Stephane Richard

Stephane Richard

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CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis-Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation.

Hepatology 2020 Apr 24;71(4):1279-1296. Epub 2020 Jan 24.

State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/hep.30923DOI Listing
April 2020

[Hereditary kidney cancers: The pathologist's view in 2020].

Ann Pathol 2020 Apr 18;40(2):148-167. Epub 2020 Mar 18.

Réseau national de référence pour cancers rares de l'adulte PREDIR (« Maladie de von Hippel-Lindau et prédispositions héréditaires au cancer rénal ») labellisée par l'Institut national du cancer, université Paris Saclay, Assistance publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France; Génétique oncologique EPHE, PSL Université, UMR 9019 CNRS, université Paris-Saclay, institut Gustave-Roussy, Villejuif, France.

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http://dx.doi.org/10.1016/j.annpat.2020.02.022DOI Listing
April 2020

The Crossroads of Precision Medicine and Therapeutic Decision-Making: Use of an Analytical Computational Platform to Predict Response to Cancer Treatments.

Cancers (Basel) 2020 Jan 9;12(1). Epub 2020 Jan 9.

Center for Personalized Cancer Therapy, University of California Moores Cancer Center, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.3390/cancers12010166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017109PMC
January 2020

Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.

J Mol Cell Cardiol 2019 12 19;137:82-92. Epub 2019 Oct 19.

Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Molecular Cardiology Program, Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889069PMC
December 2019

Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons.

Cell Rep 2019 11;29(7):1789-1799.e6

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871770PMC
November 2019

The regulation, functions and clinical relevance of arginine methylation.

Nat Rev Mol Cell Biol 2019 10 26;20(10):642-657. Epub 2019 Jul 26.

Segal Cancer Center, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital and Gerald Bronfman Department of Oncology and Departments of Medicine, Biochemistry and Human Genetics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/s41580-019-0155-xDOI Listing
October 2019

Author Correction: The regulation, functions and clinical relevance of arginine methylation.

Nat Rev Mol Cell Biol 2019 Sep;20(9):567

Segal Cancer Center, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital and Gerald Bronfman Department of Oncology and Departments of Medicine, Biochemistry and Human Genetics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/s41580-019-0166-7DOI Listing
September 2019

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.

EMBO J 2019 08 21;38(15):e100986. Epub 2019 Jun 21.

Departments of Oncology and Medicine, Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.15252/embj.2018100986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669924PMC
August 2019

M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge.

Cancer Cell 2019 07;36(1):3-5

Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.004DOI Listing
July 2019

Optimization of Next-Generation Sequencing Technologies for von Hippel Lindau (VHL) Mosaic Mutation Detection and Development of Confirmation Methods.

J Mol Diagn 2019 05 5;21(3):462-470. Epub 2019 Feb 5.

UMR-S 1172-Jean-Pierre Aubert Research Center, University of Lille, Lille, France; INSERM, UMR-S 1172, Team on Mucins, Epithelial Differentiation and Carcinogenesis, Lille, France; Department of Biochemistry and Molecular Biology, Centre Hospitalier Régional et Universitaire de Lille, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.005DOI Listing
May 2019

A Simple Method to Determine Cytotoxicity of Water-Soluble Organic Compounds and Solid Particles from Biomass Combustion in Lung Cells in Vitro.

Environ Sci Technol 2019 04 13;53(7):3959-3968. Epub 2019 Mar 13.

Lucerne University of Applied Sciences and Arts , School of Engineering and Architecture, Bioenergy Research Group , Technikumstrasse 21 , 6048 Horw , Switzerland.

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http://dx.doi.org/10.1021/acs.est.8b03101DOI Listing
April 2019

Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination.

Dev Cell 2018 08 26;46(4):426-440.e5. Epub 2018 Jul 26.

Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.06.025DOI Listing
August 2018

Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.

Oncotarget 2018 Mar 23;9(22):15915-15930. Epub 2018 Mar 23.

Genome Stability Laboratory, Centre for Chromosome Biology, National University of Ireland, Galway, Ireland.

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http://dx.doi.org/10.18632/oncotarget.24636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882307PMC
March 2018

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets.

Oncotarget 2017 Oct 11;8(47):81994-82005. Epub 2017 May 11.

Segal Cancer Center, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.18632/oncotarget.17813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669865PMC
October 2017

Correction for Yu et al., "A Mouse Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation".

Mol Cell Biol 2017 09 11;37(17). Epub 2017 Aug 11.

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Oncology and Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00298-17
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http://dx.doi.org/10.1128/MCB.00298-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559678PMC
September 2017

Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress.

