Stephan R Targan

Stephan R Targan

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Stephan R Targan

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Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups.

J Crohns Colitis 2019 Aug;13(8):1055-1066

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1093/ecco-jcc/jjz021DOI Listing
August 2019

A role for BATF3 in T9 differentiation and T-cell-driven mucosal pathologies.

Mucosal Immunol 2019 05 7;12(3):644-655. Epub 2019 Jan 7.

F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

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http://www.nature.com/articles/s41385-018-0122-4
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http://dx.doi.org/10.1038/s41385-018-0122-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462229PMC
May 2019

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.

Cell Host Microbe 2019 Mar 5;25(3):377-388.e6. Epub 2019 Mar 5.

F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417942PMC
March 2019

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics.

Inflamm Bowel Dis 2018 10;24(11):2413-2422

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1093/ibd/izy148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195175PMC
October 2018

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome.

Mucosal Immunol 2018 09 9;11(5):1466-1476. Epub 2018 Jul 9.

F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1038/s41385-018-0055-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162160PMC
September 2018

TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice.

Pathol Res Pract 2018 Feb 26;214(2):217-227. Epub 2017 Nov 26.

Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050035, China. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2017.11.017DOI Listing
February 2018

Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.

Inflamm Bowel Dis 2017 08;23(8):1382-1393

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea; ‡Division of Hematology and Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; §Department of Gastroenterology and Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; and ‖Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000001150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510223PMC
August 2017

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.

Gastroenterology 2017 07 9;153(1):219-232. Epub 2017 Apr 9.

F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484733PMC
July 2017

The TNF family member TL1A induces IL-22 secretion in committed human T17 cells via IL-9 induction.

J Leukoc Biol 2017 03 12;101(3):727-737. Epub 2016 Oct 12.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://doi.wiley.com/10.1189/jlb.3A0316-129R
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http://dx.doi.org/10.1189/jlb.3A0316-129RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608031PMC
March 2017

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

J Immunol 2017 03 27;198(5):2133-2146. Epub 2017 Jan 27.

F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048;

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http://dx.doi.org/10.4049/jimmunol.1601293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322190PMC
March 2017

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Gastroenterology 2017 01 28;152(1):206-217.e2. Epub 2016 Sep 28.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164948PMC
January 2017

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.

United European Gastroenterol J 2016 Aug 10;4(4):531-40. Epub 2016 May 10.

F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/2050640616649356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971798PMC
August 2016

Clinical Factors Associated with the Development of Crohn's Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch-anal Anastomosis.

Inflamm Bowel Dis 2016 06;22(6):1397-402

Divisions of Colon and Rectal Surgery and Gastroenterology, Departments of Surgery and Medicine, Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000744DOI Listing
June 2016

TNFRSF1B Is Associated with ANCA in IBD.

Inflamm Bowel Dis 2016 06;22(6):1346-52

*Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Mount Sinai Hospital, Toronto, Ontario, Canada; ‡The Susan and Leonard Feinstein IBD Clinical Center, East New York, New York; and §Institute for Translational Genomics and Population Science, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1097/MIB.0000000000000771DOI Listing
June 2016

Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.

Inflamm Bowel Dis 2016 Apr;22(4):862-9

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; †Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas; ‡Division of Hematology and Oncology, Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; and §Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220246PMC
April 2016

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.

Inflamm Bowel Dis 2016 Mar;22(3):548-59

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752386PMC
March 2016

Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis.

Dig Dis Sci 2016 Feb 5;61(2):550-9. Epub 2015 Oct 5.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians Building, 2nd Floor East, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1007/s10620-015-3886-3DOI Listing
February 2016

Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines.

Stem Cells Transl Med 2014 Dec 8;3(12):1429-34. Epub 2014 Oct 8.

Regenerative Medicine Institute, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.5966/sctm.2014-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250214PMC
December 2014

IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.

Inflamm Bowel Dis 2014 Oct;20(10):1794-801

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1097/MIB.0000000000000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327845PMC
October 2014

Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease.

Antimicrob Agents Chemother 2014 Sep 9;58(9):5054-9. Epub 2014 Jun 9.

