Stephan Beck

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EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI.

Bioinformatics 2019 Nov 9. Epub 2019 Nov 9.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China.

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http://dx.doi.org/10.1093/bioinformatics/btz833DOI Listing
November 2019

Making multi-omics data accessible to researchers.

Sci Data 2019 10 31;6(1):251. Epub 2019 Oct 31.

UCL Cancer institute, University College London, London, UK.

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http://dx.doi.org/10.1038/s41597-019-0258-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823467PMC
October 2019

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data.

Bioinformatics 2019 Jun 4. Epub 2019 Jun 4.

Medical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, United Kingdom.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/btz456DOI Listing
June 2019

A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.

Angew Chem Int Ed Engl 2019 May 12;58(20):6620-6624. Epub 2019 Apr 12.

Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

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http://doi.wiley.com/10.1002/anie.201901139
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http://dx.doi.org/10.1002/anie.201901139DOI Listing
May 2019

Points-to-consider on the return of results in epigenetic research.

Genome Med 2019 05 23;11(1):31. Epub 2019 May 23.

Centre of Genomics and Policy, Faculty of Medicine, McGill University, Montreal, Quebec, H3A 0G1, Canada.

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http://dx.doi.org/10.1186/s13073-019-0646-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533659PMC
May 2019

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.

Clin Epigenetics 2019 May 30;11(1):86. Epub 2019 May 30.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13148-019-0678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543588PMC
May 2019

The epigenetic clock: a molecular crystal ball for human aging?

Aging (Albany NY) 2019 01;11(2):833-835

UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.18632/aging.101712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366965PMC
January 2019

Identification of differentially methylated cell types in epigenome-wide association studies.

Nat Methods 2018 12 30;15(12):1059-1066. Epub 2018 Nov 30.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/s41592-018-0213-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277016PMC
December 2018

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.

Genome Med 2018 09 4;10(1):64. Epub 2018 Sep 4.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13073-018-0575-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122744PMC
September 2018

A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix.

Epigenomics 2018 07 25;10(7):925-940. Epub 2018 Apr 25.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, 320 Yue Yang Road, Shanghai 200031, PR China.

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https://www.futuremedicine.com/doi/10.2217/epi-2018-0037
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http://dx.doi.org/10.2217/epi-2018-0037DOI Listing
July 2018

Getting up close and personal with UK genomics and beyond.

Authors:
Stephan Beck

Genome Med 2018 05 24;10(1):38. Epub 2018 May 24.

University College London Cancer Institute, 72 Huntley Street, London, WC1E6BT, UK.

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http://dx.doi.org/10.1186/s13073-018-0552-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968574PMC
May 2018

Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor.

Cancer Cell 2018 04;33(4):620-633.e6

Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896242PMC
April 2018

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.

Bioessays 2018 02 18;40(2). Epub 2017 Dec 18.

MRC/BHF Cardiovascular Epidemiology Unit Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

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http://dx.doi.org/10.1002/bies.201700148DOI Listing
February 2018

Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours.

Clin Epigenetics 2017 4;9:33. Epub 2017 Apr 4.

Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Box 425, 405 30, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s13148-017-0333-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379646PMC
December 2017

ChAMP: updated methylation analysis pipeline for Illumina BeadChips.

Bioinformatics 2017 Dec;33(24):3982-3984

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1093/bioinformatics/btx513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860089PMC
December 2017

Nano-MeDIP-seq Methylome Analysis Using Low DNA Concentrations.

Methods Mol Biol 2017 ;1589:115-138

UCL Cancer Institute, University College London, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1007/7651_2015_259DOI Listing
October 2017

Cell-free DNA: Treasure trove for cancer medicine.

Nat Mater 2017 10;16(11):1056-1057

UCL Cancer Institute, University College London, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1038/nmat5019DOI Listing
October 2017

Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection.

BMC Bioinformatics 2017 Jul 25;18(1):354. Epub 2017 Jul 25.

UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1186/s12859-017-1753-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526259PMC
July 2017

DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve.

Cardiovasc Res 2017 May;113(6):692-704

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

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http://dx.doi.org/10.1093/cvr/cvx050DOI Listing
May 2017

Efficient Hybrid Image Warping for High Frame-Rate Stereoscopic Rendering.

IEEE Trans Vis Comput Graph 2017 04 25;23(4):1332-1341. Epub 2017 Jan 25.

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http://dx.doi.org/10.1109/TVCG.2017.2657078DOI Listing
April 2017

Epigenetic variation taking center stage in immunological research.

Epigenomics 2017 04 21;9(4):375-378. Epub 2017 Mar 21.

UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.2217/epi-2017-0006DOI Listing
April 2017

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies.

BMC Bioinformatics 2017 Feb 13;18(1):105. Epub 2017 Feb 13.

Medical Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT, London, United Kingdom.

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http://dx.doi.org/10.1186/s12859-017-1511-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307731PMC
February 2017

Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses.

Nat Methods 2017 02;14(3):216-217

CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/nmeth.4187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659733PMC
February 2017

Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges.

