Stephan J Sigrist

Stephan J Sigrist

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Stephan J Sigrist

Stephan J Sigrist

Publications by authors named "Stephan J Sigrist"

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Phosphorylation of the Bruchpilot N-terminus in unlocks axonal transport of active zone building blocks.

J Cell Sci 2019 Mar 18;132(6). Epub 2019 Mar 18.

Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, D-14195 Berlin, Germany

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http://dx.doi.org/10.1242/jcs.225151DOI Listing
March 2019

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.

Nat Commun 2019 03 21;10(1):1318. Epub 2019 Mar 21.

Institute for Biology/Genetics, Freie Universität Berlin, Takustr. 6, 14195, Berlin, Germany.

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http://dx.doi.org/10.1038/s41467-019-09262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428838PMC
March 2019

The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly.

Neuron 2018 10;100(1):6-8

Freie Universität Berlin, Institute for Biology/Genetics, Takustrasse 6, 14195 Berlin, Germany; NeuroCure, Charite, Chariteplatz 1, 10117 Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183083
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http://dx.doi.org/10.1016/j.neuron.2018.09.035DOI Listing
October 2018

Coupling the Structural and Functional Assembly of Synaptic Release Sites.

Front Neuroanat 2018 16;12:81. Epub 2018 Oct 16.

Faculty of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany.

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https://www.frontiersin.org/article/10.3389/fnana.2018.00081
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http://dx.doi.org/10.3389/fnana.2018.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198076PMC
October 2018

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

Neuron 2018 09 30;99(6):1216-1232.e7. Epub 2018 Aug 30.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany; Freie Universität Berlin, Faculty of Biology, Chemistry, Pharmacy, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273183067
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http://dx.doi.org/10.1016/j.neuron.2018.08.004DOI Listing
September 2018

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses.

Cell Rep 2018 05;23(5):1259-1274

Institute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436828PMC
May 2018

Vesicle release site organization at synaptic active zones.

Neurosci Res 2018 Feb 21;127:3-13. Epub 2017 Dec 21.

Freie Universität Berlin, Institute for Biology/Genetics, Takustraße 6, 14195 Berlin, Germany; NeuroCure, Cluster of Excellence, Charité Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2017.12.006DOI Listing
February 2018

Guidelines and recommendations on yeast cell death nomenclature.

Microb Cell 2018 Jan 1;5(1):4-31. Epub 2018 Jan 1.

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

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http://dx.doi.org/10.15698/mic2018.01.607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772036PMC
January 2018

Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.

Curr Opin Neurobiol 2017 04 5;43:119-129. Epub 2017 Apr 5.

Institut für Biologie/Genetik and NeuroCure, Freie Universität Berlin, Takustrasse 6, D-14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501089PMC
April 2017

Spermidine boosts autophagy to protect from synapse aging.

Autophagy 2017 Feb 27;13(2):444-445. Epub 2016 Dec 27.

a Institute for Biology, Freie Universität Berlin , Berlin , Germany.

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http://dx.doi.org/10.1080/15548627.2016.1265193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324840PMC
February 2017

Mechanisms controlling assembly and plasticity of presynaptic active zone scaffolds.

Curr Opin Neurobiol 2016 08 29;39:69-76. Epub 2016 Apr 29.

Neurogenetik, Institut für Biologie, Freie Universität Berlin, 14195 Berlin, Germany; Cluster of Excellence NeuroCure, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2016.04.009DOI Listing
August 2016

Neuroscience: Nanocolumns at the heart of the synapse.

Nature 2016 08 27;536(7615):151-2. Epub 2016 Jul 27.

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http://dx.doi.org/10.1038/nature18917DOI Listing
August 2016

Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics.

Nat Methods 2015 Sep 27;12(9):827-30. Epub 2015 Jul 27.

German Cancer Research Center (DKFZ), Optical Nanoscopy Division, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nmeth.3481DOI Listing
September 2015

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.

PLoS Comput Biol 2015 Sep 14;11(9):e1004407. Epub 2015 Sep 14.

Department of Mathematics, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1004407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569342PMC
September 2015

Lights on for the molecular players of presynaptic plasticity.

Neuron 2015 May;86(3):603-4

Freie Universität Berlin, Institute for Biology/Genetics, Takustrasse 6, 14195 Berlin, Germany; NeuroCure, Charité, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.04.021DOI Listing
May 2015

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.

Acta Crystallogr F Struct Biol Commun 2015 Jan 1;71(Pt 1):34-40. Epub 2015 Jan 1.

Institut für Chemie und Biochemie Abteilung Strukturbiochemie, Freie Universität Berlin, Takustrasse 6, 15195 Berlin, Germany.

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http://dx.doi.org/10.1107/S2053230X1402617XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304744PMC
January 2015

Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.

Nat Protoc 2014 Dec 13;9(12):2796-808. Epub 2014 Nov 13.

