Publications by authors named "Sten Linnarsson"

76Publications

Srebf1 Controls Midbrain Dopaminergic Neurogenesis.

Cell Rep 2020 May;31(5):107601

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum, Solnavägen 9, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107601DOI Listing
May 2020

Spatial organization of the somatosensory cortex revealed by osmFISH.

Nat Methods 2018 11 30;15(11):932-935. Epub 2018 Oct 30.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://www.nature.com/articles/s41592-018-0175-z
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http://dx.doi.org/10.1038/s41592-018-0175-zDOI Listing
November 2018

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Authors:
Jeanne E Savage Philip R Jansen Sven Stringer Kyoko Watanabe Julien Bryois Christiaan A de Leeuw Mats Nagel Swapnil Awasthi Peter B Barr Jonathan R I Coleman Katrina L Grasby Anke R Hammerschlag Jakob A Kaminski Robert Karlsson Eva Krapohl Max Lam Marianne Nygaard Chandra A Reynolds Joey W Trampush Hannah Young Delilah Zabaneh Sara Hägg Narelle K Hansell Ida K Karlsson Sten Linnarsson Grant W Montgomery Ana B Muñoz-Manchado Erin B Quinlan Gunter Schumann Nathan G Skene Bradley T Webb Tonya White Dan E Arking Dimitrios Avramopoulos Robert M Bilder Panos Bitsios Katherine E Burdick Tyrone D Cannon Ornit Chiba-Falek Andrea Christoforou Elizabeth T Cirulli Eliza Congdon Aiden Corvin Gail Davies Ian J Deary Pamela DeRosse Dwight Dickinson Srdjan Djurovic Gary Donohoe Emily Drabant Conley Johan G Eriksson Thomas Espeseth Nelson A Freimer Stella Giakoumaki Ina Giegling Michael Gill David C Glahn Ahmad R Hariri Alex Hatzimanolis Matthew C Keller Emma Knowles Deborah Koltai Bettina Konte Jari Lahti Stephanie Le Hellard Todd Lencz David C Liewald Edythe London Astri J Lundervold Anil K Malhotra Ingrid Melle Derek Morris Anna C Need William Ollier Aarno Palotie Antony Payton Neil Pendleton Russell A Poldrack Katri Räikkönen Ivar Reinvang Panos Roussos Dan Rujescu Fred W Sabb Matthew A Scult Olav B Smeland Nikolaos Smyrnis John M Starr Vidar M Steen Nikos C Stefanis Richard E Straub Kjetil Sundet Henning Tiemeier Aristotle N Voineskos Daniel R Weinberger Elisabeth Widen Jin Yu Goncalo Abecasis Ole A Andreassen Gerome Breen Lene Christiansen Birgit Debrabant Danielle M Dick Andreas Heinz Jens Hjerling-Leffler M Arfan Ikram Kenneth S Kendler Nicholas G Martin Sarah E Medland Nancy L Pedersen Robert Plomin Tinca J C Polderman Stephan Ripke Sophie van der Sluis Patrick F Sullivan Scott I Vrieze Margaret J Wright Danielle Posthuma

Nat Genet 2018 07 25;50(7):912-919. Epub 2018 Jun 25.

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41588-018-0152-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411041PMC
July 2018

Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.

PLoS Biol 2018 06 18;16(6):e2006387. Epub 2018 Jun 18.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pbio.2006387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029811PMC
June 2018

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.

Nat Neurosci 2018 06 23;21(6):869-880. Epub 2018 Apr 23.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41593-018-0141-1DOI Listing
June 2018

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.

Mol Psychiatry 2019 02 8;24(2):182-197. Epub 2018 Mar 8.

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

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http://dx.doi.org/10.1038/s41380-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330082PMC
February 2019

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.

Nat Neurosci 2018 02 15;21(2):290-299. Epub 2018 Jan 15.

Division of Molecular Neurobiology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://www.nature.com/articles/s41593-017-0056-2
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http://dx.doi.org/10.1038/s41593-017-0056-2DOI Listing
February 2018

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing.

Science 2017 10;358(6359):64-69

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aan6827DOI Listing
October 2017

Alternative TSSs are co-regulated in single cells in the mouse brain.

Mol Syst Biol 2017 05 11;13(5):930. Epub 2017 May 11.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448164PMC
http://dx.doi.org/10.15252/msb.20167374DOI Listing
May 2017

Single-cell mRNA isoform diversity in the mouse brain.

BMC Genomics 2017 02 3;18(1):126. Epub 2017 Feb 3.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12864-017-3528-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291953PMC
February 2017

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.

Cell 2016 Oct;167(2):566-580.e19

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden; Science for Life Laboratory, 17121 Solna, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055122PMC
October 2016

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.

Cell Syst 2016 09 15;3(3):221-237.e9. Epub 2016 Sep 15.

Department of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Novum, 141 83 Huddinge, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712163026
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052454PMC
http://dx.doi.org/10.1016/j.cels.2016.08.010DOI Listing
September 2016

The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation.

Development 2016 10 30;143(19):3459-3469. Epub 2016 Aug 30.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge 141 83, Sweden Science for Life Laboratory, Tomtebodavägen 23 A, Solna 171 21, Sweden Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland

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http://dx.doi.org/10.1242/dev.134510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087614PMC
October 2016

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control.

Nat Neurosci 2016 10 29;19(10):1331-40. Epub 2016 Aug 29.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nn.4376DOI Listing
October 2016

Single-cell genomics: coming of age.