F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Institute, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.1128/AAC.02606-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135854PMC
September 2014

Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.

J Immunol 2014 Jul 16;193(2):940-9. Epub 2014 Jun 16.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095;

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http://dx.doi.org/10.4049/jimmunol.1400093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096688PMC
July 2014

Microbiota activation and regulation of innate and adaptive immunity.

Immunol Rev 2014 Jul;260(1):206-20

Department of Immunology, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1111/imr.12180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080089PMC
July 2014

Weeding out the facts: the reality about cannabis and Crohn's disease.

Clin Gastroenterol Hepatol 2014 May 20;12(5):898-9. Epub 2013 Nov 20.

Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1016/j.cgh.2013.11.016DOI Listing
May 2014

Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients.

Inflamm Bowel Dis 2014 Mar;20(3):525-33

*F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; †Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California; ‡Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland; §Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; ‖Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut; ¶Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; **Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada; ††Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada; ‡‡Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California; and §§Medical Genetics Research Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

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http://pdfs.journals.lww.com/ibdjournal/2014/03000/Clinical,
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/01.MIB.0000442011.60285.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046633PMC
March 2014

Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes.

Antimicrob Agents Chemother 2013 Jul 29;57(7):3214-23. Epub 2013 Apr 29.

Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1128/AAC.02633-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697353PMC
July 2013

Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells.

Cytokine 2013 Jul 30;63(1):36-42. Epub 2013 Apr 30.

F. Widjaja Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889718PMC
July 2013

Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale.

Dig Dis Sci 2013 May 19;58(5):1313-21. Epub 2012 Dec 19.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8635 W. 3rd St. #960-Wv, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/s10620-012-2500-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161217PMC
May 2013

SUSTAINED TL1A EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS.

Eur J Microbiol Immunol (Bp) 2013 Mar;3(1):11-20

F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ; Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.

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http://www.akademiai.com/doi/abs/10.1556/EuJMI.3.2013.1.2
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http://dx.doi.org/10.1556/EuJMI.3.2013.1.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638202PMC
March 2013

Andrographis paniculata extract (HMPL-004) for active ulcerative colitis.

Am J Gastroenterol 2013 Jan 9;108(1):90-8. Epub 2012 Oct 9.

University of California San Diego, La Jolla, CA 92093-0956, USA.

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http://dx.doi.org/10.1038/ajg.2012.340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538174PMC
January 2013

HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.

Inflamm Bowel Dis 2013 Jan;19(1):151-64

F Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://www.hmplglobal.com/wp-content/uploads/HMPL_004_Noncli
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http://dx.doi.org/10.1002/ibd.22983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465822PMC
January 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Colorectal cancer screening and surveillance in Crohn's colitis.

J Crohns Colitis 2012 Sep 5;6(8):824-9. Epub 2012 Feb 5.

Department of Medicine and Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.crohns.2012.01.005DOI Listing
September 2012

Abatacept for Crohn's disease and ulcerative colitis.

Gastroenterology 2012 Jul 12;143(1):62-69.e4. Epub 2012 Apr 12.

Division of Gastroenterology, University of California San Diego, La Jolla, California, 92093-0956,USA.

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http://dx.doi.org/10.1053/j.gastro.2012.04.010DOI Listing
July 2012

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice.

Gastroenterology 2011 Nov 14;141(5):1852-63.e1-3. Epub 2011 Jul 14.

Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.06.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199285PMC
November 2011

Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells.

Am J Pathol 2011 Nov 23;179(5):2315-26. Epub 2011 Sep 23.

Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401100760
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http://dx.doi.org/10.1016/j.ajpath.2011.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204086PMC
November 2011

Future therapeutic approaches for inflammatory bowel diseases.

Gastroenterology 2011 May;140(6):1838-46

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076881PMC
http://dx.doi.org/10.1053/j.gastro.2011.02.014DOI Listing
May 2011

A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease.

World J Gastroenterol 2011 May;17(19):2446-9

Lola Y Kwan, Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, United States.

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http://dx.doi.org/10.3748/wjg.v17.i19.2446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103799PMC
May 2011

Introductory words about TL1A/DR3.

