Stephan A Grupp

Stephan A Grupp

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Stephan A Grupp

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Biol Blood Marrow Transplant 2019 Jun 23;25(6):e211-e212. Epub 2019 Mar 23.

The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.03.019DOI Listing
June 2019

Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

CPT Pharmacometrics Syst Pharmacol 2019 May 7;8(5):285-295. Epub 2019 Mar 7.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/psp4.12388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539725PMC
May 2019

Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.

Cancer Discov 2019 Apr 10;9(4):492-499. Epub 2019 Jan 10.

Division of Oncology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676489PMC
April 2019

CD3/CD19 Depleted Matched and Mismatched Unrelated Donor Hematopoietic Stem Cell Transplant with Targeted T Cell Addback Is Associated with Excellent Outcomes in Pediatric Patients with Nonmalignant Hematologic Disorders.

Biol Blood Marrow Transplant 2019 03 9;25(3):549-555. Epub 2018 Oct 9.

Cellular Therapy and Transplant Section, Division of Oncology Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183061
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http://dx.doi.org/10.1016/j.bbmt.2018.10.003DOI Listing
March 2019

Tisagenlecleucel for the treatment of B-cell acute lymphoblastic leukemia.

Expert Rev Anticancer Ther 2018 10;18(10):959-971

a Divisions of Pediatric Hematology and Oncology , Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine , Philadelphia , PA , USA.

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https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1
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http://dx.doi.org/10.1080/14737140.2018.1512411DOI Listing
October 2018

CAR-T in the clinic: drive with care.

Gene Ther 2018 06 1;25(3):157-161. Epub 2018 Jul 1.

Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41434-018-0023-x
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http://dx.doi.org/10.1038/s41434-018-0023-xDOI Listing
June 2018

Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL'.

Nat Rev Clin Oncol 2018 04 13;15(4):218. Epub 2018 Feb 13.

Department of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/nrclinonc.2018.19DOI Listing
April 2018

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel.

J Hematol Oncol 2018 03 2;11(1):35. Epub 2018 Mar 2.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/s13045-018-0571-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833070PMC
March 2018

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

N Engl J Med 2018 02;378(5):439-448

From the Departments of Pediatrics (S.L.M., S.A.G.) and Pathology and Laboratory Medicine (C.H.J., B.L.L.), Perelman School of Medicine, and Abramson Cancer Center (C.H.J., B.L.L.), University of Pennsylvania, and the Division of Oncology, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia; the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Health, Dallas (T.W.L.); the Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo (J.B.); the Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu Barcelona, Barcelona (S.R.); the Department of Pediatrics and Internal Medicine, University of Utah, Salt Lake City (M.B.); the Department of Pediatrics, Faculty of Medicine, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montreal (H.B.), and the Division of Haematology/Oncology/Bone Marrow Transplantation, Hospital for Sick Children, Toronto (J.K.) - all in Canada; the Division of Stem Cell Transplantation and Immunology, Hospital for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany (P.B.); the Division of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis (M.R.V., H.E.S.); Children's Mercy Hospital and Clinics, Kansas City, MO (G.D.M.); Aflac Cancer and Blood Disorders Center, Emory University, Atlanta (M.Q.); the Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Ghent, Belgium (B.D.M.); the Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan (H.H.); the Department of Pediatrics, Stanford University School of Medicine, Stanford (K. Schlis, K.L.D.), and the Division of Hematology, Oncology, Blood and Marrow Transplant, Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles (M.A.P.) - all in California; the Division of Pediatric Blood and Marrow Transplant, Duke University Medical Center, Durham, NC (P.L.M.); Oregon Health and Science University, Portland (E.R.N.); C.S. Mott Children's Hospital, Ann Arbor, MI (G.A.Y.); the Stem Cell Transplantation Unit, St. Anna Children's Hospital, Vienna (C.P.); University Hospital Robert Debré and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris; the Royal Children's Hospital, Melbourne, VIC, Australia (F.M.); Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy (A. Balduzzi); and Novartis Pharmaceuticals (P.W., T.T., M.L., Y.Z., K. Sen, D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover, NJ.

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http://dx.doi.org/10.1056/NEJMoa1709866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996391PMC
February 2018

High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model.

Cancer Immunol Res 2018 01 27;6(1):36-46. Epub 2017 Nov 27.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004321PMC
January 2018

Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome with multiorgan failure.

Int J Hematol Oncol 2017 Nov 11;6(3):75-93. Epub 2017 Aug 11.

Department of Pediatric Hematology, Oncology & Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.

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https://www.futuremedicine.com/doi/10.2217/ijh-2017-0015
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http://dx.doi.org/10.2217/ijh-2017-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171967PMC
November 2017

Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function.

Cytotherapy 2017 07 11;19(7):867-880. Epub 2017 May 11.

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jcyt.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676485PMC
July 2017

IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life.

Eur J Immunol 2017 05 11;47(5):892-899. Epub 2017 Apr 11.

Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/eji.201646806DOI Listing
May 2017

Refining megatherapy, improving outcome in neuroblastoma.

