Stephan W Morris

Stephan W Morris

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Stephan W Morris

Stephan W Morris

Publications by authors named "Stephan W Morris"

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MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.

Biochim Biophys Acta Mol Cell Res 2017 Apr 27;1864(4):719-727. Epub 2017 Jan 27.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2017.01.016DOI Listing
April 2017

Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.

J Physiol Biochem 2015 Dec 12;71(4):807-21. Epub 2015 Nov 12.

Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s13105-015-0445-5DOI Listing
December 2015

Bcl10 is an essential regulator for A20 gene expression.

J Physiol Biochem 2013 Dec 16;69(4):821-34. Epub 2013 May 16.

Department of Chemistry, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA,

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http://dx.doi.org/10.1007/s13105-013-0259-2DOI Listing
December 2013

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.

Am J Respir Cell Mol Biol 2012 Sep 29;47(3):340-8. Epub 2012 Mar 29.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Tinsley Harrison Tower 437B, 1900 University Blvd., Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0050OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488695PMC
September 2012

Inhibition of caspase-8 activity caused by overexpression of BCL10 contributes to the pathogenesis of high-grade MALT lymphoma.

Pediatr Blood Cancer 2012 Jun 23;58(6):865-71. Epub 2011 Sep 23.

Department of Immunology, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1002/pbc.23331DOI Listing
June 2012

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

Pharmacol Biochem Behav 2012 Jan 4;100(3):566-74. Epub 2011 Nov 4.

Department of Medicine, Division of Cardiovascular Medicine, Oregon Health & Science University/UHN 62, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.pbb.2011.10.024DOI Listing
January 2012

Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.

Bioorg Med Chem Lett 2011 Aug 12;21(15):4592-6. Epub 2011 Jun 12.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X110074
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http://dx.doi.org/10.1016/j.bmcl.2011.05.103DOI Listing
August 2011

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.

Medchemcomm 2011 Jan;2(9):904-908

Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, U.S.A. ; Tel: 901 595 3928.

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http://dx.doi.org/10.1039/C1MD00040CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171832PMC
January 2011

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

J Med Chem 2009 Nov;52(22):6979-90

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, MS 1000, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm901215mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801547PMC
November 2009

c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

Blood 2009 Sep 16;114(10):2097-106. Epub 2009 Apr 16.

Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA.

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http://dx.doi.org/10.1182/blood-2009-01-197947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744571PMC
September 2009

Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.

J Biol Chem 2009 Aug 20;284(34):23125-36. Epub 2009 Jun 20.

Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA.

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http://dx.doi.org/10.1074/jbc.M109.019059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755718PMC
August 2009

Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

J Med Chem 2009 Aug;52(16):4981-5004

Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Oncologic Sciences, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1021/jm9002395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888655PMC
August 2009

Design and synthesis of a novel tyrosine kinase inhibitor template.

Bioorg Med Chem 2009 May 27;17(9):3308-16. Epub 2009 Mar 27.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN 38105-3678, United States.

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http://dx.doi.org/10.1016/j.bmc.2009.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696309PMC
May 2009

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Expert Rev Anticancer Ther 2009 Mar;9(3):331-56

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, 332 North Lauderdale Street, Mail Stop 1000, Memphis, TN 38105, USA.

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http://www.tandfonline.com/doi/full/10.1586/14737140.9.3.331
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http://dx.doi.org/10.1586/14737140.9.3.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780428PMC
March 2009

Antitumor compounds based on a natural product consensus pharmacophore.

J Med Chem 2008 Oct 13;51(19):6220-4. Epub 2008 Sep 13.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm8006195
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http://dx.doi.org/10.1021/jm8006195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701350PMC
October 2008

T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: an implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses.

J Biol Chem 2008 Sep 25;283(36):24392-9. Epub 2008 Jun 25.

Model Animal Research Center, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 225001, China.

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http://dx.doi.org/10.1074/jbc.M802344200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528987PMC
September 2008

Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.

J Immunol 2008 Jul;181(2):918-30

Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama City, Kanagawa, Japan.

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http://dx.doi.org/10.4049/jimmunol.181.2.918DOI Listing
July 2008

Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy.

