Publications by authors named "Stephan Mielke"

70Publications

Inflammation-induced tissue damage mimicking GvHD in human skin models as test-platform for immunotherapeutics.

ALTEX 2020 14;37(3):429-440. Epub 2020 Apr 14.

Karolinska Institute and University Hospital, Department of Laboratory Medicine and Medicine Huddinge, Department of Cell Therapy and Allogeneic Stem Cell Transplantation (CAST), Stockholm, Sweden.

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http://dx.doi.org/10.14573/altex.1907181DOI Listing
April 2020

Donor-cell leukemia with novel genetic features 2 years after sex-mismatched T cell-depleted haploidentical stem cell transplantation.

Ann Hematol 2020 Apr 22;99(4):899-901. Epub 2020 Feb 22.

Department of Internal Medicine II, University Hospital of Würzburg, Oberdürrbacher Str. 6, D-97080, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00277-020-03905-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069896PMC
April 2020

ATIR101 administered after T-cell-depleted haploidentical HSCT reduces NRM and improves overall survival in acute leukemia.

Leukemia 2020 07 11;34(7):1907-1923. Epub 2020 Feb 11.

Department of Internal Medicine II, Center of Allogeneic Stem Cell Transplantation, University of Wuerzburg, Wuerzburg University Medical Center, Wuerzburg, Germany.

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http://dx.doi.org/10.1038/s41375-020-0733-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326707PMC
July 2020

Excretion of Ascaris lumbricoides following reduced-intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole.

Transpl Infect Dis 2020 Feb 19;22(1):e13224. Epub 2020 Feb 19.

Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/tid.13224DOI Listing
February 2020

Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial.

Lancet Haematol 2020 Jan 9;7(1):e28-e39. Epub 2019 Oct 9.

Department of Haematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland; Faculty of Medicine, University of Rzeszow, Rzeszow, Poland.

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https://linkinghub.elsevier.com/retrieve/pii/S23523026193015
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http://dx.doi.org/10.1016/S2352-3026(19)30157-7DOI Listing
January 2020

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 01 1;380(1):45-56. Epub 2018 Dec 1.

From the Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia (S.J.S.); the Hematopoietic Cellular Therapy Program, University of Chicago Medicine, Chicago (M.R.B.); Peter MacCallum Cancer Centre, St. Vincent's Hospital and University of Melbourne, Melbourne, VIC (C.S.T.), and the Royal Prince Alfred Hospital and Department of Medicine, University of Sydney, Sydney (P.J.H.) - both in Australia; Winship Cancer Institute of Emory University, Bone Marrow and Stem Cell Transplant Center, Atlanta (E.K.W.); the Department of Hematology and Oncology, University Hospital of Cologne, Cologne (P.B.), and the Würzburg University Medical Center, Center for Allogeneic Stem Cell Transplantation, Würzburg (S.M.) - both in Germany; the Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Kansas City (J.P.M.); the Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna (U.J.); James Cancer Hospital and Solove Research Institute, Ohio State University Comprehensive Cancer Center, Columbus (S.J.); the Department of Hematology and Blood and Marrow Transplant, University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (C.A.); the Department of Lymphoma and Myeloma, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (J.R.W.); Maisonneuve-Rosemont Hospital, University of Montreal, Montreal (I.F.), and the Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON (S.R.F.) - both in Canada; the Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis (V.B.); Karolinska Institutet and University Hospital, Department of Laboratory Medicine/Department of Cell Therapy and Allogeneic Stem Cell Transplantation, Stockholm (S.M.); University of Michigan Comprehensive Cancer Center, Ann Arbor (J.M.M.); the Department of Oncology, Oslo University Hospital, Oslo (H.H.); Novartis Pharma, Basel, Switzerland (S.P., O.A.); Novartis Pharmaceuticals (L.B.P., J.C.) and Novartis Institutes for BioMedical Research (R.A.), East Hanover, NJ; the Department of Hematology, Hospices Civils de Lyon, Université de Lyon, Lyon, France (G.S.); and the Center for Hematologic Malignancies, Oregon Health and Science University Knight Cancer Institute, Portland (R.T.M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1804980
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http://dx.doi.org/10.1056/NEJMoa1804980DOI Listing
January 2019

Dasatinib and allogeneic stem cell transplantation enable sustained response in an elderly patient with -positive acute lymphoblastic leukemia.

Haematologica 2017 04 5;102(4):e160-e162. Epub 2017 Jan 5.

Department of Internal Medicine and Hematology, Oncology and Immunology, Philipps University Marburg, and University Hospital Giessen and Marburg, Baldingerstrasse, Germany

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http://dx.doi.org/10.3324/haematol.2016.160531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395131PMC
April 2017

A first vascularized skin equivalent as an alternative to animal experimentation.

ALTEX 2016 15;33(4):415-422. Epub 2016 May 15.

Translational Center Würzburg, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) Würzburg, Germany.