Oncotarget 2017 Sep 22;8(39):64918-64931. Epub 2017 May 22.

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada.

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http://dx.doi.org/10.18632/oncotarget.18070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630301PMC
September 2017

Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing.

Sci Rep 2017 08 8;7(1):7554. Epub 2017 Aug 8.

Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.

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http://www.nature.com/articles/s41598-017-06211-1
Publisher Site
http://dx.doi.org/10.1038/s41598-017-06211-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548867PMC
August 2017

Biphasic Squamoid Alveolar Renal Cell Carcinoma: 2 Cases in a Family Supporting a Continuous Spectrum With Papillary Type I Renal Cell Carcinoma.

Am J Surg Pathol 2017 07;41(7):1011-1012

*Department of Pathology †Department of Urology, European Georges Pompidou Hospital, APHP ‡Medical Faculty of Paris-Descartes University, Paris §PREDIR, National Expert Network of INCA for Rare Adult Cancers "Hereditary Predisposition to Renal Tumours", APHP, Bicetre Hospital, Le Kremlin-Bicêtre ∥INSERM U1186, Oncogenetic Laboratory, EPHE, PSL, Institut of Cancerology Gustave Roussy, Villejuif ¶Department of Pathology, Necker-Enfants Malades hospital, APHP, Paris **INSERM, UMR970, Paris-Centre de Recherche Cardiovasculaire, Paris, France.

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http://dx.doi.org/10.1097/PAS.0000000000000870DOI Listing
July 2017

Regenerating muscle with arginine methylation.

Transcription 2017 05 17;8(3):175-178. Epub 2017 Feb 17.

a Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital , Montréal , Québec , Canada.

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http://dx.doi.org/10.1080/21541264.2017.1291083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501374PMC
May 2017

CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.

Sci Adv 2017 May 24;3(5):e1601898. Epub 2017 May 24.

Departments of Oncology and Experimental Medicine, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, 3755 Chemin Côte-Ste-Catherine, Montréal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1126/sciadv.1601898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443639PMC
May 2017

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

Proc Natl Acad Sci U S A 2017 03 20;114(13):E2563-E2570. Epub 2017 Mar 20.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1621513114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380080PMC
March 2017

Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate.

Mol Cell Biol 2017 02 19;37(3). Epub 2017 Jan 19.

Terry Fox Molecular Oncology Group and Segal Cancer Center, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, and Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/MCB.00457-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247616PMC
February 2017

Arginine Methylation: The Coming of Age.

Mol Cell 2017 Jan;65(1):8-24

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Departments of Oncology and Medicine, McGill University, Montréal, QC H2W 1S6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.003DOI Listing
January 2017

Decontamination of a field laboratory dedicated to Ebola virus-infected patients.

Am J Infect Control 2016 12 26;44(12):1687-1688. Epub 2016 Aug 26.

Microbiology Laboratory, Hôpital d'Instruction des Armées Bégin, Saint Mandé, France.

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http://dx.doi.org/10.1016/j.ajic.2016.05.034DOI Listing
December 2016

The p53 status can influence the role of Sam68 in tumorigenesis.

Oncotarget 2016 Nov;7(44):71651-71659

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.18632/oncotarget.12305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342108PMC
November 2016

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.

Eur Urol 2016 10 23;70(4):623-632. Epub 2015 Dec 23.

INSERM (Institut National de la Santé et de la Recherche Médicale) UMR1186, Laboratory Integrative Tumor Immunology and Genetic Oncology, Villejuif, France; INSERM, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, F-94805, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.11.029DOI Listing
October 2016

Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor.

Nucleic Acids Res 2016 Oct 30;44(18):8726-8741. Epub 2016 Jun 30.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada Department of Medicine and Oncology, McGill University, Montréal, Québec H3A 1A1, Canada

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http://dx.doi.org/10.1093/nar/gkw582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062974PMC
October 2016

RNA G-quadruplexes and their potential regulatory roles in translation.

Translation (Austin) 2016 4;4(2):e1244031. Epub 2016 Oct 4.

Terry Fox Molecular Oncology Group and Segal Cancer Center, McGill University, Montréal, Québec, Canada; Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec, Canada; Department of Oncology, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1080/21690731.2016.1244031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173311PMC
October 2016

Laser Photocoagulation for Peripheral Retinal Capillary Hemangioblastoma in von Hippel-Lindau Disease.

Ophthalmol Retina 2017 Jan - Feb;1(1):59-67. Epub 2016 Sep 12.

