)00752-7DOI Listing
April 2003

Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?

Environ Health Perspect 2002 Nov;110(11):1097-103

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241065PMC
http://dx.doi.org/10.1289/ehp.021101097DOI Listing
November 2002