Stephane Haik

Stephane Haik

UNVERIFIED PROFILE

Are you Stephane Haik?   Register this Author

Register author
Stephane Haik

Stephane Haik

Publications by authors named "Stephane Haik"

Are you Stephane Haik?   Register this Author

62Publications

1839Reads

34Profile Views

Age at onset in genetic prion disease and the design of preventive clinical trials.

Neurology 2019 Jul 6;93(2):e125-e134. Epub 2019 Jun 6.

From Broad Institute of MIT and Harvard (E.V.M., S.M.V.), Cambridge; Analytical and Translational Genetics Unit (E.V.M.), Massachusetts General Hospital; Program in Biological and Biomedical Sciences (E.V.M., S.M.V.), Harvard Medical School, Boston; Prion Alliance (E.V.M., S.M.V.), Cambridge; Harvard Business School (M.C.O.), Boston, MA; Institut du Cerveau et de la Moelle Épinière (J.-P.B., S.H.), ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université; Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob (J.-P.B., S.H., J.-L.P.), Assistance Publique-Hôpitaux de Paris, France; National Reference Center for TSE (I.Z., C.P., P.H., T.K.), Georg-August University, Göttingen, Germany; IRCCS-Istituto delle Scienze Neurologiche di Bologna (P.P., S.C.); Departments of Experimental, Diagnostic and Specialty Medicine (P.P.) and Biomedical and Neuromotor Sciences (S.C.), University of Bologna, Italy; National Prion Disease Pathology Surveillance Center (J.S.), Case Western Reserve University, Cleveland, OH; MRC Prion Unit at UCL (J.K., S.M.), Institute of Prion Diseases, University College London, UK; Memory and Aging Center (J.C.F., L.T.T., M.D.G.), University of California San Francisco; Australian National CJD Registry (C.S., S.J.C.), University of Melbourne, Parkville, Australia; Department of Neurological Science (T.K.), Tohoku University Graduate School of Medicine, Sendai; Department of Public Health (R.A., Y.N.), Jichi Medical University, Shimotsuke; Department of Neurology and Neurobiology of Aging (T.H., M.Y.), Kanazawa University Graduate School of Medical Sciences, Kanazawa; Department of Neurology and Neurological Science (N.S.), Tokyo Medical and Dental University; National Center of Neurology and Psychiatry (T.T., H.M.), Kodaira, Japan; Laboratory of Prion Neurobiology (R.C.), Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan; AULSS2 Ca' Foncello Hospital (I.R.), Treviso, Italy; Spanish National Reference Center for CJD (J.d.P.-C., M.C.), Instituto de Salud Carlos III and CIBERNED, Madrid, Spain; and NHS National Prion Clinic (S.M.), National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, London, WC1N 3BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656649PMC
July 2019

Factors influencing the incubation of an infectious form of Creutzfeldt-Jakob disease.

Clin Infect Dis 2019 Jul 28. Epub 2019 Jul 28.

Sorbonne Université, INSERM, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz692DOI Listing
July 2019

In vitro Modeling of Prion Strain Tropism.

Viruses 2019 03 9;11(3). Epub 2019 Mar 9.

Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11030236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466166PMC
March 2019

Susceptibility to Creutzfeldt-Jakob disease after human growth hormone treatment in France.

Neurology 2018 08 25;91(8):e724-e731. Epub 2018 Jul 25.

From INSERM U1127 (L.P., J.-P.B., A.W., S.H.), CNRS UMR 7225, Institut du Cerveau et de la Moelle Épinière, Sorbonne Universités; AP-HP (J.-P.B., A.W., S.H.), Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière; INSERM (D.C.), Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Sorbonne Universités; and AP-HP (S.H.), Laboratoire de Neuropathologie R Escourolle, Hôpital de la Pitié-Salpêtrière, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006028DOI Listing
August 2018

Quantifying prion disease penetrance using large population control cohorts.

Sci Transl Med 2016 Jan;8(322):322ra9

Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aad5169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774245PMC
January 2016

History of Prions and transmission of protein misfolding.