Lancet Oncol 2017 04 2;18(4):423-424. Epub 2017 Mar 2.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30069-4DOI Listing
April 2017

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

Crit Care Med 2017 Feb;45(2):e124-e131

1Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 2Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 3Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 4Department of Biostatistics and Epidemiology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452983PMC
February 2017

Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma.

Am J Hematol 2017 Jan 21;92(1):E11-E13. Epub 2016 Nov 21.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Pennsylvania.

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http://doi.wiley.com/10.1002/ajh.24594
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http://dx.doi.org/10.1002/ajh.24594DOI Listing
January 2017

Cytokine Release Syndrome after Haploidentical Stem Cell Transplantation.

Biol Blood Marrow Transplant 2016 10 16;22(10):1736-1737. Epub 2016 Aug 16.

Division of Oncology, The Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.08.010DOI Listing
October 2016

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy.

J Immunol Methods 2016 07 3;434:1-8. Epub 2016 Apr 3.

University of Pennsylvania, Department of Pathology and Laboratory Medicine, Product Development & Correlative Sciences Laboratory, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490247PMC
July 2016

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Cancer Discov 2016 06 13;6(6):664-79. Epub 2016 Apr 13.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448406PMC
June 2016

CAR T Cell Therapy in Acute Lymphoblastic Leukemia and Potential for Chronic Lymphocytic Leukemia.

Curr Treat Options Oncol 2016 06;17(6):28

Division of Oncology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, 3012 CTRB, 3501 Civic Center Blvd., Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11864-016-0406-4DOI Listing
June 2016

Corrigendum to "Advances in T-cell therapy for ALL" [Best Pract Res Clin Haematol 27 (2014) 222-228].

Authors:
Stephan A Grupp

Best Pract Res Clin Haematol 2016 03 16;29(1):133. Epub 2016 Jul 16.

Perelman School of Medicine, University of Pennsylvania, USA; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.07.001DOI Listing
March 2016

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial.

Blood 2016 Jan 26;127(1):17-28. Epub 2015 Oct 26.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2015-07-657981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705607PMC
January 2016

Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies.

Sci Transl Med 2016 Jan;8(320):320ra3

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad5222DOI Listing
January 2016

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Cancer Discov 2015 Dec 29;5(12):1282-95. Epub 2015 Oct 29.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Cell & Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670800PMC
December 2015

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.

J Immunol 2015 Aug;195(3):755-61

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

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http://dx.doi.org/10.4049/jimmunol.1500751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507286PMC
August 2015

T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.

Oncoimmunology 2016;5(1):e1040216. Epub 2015 Aug 12.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1040216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760344PMC
August 2015

Advances in T-cell therapy for ALL.

Authors:
Stephan A Grupp

Best Pract Res Clin Haematol 2014 Sep-Dec;27(3-4):222-8. Epub 2014 Oct 27.

Perelman School of Medicine, University of Pennsylvania, USA; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2014.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277205PMC
July 2015

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia.

Blood 2015 Jun 21;125(26):4017-23. Epub 2015 May 21.

Division of Oncology, The Children's Hospital of Philadelphia, Department of Pediatrics, Department of Pathology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2014-12-580068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481592PMC
June 2015

IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients.

Blood 2015 May 10;125(22):3501-8. Epub 2015 Apr 10.

Division of Oncology, Children's Hospital of Philadelphia, and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Pathology, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-615757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447864PMC
May 2015

Will post-transplantation cell therapies for pediatric patients become standard of care?

Biol Blood Marrow Transplant 2015 Mar 23;21(3):402-11. Epub 2014 Jul 23.

Departments of Pediatrics and Microbiology, Immunology and Tropical Medicine, Children's National Health System and George Washington University, Division of Pediatric Hematology-Oncology, Washington, DC.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791140044
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http://dx.doi.org/10.1016/j.bbmt.2014.07.018DOI Listing
March 2015

Chimeric antigen receptor T-cell therapy for ALL.

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):559-64. Epub 2014 Nov 18.

Division of Oncology and Department of Pathology, The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/asheducation-2014.1.559DOI Listing
December 2014

Roadblocks to success for RNA CARs in solid tumors.

Oncoimmunology 2014 Dec 7;3(12):e962974. Epub 2015 Jan 7.

Division of Oncology; Children's Hospital of Philadelphia ; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/21624011.2014.962974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353174PMC
December 2014

Managing cytokine release syndrome associated with novel T cell-engaging therapies.

Cancer J 2014 Mar-Apr;20(2):119-22

From the *Division of Pediatric Oncology, and †Department of Pathology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119809PMC
November 2014

Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma.

Cancer Immunol Res 2014 Nov 7;2(11):1059-70. Epub 2014 Aug 7.

Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584373PMC
November 2014

Chimeric antigen receptor T cells for sustained remissions in leukemia.