Laboratory of Glia Biology, Vlaams Instituut voor Biotechnologie (VIB) Center for the Biology of Disease, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

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http://search.proquest.com/openview/e083477efe62ff735e289f25
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http://dx.doi.org/10.1038/nprot.2014.192DOI Listing
December 2014

Synaptogenesis.

Curr Biol 2014 Nov 17;24(22):R1076-80. Epub 2014 Nov 17.

Neurogenetik, Institut für Biologie, Freie Universität Berlin, 14195 Berlin, Germany; Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.10.024DOI Listing
November 2014

Gating characteristics control glutamate receptor distribution and trafficking in vivo.

Curr Biol 2014 Sep 14;24(17):2059-65. Epub 2014 Aug 14.

Neurogenetik, Institut für Biologie, Freie Universität Berlin, 14195 Berlin, Germany; Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.07.051DOI Listing
September 2014

A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.

Cell Rep 2014 Jun 29;7(5):1417-1425. Epub 2014 May 29.

Leibniz Institute for Molecular Pharmacology, Robert Rössle Strasse 10, 13125 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin Berlin, Virchowweg 6, 10117 Berlin, Germany; Membrane Biochemistry, Institute of Chemistry & Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.051DOI Listing
June 2014

Neurotransmission: spontaneous and evoked release filing for divorce.

Curr Biol 2014 Mar;24(5):R192-4

Freie Universität Berlin, Department of Biology, Chemistry, Pharmacy, Takustrasse 6, 14195 Berlin, Germany; Neurocure Cluster of Excellence, Charité Universitätsmedizin Berlin, CCO, Virchowweg 6, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.01.037DOI Listing
March 2014

Spermidine-triggered autophagy ameliorates memory during aging.

Autophagy 2014 Jan 15;10(1):178-9. Epub 2013 Nov 15.

Institute for Molecular Biosciences; University of Graz; Graz, Austria.

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http://dx.doi.org/10.4161/auto.26918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389874PMC
January 2014

Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences.

Nat Neurosci 2013 Jul 25;16(7):790-7. Epub 2013 Jun 25.

Department of Genetics, Institute for Biology, Free University Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/nn.3403DOI Listing
July 2013

Sperm(idine) answers the next generation.

Cell Cycle 2013 Feb 31;12(4):542-3. Epub 2013 Jan 31.

Institute for Biology/Genetics, Freie Universität, Berlin, Germany.

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http://dx.doi.org/10.4161/cc.23676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594251PMC
February 2013

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.

J Neurosci 2012 Nov;32(47):16574-85

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158-0822, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0981-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523185PMC
November 2012

Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.

Nat Neurosci 2012 Sep 5;15(9):1219-26. Epub 2012 Aug 5.

Freie Universität Berlin, Institute for Biology/Genetics, Berlin, Germany.

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http://dx.doi.org/10.1038/nn.3183DOI Listing
September 2012

Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila.

J Cell Sci 2012 Aug 14;125(Pt 15):3621-9. Epub 2012 Apr 14.

Cajal Institute, Consejo Superior de Investigaciones Científicas, Ave Dr Arce 37, Madrid 28002, Spain.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.102806
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http://dx.doi.org/10.1242/jcs.102806DOI Listing
August 2012

Glutamate receptors in synaptic assembly and plasticity: case studies on fly NMJs.

Adv Exp Med Biol 2012 ;970:3-28

Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany.

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http://dx.doi.org/10.1007/978-3-7091-0932-8_1DOI Listing
June 2012

Multi-colour direct STORM with red emitting carbocyanines.

Biol Cell 2012 Apr 20;104(4):229-37. Epub 2012 Jan 20.

Institute of Chemistry, Freie Universität Berlin, 14195 Berlin, Germany.

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http://dx.doi.org/10.1111/boc.201100011DOI Listing
April 2012

In vivo imaging of Drosophila larval neuromuscular junctions to study synapse assembly.

Cold Spring Harb Protoc 2012 Apr 1;2012(4):407-13. Epub 2012 Apr 1.

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http://dx.doi.org/10.1101/pdb.top068577DOI Listing
April 2012

Building an imaging chamber for in vivo imaging of Drosophila larvae.

Cold Spring Harb Protoc 2012 Apr 1;2012(4):476-80. Epub 2012 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot068585DOI Listing
April 2012

In vivo imaging of the Drosophila larval neuromuscular junction.

Cold Spring Harb Protoc 2012 Apr 1;2012(4):481-9. Epub 2012 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot068593DOI Listing
April 2012

Quantitative analysis of Drosophila larval neuromuscular junction morphology.

Cold Spring Harb Protoc 2012 Apr 1;2012(4):490-3. Epub 2012 Apr 1.

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http://dx.doi.org/10.1101/pdb.prot068601DOI Listing
April 2012

Optical super-resolution microscopy in neurobiology.

Curr Opin Neurobiol 2012 Feb 1;22(1):86-93. Epub 2011 Nov 1.

Cluster of Excellence NeuroCure, Institute for Biology, Freie Universität Berlin, Germany.