Curr Opin Genet Dev 2017 Feb 16;42:48-55. Epub 2017 Feb 16.

UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X173001
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http://dx.doi.org/10.1016/j.gde.2017.01.017DOI Listing
February 2017

From profiles to function in epigenomics.

Nat Rev Genet 2017 01 21;18(1):51-66. Epub 2016 Nov 21.

University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1038/nrg.2016.138DOI Listing
January 2017

Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.

Epigenetics 2016 19;11(1):74-84. Epub 2016 Jan 19.

a Sahlgrenska Cancer Center , Department of Pathology , Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Sweden.

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http://dx.doi.org/10.1080/15592294.2016.1138195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846113PMC
December 2016

CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening.

BMC Genomics 2016 11 14;17(1):917. Epub 2016 Nov 14.

Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1186/s12864-016-3268-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109649PMC
November 2016

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

Cell 2016 11;167(5):1398-1414.e24

Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163144
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http://dx.doi.org/10.1016/j.cell.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119954PMC
November 2016

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

Correlation of an epigenetic mitotic clock with cancer risk.

Genome Biol 2016 10 3;17(1):205. Epub 2016 Oct 3.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046977PMC
http://dx.doi.org/10.1186/s13059-016-1064-3DOI Listing
October 2016

The multi-omic landscape of transcription factor inactivation in cancer.

Genome Med 2016 08 25;8(1):89. Epub 2016 Aug 25.

Department of Women's Cancer, University College London, 74 Huntley Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1186/s13073-016-0342-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997779PMC
August 2016

Saturation analysis for whole-genome bisulfite sequencing data.

Nat Biotechnol 2016 07 27;34(7):691-693. Epub 2016 Jun 27.

Medical Genomics, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/nbt.3524DOI Listing
July 2016

3-methylcytosine in cancer: an underappreciated methyl lesion?

Epigenomics 2016 Apr 1;8(4):451-4. Epub 2016 Apr 1.

Department of Cancer Biology, UCL Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK.

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http://dx.doi.org/10.2217/epi.15.121DOI Listing
April 2016

Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer.

Epigenetics Chromatin 2016 8;9:10. Epub 2016 Mar 8.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 China ; Statistical Cancer Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK ; Department of Women's Cancer, University College London, 74 Huntley Street, London, WCIE 6AU UK.

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http://dx.doi.org/10.1186/s13072-016-0058-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782576PMC
March 2016

Differentiation therapy for glioblastoma - too many obstacles?

Mol Cell Oncol 2016 Mar 28;3(2):e1124174. Epub 2015 Dec 28.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh bioQuarter , 5 Little France Drive , Edinburgh EH16 4UU, UK.

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http://dx.doi.org/10.1080/23723556.2015.1124174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905420PMC
March 2016

Global hypomethylation in myeloma is associated with poor prognosis.

Br J Haematol 2016 Feb 26;172(3):473-5. Epub 2015 May 26.

Department of Haematology, University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.13506DOI Listing
February 2016

Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome.

Front Genet 2015 1;6:339. Epub 2015 Dec 1.

Unité des Interactions Bactéries-Cellules, Institut Pasteur Paris, France ; Institut National de la Santé et de la Recherche Médicale U604 Paris, France ; Institut National de la Recherche Agronomique USC2020 Paris, France ; Institut National de la Recherche Agronomique, UMR1319 MICALIS Jouy-en-Josas, France ; AgroParistech, UMR MICALIS Jouy-en-Josas, France.

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http://dx.doi.org/10.3389/fgene.2015.00339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664705PMC
December 2015

Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).

PLoS One 2015 23;10(2):e0118202. Epub 2015 Feb 23.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118202PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338296PMC
November 2015

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest.

Stem Cell Reports 2015 Nov;5(5):829-842

Department of Cancer Biology, UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Samantha Dickson Brain Cancer Unit, University College London, London WC1E 6BT, UK; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649264PMC
November 2015

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.

Clin Epigenetics 2015 8;7:109. Epub 2015 Oct 8.

Molecular Oncology Unit, CIEMAT (ed70A), Av Complutense 40, 28040 Madrid, Spain ; Biomedical Research Institute I+12, University Hospital "12 de Octubre", Av Córdoba s/n., 28041 Madrid, Spain.

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http://dx.doi.org/10.1186/s13148-015-0141-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599691PMC
October 2015

Erratum to: Brave new epigenomes: the dawn of epigenetic engineering.

Genome Med 2015 5;7(1):75. Epub 2015 Aug 5.

Medical Genomics, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK.

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http://dx.doi.org/10.1186/s13073-015-0194-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525747PMC
August 2015

Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours.

Endocr Relat Cancer 2015 Jun 21;22(3):L13-8. Epub 2015 Apr 21.

Medical Genomics Laboratory, University College London Cancer Institute, University College London72 Huntley Street, London, WC1E 6BT, UK Medical Genomics Laboratory, University College London Cancer Institute, University College London72 Huntley Street, London, WC1E 6BT, UK

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http://dx.doi.org/10.1530/ERC-15-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496774PMC
June 2015

Brave new epigenomes: the dawn of epigenetic engineering.