N Engl J Med 2014 Oct;371(16):1507-17

From the Division of Oncology, Children's Hospital of Philadelphia (S.L.M., R.A., D.M.B., N.J.B., S.R.R., D.T.T., S.A.G.), the Departments of Pediatrics (S.L.M., R.A., D.M.B., N.J.B., S.R.R., D.T.T., S.A.G.), Biostatistics and Epidemiology (P.A.S., R.A.), and Pathology and Laboratory Medicine (J.J.M., B.L.L., C.H.J., S.A.G.), the Division of Hematology-Oncology (N.F., D.L.P.), and Abramson Cancer Center (N.F., A.C., V.E.G., Z.Z., S.F.L., Y.D.M., J.J.M., B.L.L., C.H.J., D.L.P., S.A.G.), Perelman School of Medicine, University of Pennsylvania - all in Philadelphia; and Novartis Pharmaceuticals, East Hanover, NJ (A.S.).

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http://dx.doi.org/10.1056/NEJMoa1407222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531PMC
October 2014

Chimeric antigen receptor therapy for cancer.

Annu Rev Med 2014 20;65:333-47. Epub 2013 Nov 20.

Abramson Cancer Center and the Departments of Medicine, Pediatrics, and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:

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http://dx.doi.org/10.1146/annurev-med-060512-150254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120077PMC
September 2014

Engineered T cells for cancer therapy.

Cancer Immunol Immunother 2014 Sep 19;63(9):969-75. Epub 2014 Jun 19.

Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, 8th Floor, Philadelphia, PA, 19104-5156, USA,

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http://dx.doi.org/10.1007/s00262-014-1568-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142345PMC
September 2014

Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy.

Cytotherapy 2014 May 16;16(5):619-30. Epub 2014 Jan 16.

Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jcyt.2013.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988256PMC
May 2014

Toxicity management for patients receiving novel T-cell engaging therapies.

Curr Opin Pediatr 2014 Feb;26(1):43-9

Division of Pediatric Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOP.0000000000000043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198063PMC
February 2014

Children's Oncology Group's 2013 blueprint for research: stem cell transplantation.

Pediatr Blood Cancer 2013 06 19;60(6):1044-7. Epub 2012 Dec 19.

Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1002/pbc.24437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064788PMC
June 2013

Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantation.

Biol Blood Marrow Transplant 2013 Apr 21;19(4):569-75. Epub 2012 Dec 21.

Division of Blood and Marrow Transplantation and Cellular Therapies, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231793PMC
April 2013

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

N Engl J Med 2013 Apr 25;368(16):1509-1518. Epub 2013 Mar 25.

Children's Hospital of Philadelphia (S.A.G., D.B., R.A., S.R.R., D.T.T., B.H., J.F.W.); the Department of Pediatrics (S.A.G., D.B., R.A., S.R.R., D.T.T.), Abramson Cancer Center (S.A.G., M.K., R.A., D.L.P., S.R.R., D.T.T., M.C.M., B.L.L., C.H.J.); and the Departments of Pathology and Laboratory Medicine (M.K., A.C., B.H., J.F.W., M.C.M., B.L.L., C.H.J.) and Medicine (D.L.P.), University of Pennsylvania - all in Philadelphia.

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http://dx.doi.org/10.1056/NEJMoa1215134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058440PMC
April 2013

Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies.

Paediatr Drugs 2012 Oct;14(5):299-316

Department of Pediatrics, Division of Oncology, Childrens Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2165/11594740-000000000-00000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214862PMC
October 2012

The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer.

Clin Cancer Res 2012 05;18(10):2780-90

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1104, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-1920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119811PMC
May 2012

Neuroblastoma: issues in transplantation.

Biol Blood Marrow Transplant 2012 Jan;18(1 Suppl):S92-100

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.bbmt.2011.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260463PMC
January 2012

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031.

Biol Blood Marrow Transplant 2011 Dec 25;17(12):1804-13. Epub 2011 May 25.

Children's Oncology Group, Pediatric Hematology/Oncology/Bone Marrow Transplantation, British Columbia Children's Hospital/University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2011.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190042PMC
December 2011

Treatment of advanced leukemia in mice with mRNA engineered T cells.

Hum Gene Ther 2011 Dec 23;22(12):1575-86. Epub 2011 Sep 23.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1089/hum.2011.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237694PMC
December 2011

Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling.

Blood 2011 Oct 19;118(15):e112-7. Epub 2011 Aug 19.

Department of Pediatrics, Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-04-34
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http://dx.doi.org/10.1182/blood-2011-04-346528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204743PMC
October 2011

Adoptive cellular therapy.

Curr Top Microbiol Immunol 2011 ;344:149-72

Division of Oncology and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/82_2010_94DOI Listing
June 2011

Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.

J Immunol 2010 Dec 12;185(12):7151-5. Epub 2010 Nov 12.

Abramson Family Cancer Research Institute, Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1003193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997140PMC
December 2010

Autologous and allogeneic cellular therapies for high-risk pediatric solid tumors.

Pediatr Clin North Am 2010 Feb;57(1):47-66

Division of Oncology, Children's Hospital of Philadelphia, 3006 Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.pcl.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257217PMC
February 2010