Med Res Rev 2008 May;28(3):372-412

High-Throughput Medicinal Chemistry, ChemBridge Research Laboratories, 16981 Via Tazon, Suites K, San Diego, California 92127, USA.

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http://dx.doi.org/10.1002/med.20109DOI Listing
May 2008

Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1.

J Biol Chem 2007 Jun 27;282(22):15965-72. Epub 2007 Mar 27.

Department of Internal Medicine III, Technical University of Munich, 81675 Munich, Germany, and Department of Pathology, St. Jude Chidren's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1074/jbc.M610819200DOI Listing
June 2007

Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.

Mol Cell Biol 2007 Apr 5;27(8):3056-64. Epub 2007 Feb 5.

Yale University School of Medicine, Department of Laboratory Medicine, P.O. Box 208035, 333 Cedar Street, New Haven, CT 06520-8035, USA.

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http://dx.doi.org/10.1128/MCB.01339-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899951PMC
April 2007

Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors.

Proc Natl Acad Sci U S A 2007 Jan 19;104(1):145-50. Epub 2006 Dec 19.

Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030 [corrected] USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0601894104
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http://dx.doi.org/10.1073/pnas.0601894104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765424PMC
January 2007

B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells.

J Immunol 2007 Jan;178(1):49-57

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.4049/jimmunol.178.1.49DOI Listing
January 2007

Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.

J Med Chem 2006 Feb;49(3):1006-15

ChemBridge Research Laboratories and ChemBridge Corporation, 16981 Via Tazon, Suites K and G, San Diego, CA 92127, USA.

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http://dx.doi.org/10.1021/jm050824xDOI Listing
February 2006

NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.

Cell 2005 Jul;122(1):45-57

Department of Internal Medicine III, Technical University of Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.cell.2005.04.034DOI Listing
July 2005

cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.

Oncogene 2004 Apr;23(20):3700-7

Department of Neurosurgery, The University of Tennessee Health Science Center, 847 Monroe, Room 427, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1038/sj.onc.1207448DOI Listing
April 2004

Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity.

Blood 2004 Feb 16;103(4):1464-71. Epub 2003 Oct 16.

INSERM U563, CPTP, Departement d'Oncologenèse et Signalisation dans les Cellules Hématopoïétiques, Hôpital Purpan, 31059 Toulouse, France.

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http://dx.doi.org/10.1182/blood-2003-04-1038DOI Listing
February 2004

ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases.

Blood 2003 Oct 19;102(7):2642-4. Epub 2003 Jun 19.

Department of Pathology, St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1182/blood-2003-04-1095DOI Listing
October 2003

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells.

J Biol Chem 2003 Oct 19;278(44):43654-62. Epub 2003 Aug 19.

Blood Research Institute, the Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M307318200
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http://dx.doi.org/10.1074/jbc.M307318200DOI Listing
October 2003

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.

Nat Immunol 2003 Sep 10;4(9):857-65. Epub 2003 Aug 10.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/ni963DOI Listing
September 2003

Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).

J Biol Chem 2003 Aug 14;278(32):30028-36. Epub 2003 May 14.

Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M300883200DOI Listing
August 2003

Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values.

Bioinformatics 2003 Jul;19(10):1236-42

Department of Biostatistics, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1093/bioinformatics/btg148DOI Listing
July 2003

Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.

Genes Chromosomes Cancer 2003 May;37(1):98-105

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1002/gcc.10177DOI Listing
May 2003

Hammerhead ribozyme-mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma.

Exp Hematol 2003 Mar;31(3):226-33

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/s0301-472x(02)01084-6DOI Listing
March 2003

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.

J Biol Chem 2002 Oct 9;277(43):40997-1008. Epub 2002 Aug 9.

Laboratory for Cancer Medicine, Medical Research Foundation, Royal Perth Hospital, Western Australian Institute for Medical Research, Rear 50 Murray Street, Perth, WA 6000, Australia.

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http://dx.doi.org/10.1074/jbc.M206041200DOI Listing
October 2002

Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma.

Hematology Am Soc Hematol Educ Program 2000 :180-204

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http://dx.doi.org/10.1182/asheducation-2000.1.180DOI Listing
January 2000