Stephan Singer

Sonographic findings in coronavirus disease-19 associated liver damage.

Authors:

Jakob Spogis Florian Hagen Wolfgang M Thaiss Tatjana Hoffmann Nisar Malek Konstantin Nikolaou Christoph P Berg Stephan Singer Hans Bösmüller Florian Kreth Sascha Kaufmann

PLoS One 2021 19;16(2):e0244781. Epub 2021 Feb 19.

Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany.

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February 2021

Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria.

Authors:

Carolin Ploeger Thorben Huth Raisatun Nisa Sugiyanto Stefan Pusch Benjamin Goeppert Stephan Singer Redouane Tabti Ingrid Hausser Peter Schirmacher Laurent Désaubry Stephanie Roessler

Cell Death Dis 2020 11 30;11(11):1023. Epub 2020 Nov 30.

Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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November 2020

The effects of incidental findings from whole-body MRI on the frequency of biopsies and detected malignancies or benign conditions in a general population cohort study.

Authors:

Adrian Richter Elizabeth Sierocinski Stephan Singer Robin Bülow Carolin Hackmann Jean-François Chenot Carsten Oliver Schmidt

Eur J Epidemiol 2020 Oct 29;35(10):925-935. Epub 2020 Aug 29.

Department SHIP-KEF, Institute for Community Medicine, Greifswald University Medical Center, Walther Rathenau Str. 48, 17475, Greifswald, Germany.

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October 2020

Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.

Authors:

Katarzyna Buczak Joanna M Kirkpatrick Felicia Truckenmueller Deolinda Santinha Lino Ferreira Stephanie Roessler Stephan Singer Martin Beck Alessandro Ori

Nat Protoc 2020 09 31;15(9):2956-2979. Epub 2020 Jul 31.

Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany.

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September 2020

NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Authors:

Sarah Luiken Angelika Fraas Matthias Bieg Raisatun Sugiyanto Benjamin Goeppert Stephan Singer Carolin Ploeger Gregor Warsow Jens U Marquardt Carsten Sticht Carolina De La Torre Stefan Pusch Arianeb Mehrabi Norbert Gretz Matthias Schlesner Roland Eils Peter Schirmacher Thomas Longerich Stephanie Roessler

Oncogene 2020 04 13;39(15):3128-3144. Epub 2020 Feb 13.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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April 2020

Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity.

Authors:

Sandra Voringer Laura Schreyer Wiebke Nadolni Melanie A Meier Katharina Woerther Constanze Mittermeier Silvia Ferioli Stephan Singer Kerstin Holzer Susanna Zierler Vladimir Chubanov Bernhard Liebl Thomas Gudermann Susanne Muehlich

Oncogene 2020 03 16;39(11):2328-2344. Epub 2019 Dec 16.

Walther-Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.

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March 2020

HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.

Virchows Arch 2020 Jun 14;476(6):871-880. Epub 2019 Dec 14.

Institute of Pathology, Heidelberg University Hospital, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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June 2020

Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.

Authors:

Elisabeth Drucker Kerstin Holzer Stefan Pusch Juliane Winkler Diego F Calvisi Eva Eiteneuer Esther Herpel Benjamin Goeppert Stephanie Roessler Alessandro Ori Peter Schirmacher Kai Breuhahn Stephan Singer

Cell Commun Signal 2019 11 29;17(1):159. Epub 2019 Nov 29.

Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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November 2019

Nucleoporin Nup155 is part of the p53 network in liver cancer.

Authors:

Kerstin Holzer Alessandro Ori Amy Cooke Daniel Dauch Elisabeth Drucker Philip Riemenschneider Amparo Andres-Pons Amanda L DiGuilio Marie-Therese Mackmull Jochen Baßler Stephanie Roessler Kai Breuhahn Lars Zender Joseph S Glavy Frank Dombrowski Ed Hurt Peter Schirmacher Martin Beck Stephan Singer

Nat Commun 2019 05 14;10(1):2147. Epub 2019 May 14.

Institute of Pathology, University Hospital Heidelberg, 69120, Heidelberg, Germany.

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May 2019

Low frequency of mismatch repair deficiency in gallbladder cancer.

Authors:

Benjamin Goeppert Stephanie Roessler Marcus Renner Moritz Loeffler Stephan Singer Melina Rausch Thomas Albrecht Arianeb Mehrabi Monika Nadja Vogel Anita Pathil Elena Czink Bruno Köhler Christoph Springfeld Christian Rupp Karl Heinz Weiss Peter Schirmacher Magnus von Knebel Doeberitz Matthias Kloor

Diagn Pathol 2019 May 8;14(1):36. Epub 2019 May 8.

Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

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May 2019

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.

Authors:

Santosh Krishna-Subramanian Stephan Singer Marietta Armaka Jesus M Banales Kerstin Holzer Peter Schirmacher Henning Walczak George Kollias Manolis Pasparakis Vangelis Kondylis

Cell Death Differ 2019 Dec 15;26(12):2710-2726. Epub 2019 Apr 15.

