Publications Authored by Steffan D Bos

No differential gene expression for CD4 T cells of MS patients and healthy controls.

Authors:

Ina S Brorson Anna Eriksson Ingvild S Leikfoss Elisabeth G Celius Pål Berg-Hansen Lisa F Barcellos Tone Berge Hanne F Harbo Steffan D Bos

Mult Scler J Exp Transl Clin 2019 Apr-Jun;5(2):2055217319856903. Epub 2019 Jun 13.

Institute of Clinical Medicine, University of Oslo, Norway.

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http://dx.doi.org/10.1177/2055217319856903	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566490	PMC

June 2019

Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients.

Authors:

Brooke Rhead Ina S Brorson Tone Berge Cameron Adams Hong Quach Stine Marit Moen Pål Berg-Hansen Elisabeth Gulowsen Celius Dipen P Sangurdekar Paola G Bronson Rodney A Lea Sean Burnard Vicki E Maltby Rodney J Scott Jeannette Lechner-Scott Hanne F Harbo Steffan D Bos Lisa F Barcellos

PLoS One 2018 31;13(10):e0206511. Epub 2018 Oct 31.

Computational Biology Graduate Group, University of California, Berkeley, Berkeley, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206511	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209300	PMC

April 2019

Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.

Authors:

Yunpeng Wang Steffan D Bos Hanne F Harbo Wesley K Thompson Andrew J Schork Francesco Bettella Aree Witoelar Benedicte A Lie Wen Li Linda K McEvoy Srdjan Djurovic Rahul S Desikan Anders M Dale Ole A Andreassen

Mult Scler 2016 12 26;22(14):1783-1793. Epub 2016 Feb 26.

NORMENT, K.G. Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway/Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway/Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1352458516635873	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001937	PMC

December 2016

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies.

Neurol Genet 2016 Aug 4;2(4):e87. Epub 2016 Aug 4.

Author affiliations are listed at the end of the article.

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http://dx.doi.org/10.1212/NXG.0000000000000087	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974846	PMC

August 2016

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.

Authors:

Ingvild S Leikfoss Pankaj K Keshari Marte W Gustavsen Anja Bjølgerud Ina S Brorson Elisabeth G Celius Anne Spurkland Steffan D Bos Hanne F Harbo Tone Berge

PLoS One 2015 23;10(7):e0132957. Epub 2015 Jul 23.

Department of Neurology, Oslo University Hospital, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132957	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512731	PMC

May 2016

Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood.

Authors:

Pankaj K Keshari Hanne F Harbo Kjell-Morten Myhr Jan H Aarseth Steffan D Bos Tone Berge

BMC Genet 2016 Apr 14;17:59. Epub 2016 Apr 14.

Department of Neurology, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1186/s12863-016-0367-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832550	PMC

April 2016

Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.

Authors:

Steffan D Bos Christian M Page Bettina K Andreassen Emon Elboudwarej Marte W Gustavsen Farren Briggs Hong Quach Ingvild S Leikfoss Anja Bjølgerud Tone Berge Hanne F Harbo Lisa F Barcellos

PLoS One 2015 3;10(3):e0117403. Epub 2015 Mar 3.

Genetic Epidemiology and Genomics Laboratory, Division of Epidemiology, School of Public Health, University of California, Berkeley, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117403	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348521	PMC

January 2016

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

Authors:

Yolande F M Ramos Wouter den Hollander Judith V M G Bovée Nils Bomer Ruud van der Breggen Nico Lakenberg J Christiaan Keurentjes Jelle J Goeman P Eline Slagboom Rob G H H Nelissen Steffan D Bos Ingrid Meulenbelt

PLoS One 2014 23;9(7):e103056. Epub 2014 Jul 23.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; The Netherlands Genomics Initiative, sponsored by the NCHA, Leiden-Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103056	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108379	PMC

November 2015

A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis.

Authors:

Yolande F M Ramos Steffan D Bos Ruud van der Breggen Margreet Kloppenburg Kai Ye Eric-Wubbo E M W Lameijer Rob G H H Nelissen P Eline Slagboom Ingrid Meulenbelt

Ann Rheum Dis 2015 Sep 17;74(9):1756-62. Epub 2014 Apr 17.

Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20514	Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2013-205149	DOI Listing

September 2015

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.

Authors:

Nils Bomer Wouter den Hollander Yolande F M Ramos Steffan D Bos Ruud van der Breggen Nico Lakenberg Barry A Pepers Annelies E van Eeden Arash Darvishan Elmar W Tobi Bouke J Duijnisveld Erik B van den Akker Bastiaan T Heijmans Willeke Mc van Roon-Mom Fons J Verbeek Gerjo J V M van Osch Rob G H H Nelissen P Eline Slagboom Ingrid Meulenbelt

Ann Rheum Dis 2015 Aug 2;74(8):1571-9. Epub 2014 Apr 2.

Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands Genomics Initiative, sponsored by the NCHA, Leiden, The Netherlands.

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http://ard.bmj.com/content/early/2014/04/02/annrheumdis-2013	Web Search
http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20473	Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2013-204739	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516000	PMC

August 2015

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.

Authors:

Wouter den Hollander Yolande F M Ramos Nils Bomer Stefan Elzinga Ruud van der Breggen Nico Lakenberg Wesley J de Dijcker H Eka D Suchiman Bouke J Duijnisveld Jeanine J Houwing-Duistermaat P Eline Slagboom Steffan D Bos Rob G H H Nelissen Ingrid Meulenbelt

Arthritis Rheumatol 2015 May;67(8):2108-16

Leiden University Medical Center, Leiden, The Netherlands, and The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/art.39162	DOI Listing

May 2015

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.

Brain 2015 Mar 22;138(Pt 3):632-43. Epub 2015 Jan 22.

2 Department of Neurology, Oslo University Hospital Ullevål, Oslo, Norway 3 Institute of Clinical Medicine, University of Oslo, Norway.

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http://dx.doi.org/10.1093/brain/awu405	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408440	PMC

March 2015

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Authors:

Evangelos Evangelou Hanneke J Kerkhof Unnur Styrkarsdottir Evangelia E Ntzani Steffan D Bos Tonu Esko Daniel S Evans Sarah Metrustry Kalliope Panoutsopoulou Yolande F M Ramos Gudmar Thorleifsson Konstantinos K Tsilidis Nigel Arden Nadim Aslam Nicholas Bellamy Fraser Birrell Francisco J Blanco Andrew Carr Kay Chapman Aaron G Day-Williams Panos Deloukas Michael Doherty Gunnar Engström Hafdis T Helgadottir Albert Hofman Thorvaldur Ingvarsson Helgi Jonsson Aime Keis J Christiaan Keurentjes Margreet Kloppenburg Penelope A Lind Andrew McCaskie Nicholas G Martin Lili Milani Grant W Montgomery Rob G H H Nelissen Michael C Nevitt Peter M Nilsson William Er Ollier Neeta Parimi Ashok Rai Stuart H Ralston Mike R Reed Jose A Riancho Fernando Rivadeneira Cristina Rodriguez-Fontenla Lorraine Southam Unnur Thorsteinsdottir Aspasia Tsezou Gillian A Wallis J Mark Wilkinson Antonio Gonzalez Nancy E Lane L Stefan Lohmander John Loughlin Andres Metspalu Andre G Uitterlinden Ingileif Jonsdottir Kari Stefansson P Eline Slagboom Eleftheria Zeggini Ingrid Meulenbelt John Pa Ioannidis Tim D Spector Joyce B J van Meurs Ana M Valdes

Ann Rheum Dis 2014 Dec 29;73(12):2130-6. Epub 2013 Aug 29.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK Department of Academic Rheumatology, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-203114	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251181	PMC

December 2014

Genes expressed in blood link osteoarthritis with apoptotic pathways.

Authors:

Yolande F M Ramos Steffan D Bos Nico Lakenberg Stefan Böhringer Wouter J den Hollander Margreet Kloppenburg P Eline Slagboom Ingrid Meulenbelt

Ann Rheum Dis 2014 Oct 17;73(10):1844-53. Epub 2013 Jul 17.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands The Netherlands Genomics Initiative, sponsored by the NCHA, Leiden-Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2013-203405	DOI Listing

October 2014

Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis.

Authors:

Hanne F Harbo Noriko Isobe Pål Berg-Hansen Steffan D Bos Stacy J Caillier Marte W Gustavsen Inger-Lise Mero Elisabeth Gulowsen Celius Stephen L Hauser Jorge R Oksenberg Pierre-Antoine Gourraud

Mult Scler 2014 May 7;20(6):660-8. Epub 2013 Oct 7.

Department of Neurology, Oslo University Hospital, Norway.

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http://dx.doi.org/10.1177/1352458513506503	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066985	PMC

May 2014

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

Authors:

Jeroen C H Leijten Steffan D Bos Ellie B M Landman Nicole Georgi Holger Jahr Ingrid Meulenbelt Janine N Post Clemens A van Blitterswijk Marcel Karperien

Arthritis Res Ther 2013 Sep 19;15(5):R126. Epub 2013 Sep 19.

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http://www.molepi.nl/uploads/publicaties/2013/2013_leijten_a	Web Search
http://arthritis-research.biomedcentral.com/articles/10.1186	Publisher Site
http://dx.doi.org/10.1186/ar4306	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978825	PMC

September 2013

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array.

