Publications by authors named "Stephane Blanche"

100Publications

Nocardiosis Associated with Primary Immunodeficiencies (Nocar-DIP): an International Retrospective Study and Literature Review.

J Clin Immunol 2020 Nov 12;40(8):1144-1155. Epub 2020 Sep 12.

Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker -Pasteur, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker-Enfants Malades University Hospital, Université de Paris, Paris, France.

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http://dx.doi.org/10.1007/s10875-020-00866-8DOI Listing
November 2020

Improving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation sequencing.

J Allergy Clin Immunol 2020 Jun 10. Epub 2020 Jun 10.

University of Paris, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1163, Imagine Institute, Paris, France; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children-Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, INSERM-UMR 1163, Paris, France; Pediatric Immuno-Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France; French National Reference Center for Primary Immune Deficiencies, Le Centre de Référence Déficits Immunitaires Héréditaires, Necker Hospital for Sick Children, AP-HP, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2020.05.046DOI Listing
June 2020

Management of childhood aplastic anemia following liver transplantation for nonviral hepatitis: A French survey.

Pediatr Blood Cancer 2020 04 11;67(4):e28177. Epub 2020 Jan 11.

Department of Pediatric Hematology and Immunology, AP-HP, Robert-Debré Hospital, Paris, France.

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http://dx.doi.org/10.1002/pbc.28177DOI Listing
April 2020

Mini review: Prevention of mother-child transmission of HIV: 25 years of continuous progress toward the eradication of pediatric AIDS?

Virulence 2020 12;11(1):14-22

Pediatric Immunology-Hematology Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP) and Faculté de Médecine Paris Descartes, Paris, France.

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http://dx.doi.org/10.1080/21505594.2019.1697136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961731PMC
December 2020

Bone Marrow Transplantation in Congenital Erythropoietic Porphyria: Sustained Efficacy but Unexpected Liver Dysfunction.

Biol Blood Marrow Transplant 2020 Apr 14;26(4):704-711. Epub 2019 Dec 14.

Pediatric Immuno-Hematology and Rheumatology Unit, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France.

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http://dx.doi.org/10.1016/j.bbmt.2019.12.005DOI Listing
April 2020

A 1-Year Prospective French Nationwide Study of Emergency Hospital Admissions in Children and Adults with Primary Immunodeficiency.

Authors:
Hélène Coignard-Biehler Nizar Mahlaoui Benoit Pilmis Vincent Barlogis Pauline Brosselin Nathalie De Vergnes Marianne Debré Marion Malphettes Pierre Frange Emilie Catherinot Isabelle Pellier Isabelle Durieu Antoinette Perlat Bruno Royer Alain Le Quellec Eric Jeziorski Alain Fischer Olivier Lortholary Laurent Aaron Daniel Adoue Claire Aguilar Nathalie Aladjidi Alexandre Alcais Zahir Amoura Philippe Arlet Corinne Armari-Alla Brigitte Bader-Meunier Sophie Bayart Yves Bertrand Boris Bienvenu Stéphane Blanche Damien Bodet Bernard Bonnotte Raphaël Borie Patrick Boutard Claire Briandet Jean-Paul Brion Jacques Brouard Sarah Cohen-Beaussant Laurence Costes Louis-Jean Couderc Pierre Cougoul Virginie Courteille Geneviève de Saint Basile Catherine Devoldere Anne Deville Jean Donadieu Eric Dore Fabienne Dulieu Christine Edan Natacha Entz-Werle Claire Fieschi Amandine Forestier Fanny Fouyssac Vincent Gajdos Lionel Galicier Virginie Gandemer Martine Gardembas Catherine Gaud Gaelle Guillerm Eric Hachulla Mohamed Hamidou Olivier Hermine Cyrille Hoarau Sébastien Humbert Arnaud Jaccard Serge Jacquot Jean-Philippe Jais Roland Jaussaud Pierre-Yves Jeandel Kamila Kebaili Anne-Sophie Korganow Olivier Lambotte Fanny Lanternier Claire Larroche Anne-Sophie Lascaux Emmanuelle Le Moigne Vincent Le Moing Yvon Lebranchu Marc Lecuit Guillaume Lefevre Richard Lemal Valérie Li Thiao Te Aude Marie-Cardine Nicolas Martin Silva Agathe Masseau Christian Massot Françoise Mazingue Etienne Merlin Gérard Michel Frédéric Millot Béatrice Monlibert Fabrice Monpoux Despina Moshous Luc Mouthon Martine Munzer Bénédicte Neven Raphaëlle Nove-Josserand Eric Oksenhendler Marie Ouachée-Chardin Caroline Oudot Anne Pagnier Jean-Louis Pasquali Marlène Pasquet Yves Perel Capucine Picard Christophe Piguet Dominique Plantaz Johan Provot Pierre Quartier Frédéric Rieux-Laucat Pascal Roblot Pierre-Marie Roger Pierre-Simon Rohrlich Hervé Rubie Valéry Salle Françoise Sarrot-Reynauld Amélie Servettaz Jean-Louis Stephan Nicolas Schleinitz Felipe Suarez Laure Swiader Sophie Taque Caroline Thomas Olivier Tournilhac Caroline Thumerelle François Tron Jean-Pierre Vannier Jean-François Viallard