Genome Med 2015 19;7(1):59. Epub 2015 Jun 19.

Medical Genomics, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT UK.

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http://dx.doi.org/10.1186/s13073-015-0185-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472160PMC
June 2015

Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer.

Clin Cancer Res 2015 Mar 23;21(5):1196-206. Epub 2014 Dec 23.

UCL Cancer Institute, University College London, London, United Kingdom. Division of Surgery and Interventional Science, UCL Medical School, University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351916PMC
March 2015

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

PLoS Genet 2015 Feb 18;11(2):e1004996. Epub 2015 Feb 18.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, Shanghai, China; Statistical Genomics Group, UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334892PMC
February 2015

oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips.

Methods 2015 Jan 28;72:9-15. Epub 2014 Aug 28.

Department of Cancer Biology, UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304834PMC
January 2015

Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data.

Methods 2015 Jan 16;72:3-8. Epub 2014 Sep 16.

UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.ymeth.2014.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304832PMC
January 2015

Probe Lasso: a novel method to rope in differentially methylated regions with 450K DNA methylation data.

Methods 2015 Jan 24;72:21-8. Epub 2014 Nov 24.

UCL Cancer Institute, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.ymeth.2014.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304833PMC
January 2015

Epigenetic noise fuels cancer evolution.

Cancer Cell 2014 Dec;26(6):775-776

UCL Cancer Institute, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.003DOI Listing
December 2014

Functional importance of avian seed dispersers changes in response to human-induced forest edges in tropical seed-dispersal networks.

Oecologia 2014 Nov 3;176(3):837-48. Epub 2014 Sep 3.

Institute of Biology/Geobotany and Botanical Garden, Martin Luther University Halle-Wittenberg, Am Kirchtor 1, 06108, Halle (Saale), Germany,

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http://dx.doi.org/10.1007/s00442-014-3056-xDOI Listing
November 2014

Advances in epigenome-wide association studies for common diseases.

Trends Mol Med 2014 Oct 1;20(10):541-3. Epub 2014 Aug 1.

UCL Cancer Institute, University College London, London, WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186777PMC
October 2014

Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis.

Inflamm Bowel Dis 2014 Oct;20(10):1802-12

*Centre for Molecular Medicine, Division of Medicine, University College London, London, United Kingdom; †Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; ‡Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom; §Division of Bioscience, University College London, London, United Kingdom; ‖Research Pathology and Advanced Diagnostics, UCL Cancer Institute, University College London, London, United Kingdom; and ¶Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531309PMC
October 2014

Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases.

Genome Med 2014 5;6(3):19. Epub 2014 Mar 5.

Medical Genomics, UCL Cancer Institute, University College London, London, UK ; Current address: Department of Twin Research & Genetic Epidemiology, St Thomas' Hospital, King's College London, London, UK.

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http://dx.doi.org/10.1186/gm536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062055PMC
August 2014

The dynamics of DNA methylation covariation patterns in carcinogenesis.

PLoS Comput Biol 2014 Jul 10;10(7):e1003709. Epub 2014 Jul 10.

Key Laboratory of Systems Biology, SIBS-Nordisk Translational Research Centre for PreDiabetes, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1371/journal.pcbi.1003709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091688PMC
July 2014

Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.

PLoS Genet 2014 Jun 5;10(6):e1004417. Epub 2014 Jun 5.

Basel Institute for Immunology, Basel, Switzerland; Department of Pathology, University of Cambridge, Cambridge, United Kingdom; Pirbright Institute (formerly Institute for Animal Health), Compton, United Kingdom; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046983PMC
June 2014

C2c: turning cancer into chronic disease.

Genome Med 2014 28;6(5):38. Epub 2014 May 28.

Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer Studies, Kings College London, Guy's Medical School Campus, London SE1 1UL, UK ; Department of Molecular Oncology, UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6BT, UK ; Breakthrough Breast Cancer Research Unit, Department of Research Oncology, Guy's Hospital King's College London School of Medicine, London SE1 9RT, UK.

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http://dx.doi.org/10.1186/gm555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062053PMC
June 2014

Functional interpretation of non-coding sequence variation: concepts and challenges.

Bioessays 2014 Feb 5;36(2):191-9. Epub 2013 Dec 5.

UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/bies.201300126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992842PMC
February 2014

ChAMP: 450k Chip Analysis Methylation Pipeline.

Bioinformatics 2014 Feb 12;30(3):428-30. Epub 2013 Dec 12.

Medical Genomics, and Statistical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Shanghai 200031, China and Institute of Environmental Medicine, Karolinska Instytutet, 17177 Stockholm, Sweden.

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http://www.ideal-ageing.eu/uploads/publicaties/2014_morris_b
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http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
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http://dx.doi.org/10.1093/bioinformatics/btt684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904520PMC
February 2014

Human-specific CpG 'beacons' identify human-specific prefrontal cortex H3K4me3 chromatin peaks.

Epigenomics 2014 Feb;6(1):21-31

Medical Genomics, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.2217/epi.13.74DOI Listing
February 2014