Stepan Gambaryan

Stepan Gambaryan

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Stepan Gambaryan

Publications by authors named "Stepan Gambaryan"

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The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbα-Mediated Platelet Aggregation.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1055/s-0039-1685139DOI Listing
April 2019

Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets.

Thromb Res 2018 11 13;171:22-30. Epub 2018 Sep 13.

Interdisciplinary Bank of Biomaterials and Data, Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2018.09.047DOI Listing
November 2018

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets.

Nitric Oxide 2018 06 14;76:71-80. Epub 2018 Mar 14.

University Medical Center Mainz, Center for Thrombosis and Hemostasis (CTH), Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2018.03.008DOI Listing
June 2018

Hypoxia inhibits the regulatory volume decrease in red blood cells of common frog (Rana temporaria).

Comp Biochem Physiol A Mol Integr Physiol 2018 05 1;219-220:44-47. Epub 2018 Mar 1.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Toreza, 21, 194223 St. Petersburg, Russia.

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https://linkinghub.elsevier.com/retrieve/pii/S10956433183003
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http://dx.doi.org/10.1016/j.cbpa.2018.02.016DOI Listing
May 2018

Hypoxia impairs agonist-induced integrin αβ activation and platelet aggregation.

Sci Rep 2017 08 8;7(1):7621. Epub 2017 Aug 8.

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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http://www.nature.com/articles/s41598-017-07988-x
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http://dx.doi.org/10.1038/s41598-017-07988-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548784PMC
August 2017

Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis.

Cell Death Dis 2017 06 29;8(6):e2898. Epub 2017 Jun 29.

Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/cddis.2017.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520940PMC
June 2017

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

Thromb Haemost 2017 02 12;117(3):556-569. Epub 2017 Jan 12.

Kerstin Jurk, Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany, Tel.: +49 6131 178278, Fax: +49 6131 176238, E-mail:

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http://dx.doi.org/10.1160/TH16-07-0515DOI Listing
February 2017

Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets.

Cell Commun Signal 2016 09 13;14(1):21. Epub 2016 Sep 13.

Centre for Experimental Medicine, Medical Biology Center (MBC) building, Queen's University of Belfast, Third floor, 97 Lisburn Road, BT9 7BL, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1186/s12964-016-0144-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020514PMC
September 2016

Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets.

Amino Acids 2016 07 29;48(7):1695-706. Epub 2016 Apr 29.

Centre of Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00726-016-2234-zDOI Listing
July 2016

Human blood platelets lack nitric oxide synthase activity.

Platelets 2015 31;26(6):583-8. Epub 2014 Oct 31.

Hannover Medical School, Institute of Clinical Pharmacology , Hannover , Germany .

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http://dx.doi.org/10.3109/09537104.2014.974024DOI Listing
May 2016

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

J Biol Chem 2015 Dec 27;290(50):29974-83. Epub 2015 Oct 27.

From the UCD Conway Institute and the School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland,

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http://dx.doi.org/10.1074/jbc.M115.678003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705978PMC
December 2015

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from L-arginine or nitrite?

Amino Acids 2015 Sep 1;47(9):1779-93. Epub 2015 May 1.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez Prosp, St. Petersburg, 194223, Russia,

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http://dx.doi.org/10.1007/s00726-015-1986-1DOI Listing
September 2015

A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling.

Mol Biosyst 2014 Aug;10(8):2082-9

Department of Bioinformatics, Biocenter, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1039/c4mb00170bDOI Listing
August 2014

[Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 28;965:173-82. Epub 2014 Jun 28.

Institute of Clinical Pharmacology, Hannover Medical School, 30623 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2014.06.025DOI Listing
August 2014

What can proteomics tell us about platelets?

Circ Res 2014 Mar;114(7):1204-19

From the Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (J.M.B., A.S., R.P.Z); Institut für Klinische Biochemie und Pathobiochemie, Universitätsklinikum Würzburg, Würzburg, Germany (S.G.); Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia (S.G.); Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (S.P.W.); Center for Thrombosis and Hemostasis, Universitätsklinikum der Johannes Gutenberg-Universität Mainz, Mainz, Germany (K.J., U.W.); Medizinisches Proteom Center, Ruhr Universität Bochum, Bochum, Germany (A.S.); Department of Chemistry, College of Physical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom (A.S.); and Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands (J.W.M.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.301598DOI Listing
March 2014

Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.