J Clin Immunol 2019 10 10;39(7):702-712. Epub 2019 Aug 10.

Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker Pasteur, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université de Paris, Paris, France.

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http://dx.doi.org/10.1007/s10875-019-00658-9DOI Listing
October 2019

Growth in HIV-1-exposed but uninfected infants treated with lopinavir-ritonavir versus lamivudine: a secondary analysis of the ANRS 12174 trial.

Lancet HIV 2019 05 24;6(5):e307-e314. Epub 2019 Feb 24.

Pathogenesis and Control of Chronic Infections, INSERM U1058, Université de Montpellier, Etablissement Français du Sang, Montpellier, France; Centre Hospitalo-Universitaire de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1016/S2352-3018(18)30361-8DOI Listing
May 2019

Liver Enzyme Elevation in Pregnant Women Receiving Antiretroviral Therapy in the ANRS-French Perinatal Cohort.

J Acquir Immune Defic Syndr 2019 05;81(1):83-94

Department of Epidemiology, Centre de Recherche en Épidémiologie et Santé des Populations, Institut National de la Santé et de la Recherche Médicale (INSERM) U1018, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1097/QAI.0000000000001963DOI Listing
May 2019

Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study.

J Allergy Clin Immunol 2019 06 17;143(6):2238-2253. Epub 2019 Jan 17.

Department of Pediatric Immunology and HSCT, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193003
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http://dx.doi.org/10.1016/j.jaci.2018.12.1010DOI Listing
June 2019

Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency.

J Allergy Clin Immunol 2019 02 10;143(2):775-778.e6. Epub 2018 Oct 10.

French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker-Enfants Malades University Hospital, APHP, Paris, France; Paediatric Haematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, APHP, Paris, France; INSERM UMR 1163, Imagine Institute, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Imagine Institute, Paris, France; Collège de France, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183142
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http://dx.doi.org/10.1016/j.jaci.2018.09.021DOI Listing
February 2019

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency.

Ann Rheum Dis 2019 03 3;78(3):431-433. Epub 2018 Oct 3.

Department of Paediatric Haematology-Immunology and Rheumatology, Hôpital Necker-Enfants Malades, AP-HP, Paris, France

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21403
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http://dx.doi.org/10.1136/annrheumdis-2018-214037DOI Listing
March 2019

Model of population pharmacokinetics of cidofovir in immunocompromised children with cytomegalovirus and adenovirus infection.

J Antimicrob Chemother 2018 09;73(9):2422-2429

Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, AP-HP, Hôpital universitaire Necker - Enfants malades, Paris, France.

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http://dx.doi.org/10.1093/jac/dky192DOI Listing
September 2018

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.