Bull Acad Natl Med 2015 Jun;199(6):787-796

View Article

Download full-text PDF

Source
June 2015

Molecular modeling of prion transmission to humans.

Viruses 2014 Oct 2;6(10):3766-77. Epub 2014 Oct 2.

Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ. Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v6103766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213560PMC
October 2014

Infectious prion diseases in humans: cannibalism, iatrogenicity and zoonoses.

Infect Genet Evol 2014 Aug 20;26:303-12. Epub 2014 Jun 20.

Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm, U 1127, CNRS UMR 7225, ICM, F-75013 Paris, France; AP-HP, Groupe hospitalier Pitié-Salpêtrière, Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, F-75013 Paris, France; Centre National de Référence des Agents Transmissibles Non Conventionnels, F-75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2014.06.010DOI Listing
August 2014

Prions in the urine of patients with variant Creutzfeldt-Jakob disease.

N Engl J Med 2014 Aug;371(6):530-9

From the Mitchell Center for Research in Alzheimer's Disease and Related Brain Disorders, University of Texas Medical School at Houston, Houston (F.M., L.C.-M., K.-W.P., C.S.); Foundation Carlo Besta Neurologic Institute, Milan (F.M., M.C., E.M., S.S., F.T.); National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland (P.G., S.N.); Universidad de los Andes, Facultad de Medicina, Santiago, Chile (L.C.-M.); Assistance Publique-Hôpitaux de Paris, Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière, INSERM Unité 1127, Université Pierre et Marie Curie-Paris 6, and Centre Nationale de la Recherche Scientifique, Unité Mixte de Recherche - all in Paris (S.H., J.-P.B.); and the National CJD Research and Surveillance Unit, Western General Hospital, University of Edinburgh, Edinburgh (J.I., R.K.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1404401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162740PMC
August 2014

Cycline efficacy on the propagation of human prions in primary cultured neurons is strain-specific.

J Infect Dis 2014 Apr 21;209(7):1144-8. Epub 2013 Nov 21.

Université Pierre et Marie Curie - Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), UMRS 975, Equipe "Alzheimer's and Prion Diseases"

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jit623DOI Listing
April 2014

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.

Nat Med 2013 Sep 18;19(9):1124-31. Epub 2013 Aug 18.

1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S 747, Paris, France. [2] Université Paris Descartes, Sorbonne Paris Cité, UMR-S 747, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3302DOI Listing
September 2013

Rapidly progressive Alzheimer's disease: a multicenter update.

J Alzheimers Dis 2012 ;30(4):751-6

National Reference Center for TSE Surveillance, Department of Neurology, Georg-August-University, Goettingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2012-120007DOI Listing
May 2013

Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type.

J Virol 2013 Mar 19;87(5):2535-48. Epub 2012 Dec 19.

Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière (CRICM), UMRS 975, Equipe Alzheimer's and Prion Diseases, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03082-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571390PMC
March 2013

Can mortality data provide reliable indicators for Creutzfeldt-Jakob disease surveillance? A study in France from 2000 to 2008.

Neuroepidemiology 2011 2;37(3-4):188-92. Epub 2011 Nov 2.

AP-HP, Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000332764DOI Listing
March 2012

Biochemical and strain properties of CJD prions: complexity versus simplicity.

J Neurochem 2011 Oct 20;119(2):251-61. Epub 2011 Sep 20.

Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), UMRS 975, Equipe "Alzheimer's and Prion Diseases", Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2011.07399.xDOI Listing
October 2011

Tau-positive grains are constant in centenarians' hippocampus.

Neurobiol Aging 2011 Jul 19;32(7):1296-303. Epub 2009 Aug 19.

Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Pitié-Salpétrière, 47-83 boulevard de l'Hôpital, Paris Cedex 13, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2009.07.009DOI Listing
July 2011

Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.

