Stephan Steckelbroeck

Stephan Steckelbroeck

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Stephan Steckelbroeck

Stephan Steckelbroeck

Publications by authors named "Stephan Steckelbroeck"

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21Publications

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Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells.

Int J Cancer 2010 Jul;127(1):55-66

Junior Research Group, Paul-Ehrlich-Institute, Langen, Germany.

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http://dx.doi.org/10.1002/ijc.25010DOI Listing
July 2010

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes.

J Allergy Clin Immunol 2008 Jun 9;121(6):1323-30. Epub 2008 May 9.

Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.

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http://dx.doi.org/10.1016/j.jaci.2008.04.008DOI Listing
June 2008

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies.

Biochem Pharmacol 2008 Jan 14;75(2):484-93. Epub 2007 Sep 14.

Center for Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, United States.

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http://dx.doi.org/10.1016/j.bcp.2007.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2245880PMC
January 2008

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.

Endocrinology 2006 Dec 7;147(12):5806-16. Epub 2006 Sep 7.

Department of Pharmacology, Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1210/en.2006-0627DOI Listing
December 2006

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.

J Pharmacol Exp Ther 2006 Mar 8;316(3):1300-9. Epub 2005 Dec 8.

Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.09158
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http://dx.doi.org/10.1124/jpet.105.091587DOI Listing
March 2006

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Mol Cell Endocrinol 2006 Mar 18;248(1-2):182-91. Epub 2006 Jan 18.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.mce.2005.12.009DOI Listing
March 2006

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.

Mol Endocrinol 2006 Feb 22;20(2):444-58. Epub 2005 Sep 22.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1210/me.2005-0287DOI Listing
February 2006

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.

Mol Pharmacol 2004 Dec 21;66(6):1702-11. Epub 2004 Sep 21.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1124/mol.104.004515DOI Listing
December 2004

The roles of aldo-keto reductases in steroid hormone action.

Drug News Perspect 2004 Nov;17(9):563-78

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 135 John Morgan Building, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1358/dnp.2004.17.9.872570DOI Listing
November 2004

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

J Biol Chem 2004 Mar 12;279(11):10784-95. Epub 2003 Dec 12.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1074/jbc.M313308200DOI Listing
March 2004

Infection of barley roots by Chaetomium globosum: evidence for a protective role of the exodermis.

Mycol Res 2003 Sep;107(Pt 9):1094-102

Soil Ecosystem Phytopathology, Institute for Plant Diseases, University of Bonn, Nussallee 9, 53115 Bonn, Germany.

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http://dx.doi.org/10.1017/s0953756203008189DOI Listing
September 2003

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

Endocrinology 2003 Jul;144(7):2922-32

Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2002-0032DOI Listing
July 2003

Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain.

J Steroid Biochem Mol Biol 2003 Jul;86(1):79-92

Department of Pharmacology, University of Pennsylvania School of Medicine, 130C John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/s0960-0760(03)00251-6DOI Listing
July 2003

Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism.

J Steroid Biochem Mol Biol 2003 Apr;84(5):569-76

Department of Clinical Biochemistry, Institut für Klinische Biochemie, Universität Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany.

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http://dx.doi.org/10.1016/s0960-0760(03)00074-8DOI Listing
April 2003

Effects of butyltins on human 5alpha-reductase type 1 and type 2 activity.

Steroids 2002 Sep;67(10):859-67

Department of Clinical Biochemistry, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://dx.doi.org/10.1016/s0039-128x(02)00051-xDOI Listing
September 2002