Br J Pharmacol 2013 Sep;170(2):317-27

Institute of Physiology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/bph.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834756PMC
September 2013

Immune escape of AKT overexpressing ovarian cancer cells.

Int J Oncol 2013 May 4;42(5):1630-5. Epub 2013 Mar 4.

Department of Gynecology, University Hospital of Würzburg, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.3892/ijo.2013.1846DOI Listing
May 2013

Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay.

Transfus Med Hemother 2013 Apr 15;40(2):109-16. Epub 2013 Mar 15.

Institute for Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Germany.

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http://dx.doi.org/10.1159/000350294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638993PMC
April 2013

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Exp Hematol 2013 Jan 11;41(1):91-101.e4. Epub 2012 Sep 11.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.exphem.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638753PMC
January 2013

The Thr715Pro variant impairs terminal glycosylation of P-selectin.

Thromb Haemost 2012 Nov 26;108(5):963-72. Epub 2012 Sep 26.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1160/TH12-01-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176910PMC
November 2012

Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and L-arginine uptake.

Am J Physiol Regul Integr Comp Physiol 2012 Nov 26;303(10):R1042-52. Epub 2012 Sep 26.

I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia.

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http://dx.doi.org/10.1152/ajpregu.00045.2012DOI Listing
November 2012

The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells.

Br J Pharmacol 2012 Oct;167(4):826-38

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1111/j.1476-5381.2012.02044.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575782PMC
October 2012

The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets.

Thromb Haemost 2012 Mar 11;107(3):521-9. Epub 2012 Jan 11.

Institut fuer Klinische Biochemie und Pathobiochemie-Zentrallabor, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1160/TH11-07-0461DOI Listing
March 2012

Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways.

Thromb Haemost 2011 Dec 10;106(6):1127-38. Epub 2011 Nov 10.

Institute of Clinical Biochemistry and Pathobiochemistry /Central Laboratory, University of Wuerzburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH11-07-0491
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http://dx.doi.org/10.1160/TH11-07-0491DOI Listing
December 2011

cGMP and cGMP-dependent protein kinase in platelets and blood cells.

Handb Exp Pharmacol 2009 (191):533-48

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef-Schneider-Str. 2, Wuerzburg, 97080, Germany.

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http://dx.doi.org/10.1007/978-3-540-68964-5_23DOI Listing
March 2009

Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizes.

Br J Haematol 2009 Feb 20;144(4):591-602. Epub 2008 Nov 20.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07506.xDOI Listing
February 2009

Phosphoproteome of resting human platelets.

J Proteome Res 2008 Feb 19;7(2):526-34. Epub 2007 Dec 19.

Rudolf Virchow Center/DFG Research Center for Experimental Biomedicine, University of Würzburg, Protein Mass Spectrometry and Functional Proteomics Group, Würzburg, D-97078 Germany.

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http://dx.doi.org/10.1021/pr0704130DOI Listing
February 2008

Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.

J Cell Biochem 2007 Oct;102(2):368-76

Department of Anaesthesiology, University of Würzburg, Center of Operative Medicine, Würzburg, Germany.

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http://dx.doi.org/10.1002/jcb.21294DOI Listing
October 2007

Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS.

Blood Cells Mol Dis 2006 Mar-Apr;36(2):166-70. Epub 2006 Feb 15.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, 97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.bcmd.2005.12.028DOI Listing
September 2007

Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway.

Am J Physiol Regul Integr Comp Physiol 2007 Jul 15;293(1):R528-37. Epub 2007 Mar 15.

Laboratory of Renal Physiology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, M. Torez Avenue 44, 194223 St. Petersburg, Russia.

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http://dx.doi.org/10.1152/ajpregu.00811.2006DOI Listing
July 2007

Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor.

J Biol Chem 2007 May 28;282(18):13656-63. Epub 2007 Feb 28.

Institute of Biochemistry II, University of Frankfurt Medical School, 60590 Frankfurt, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M610942200
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http://dx.doi.org/10.1074/jbc.M610942200DOI Listing
May 2007

Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase.

