Publications by authors named "Stephane Flibotte"

66Publications

Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation.

Curr Biol 2021 Jan 5;31(1):128-137.e5. Epub 2020 Nov 5.

Department of Anesthesiology and Pain Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6540, USA; Mitochondria and Metabolism Center, University of Washington, 850 Republican Street, Seattle, WA 98105, USA; Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98105, USA. Electronic address:

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January 2021

Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.

Biochim Biophys Acta Mol Basis Dis 2020 10 8;1866(10):165832. Epub 2020 May 8.

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada. Electronic address:

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October 2020

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in .

Genetics 2020 Jul 15;215(3):609-621. Epub 2020 May 15.

Michael Smith Laboratories, University of British Columbia, Vancouver, V6T 1Z4, Canada

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July 2020

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis.

Sci Adv 2019 12 4;5(12):eaax0292. Epub 2019 Dec 4.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

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December 2019

Heparanase protects the heart against chemical or ischemia/reperfusion injury.

J Mol Cell Cardiol 2019 06 17;131:29-40. Epub 2019 Apr 17.

Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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June 2019

Mutational and transcriptional landscape of spontaneous gene duplications and deletions in .

Proc Natl Acad Sci U S A 2018 07 25;115(28):7386-7391. Epub 2018 Jun 25.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77845;

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July 2018

A Strategy To Isolate Modifiers of Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.

G3 (Bethesda) 2018 05 4;8(5):1425-1437. Epub 2018 May 4.

Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

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May 2018

Ribosomal Protein S12e Has a Distinct Function in Cell Competition.

Dev Cell 2018 01 8;44(1):42-55.e4. Epub 2018 Jan 8.

Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Electronic address:

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January 2018

Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.

FASEB J 2018 03 3;32(3):1196-1206. Epub 2018 Jan 3.

Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2018

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.

Cell Rep 2017 07;20(2):451-463

Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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July 2017

Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae.

Sci Rep 2017 06 23;7(1):4183. Epub 2017 Jun 23.

Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

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June 2017

Phenotypic diversity and genotypic flexibility of during long-term chronic infection of cystic fibrosis lungs.

Genome Res 2017 04 21;27(4):650-662. Epub 2017 Mar 21.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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April 2017

Genome-Wide Screen Reveals Mutants of Are Methotrexate-Resistant.

G3 (Bethesda) 2017 04 3;7(4):1251-1257. Epub 2017 Apr 3.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

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April 2017

Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

PLoS Genet 2016 08 10;12(8):e1006235. Epub 2016 Aug 10.

Department of Molecular Biology and Biochemistry and Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.

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August 2016

The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans.

Dev Biol 2016 07 17;415(1):46-63. Epub 2016 May 17.

Princess Margaret Cancer Centre/University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7. Electronic address:

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July 2016

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo.

G3 (Bethesda) 2016 06 1;6(6):1751-6. Epub 2016 Jun 1.

Institute of Gerontology and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109

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June 2016

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans.

G3 (Bethesda) 2015 Dec 1;6(2):351-6. Epub 2015 Dec 1.

Institute of Gerontology, University of Michigan Medical School, Ann Arbor, Michigan 48109 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109

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December 2015

Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation.

BMC Genomics 2015 Mar 18;16:210. Epub 2015 Mar 18.

Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada.

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March 2015

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon.

Nat Methods 2014 May 16;11(5):529-34. Epub 2014 Mar 16.

1] Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA. [2] Department of Biology, University of Utah, Salt Lake City, Utah, USA.

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May 2014

A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.

PLoS One 2013 16;8(9):e74908. Epub 2013 Sep 16.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland ; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.

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May 2014

Genetic control of vulval development in Caenorhabditis briggsae.

G3 (Bethesda) 2012 Dec 1;2(12):1625-41. Epub 2012 Dec 1.

Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

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December 2012

DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions.

Science 2011 Apr;332(6028):468-71

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

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April 2011

Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization.

BMC Genomics 2011 Mar 7;12:139. Epub 2011 Mar 7.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA.

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March 2011

C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization.

Dev Biol 2011 Apr 21;352(1):92-103. Epub 2011 Jan 21.

Department of Biology, Queens College, and The Graduate School and University Center, City University of New York, Flushing, NY 11367, USA.

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April 2011

Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans.

BMC Genomics 2010 Jan 25;11:62. Epub 2010 Jan 25.

Department of Zoology, University of British Columbia, British Columbia, Canada.

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January 2010

New tools for investigating the comparative biology of Caenorhabditis briggsae and C. elegans.

Genetics 2010 Mar 14;184(3):853-63. Epub 2009 Dec 14.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA.

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March 2010

Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development.

Genetics 2009 Apr 2;181(4):1679-86. Epub 2009 Feb 2.

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.

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April 2009

De Novo identification of single nucleotide mutations in Caenorhabditis elegans using array comparative genomic hybridization.

Genetics 2009 Apr 2;181(4):1673-7. Epub 2009 Feb 2.

Department of Zoology, University of British Columbia V6T 1Z4, Vancouver, British Columbia, Canada.

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April 2009

Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans.

Genetics 2009 Jan 28;181(1):33-7. Epub 2008 Oct 28.

Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

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January 2009

Experimental analysis of oligonucleotide microarray design criteria to detect deletions by comparative genomic hybridization.

BMC Genomics 2008 Oct 21;9:497. Epub 2008 Oct 21.

Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.

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October 2008

Transcription of foreign DNA in Escherichia coli.

Genome Res 2008 Nov 13;18(11):1798-805. Epub 2008 Aug 13.

BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 4S6, Canada.

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November 2008

Rebuilding microbial genomes.

Bioessays 2007 Jun;29(6):580-90

Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.

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June 2007

DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling.

Hum Mol Genet 2006 Mar 24;15(5):743-9. Epub 2006 Jan 24.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Suite 100, 570 West 7th Avenue, Vancouver, BC, Canada V5Z 4S6.

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March 2006

Automated ordering of fingerprinted clones.

Bioinformatics 2004 May 10;20(8):1264-71. Epub 2004 Feb 10.

Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC Canada, V5Z 4E6.

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May 2004