Service d'Opthalmologie, AP-HP, Hôpital Lariboisière, Université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Centre de Référence des maladies Vasculaires rares du Cerveau et de l'Œil (CERVCO), Hôpital Lariboisière, AP-HP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.oret.2016.08.004DOI Listing
September 2016

p38 Mitogen-Activated Protein Kinase Pathway Regulates Genes during Proliferation and Differentiation in Oligodendrocytes.

PLoS One 2015 29;10(12):e0145843. Epub 2015 Dec 29.

Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada, H3G 1Y6.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145843PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699908PMC
July 2016

Surgical resection of medulla oblongata hemangioblastomas: outcome and complications.

Acta Neurochir (Wien) 2016 07 16;158(7):1333-41. Epub 2016 May 16.

Department of Neurosurgery, Bicêtre University Hospital, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1007/s00701-016-2834-0DOI Listing
July 2016

Von Hippel-Lindau Disease: Genetics and Role of Genetic Counseling in a Multiple Neoplasia Syndrome.

J Clin Oncol 2016 06 25;34(18):2172-81. Epub 2016 Apr 25.

Sarah M. Nielsen and Lindsay Rhodes, The University of Chicago, Chicago, IL; Ignacio Blanco, Hospital Universitari Germans Trias i Pujol, UAB - Universitat Autònoma de Barcelona, Barcelona, Spain; Wendy K. Chung, Columbia University, New York, NY; Charis Eng, Cleveland Clinic; Charis Eng, Case Western Reserve University School of Medicine, Cleveland, OH; Eamonn R. Maher, University of Cambridge and Cambridge NIHR Biomedical Research Centre, Cambridge, United Kingdom; Stéphane Richard, Réseau National pour Cancers Rares de l'Adulte PREDIR, INCa/AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre; Stéphane Richard, INSERM U1186, Gustave Roussy Cancer Campus, Villejuif, France; Rachel H. Giles, University Medical Center Utrecht, Regenerative Medicine Center Utrecht, Utrecht; and Rachel H. Giles, Dutch VHL Patient Organization, Gouda, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2015.65.6140DOI Listing
June 2016

Emerging functions of the Quaking RNA-binding proteins and link to human diseases.

Wiley Interdiscip Rev RNA 2016 05 14;7(3):399-412. Epub 2016 Mar 14.

Terry Fox Molecular Oncology Group, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Canada, H3T 1E2.

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http://dx.doi.org/10.1002/wrna.1344DOI Listing
May 2016

Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.

J Neurosci 2016 Apr;36(14):4106-20

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Oncology and Medicine, Montréal, Québec H3T 1E2, Canada, and

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http://dx.doi.org/10.1523/JNEUROSCI.3529-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705516PMC
April 2016

miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.

Cell Rep 2016 Mar 18;14(8):1966-78. Epub 2016 Feb 18.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.068DOI Listing
March 2016

PRMT7 Preserves Satellite Cell Regenerative Capacity.

Cell Rep 2016 Feb 4;14(6):1528-1539. Epub 2016 Feb 4.

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.022DOI Listing
February 2016

Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2.

Anticancer Res 2015 Dec;35(12):6639-53

Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Republic of Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore

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December 2015

Simulated microgravity: critical review on the use of random positioning machines for mammalian cell culture.

Biomed Res Int 2015 14;2015:971474. Epub 2015 Jan 14.

Lucerne University of Applied Sciences and Arts, School of Engineering and Architecture, CC Aerospace Biomedical Science and Technology, Space Biology Group, Lucerne University of Applied Sciences and Arts, Seestraße 41, 6052 Hergiswil, Switzerland.

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http://dx.doi.org/10.1155/2015/971474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310317PMC
November 2015

Emerging Roles of Disordered Sequences in RNA-Binding Proteins.

Trends Biochem Sci 2015 Nov 15;40(11):662-672. Epub 2015 Oct 15.

Terry Fox Molecular Oncology Group and Segal Cancer Center, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Québec, H3T 1E2, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680004150016
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http://dx.doi.org/10.1016/j.tibs.2015.08.012DOI Listing
November 2015

Long-term Prognosis of Resected Pancreatic Neuroendocrine Tumors in von Hippel-Lindau Disease Is Favorable and Not Influenced by Small Tumors Left in Place.