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http://dx.doi.org/10.1016/j.conb.2011.10.014DOI Listing
February 2012

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.

Nat Rev Neurosci 2011 Mar 9;12(3):127-38. Epub 2011 Feb 9.

Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität, and Charité Universitätsmedizin Berlin, Takustraße 6, 14195 Berlin, Germany.

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http://dx.doi.org/10.1038/nrn2948DOI Listing
March 2011

Structural and functional plasticity of the cytoplasmic active zone.

Curr Opin Neurobiol 2011 Feb 9;21(1):144-50. Epub 2010 Sep 9.

Genetics Institute of Biology, Freie Universität Berlin, Takustr. 6, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.conb.2010.08.012DOI Listing
February 2011

Fighting the famine with an amine: synaptic strategies for smart search.

Nat Neurosci 2011 Feb;14(2):124-6

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http://dx.doi.org/10.1038/nn0211-124DOI Listing
February 2011

Structural long-term changes at mushroom body input synapses.

Curr Biol 2010 Nov 14;20(21):1938-44. Epub 2010 Oct 14.

Department of Molecular Neurobiology, Dendrite Differentiation Group, Max Planck Institute (MPI) of Neurobiology, Munich-Martinsried 82152, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822100121
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http://dx.doi.org/10.1016/j.cub.2010.09.060DOI Listing
November 2010

The active zone T-bar--a plasticity module?

J Neurogenet 2010 Sep;24(3):133-45

NeuroCure Cluster of Excellence, Charité Berlin, Berlin, Germany.

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http://dx.doi.org/10.3109/01677063.2010.489626DOI Listing
September 2010

Synaptic organization of lobula plate tangential cells in Drosophila: Dalpha7 cholinergic receptors.

J Neurogenet 2009 ;23(1-2):200-9

Department of Systems and Computational Neurobiology, Max-Planck-Institute of Neurobiology, Martinsried, Germany.

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http://dx.doi.org/10.1080/01677060802471684DOI Listing
January 2010

Relax? Don't do it!-Linking presynaptic vesicle clustering with mechanical tension.

HFSP J 2009 Dec 10;3(6):367-72. Epub 2009 Dec 10.

Institut für Biologie-Neurogenetik, Freie Universität Berlin, 14195 Berlin, Germany.

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http://dx.doi.org/10.2976/1.3260842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839808PMC
December 2009

How to button a bouton with alpha2deltas.

Nat Neurosci 2009 Nov;12(11):1357-8

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http://www.nature.com/articles/nn1109-1357
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http://dx.doi.org/10.1038/nn1109-1357DOI Listing
November 2009

Assembling the presynaptic active zone.

Curr Opin Neurobiol 2009 Jun 22;19(3):311-8. Epub 2009 Apr 22.

NeuroCure Cluster of Excellence, Charité Berlin, Berlin, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09594388090001
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http://dx.doi.org/10.1016/j.conb.2009.03.003DOI Listing
June 2009

Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission.

Dev Neurobiol 2009 May;69(6):365-77

University of Bern, Institute of Cell Biology, Baltzerstrasse 4, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1002/dneu.20711DOI Listing
May 2009

The Yin and Yang of synaptic active zone assembly.

Sci Signal 2009 May 12;2(70):pe32. Epub 2009 May 12.

Genetics, Institute for Biology, Free University Berlin, Takustrasse 6, 14195 Berlin, Germany.

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http://dx.doi.org/10.1126/scisignal.270pe32DOI Listing
May 2009

Analysis of neuromuscular junctions: histology and in vivo imaging.

Methods Mol Biol 2008 ;420:239-51

European Neuroscience Institute-Göttingen (ENI-G), Göttingen, Germany.

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http://dx.doi.org/10.1007/978-1-59745-583-1_14DOI Listing
August 2008

Activity-dependent site-specific changes of glutamate receptor composition in vivo.

Nat Neurosci 2008 Jun 11;11(6):659-66. Epub 2008 May 11.

Institute for Clinical Neurobiology, Medical Faculty, University of Würzburg, Zinklesweg 10, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1038/nn.2122DOI Listing
June 2008

Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses.

Nat Protoc 2007 ;2(12):3285-98

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, Tübingen D-72076, Germany.

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http://dx.doi.org/10.1038/nprot.2007.472DOI Listing
February 2008

Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.

Proc Natl Acad Sci U S A 2006 May 8;103(20):7841-6. Epub 2006 May 8.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.1073/pnas.0600387103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472532PMC
May 2006

Neurobiology tools: flashdancing worms.

Curr Biol 2006 Feb;16(3):R100-2

European Neuroscience Institute-Goettingen, Germany.

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http://dx.doi.org/10.1016/j.cub.2006.01.024DOI Listing
February 2006

Glutamate receptor dynamics organizing synapse formation in vivo.

Nat Neurosci 2005 Jul;8(7):898-905

European Neuroscience Institute Göttingen, Max-Planck-Society, Waldweg 33, D-37073 Göttingen, Germany.

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July 2005