Authors:
Stephan R Targan

Adv Exp Med Biol 2011 ;691:271-4

Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Suite D4063, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/978-1-4419-6612-4_27DOI Listing
April 2011

Insights into TL1A and IBD pathogenesis.

Adv Exp Med Biol 2011 ;691:279-88

Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Suite D4063, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/978-1-4419-6612-4_29DOI Listing
April 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.

Inflamm Bowel Dis 2011 Jan;17(1):171-8

Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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https://academic.oup.com/ibdjournal/article/17/1/171-178/463
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http://dx.doi.org/10.1002/ibd.21352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400263PMC
January 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.

Inflamm Bowel Dis 2010 Aug;16(8):1357-66

Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/ibd.21174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889173PMC
August 2010

TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.

J Clin Immunol 2010 Jul 27;30(4):531-8. Epub 2010 Mar 27.

Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd., D4063, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1007/s10875-010-9382-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900590PMC
July 2010

Functional signaling of membrane-bound TL1A induces IFN-gamma expression.

FEBS Lett 2010 Jun 18;584(11):2376-80. Epub 2010 Apr 18.

Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.04.030DOI Listing
June 2010

Future biologic targets for IBD: potentials and pitfalls.

Nat Rev Gastroenterol Hepatol 2010 Feb;7(2):110-7

Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, 8635 West 3rd Street, 960-W Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1038/nrgastro.2009.218DOI Listing
February 2010

Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease.

Am J Gastroenterol 2010 Jan 15;105(1):148-54. Epub 2009 Sep 15.

Department of Medicine, Cedars-Sinai Medical Center, University of California, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1038/ajg.2009.523DOI Listing
January 2010

Insights into IBD Pathogenesis.

Curr Gastroenterol Rep 2009 Dec;11(6):473-80

Cedars-Sinai Inflammatory Bowel Disease Center, Suite D4063, Los Angeles, CA 90048, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895981PMC
December 2009

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.

Eur J Immunol 2009 Nov;39(11):3239-50

Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1002/eji.200839087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839414PMC
November 2009

TLR8-mediated activation of human monocytes inhibits TL1A expression.

Eur J Immunol 2009 Aug;39(8):2195-202

Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1002/eji.200939216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839407PMC
August 2009

Distinct Methylation of IFNG in the Gut.

J Interferon Cytokine Res 2009 Jul;29(7):407-14

Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1089/jir.2008.0109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956574PMC
July 2009

Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease.

Am J Gastroenterol 2009 Apr 24;104(4):868-76. Epub 2009 Feb 24.

Division of Gastroenterology and Hepatology, Department of Medicine, Charité Medical School, Humboldt University of Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/ajg.2008.138DOI Listing
April 2009

High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.

Inflamm Bowel Dis 2009 Mar;15(3):321-7

Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1002/ibd.20754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643315PMC
March 2009

MAGI2 genetic variation and inflammatory bowel disease.

Inflamm Bowel Dis 2009 Jan;15(1):75-83

Medical Genetics Institute & Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1002/ibd.20611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614310PMC
January 2009

Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease.

Inflamm Bowel Dis 2008 Dec;14(12):1641-51

Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1002/ibd.20645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346963PMC
December 2008

Recent advances in IBD pathogenesis: genetics and immunobiology.

Curr Gastroenterol Rep 2008 Dec;10(6):568-75

Cedars-Sinai Inflammatory Bowel Disease Center, 8700 Beverly Boulevard, Suite D4059, Los Angeles, CA 90048, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734390PMC
December 2008

IL23R haplotypes provide a large population attributable risk for Crohn's disease.

Inflamm Bowel Dis 2008 Sep;14(9):1185-91

Medical Genetics Institute & Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1002/ibd.20478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574614PMC
September 2008

Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.

Gastroenterology 2008 Sep 17;135(3):744-55. Epub 2008 Jul 17.

Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752978PMC
September 2008

Certolizumab pegol.

Nat Rev Drug Discov 2008 Aug;7(8):641-2

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http://dx.doi.org/10.1038/nrd2654DOI Listing
August 2008