Stephanie Le Gras

Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.

Authors:

Nour El Houda Mimouni Isabel Paiva Anne-Laure Barbotin Fatima Ezzahra Timzoura Damien Plassard Stephanie Le Gras Gaetan Ternier Pascal Pigny Sophie Catteau-Jonard Virginie Simon Vincent Prevot Anne-Laurence Boutillier Paolo Giacobini

Cell Metab 2021 Jan 29. Epub 2021 Jan 29.

Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, FHU 1000 days for health, 59000 Lille, France. Electronic address:

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January 2021

Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

Authors:

Beate Heizmann Stéphanie Le Gras Célestine Simand Patricia Marchal Susan Chan Philippe Kastner

PLoS One 2021 29;16(1):e0246570. Epub 2021 Jan 29.

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January 2021

Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.

Authors:

Lara Zorro Shahidian Mariska Haas Stephanie Le Gras Sandra Nitsch André Mourão Arie Geerlof Raphael Margueron Jens Michaelis Sylvain Daujat Robert Schneider

EMBO Rep 2021 Jan 29:e51009. Epub 2021 Jan 29.

Institute of Functional Epigenetics, Helmholtz Zentrum München, Neuherberg, Germany.

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January 2021

Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

Authors:

Beate Heizmann Stéphanie Le Gras Célestine Simand Patricia Marchal Susan Chan Philippe Kastner

PLoS One 2020 12;15(11):e0242211. Epub 2020 Nov 12.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.

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January 2021

CpG Islands Shape the Epigenome Landscape.

Authors:

Christophe Papin Stéphanie Le Gras Abdulkhaleg Ibrahim Hatem Salem Mohammad Mahdi Karimi Isabelle Stoll Iva Ugrinova Maria Schröder Emeline Fontaine-Pelletier Ziad Omran Christian Bronner Stefan Dimitrov Ali Hamiche

J Mol Biol 2020 Oct 1:166659. Epub 2020 Oct 1.

Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), UdS, CNRS, INSERM, Equipe labellisée Ligue contre le Cancer, 1 rue Laurent Fries, B.P. 10142,67404 Illkirch Cedex, France. Electronic address:

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October 2020

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3.

Authors:

Adam Burton Vincent Brochard Carmen Galan Elias R Ruiz-Morales Quirze Rovira Diego Rodriguez-Terrones Kai Kruse Stéphanie Le Gras Vishnu S Udayakumar Hang Gyeong Chin André Eid Xiaoyu Liu Chenfei Wang Shaorong Gao Sriharsa Pradhan Juan M Vaquerizas Nathalie Beaujean Thomas Jenuwein Maria-Elena Torres-Padilla

Nat Cell Biol 2020 07 29;22(7):767-778. Epub 2020 Jun 29.

Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, München, Germany.

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July 2020

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

Brain 2019 11;142(11):3636-3654

University of Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc, LabEx DISTALZ, F Lille, France.

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November 2019

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures.

Authors:

Nicolas Merienne Cécile Meunier Anne Schneider Jonathan Seguin Satish S Nair Anne B Rocher Stéphanie Le Gras Céline Keime Richard Faull Luc Pellerin Jean-Yves Chatton Christian Neri Karine Merienne Nicole Déglon

Cell Rep 2019 02;26(9):2477-2493.e9

Department of Clinical Neurosciences, Laboratory of Neurotherapies and Neuromodulation (LNTM), Lausanne University Hospital, 1011 Lausanne, Switzerland; Neuroscience Research Center, LNTM, Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:

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February 2019

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.

EMBO Mol Med 2018 11;10(11)

Laboratoire de Neuroscience Cognitives et Adaptatives (LNCA), Université de Strasbourg, Strasbourg, France

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November 2018

Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder.

Authors:

Angélique Quartier Laure Chatrousse Claire Redin Céline Keime Nicolas Haumesser Anne Maglott-Roth Laurent Brino Stéphanie Le Gras Alexandra Benchoua Jean-Louis Mandel Amélie Piton

Biol Psychiatry 2018 08 9;84(4):239-252. Epub 2018 Jan 9.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Laboratory of Genetic Diagnostics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:

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August 2018

Histone propionylation is a mark of active chromatin.