Authors:

Roderick C Slieker Steffan D Bos Jelle J Goeman Judith Vmg Bovée Rudolf P Talens Ruud van der Breggen H Eka D Suchiman Eric-Wubbo Lameijer Hein Putter Erik B van den Akker Yanju Zhang J Wouter Jukema P Eline Slagboom Ingrid Meulenbelt Bastiaan T Heijmans

Epigenetics Chromatin 2013 Aug 6;6(1):26. Epub 2013 Aug 6.

Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1756-8935-6-26	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750594	PMC

August 2013

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Authors:

Eleonora Porcu Marco Medici Giorgio Pistis Claudia B Volpato Scott G Wilson Anne R Cappola Steffan D Bos Joris Deelen Martin den Heijer Rachel M Freathy Jari Lahti Chunyu Liu Lorna M Lopez Ilja M Nolte Jeffrey R O'Connell Toshiko Tanaka Stella Trompet Alice Arnold Stefania Bandinelli Marian Beekman Stefan Böhringer Suzanne J Brown Brendan M Buckley Clara Camaschella Anton J M de Craen Gail Davies Marieke C H de Visser Ian Ford Tom Forsen Timothy M Frayling Laura Fugazzola Martin Gögele Andrew T Hattersley Ad R Hermus Albert Hofman Jeanine J Houwing-Duistermaat Richard A Jensen Eero Kajantie Margreet Kloppenburg Ee M Lim Corrado Masciullo Stefano Mariotti Cosetta Minelli Braxton D Mitchell Ramaiah Nagaraja Romana T Netea-Maier Aarno Palotie Luca Persani Maria G Piras Bruce M Psaty Katri Räikkönen J Brent Richards Fernando Rivadeneira Cinzia Sala Mona M Sabra Naveed Sattar Beverley M Shields Nicole Soranzo John M Starr David J Stott Fred C G J Sweep Gianluca Usala Melanie M van der Klauw Diana van Heemst Alies van Mullem Sita H Vermeulen W Edward Visser John P Walsh Rudi G J Westendorp Elisabeth Widen Guangju Zhai Francesco Cucca Ian J Deary Johan G Eriksson Luigi Ferrucci Caroline S Fox J Wouter Jukema Lambertus A Kiemeney Peter P Pramstaller David Schlessinger Alan R Shuldiner Eline P Slagboom André G Uitterlinden Bijay Vaidya Theo J Visser Bruce H R Wolffenbuttel Ingrid Meulenbelt Jerome I Rotter Tim D Spector Andrew A Hicks Daniela Toniolo Serena Sanna Robin P Peeters Silvia Naitza

PLoS Genet 2013 7;9(2):e1003266. Epub 2013 Feb 7.

Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1003266	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567175	PMC

June 2013

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

Authors:

Eleftheria Zeggini Kalliope Panoutsopoulou Lorraine Southam Nigel W Rayner Aaron G Day-Williams Margarida C Lopes Vesna Boraska Tonu Esko Evangelos Evangelou Albert Hoffman Jeanine J Houwing-Duistermaat Thorvaldur Ingvarsson Ingileif Jonsdottir Helgi Jonnson Hanneke J Kerkhof Margreet Kloppenburg Steffan D Bos Massimo Mangino Sarah Metrustry P Eline Slagboom Gudmar Thorleifsson Emma V A Raine Madhushika Ratnayake Michelle Ricketts Claude Beazley Hannah Blackburn Suzannah Bumpstead Katherine S Elliott Sarah E Hunt Simon C Potter So-Youn Shin Vijay K Yadav Guangju Zhai Kate Sherburn Kate Dixon Elizabeth Arden Nadim Aslam Phillippa-kate Battley Ian Carluke Sally Doherty Andrew Gordon John Joseph Richard Keen Nicola C Koller Sheryl Mitchell Fiona O'Neill Ellen Paling Mike R Reed Fernando Rivadeneira Diane Swift Kirsten Walker Bridget Watkins Maggie Wheeler Fraser Birrell John P A Ioannidis Ingrid Meulenbelt Andres Metspalu Ashok Rai Donald Salter Kari Stefansson Unnur Stykarsdottir André G Uitterlinden Joyce B J van Meurs Kay Chapman Panos Deloukas William E R Ollier Gillian A Wallis Nigel Arden Andrew Carr Michael Doherty Andrew McCaskie J Mark Willkinson Stuart H Ralston Ana M Valdes Tim D Spector John Loughlin

Lancet 2012 Sep 3;380(9844):815-23. Epub 2012 Jul 3.

Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(	Web Search
http://linkinghub.elsevier.com/retrieve/pii/S014067361260681	Publisher Site
http://dx.doi.org/10.1016/S0140-6736(12)60681-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443899	PMC