N Engl J Med 2018 04;378(16):1479-1493

From the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.A.T., M.K.); University of California, San Francisco, Benioff Children's Hospital, Oakland (M.C.W., E.V.), Lucile Salter Packard Children's Hospital at Stanford, Palo Alto (S.S.), and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (G.J.S.) - all in California; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia (J.K., D.T.T.); Centenary Institute (J.E.J.R.), University of Sydney, Sydney Medical School (J.E.J.R., P.J.H.), and Royal Prince Alfred Hospital (J.E.J.R., P.J.H.), Camperdown, NSW, Australia; Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (J.-A.R., E.M., D.M., F.L., P.B., A.M., L.C., J.-S.D., F.S., F.M., V.B., C.B., O.H., M.D.M., S.B., M.C.), Groupe Hospitalier Universitaire Ouest (J.-A.R., A.M., L.C., M.C.), IMAGINE Institute (E.M., M.S., D.M., M.C.), Université Paris Descartes (M.S., C. Poirot, S.H.-B.-A.), Université Paris Diderot (H.P., T.L.), Pierre et Marie Curie University (C. Poirot), and Hôpital Cochin (J.-F.M.), Paris, CEA University Paris-Sud, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Hôpital Louis-Mourier, Colombes (H.P., T.L.), Centre Hospitalier Intercommunal de Créteil, Créteil (C. Pondarré), and Hôpital Bicêtre, Le Kremlin-Bicêtre (S.H.-B.-A.) - all in France; Bluebird Bio, Cambridge (J.-A.R., S.S., G.V., O.N., R.W.R., D.D., A.P., L.S., M.A.), and Harvard Medical School, Brigham and Women's Hospital, Boston (P.L.) - both in Massachusetts; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (S.H., U.A., P.L.); and the National Center for Tumor Diseases-German Cancer Research Center, Heidelberg, Germany (C.K.).

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http://dx.doi.org/10.1056/NEJMoa1705342DOI Listing
April 2018

Poor palatability of the new ritonavir formulation is a major obstacle to adherence to treatment in young children.

J Antimicrob Chemother 2018 05;73(5):1435-1437

Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1093/jac/dky029DOI Listing
May 2018

Pediatric-onset Evans syndrome: Heterogeneous presentation and high frequency of monogenic disorders including LRBA and CTLA4 mutations.

Clin Immunol 2018 03 10;188:52-57. Epub 2018 Jan 10.

INSERM UMR 1163, Laboratory of Immunogenetics of pediatric autoimmune diseases, Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France; Pediatric immuno-hematology and rhumatology unit, RAISE reference centre for pediatric inflammatory rheumatic diseases and systemic autoimmune diseases, Necker-Enfants Malades University Hospital, Assistance publique - Hôpitaux de Paris, France.

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http://dx.doi.org/10.1016/j.clim.2017.12.009DOI Listing
March 2018

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience.

Environ Mol Mutagen 2019 06 5;60(5):404-409. Epub 2017 Dec 5.

Immunology Hematology Rheumatology Unit, Pediatric Department, Hôpital Necker-Enfants Malades AP-HP, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1002/em.22162DOI Listing
June 2019

Burden of Poor Health Conditions and Quality of Life in 656 Children with Primary Immunodeficiency.

J Pediatr 2018 03 6;194:211-217.e5. Epub 2017 Dec 6.

French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Pediatric Immuno-Haematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM UMR1163, Imagine Institute, Sorbonne Paris Cité, University Paris Descartes, Paris, France; Division of Médecine Expérimentale, Collège de France, Paris, France.

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http://dx.doi.org/10.1016/j.jpeds.2017.10.029DOI Listing
March 2018

Pathogenesis of infections in HIV-infected individuals: insights from primary immunodeficiencies.

Curr Opin Immunol 2017 Oct 6;48:122-133. Epub 2017 Oct 6.

Pediatric Hematology and Immunology Unit, Hôpital Necker Enfants Malades, AP-HP, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Hôpital Necker Enfants Malades, Paris, France; Paris Descartes University, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA.

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http://dx.doi.org/10.1016/j.coi.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682227PMC
October 2017

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia.

J Clin Immunol 2017 Oct 31;37(7):727-731. Epub 2017 Aug 31.

Université Paris Descartes - Sorbonne Paris Cité, Service de Maladies infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Assistance Publique - Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1007/s10875-017-0437-zDOI Listing
October 2017

[Gene therapy for sickle cell disease].

Med Sci (Paris) 2017 May 14;33(5):463-465. Epub 2017 Jun 14.

Département de biothérapie, hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France - Centre d'investigation clinique de biothérapie, Groupe hospitalier universitaire Ouest, Assistance Publique-Hôpitaux de Paris, Inserm, Paris, France - Département d'imunologie pédiatrique-hématologie, Assistance Publique-Hôpitaux de Paris, Paris, France - Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France.