Blood 2007 Jan 21;109(2):616-8. Epub 2006 Sep 21.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Germany.

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http://dx.doi.org/10.1182/blood-2006-07-038158DOI Listing
January 2007

Phosphoproteomics of human platelets: A quest for novel activation pathways.

Biochim Biophys Acta 2006 Dec 7;1764(12):1963-76. Epub 2006 Sep 7.

Protein Mass Spectrometry and Functional Proteomics Group, Rudolf-Virchow-Center for Experimental Biomedicine, University of Wuerzburg, Versbacher Str. 9, 97078 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2006.08.017DOI Listing
December 2006

L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats.

Nephron Physiol 2005 30;101(3):p39-50. Epub 2005 Jun 30.

Division of Nephrology, Department of Medicine, Julius Maximilian University, Würzburg, Germany.

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http://dx.doi.org/10.1159/000086647DOI Listing
May 2006

Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.

Am J Physiol Endocrinol Metab 2006 Mar 11;290(3):E423-33. Epub 2005 Oct 11.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Wurzburg, Germany.

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http://dx.doi.org/10.1152/ajpendo.00128.2005DOI Listing
March 2006

Fluorescent sensors for rapid monitoring of intracellular cGMP.

Nat Methods 2006 Jan;3(1):23-5

Institute of Pharmacology and Toxicology, Versbacher Str. 9, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1038/nmeth816DOI Listing
January 2006

Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway.

Blood 2005 Oct 23;106(8):2757-60. Epub 2005 Jun 23.

Institut für Klinische Biochemie & Pathobiochemie, Josef Schneider Str 2, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1182/blood-2005-03-1047DOI Listing
October 2005

Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis.

J Biol Chem 2005 Jan 22;280(3):1716-9. Epub 2004 Nov 22.

Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.C400505200DOI Listing
January 2005

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.

Biochem Biophys Res Commun 2004 Nov;324(1):308-16

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.235DOI Listing
November 2004

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase.

Blood 2004 Apr 26;103(7):2593-600. Epub 2003 Nov 26.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Germany.

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http://dx.doi.org/10.1182/blood-2003-09-3349DOI Listing
April 2004

cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.

J Biol Chem 2003 Aug 29;278(32):29640-8. Epub 2003 May 29.

Institute of Clinical Biochemistry and Pathobiochemistry Medical University Clinic Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M302143200DOI Listing
August 2003

Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.

J Biol Chem 2003 May 5;278(18):15601-7. Epub 2003 Feb 5.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M209009200DOI Listing
May 2003

Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor.

J Biol Chem 2003 May 11;278(20):17963-8. Epub 2003 Mar 11.

Institute of Pharmacology and Toxicology, Universitätsklinikum Münster, D-48149 Münster, Germany.

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http://dx.doi.org/10.1074/jbc.M213113200DOI Listing
May 2003

Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.

J Biol Chem 2003 Mar 2;278(11):9778-83. Epub 2003 Jan 2.

Department of Medicine, University of Wuerzburg, D-97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M212507200DOI Listing
March 2003

Inhibition of cGMP-dependent protein kinase II by its own splice isoform.

Biochem Biophys Res Commun 2002 May;293(5):1438-44

Institute of Clinical Biochemistry and Pathobiochemistry, Medical University Clinic, Josef Schneider Strasse 2, Wuerzburg D-97080, Germany.

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http://dx.doi.org/10.1016/S0006-291X(02)00412-6DOI Listing
May 2002

Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice.

Cardiovasc Res 2002 Mar;53(4):852-61

Institute of Pharmacology and Toxicology, University of Münster, Domagkstrasse 12, D-48129 Münster, Germany.

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http://dx.doi.org/10.1016/s0008-6363(01)00543-0DOI Listing
March 2002

Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.

Hypertension 2002 Jan;39(1):87-92

Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Hannover, Germany.

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January 2002

Microdissectional investigation of the nephrons in some fishes, amphibians, and reptiles inhabiting different environment.

J Morphol 1994 Mar;219(3):319-339

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia.

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http://dx.doi.org/10.1002/jmor.1052190311DOI Listing
March 1994