Genome Biol 2016 May 10;17:97. Epub 2016 May 10.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-016-0960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862185PMC
May 2016

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos.

Cell 2016 May 7;165(4):1012-26. Epub 2016 Apr 7.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, and Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868821PMC
May 2016

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes.

Nat Biotechnol 2016 Feb 21;34(2):175-183. Epub 2015 Dec 21.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nbt.3443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745137PMC
February 2016

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.

Stem Cell Reports 2015 Nov;5(5):843-855

Karolinska Institutet, Department of Biosciences and Nutrition and Center for Innovative Medicine, Novum, 141 83 Huddinge, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649262PMC
November 2015

NEUROSCIENCE. A tree of the human brain.

Authors:
Sten Linnarsson

Science 2015 Oct;350(6256):37

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aad2792DOI Listing
October 2015

Sequencing Single Cells Reveals Sequential Stem Cell States.

Authors:
Sten Linnarsson

Cell Stem Cell 2015 Sep;17(3):251-2

Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.016DOI Listing
September 2015

Reprogramming Roadblocks Are System Dependent.

Stem Cell Reports 2015 Sep 13;5(3):350-64. Epub 2015 Aug 13.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, Scotland. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618455PMC
September 2015

Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.

Science 2015 Mar 19;347(6226):1138-42. Epub 2015 Feb 19.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aaa1934DOI Listing
March 2015

Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine.

J Biol Chem 2015 Mar 19;290(13):8348-59. Epub 2015 Feb 19.

From the Department of Molecular Biology, Umeå University, 90187 Umeå, Sweden, the Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden, Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, 17177 Stockholm, Sweden, and

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http://dx.doi.org/10.1074/jbc.M114.618769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375488PMC
March 2015

Amplification-free sequencing of cell-free DNA for prenatal non-invasive diagnosis of chromosomal aberrations.

Genomics 2015 Mar 24;105(3):150-8. Epub 2014 Dec 24.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2014.12.005DOI Listing
March 2015

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.

Nat Neurosci 2015 Jan 24;18(1):145-53. Epub 2014 Nov 24.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nn.3881DOI Listing
January 2015

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Base preferences in non-templated nucleotide incorporation by MMLV-derived reverse transcriptases.

PLoS One 2013 31;8(12):e85270. Epub 2013 Dec 31.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877366PMC
September 2014

Quantitative single-cell RNA-seq with unique molecular identifiers.

Nat Methods 2014 Feb 22;11(2):163-6. Epub 2013 Dec 22.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nmeth.2772DOI Listing
February 2014

SAMstrt: statistical test for differential expression in single-cell transcriptome with spike-in normalization.

Bioinformatics 2013 Nov 31;29(22):2943-5. Epub 2013 Aug 31.

Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden, Science for Life Laboratory, Karolinska Institutet Science Park, 171 21 Solna, Sweden and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/bioinformatics/btt511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810855PMC
November 2013

Single-cell sequencing-based technologies will revolutionize whole-organism science.

Nat Rev Genet 2013 Sep 30;14(9):618-30. Epub 2013 Jul 30.

1] Department of Computer Science and Applied Math, Weizmann Institute of Science, Rehovot 76100, Israel. [2] Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1038/nrg3542DOI Listing
September 2013

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.

Nature 2013 Jul 2;499(7456):88-91. Epub 2013 Jun 2.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK.

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http://dx.doi.org/10.1038/nature12243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743022PMC
July 2013

Single-cell biology meeting marks rebirth of an old science.

Authors:
Sten Linnarsson

Genome Biol 2013 Apr 19;14(4):305. Epub 2013 Apr 19.

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http://dx.doi.org/10.1186/gb-2013-14-4-305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663110PMC
April 2013

Highly multiplexed and strand-specific single-cell RNA 5' end sequencing.

Nat Protoc 2012 Apr 5;7(5):813-28. Epub 2012 Apr 5.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nprot.2012.022DOI Listing
April 2012

Magnetic sequencing.

Authors:
Sten Linnarsson

Nat Methods 2012 Mar 27;9(4):339, 341. Epub 2012 Mar 27.

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http://www.nature.com/articles/nmeth.1934
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http://dx.doi.org/10.1038/nmeth.1934DOI Listing
March 2012

Counting absolute numbers of molecules using unique molecular identifiers.

Nat Methods 2011 Nov 20;9(1):72-4. Epub 2011 Nov 20.

Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/nmeth.1778DOI Listing
November 2011

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq.

Genome Res 2011 Jul 4;21(7):1160-7. Epub 2011 May 4.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1101/gr.110882.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129258PMC
July 2011

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons.

Proc Natl Acad Sci U S A 2010 Sep 24;107(37):16336-41. Epub 2010 Aug 24.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0914705107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941336PMC
September 2010

Recent advances in DNA sequencing methods - general principles of sample preparation.

Authors:
Sten Linnarsson

Exp Cell Res 2010 May 6;316(8):1339-43. Epub 2010 Mar 6.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.yexcr.2010.02.036DOI Listing
May 2010

Rapid genome sequencing with short universal tiling probes.

Nat Biotechnol 2008 Jun 25;26(6):676-84. Epub 2008 May 25.

Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 1, SE-171 77 Stockholm, Sweden.

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http://www.nature.com/articles/nbt1405
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http://dx.doi.org/10.1038/nbt1405DOI Listing
June 2008