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http://dx.doi.org/10.1051/medsci/20173305002DOI Listing
May 2017

Gene Therapy in a Patient with Sickle Cell Disease.

N Engl J Med 2017 03;376(9):848-855

From the Departments of Biotherapy (J.-A.R., A.M., E.M., L.C., M.C.), Clinical Pharmacy (P. Bourget), Pediatric Neuroradiology (D.G.), General Pediatrics (M.M.), and Pediatric Immunology-Hematology Unit (B.N., S.B.), Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (J.-A.R., A.M., E.M., L.C., L.W., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8258, INSERM Unité 1022, Faculté de Pharmacie de Paris, Université Paris Descartes, Chimie ParisTech (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, Hôpital Kremlin-Bicêtre, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), the Institute of Emerging Diseases and Innovative Therapies, Imagine Institute, Université Paris Descartes, Sorbonne Paris Cité University (M.S., B.N., L.W., M.C.), Mère-Enfant Clinical Investigation Center, Groupe Hospitalier Necker Cochin (M.S.), Université Paris Diderot, Sorbonne Paris Cité University, INSERM Institut National de Transfusion Sanguine, Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex (W.E.N.), and Laboratoires de Virologie, Hôpital Cochin (J.-F.M.), Paris, Atomic and Alternative Energy Commission, Université Paris-Sud, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Institut Mondor de Recherche Biomédicale, Equipe 2, Centre de Référence des Syndromes Drépanocytaires Majeurs, Centre Hospitalier Universitaire Henri Mondor, AP-HP, Laboratoire d'Excellence GR-Ex, Créteil (P. Bartolucci), and Université Paris Diderot, Sorbonne Paris Cité University, INSERM Unité 1149, Hôpital Louis-Mourier, AP-HP, Laboratoire d'Excellence GR-Ex, Colombes (H.P., T.L.) - all in France; Bluebird Bio, Cambridge (R.W.R., O.N., G.V., L.S., S.S.), and Brigham and Women's Hospital and Harvard Medical School, Boston (P.L.) - both in Massachusetts; and Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (P.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1609677
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http://dx.doi.org/10.1056/NEJMoa1609677DOI Listing
March 2017

Efficacy and tolerance of dolutegravir-based combined ART in perinatally HIV-1-infected adolescents: a French multicentre retrospective study.

J Antimicrob Chemother 2017 03;72(3):837-843

Unité d'Immunologie, Hématologie et Rhumatologie Pediatriques, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker - Enfants Malades, Paris, France.

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http://dx.doi.org/10.1093/jac/dkw464DOI Listing
March 2017

Resilience and Life Expectations of Perinatally HIV-1 Infected Adolescents in France.

Open AIDS J 2016 9;10:209-224. Epub 2016 Nov 9.

AP-HP, Hôpital Necker-Enfants Malades, Unité d'Immunologie-hématologie et rhumatologie pédiatriques, 149 rue de Sèvres, 75743 Paris cedex 15, France; Université Paris Descartes, Sorbonne Paris Cité, Institut IMAGINE, 24 Boulevard du Montparnasse, 75015 Paris, France.

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http://dx.doi.org/10.2174/1874613601610010209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120384PMC
November 2016

In-utero exposure to nelfinavir-ethyl methyl sulfone.

AIDS 2016 11;30(17):2729-2730

aEpidemiology and Population Health Center, Institut National de la Santé et de la Recherche Médicale, INSERM U1018, Le Kremlin-Bicêtre bEpidemiology and Biostatistics, INSERM UMR1153, Sorbonne Paris Cité Research Center, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Université Paris Descartes cFrench National Registry of Childhood Cancers, Villejuif dGynecology and Obstetrics Department, Hôpital Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, Colombes eImmunology Hematology Rhumatology Unit, Pediatric Department, Hôpital Necker-Enfants Malades AP-HP; Université Paris Descartes, Paris fHôpital Bicêtre, AP-HP; Université Paris Sud, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1097/QAD.0000000000001254DOI Listing
November 2016

A Physiologically-Based Pharmacokinetic Model to Predict Human Fetal Exposure for a Drug Metabolized by Several CYP450 Pathways.