Authors:

Adam F Kebede Anna Nieborak Lara Zorro Shahidian Stephanie Le Gras Florian Richter Diana Aguilar Gómez Marijke P Baltissen Gergo Meszaros Helena de Fatima Magliarelli Aaron Taudt Raphael Margueron Maria Colomé-Tatché Romeo Ricci Sylvain Daujat Michiel Vermeulen Gerhard Mittler Robert Schneider

Nat Struct Mol Biol 2017 Dec 23;24(12):1048-1056. Epub 2017 Oct 23.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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December 2017

Combinatorial DNA methylation codes at repetitive elements.

Authors:

Christophe Papin Abdulkhaleg Ibrahim Stéphanie Le Gras Amandine Velt Isabelle Stoll Bernard Jost Hervé Menoni Christian Bronner Stefan Dimitrov Ali Hamiche

Genome Res 2017 06 27;27(6):934-946. Epub 2017 Mar 27.

Département de Génomique Fonctionnelle et Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), UdS, CNRS, INSERM, Equipe labellisée Ligue contre le Cancer, 67404 Illkirch Cedex, France.

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June 2017

Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature.

Authors:

Stéphanie Le Gras Céline Keime Anne Anthony Caroline Lotz Lucie De Longprez Emmanuel Brouillet Jean-Christophe Cassel Anne-Laurence Boutillier Karine Merienne

Sci Rep 2017 02 22;7:42875. Epub 2017 Feb 22.

University of Strasbourg, Laboratory of Cognitive and Adaptive Neurosciences (LNCA), 12 rue Goethe, 67000 Strasbourg, France.

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February 2017

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.

Authors:

Shilpy Joshi Guillaume Davidson Stéphanie Le Gras Shuichi Watanabe Thomas Braun Gabrielle Mengus Irwin Davidson

PLoS Genet 2017 02 8;13(2):e1006600. Epub 2017 Feb 8.

Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UNISTRA, Illkirch, France.

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February 2017

Intragenic FMR1 disease-causing variants: a significant mutational mechanism leading to Fragile-X syndrome.

Eur J Hum Genet 2017 04 8;25(4):423-431. Epub 2017 Feb 8.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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April 2017

Macrophage production and activation are dependent on TRIM33.

Authors:

Anne-Sophie Gallouet Federica Ferri Vanessa Petit Aude Parcelier Daniel Lewandowski Nathalie Gault Vilma Barroca Stéphanie Le Gras Eric Soler Frank Grosveld Irwin Davidson Paul-Henri Romeo

Oncotarget 2017 Jan;8(3):5111-5122

CEA/DRF/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.

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January 2017

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.

Authors:

Attila Oravecz Apostol Apostolov Katarzyna Polak Bernard Jost Stéphanie Le Gras Susan Chan Philippe Kastner

Nat Commun 2015 Nov 9;6:8823. Epub 2015 Nov 9.

Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR 7104, Université de Strasbourg, Equipe Labellisée Ligue Contre le Cancer, 1 rue Laurent Fries, Illkirch 67404, France.

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November 2015

A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement.

Authors:

Megana K Prasad Véronique Geoffroy Serge Vicaire Bernard Jost Michael Dumas Stéphanie Le Gras Marzena Switala Barbara Gasse Virginie Laugel-Haushalter Marie Paschaki Bruno Leheup Dominique Droz Amelie Dalstein Adeline Loing Bruno Grollemund Michèle Muller-Bolla Séréna Lopez-Cazaux Maryline Minoux Sophie Jung Frédéric Obry Vincent Vogt Jean-Luc Davideau Tiphaine Davit-Beal Anne-Sophie Kaiser Ute Moog Béatrice Richard Jean-Jacques Morrier Jean-Pierre Duprez Sylvie Odent Isabelle Bailleul-Forestier Monique Marie Rousset Laure Merametdijan Annick Toutain Clara Joseph Fabienne Giuliano Jean-Christophe Dahlet Aymeric Courval Mustapha El Alloussi Samir Laouina Sylvie Soskin Nathalie Guffon Anne Dieux Bérénice Doray Stephanie Feierabend Emmanuelle Ginglinger Benjamin Fournier Muriel de la Dure Molla Yves Alembik Corinne Tardieu François Clauss Ariane Berdal Corinne Stoetzel Marie Cécile Manière Hélène Dollfus Agnès Bloch-Zupan

J Med Genet 2016 Feb 26;53(2):98-110. Epub 2015 Oct 26.