Institute for Genetics, University of Cologne, D-50674, Cologne, Germany.

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December 2019

YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells.

Authors:

Teng Wei Sofia Maria Elisabeth Weiler Marcell Tóth Carsten Sticht Teresa Lutz Stefan Thomann Carolina De La Torre Beate Straub Sabine Merker Thomas Ruppert Jens Marquardt Stephan Singer Norbert Gretz Peter Schirmacher Kai Breuhahn

Oncogene 2019 07 1;38(27):5541-5550. Epub 2019 Apr 1.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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July 2019

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma.

Authors:

Benjamin Goeppert Marcus Renner Stephan Singer Thomas Albrecht Qiangnu Zhang Arianeb Mehrabi Anita Pathil Christoph Springfeld Bruno Köhler Christian Rupp Karl Heinz Weiss Anja A Kühl Ruza Arsenic Ulrich Frank Pape Arndt Vogel Peter Schirmacher Stephanie Roessler Nalân Utku

Sci Rep 2019 03 13;9(1):4338. Epub 2019 Mar 13.

Institute for Medical Immunology, Campus Virchow, Berlin, Charité, Germany.

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March 2019

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma - correlation with clinicopathological data and comparison of antibodies.

Authors:

Mark Kriegsmann Stephanie Roessler Katharina Kriegsmann Marcus Renner Rémi Longuespée Thomas Albrecht Moritz Loeffler Stephan Singer Arianeb Mehrabi Monika Nadja Vogel Anita Pathil Bruno Köhler Christoph Springfeld Christian Rupp Karl Heinz Weiss Benjamin Goeppert

BMC Cancer 2019 Jan 15;19(1):72. Epub 2019 Jan 15.

Institute of Pathology, University Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany.

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January 2019

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.

Authors:

Benjamin Goeppert Reka Toth Stephan Singer Thomas Albrecht Daniel B Lipka Pavlo Lutsik David Brocks Marion Baehr Oliver Muecke Yassen Assenov Lei Gu Volker Endris Albrecht Stenzinger Arianeb Mehrabi Peter Schirmacher Christoph Plass Dieter Weichenhan Stephanie Roessler

Hepatology 2019 05 28;69(5):2091-2106. Epub 2019 Feb 28.

Institute of Pathology, University Clinic of Heidelberg, Heidelberg, Germany.

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May 2019

Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma.

Authors:

Benjamin Goeppert Stephanie Roessler Marcus Renner Stephan Singer Arianeb Mehrabi Monika Nadja Vogel Anita Pathil Elena Czink Bruno Köhler Christoph Springfeld Jan Pfeiffenberger Christian Rupp Karl Heinz Weiss Peter Schirmacher Magnus von Knebel Doeberitz Matthias Kloor

Br J Cancer 2019 01 31;120(1):109-114. Epub 2018 Oct 31.

Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.

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January 2019

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

Authors:

Ivonne Heinze Martin Bens Enrico Calzia Susanne Holtze Oleksandr Dakhovnik Arne Sahm Joanna M Kirkpatrick Karol Szafranski Natalie Romanov Sai Nagender Sama Kerstin Holzer Stephan Singer Maria Ermolaeva Matthias Platzer Thomas Hildebrandt Alessandro Ori

BMC Biol 2018 08 2;16(1):82. Epub 2018 Aug 2.

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.

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August 2018

Platelet activation parameters and platelet-leucocyte-conjugate formation in glioblastoma multiforme patients.

Authors:

Sascha Marx Maximilian Splittstöhser Frederik Kinnen Eileen Moritz Christy Joseph Sebastian Paul Heiko Paland Carolin Seifert Madlen Marx Andreas Böhm Edzard Schwedhelm Kerstin Holzer Stephan Singer Christoph A Ritter Sandra Bien-Möller Henry W S Schroeder Bernhard H Rauch

Oncotarget 2018 May 25;9(40):25860-25876. Epub 2018 May 25.

Department of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University of Medicine Greifswald, Greifswald, Germany.

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May 2018

Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC).

Authors:

Katarzyna Buczak Alessandro Ori Joanna M Kirkpatrick Kerstin Holzer Daniel Dauch Stephanie Roessler Volker Endris Felix Lasitschka Luca Parca Alexander Schmidt Lars Zender Peter Schirmacher Jeroen Krijgsveld Stephan Singer Martin Beck

Mol Cell Proteomics 2018 04 23;17(4):810-825. Epub 2018 Jan 23.

From the ‡European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany;

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April 2018

Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness.

Authors:

Shan Wan Anne-Sophie Meyer Sofia Maria Elisabeth Weiler Christian Rupp Marcell Tóth Carsten Sticht Stephan Singer Stefan Thomann Stephanie Roessler Marina Schorpp-Kistner Jennifer Schmitt Norbert Gretz Peter Angel Darjus Felix Tschaharganeh Jens Marquardt Peter Schirmacher Federico Pinna Kai Breuhahn

Hepatology 2018 05 1;67(5):1842-1856. Epub 2018 Apr 1.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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May 2018

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