Clin Pharmacokinet 2017 05;56(5):537-550

EA 7323: Evaluation des thérapeutiques et pharmacologie périnatale et pédiatrique, Unité de recherche clinique Paris centre, 75006, Paris, France.

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http://dx.doi.org/10.1007/s40262-016-0457-5DOI Listing
May 2017

Childhood-onset autoimmune cytopenia as the presenting feature of biallelic ACP5 mutations.

Pediatr Blood Cancer 2017 02 8;64(2):306-310. Epub 2016 Oct 8.

Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, APHP, Paris, France.

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http://dx.doi.org/10.1002/pbc.26195DOI Listing
February 2017

Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease.

J Allergy Clin Immunol 2017 May 1;139(5):1641-1649.e6. Epub 2016 Oct 1.

Biotherapy Department, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France; University Paris Descartes Sorbonne Paris Cité, Institut Imagine, Paris, France; Inserm UMR 1163, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.08.033DOI Listing
May 2017

Physical health conditions and quality of life in adults with primary immunodeficiency diagnosed during childhood: A French Reference Center for PIDs (CEREDIH) study.

J Allergy Clin Immunol 2017 Apr 30;139(4):1275-1281.e7. Epub 2016 Sep 30.

French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Pediatric Immuno-Haematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM UMR1163, Imagine Institute, Necker Medical School, Sorbonne Paris Cité, University Paris Descartes, Paris, France; Collège de France, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2016.08.027DOI Listing
April 2017

Special considerations concerning the use of antiretroviral drugs in children.

Expert Rev Anti Infect Ther 2016 12 22;14(12):1155-1163. Epub 2016 Sep 22.

b Immuno-Hematology Unit, Department of Pediatrics , Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris (AP-HP) , Paris , France.

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http://dx.doi.org/10.1080/14787210.2016.1236686DOI Listing
December 2016

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

J Allergy Clin Immunol 2016 12 20;138(6):1752-1755. Epub 2016 Aug 20.

Pediatric Hematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, Paris, France; Paris Descartes University, Sorbonne-Paris-Cité, Institut Imagine, Paris, France; INSERM UMR 1163, Laboratory of Immunogenetics of Pediatric Autoimmunity, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.07.015DOI Listing
December 2016

Specific T cells for the treatment of cytomegalovirus and/or adenovirus in the context of hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2016 09 30;138(3):920-924.e3. Epub 2016 Apr 30.

Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immunology and Pediatric Hematology Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Human Lymphohematopoiesis-INSERM UMR1163, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.032DOI Listing
September 2016

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.

Blood 2016 06 25;127(25):3154-64. Epub 2016 Apr 25.

Paris Descartes University, Sorbonne Paris Cité, Institut Imagine, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Necker Medical School, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Department of Infectious and Tropical Diseases, Necker-Enfants Malades Hospital, AP-HP, Paris, France.

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http://dx.doi.org/10.1182/blood-2015-11-679902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920021PMC
June 2016

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases.

J Allergy Clin Immunol 2016 07 28;138(1):241-248.e3. Epub 2016 Feb 28.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France; Paris Descartes University, Imagine Institute, Paris, France; Center for the Study of Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.041DOI Listing
July 2016

Risk of cancer in children exposed to didanosine in utero.

AIDS 2016 05;30(8):1245-56

aEpidemiology and Population HealthCenter, Institut National de la Santé et de la Recherche Médicale (INSERM), Le Kremlin-Bicêtre bEpidemiology and Biostatistics, INSERM UMR1153, Sorbonne Paris Cité Research Center, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Université Paris Descartes cFrench National Registry of Childhood Cancers, Villejuif dEast Center of Pathology and Neuropathology, Hospices Civils de Lyon, Bron eRadiology Unit, Pediatric Department, Hôpital Necker-Enfants Malades, AP-HP, Institut IMAGINE and Faculté Paris Descartes fPediatric Oncology Unit Centre Hospitalier Universitaire, Saint-Etienne gInfectious Diseases Department, Centre Hospitalier Universitaire, Nantes hPediatric Oncology Unit, Hôpital Universitaire Hautepierre, Strasbourg iInfectious Diseases Department, Hôpital Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris (AP-HP) jPediatric Department, Hôpital Trousseau, AP-HP kPediatric Department, Hôpital Robert Debré, AP-HP and Université Paris Diderot, Sorbonne Paris-Cité, Paris lGynecology and Obstetrics Department, Hôpital Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, Colombes mHôpital Bicêtre, AP-HP and Université Paris Sud, Le Kremlin-Bicêtre nImmunology Hematology Rhumatology Unit, Pediatric Department, Hôpital Necker-Enfants Malades AP-HP and Université Paris Descartes, Paris, France. *Members are listed in the Acknowledgements.