Centre de Référence des Manifestations Odontologiques des Maladies Rares, Pôle de Médecine et Chirurgie Bucco-dentaires, Hôpitaux Universitaires de Strasbourg (HUS), Strasbourg, France Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg, France Institut de Génétique et de Biologie Moléculaire and Cellulaire-Centre Européen de Recherche en Biologie et en Médecine, CNRS UMR7104, INSERM U964 Université de Strasbourg, Illkirch, France.

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February 2016

Genome-Wide Mapping of Collier In Vivo Binding Sites Highlights Its Hierarchical Position in Different Transcription Regulatory Networks.

Authors:

Mathilde de Taffin Yannick Carrier Laurence Dubois Laetitia Bataillé Anaïs Painset Stéphanie Le Gras Bernard Jost Michèle Crozatier Alain Vincent

PLoS One 2015 23;10(7):e0133387. Epub 2015 Jul 23.

Centre de Biologie du Développement, UMR 5547 CNRS Université de Toulouse 3, 118 route de Narbonne, F-31062, Toulouse cedex 09, France.

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May 2016

A Brn2-Zic1 axis specifies the neuronal fate of retinoic-acid-treated embryonic stem cells.

Authors:

Sylvia Urban Dominique Kobi Marie Ennen Diana Langer Stéphanie Le Gras Tao Ye Irwin Davidson

J Cell Sci 2015 Jul 19;128(13):2303-18. Epub 2015 May 19.

Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UDS, 1 Rue Laurent Fries, Illkirch, Cédex 67404, France Equipe Labellisée of the Ligue Nationale Contre le Cancer, CNRS/INSERM/UDS, 1 Rue Laurent Fries, Illkirch, Cédex 67404, France

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July 2015

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells.

Authors:

Patrick Laurette Thomas Strub Dana Koludrovic Céline Keime Stéphanie Le Gras Hannah Seberg Eric Van Otterloo Hana Imrichova Robert Siddaway Stein Aerts Robert A Cornell Gabrielle Mengus Irwin Davidson

Elife 2015 Mar 24;4. Epub 2015 Mar 24.

Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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March 2015

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice.

Authors:

Mayada Achour Stéphanie Le Gras Céline Keime Frédéric Parmentier François-Xavier Lejeune Anne-Laurence Boutillier Christian Néri Irwin Davidson Karine Merienne

Hum Mol Genet 2015 Jun 17;24(12):3481-96. Epub 2015 Mar 17.

Neurogenetics and Translational Medicine Department, Laboratory of Cognitive and Adaptive Neuroscience, CNRS/University of Strasbourg, UMR 7364, 12 rue Goethe, 67000 Strasbourg, France

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June 2015

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

Authors:

Daniil Alpern Diana Langer Benoit Ballester Stephanie Le Gras Christophe Romier Gabrielle Mengus Irwin Davidson

Elife 2014 Sep 10;3:e03613. Epub 2014 Sep 10.

Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.

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September 2014

Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.

J Med Genet 2014 Nov 28;51(11):724-36. Epub 2014 Aug 28.

Département de Médicine translationnelle et Neurogénétique, IGBMC, CNRS UMR 7104/INSERM U964/Université de Strasbourg, Illkirch, France Chaire de Génétique Humaine, Collège de France, Illkirch, France.

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November 2014

The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells.

Authors:

Anne-Solen Geimer Le Lay Attila Oravecz Jérôme Mastio Claudia Jung Patricia Marchal Claudine Ebel Doulaye Dembélé Bernard Jost Stéphanie Le Gras Christelle Thibault Tilman Borggrefe Philippe Kastner Susan Chan

Sci Signal 2014 Mar 18;7(317):ra28. Epub 2014 Mar 18.

1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR 7104, Université de Strasbourg, 67404 Illkirch, France.

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March 2014

20 ans après: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition.

Eur J Hum Genet 2014 Jun 30;22(6):776-83. Epub 2013 Oct 30.

1] IGBMC, CNRS UMR 7104/INSERM U964/University of Strasbourg, Illkirch Cedex, France [2] Chaire de Génétique Humaine, Collège de France, Paris, France [3] Laboratoire de Diagnostic Génétique, Hôpitaux Universitaires de Strasbourg, France.

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June 2014