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http://dx.doi.org/10.14573/altex.1604041DOI Listing
January 2017

Interactions of donor sources and media influence the histo-morphological quality of full-thickness skin models.

Biotechnol J 2016 Oct 19;11(10):1352-1361. Epub 2016 Sep 19.

Department of Internal Medicine II, Center for Allogeneic Stem Cell Transplantation, Würzburg University Medical Center, Würzburg, Germany.

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http://dx.doi.org/10.1002/biot.201600360DOI Listing
October 2016

New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease.

Br J Clin Pharmacol 2016 11 22;82(5):1171-1179. Epub 2016 Jun 22.

Department of Internal Medicine II, Würzburg University Medical Center, Würzburg, Germany.

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http://dx.doi.org/10.1111/bcp.13022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061796PMC
November 2016

Diagnosis and treatment of cytomegalovirus 2013.

Curr Opin Hematol 2014 Nov;21(6):470-5

Department of Medicine II, Wuerzburg University Medical Center, Wuerzburg, Germany.

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http://dx.doi.org/10.1097/MOH.0000000000000090DOI Listing
November 2014

Improvement of quality of life in patients with steroid-refractory chronic graft-versus-host disease treated with the mTOR inhibitor everolimus.

Clin Transplant 2014 Dec 3;28(12):1410-5. Epub 2014 Nov 3.

Allogeneic Stem Cell Transplantation Section, Department of Internal Medicine II, Würzburg University Medical Center, Würzburg, Germany.

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http://dx.doi.org/10.1111/ctr.12472DOI Listing
December 2014

Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease.

Blood 2009 Sep 5;114(13):2829-36. Epub 2009 Aug 5.

Department of Internal Medicine II, Division of Hematology, University Hospital of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1182/blood-2009-06-224600DOI Listing
September 2009

Individualized pharmacotherapy with paclitaxel.

Authors:
Stephan Mielke

Curr Opin Oncol 2007 Nov;19(6):586-9

Department of Hematology and Oncology, University Medical Center, Freiburg, Germany.

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https://insights.ovid.com/crossref?an=00001622-200711000-000
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http://dx.doi.org/10.1097/CCO.0b013e3282a08f8cDOI Listing
November 2007

Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies.

Blood 2008 Jan 17;111(1):236-42. Epub 2007 Sep 17.

Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA.

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http://dx.doi.org/10.1182/blood-2007-08-108241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200809PMC
January 2008

Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.

Blood 2007 Sep 26;110(5):1603-6. Epub 2007 Apr 26.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2007-01-066258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1975843PMC
September 2007

Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation.

Onkologie 2007 Feb 26;30(1-2):49-52. Epub 2007 Jan 26.

Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany.

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http://dx.doi.org/10.1159/000098229DOI Listing
February 2007

Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia.

Eur J Cancer 2006 Nov 6;42(17):2893-6. Epub 2006 Sep 6.

Clinical Pharmacology Research Core, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ejca.2006.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1647318PMC
November 2006

T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization.

Clin Cancer Res 2005 Dec;11(24 Pt 1):8799-807

Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1314DOI Listing
December 2005

Paclitaxel pharmacokinetics and response to chemotherapy in patients with advanced cancer treated with a weekly regimen.

Anticancer Res 2005 Nov-Dec;25(6C):4423-7

Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany.

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January 2006

Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel.

Clin Cancer Res 2005 Nov;11(22):8097-104

Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1152DOI Listing
November 2005

Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes.

Eur J Cancer 2006 Jan 15;42(1):24-30. Epub 2005 Nov 15.

Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S095980490500843
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http://dx.doi.org/10.1016/j.ejca.2005.06.030DOI Listing
January 2006

Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia.

Blood 2006 Feb 30;107(4):1688-95. Epub 2005 Aug 30.

Stem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10, Hatfield CRC, Bethesda, MD 20892-1202, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-05-18
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http://dx.doi.org/10.1182/blood-2005-05-1897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895415PMC
February 2006

Association of Paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer.

Clin Cancer Res 2005 Jul;11(13):4843-50

Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0298DOI Listing
July 2005

Fatal outcome in a patient with metastatic prostate cancer and acquired severe hypogammaglobulinemia with complete absence of mature peripheral blood B-cells.

In Vivo 2003 Sep-Oct;17(5):505-7

Department of Hematology and Oncology, University Medical Center of Freiburg, Hugstetter Str. 55, D-79106 Freiburg i. Br., Germany.

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May 2004

Comparative neurotoxicity of weekly non-break paclitaxel infusions over 1 versus 3 h.

Anticancer Drugs 2003 Nov;14(10):785-92

Department of Hematology and Oncology, University of Freiburg Medical Center, Germany.

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http://dx.doi.org/10.1097/00001813-200311000-00003DOI Listing
November 2003

Comparative pharmacokinetics of unbound paclitaxel during 1- and 3-hour infusions.

J Clin Oncol 2002 Jan;20(2):574-81

Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2002.20.2.574DOI Listing
January 2002