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http://dx.doi.org/10.1097/QAD.0000000000001051DOI Listing
May 2016

Mother to child HIV transmission.

Authors:
Stephane Blanche

Bull Acad Natl Med 2016 Jan;200(1):91-97

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January 2016

Prediction of human fetal pharmacokinetics using ex vivo human placenta perfusion studies and physiologically based models.

Br J Clin Pharmacol 2016 Apr 12;81(4):646-57. Epub 2016 Jan 12.

EA08: Evaluation des thérapeutiques et pharmacologie périnatale et pédiatrique, Unité de Recherche Clinique Paris Centre, 75006, Paris, France.

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http://dx.doi.org/10.1111/bcp.12815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799920PMC
April 2016

No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception.

Clin Infect Dis 2015 Dec 21;61(11):1715-25. Epub 2015 Jul 21.

EA Pharmacologie, INSERM, Université Paris Descartes, Sorbonne Paris-Cité Pediatric Immunology Department, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris.

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http://dx.doi.org/10.1093/cid/civ578DOI Listing
December 2015

Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children.

J Allergy Clin Immunol 2016 Jan 17;137(1):306-309.e4. Epub 2015 Jul 17.

Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2015.06.003DOI Listing
January 2016

Population approach to analyze the pharmacokinetics of free and total lopinavir in HIV-infected pregnant women and consequences for dose adjustment.

Antimicrob Agents Chemother 2015 Sep 6;59(9):5727-35. Epub 2015 Jul 6.

EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France.

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http://dx.doi.org/10.1128/AAC.00863-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538471PMC
September 2015

Physiologically-based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women.

Br J Clin Pharmacol 2015 Nov 22;80(5):1031-41. Epub 2015 Jul 22.

EA08: Evaluation des thérapeutiques et pharmacologie périnatale et pédiatrique, unité de recherche clinique Paris centre, 75006, Paris.

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http://dx.doi.org/10.1111/bcp.12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631176PMC
November 2015

Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1.

Blood 2015 Jun 13;125(23):3563-9. Epub 2015 Apr 13.

Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France;

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http://dx.doi.org/10.1182/blood-2014-12-616003DOI Listing
June 2015

Systematic neonatal screening for severe combined immunodeficiency and severe T-cell lymphopenia: Analysis of cost-effectiveness based on French real field data.

J Allergy Clin Immunol 2015 Jun 1;135(6):1589-93. Epub 2015 Apr 1.

URC Eco (Clinical Research Unit in Health Economics), Assistance Publique-Hôpitaux de Paris, Hôtel Dieu Hospital, Paris, France; Public Health Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, INSERM UMR 1123, Créteil, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.02.004DOI Listing
June 2015

In utero exposure to zidovudine and heart anomalies in the ANRS French perinatal cohort and the nested PRIMEVA randomized trial.

Clin Infect Dis 2015 Jul 1;61(2):270-80. Epub 2015 Apr 1.

Department of Pediatrics, Hôpital Necker EA 7223: Évaluation Thérapeutique et Pharmacologie Périnatale et Pédiatrique, Université Paris Descartes, France.

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http://dx.doi.org/10.1093/cid/civ260DOI Listing
July 2015

Rotavirus vaccine virus shedding, viremia and clearance in infants with severe combined immune deficiency.

Pediatr Infect Dis J 2015 Mar;34(3):326-8

From the *National Reference Centre for Enteric Viruses, University Hospital of Dijon, Dijon, France; †Paediatric Immunology, Haematology and Rheumatology Unit, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, and Faculté Paris Descartes, Paris, France; ‡Laboratory of Virology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1097/INF.0000000000000560DOI Listing
March 2015

Hepatitis E virus in hematopoietic stem cell donors: Towards a systematic HEV screening of donors?