J Neurosci 2010 Apr;30(15):5394-403

Unit 894, Laboratory of Neuronal Cell Biology and Pathology, Institut National de la Santé et de la Recherche Médicale, Université Paris Descartes, Equipe d'accueil 4059, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5831-09.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.5831-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632766PMC
April 2010

Creutzfeldt-Jakob disease in a patient treated by etanercept for rheumatoid arthritis (RA): just a coincidence?

Joint Bone Spine 2010 Mar 25;77(2):174-5. Epub 2010 Jan 25.

Service de rhumatologie, hôpital G. Montpied, place Henri-Dunant, BP 69, 63003 Clermont-Ferrand, France.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S1297319X0900246
Publisher Site
http://dx.doi.org/10.1016/j.jbspin.2009.05.016DOI Listing
March 2010

Loss of cerebellar granule neurons is associated with punctate but not with large focal deposits of prion protein in Creutzfeldt-Jakob disease.

J Neuropathol Exp Neurol 2009 Aug;68(8):892-901

Assistance Publique-Hôpitaux de Paris, Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpêtrière, Institut Fédératif de Recherche des Neurosciences de la Pitié-Salpêtrière, Paris, France.

View Article

Download full-text PDF

Source
https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
Publisher Site
http://dx.doi.org/10.1097/NEN.0b013e3181af7f23DOI Listing
August 2009

Cerebral amyloid angiopathy with co-localization of prion protein and beta-amyloid in an 85-year-old patient with sporadic Creutzfeldt-Jakob disease.

Acta Neuropathol 2008 Nov 13;116(5):567-73. Epub 2008 Jun 13.

Service Central d'Anatomie et de Cytologie Pathologiques, APHP, Hôpital Lariboisière-Université Paris VII, 2 rue Ambroise Paré, 75475, Paris cedex 10, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-008-0394-yDOI Listing
November 2008

In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia.

Arch Neurol 2008 Apr;65(4):545-9

Institut National de la Santé et de la Recherche Médicale Equipe Avenir-Maladies Humaines à Prions, IFR70, Laboratoire de Neuropathologie, Hôpital de la Salpêtrière, 47 Blvd de l'Hopital, 75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneur.65.4.545DOI Listing
April 2008

V180I mutation of the prion protein gene associated with atypical PrPSc glycosylation.

Neurosci Lett 2006 Nov 9;408(3):165-9. Epub 2006 Oct 9.

UPRES EA 3621, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5 et Service de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, 2 rue A. Paré, 75475 Paris cedex 10, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2006.08.008DOI Listing
November 2006

Familial Creutzfeldt-Jakob disease with an R208H-129V haplotype and Kuru plaques.

Arch Neurol 2006 Mar;63(3):449-52

Institut national de la santé et de la recherche médicale U466 and Department of Pathology, Rangueil Hospital, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneur.63.3.449DOI Listing
March 2006

Truncated PrP(c) in mammalian brain: interspecies variation and location in membrane rafts.

Biol Chem 2006 Mar;387(3):297-300

INSERM Avenir Team-Human prion diseases, IFR70, Neuropathology, Salpêtrière Hospital, F-75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2006.039DOI Listing
March 2006

The N-terminal cleavage of cellular prion protein in the human brain.

FEBS Lett 2005 Nov 19;579(28):6333-7. Epub 2005 Oct 19.

INSERM Avenir Team - Human Prion Diseases, IFR70, Neuropathology, Salpêtrière Hospital, F-75013 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2005.10.013DOI Listing
November 2005

The sympathetic nervous system is involved in variant Creutzfeldt-Jakob disease.

Nat Med 2003 Sep 24;9(9):1121-3. Epub 2003 Aug 24.

Raymond Escourolle Neuropathology Laboratory, Association Claude Bernard and INSERM U360, Pitié-Salpêtrière Hospital, 75013, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm922DOI Listing
September 2003

Different isoforms of the non-integrin laminin receptor are present in mouse brain and bind PrP.

Biol Chem 2003 Feb;384(2):243-6

CEA, Département de Recherche Médicale, DSV, B.P. 6, F-92 265 Fontenay-aux-Roses Cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2003.027DOI Listing
February 2003