Ann Surg 2015 Aug;262(2):384-8

*Department of Gastroenterology and Pancreatology, Beaujon Hospital, Clichy, France; †Department of Hepato-Gastroenterology and Digestive Oncology, Robert-Debré Hospital, Reims-Champagne-Ardennes University, Reims, France; ‡Department of Hepato-Pancreatico-Biliary Surgery, Beaujon Hospital, Clichy, France; §Denis-Diderot University, Paris, France; Departments of ¶Pathology, and ‖Radiology, Beaujon Hospital, Clichy, France; **Department of Pathology, Bichat Hospital, Paris, France; ††Expert National Center for Rare Cancers PREDIR, INCa/APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, France; and ‡‡Oncogenetics EPHE Laboratory and INSERM U753, Faculty of Medicine Paris Sud, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1097/SLA.0000000000000856DOI Listing
August 2015

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis.

Mol Cell Biol 2015 Jun 16;35(11):1926-39. Epub 2015 Mar 16.

Terry Fox Molecular Oncology Group and Segal Cancer Center, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, and Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/MCB.01488-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420930PMC
June 2015

A germline mutation in PBRM1 predisposes to renal cell carcinoma.

J Med Genet 2015 Jun 24;52(6):426-30. Epub 2015 Apr 24.

Ecole Pratique des Hautes Etudes, Paris, France Laboratoire de Génétique Oncologique EPHE, INSERM U753, Villejuif, France Faculté de Médecine Université Paris-Sud, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1136/jmedgenet-2014-102912DOI Listing
June 2015

Inhibition of Sam68 triggers adipose tissue browning.

J Endocrinol 2015 Jun 1;225(3):181-9. Epub 2015 May 1.

Department of Medicine-Cardiology Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14-721, Chicago, Illinois 60611, USA Department of Cardiology Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Biochemistry University of Ottawa, Ottawa, Ontario, Canada Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China College of Life Sciences, South-Central University for Nationalities, Wuhan, Hubei, China GeneSys Research Institute CardioVascular Research Center, Tufts University School of Medicine, Boston, Massachusetts, USA Department of Medicine Medical College of Georgia, Vascular Biology Center, Georgia Regents University, Augusta, Georgia, USA Department of Surgery Roger Williams Medical Center, Boston University Medical School, Providence, Rhode Island, USA Kosair Children Hospital Research Institute Departments of Pediatrics, Radiation Oncology, Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA Lady Davis Institute for Medical Research McGill University, Montreal, Quebec, Canada Center for Translational Medicine Temple University School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1530/JOE-14-0727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482239PMC
June 2015

Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.

Sci Rep 2015 May 28;5:10475. Epub 2015 May 28.

Terry Fox Molecular Oncology Group and Segal Cancer Center, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Québec, Canada H3T 1E2.

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http://dx.doi.org/10.1038/srep10475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447065PMC
May 2015

The role of PHD2 mutations in the pathogenesis of erythrocytosis.

Hypoxia (Auckl) 2014 1;2:71-90. Epub 2014 Jul 1.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.2147/HP.S54455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045058PMC
July 2014

Management of endolymphatic sac tumors: sporadic cases and von Hippel-Lindau disease.

Otol Neurotol 2014 Jun;35(5):899-904

*Service d'ORL, AP-HP, Hôpital Bicêtre, Service ORL; and †U.693 INSERM, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre; ‡Service d'ORL, AP-HP, Hôpital Beaujon, Service ORL; §U.867 INSERM, Faculté de Médecine Xavier Bichat, Paris; ∥Centre de Référence Cancers Rares INCa "PREDIR" and Réseau National INCa, AP-HP, Service d'Urologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre; and ¶Génétique Oncologique EPHE, U.743, INSERM, Institut de Cancérologie Gustave Roussy, Villejuif and Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.

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June 2014

Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1.

Mol Biol Cell 2014 Mar 22;25(6):925-35. Epub 2014 Jan 22.

Centre de Recherche du CHU de Québec, L'Hôtel-Dieu de Québec, and Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec, QC G1R 2J6, Canada Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Oncology and Medicine, McGill University, Montréal, QC H3G 1Y6, Canada.

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http://dx.doi.org/10.1091/mbc.E13-07-0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952860PMC
March 2014

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.

Nat Commun 2013 ;4:1909

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21025, USA.

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http://www.nature.com/articles/ncomms2916
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http://dx.doi.org/10.1038/ncomms2916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684077PMC
December 2013

SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.

Epigenetics 2013 Nov 22;8(11):1162-75. Epub 2013 Aug 22.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging; Sir Mortimer B Davis Jewish General Hospital; Lady Davis Institute for Medical Research; Montréal, QC Canada; Department of Medicine and Oncology; McGill University; Montréal, QC Canada.

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http://dx.doi.org/10.4161/epi.26112DOI Listing
November 2013

Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival.

Sci Rep 2011 6;1:84. Epub 2011 Sep 6.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Oncology and Medicine, McGill University , Montréal, Québec, Canada, H3T 1E2.