J Infect 2015 Jul 26;71(1):141-4. Epub 2015 Feb 26.

Unité d'Immunologie, Hématologie et Rhumatologie pédiatriques, AP-HP, Hôpital Necker - Enfants malades, Paris, France; Institut Imagine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; EA08, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jinf.2015.02.008DOI Listing
July 2015

Tolerance of the newborn to antiretroviral drug exposure in utero.

Expert Opin Drug Saf 2015 May 1;14(5):643-54. Epub 2015 Mar 1.

Hôpital Louis Mourier, Service de Gynécologie et d'Obstétrique, Assistance Publique -Hôpitaux de Paris (APHP) , Colombes , France.

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http://dx.doi.org/10.1517/14740338.2015.1019462DOI Listing
May 2015

Fetal consequences of maternal antiretroviral nucleoside reverse transcriptase inhibitor use in human and nonhuman primate pregnancy.

Curr Opin Pediatr 2015 Apr;27(2):233-9

aCarcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, CCR, National Cancer Institute, NIH, Bethesda, Maryland, USA bGrupo Imunovirologia, School of Medicine Universidad de Antioquia, Medellin, Colombia cInstitut National de la Sante et de la Recherche Medicale, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France dUnite d'Immunologie-Hematologie Pediatrique, Hopital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1097/MOP.0000000000000193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433159PMC
April 2015

Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir.

AIDS 2015 Jul;29(11):1319-24

aInstitut National de la Santé et de la Recherche Médicale (INSERM), U1163, Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine bLaboratoire d'Hématologie Biologique, Assistance Publique-Hopitaux de Paris (AP-HP) cLaboratoire Génome et Cancer, INSERM, U944 and UMR7212, Hôpital Saint Louis dService de Gynécologie Obstétrique, Hôpital Louis Mourier, Hôpitaux Universitaire Paris Nord Val de Seine (HUPNVS), AP-HP, Colombes eINSERM U1018, Centre de recherche en Epidémiologie et Santé des Populations fUniversité Paris-Sud, Le Kremlin Bicêtre gService de Gynécologie Obstétrique, Hôpital Antoine Béclère, AP-HP, Clamart hService de Gynécologie Obstétrique, Hôpital Bichat, HUPNVS, AP-HP iUniversité Paris-Diderot jInstitut Universitaire d'Hématologie, Paris kDépartement de Biothérapie lUnité d'Immunologie Hématologie Rhumatologie Pédiatrique, Hôpital Necker Enfants Malades, AP-HP mEA 7323, Pharmacologie et évaluation des médicaments chez l'enfant et la femme enceinte, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. *Stéphane Blanche and Isabelle André-Schmutz contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/QAD.0000000000000564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502990PMC
July 2015

Efficacy and safety of darunavir/ritonavir at 48 weeks in treatment-naïve, HIV-1-infected adolescents: results from a phase 2 open-label trial (DIONE).

Pediatr Infect Dis J 2014 Sep;33(9):940-5

From the *Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; †Clinic for Treatment of HIV-infected Children, Kiev Children's Hospital, Kiev, Ukraine; ‡Department of Pediatric Immuno-Hematology, Hôpital Necker-Enfants Malades, Paris, France; §Department of Paediatrics, University of Padova, Padova, Italy; ¶Department of Pediatrics, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain; ‖Department of Pediatrics, Birmingham Heartlands Hospital, Birmingham, United Kingdom; **Janssen Research & Development LLC, Titusville, NJ; and ††Janssen Research & Development, Beerse, Belgium.

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http://dx.doi.org/10.1097/INF.0000000000000308DOI Listing
September 2014

Stem cell transplantation for primary immunodeficiencies: the European experience.

Curr Opin Allergy Clin Immunol 2014 Dec;14(6):516-20

aBiotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris bBiotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, Assistance Publique-Hôpitaux de Paris, INSERM cParis Descartes - Sorbonne Paris Cité University, Imagine Institute dINSERM UMR 1163, Laboratory of Human Lymphohematopoiesis eImmunology and Pediatric Hematology Department, Assistance Publique-Hôpitaux de Paris fCollège de France, Paris, France.

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http://dx.doi.org/10.1097/ACI.0000000000000119DOI Listing
December 2014