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http://www.nature.com/articles/srep00084
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http://dx.doi.org/10.1038/srep00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239166PMC
August 2013

The role of arginine methylation in the DNA damage response.

DNA Repair (Amst) 2013 Jul 17;12(7):459-65. Epub 2013 May 17.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Departments of Oncology and Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864130008
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http://dx.doi.org/10.1016/j.dnarep.2013.04.006DOI Listing
July 2013

Defining the RGG/RG motif.

Mol Cell 2013 Jun;50(5):613-23

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.molcel.2013.05.021DOI Listing
June 2013

Calcium-dependent deceleration of the cell cycle in muscle cells by simulated microgravity.

FASEB J 2013 May 30;27(5):2045-54. Epub 2013 Jan 30.

Space Biology Group, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1096/fj.12-218693DOI Listing
May 2013

The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells.

Mol Cell Biol 2013 Mar 14;33(6):1233-43. Epub 2013 Jan 14.

Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/MCB.01604-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592017PMC
March 2013

Von Hippel-Lindau: how a rare disease illuminates cancer biology.

Semin Cancer Biol 2013 Feb 30;23(1):26-37. Epub 2012 May 30.

Laboratoire de Génétique Oncologique EPHE, INSERM U743, Faculté de Médecine Paris-Sud, 94276 Le Kremlin-Bicêtre et Institut de cancérologie Gustave Roussy, 94800 Villejuif, France.

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http://dx.doi.org/10.1016/j.semcancer.2012.05.005DOI Listing
February 2013

SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

Epigenetics 2013 Feb 16;8(2):177-83. Epub 2013 Jan 16.

Terry Fox Molecular Oncology Group, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Oncology, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.4161/epi.23416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592903PMC
February 2013

Accelerated autofocusing of off-axis holograms using critical sampling.

Opt Lett 2012 Dec;37(24):5094-6

Microvision and Microdiagnostics Group (SCI STI CHD), École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland.

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http://dx.doi.org/10.1364/OL.37.005094DOI Listing
December 2012

JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.

Cell Rep 2012 Nov 15;2(5):1233-43. Epub 2012 Nov 15.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.celrep.2012.09.033DOI Listing
November 2012

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.

Nucleic Acids Res 2012 Oct 16;40(19):9513-21. Epub 2012 Aug 16.

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Oncology, McGill University, Montréal, Québec, Canada, H3T 1E2.

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http://dx.doi.org/10.1093/nar/gks764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479207PMC
October 2012

Stay lean without dieting: Lose Sam68.

Adipocyte 2012 Oct;1(4):246-249

Laval University Cancer Research Center; Hôtel-Dieu de Québec; CHUQ; Quebec City, QC, Canada.

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http://dx.doi.org/10.4161/adip.20819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609103PMC
October 2012

Emerging roles for Sam68 in adipogenesis and neuronal development.

RNA Biol 2012 Sep 1;9(9):1129-33. Epub 2012 Sep 1.

Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC Canada.

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http://dx.doi.org/10.4161/rna.21409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579877PMC
September 2012

K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites.

Cell Res 2012 Aug 10;22(8):1221-3. Epub 2012 Apr 10.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Segal Cancer Centre, Lady Davis Institute for Medical Research, 3755 Côte Ste-Catherine Road, Montréal, Québec, H3T 1E2, Canada.

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http://www.nature.com/articles/cr201258
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http://dx.doi.org/10.1038/cr.2012.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411168PMC
August 2012

Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients.

Clin Cancer Res 2012 May 29;18(10):2838-49. Epub 2012 Mar 29.

Service d'Anatomie Pathologique, Service de Gastroentérologie-Pancréatologie, Service de Chirurgie Hépatique et Pancréatique, AP-HP, Hôpital Beaujon, Clichy, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2759DOI Listing
May 2012

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

EMBO J 2012 Apr 28;31(8):1865-78. Epub 2012 Feb 28.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B. Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/emboj.2012.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343333PMC
April 2012

The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis.

Mol Cell 2012 Apr 15;46(2):187-99. Epub 2012 Mar 15.

Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, McGill University, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.02.007DOI Listing
April 2012

The fight of the Tudor domain "Royal family" for a broken DNA throne.

Cell Cycle 2012 Apr 15;11(8):1483-4. Epub 2012 Apr 15.

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http://dx.doi.org/10.4161/cc.20124DOI Listing
April 2012

Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.

J Biol Chem 2011 Dec 31;286(52):44424-32. Epub 2011 Oct 31.

Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.1074/jbc.M111.277046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247987PMC
December 2011