Stefano Salvioli

Stefano Salvioli

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Stefano Salvioli

Publications by authors named "Stefano Salvioli"

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Call for articles on neglected topics.

Ageing Res Rev 2019 Sep 15;54:100934. Epub 2019 Jul 15.

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2019.100934DOI Listing
September 2019

X-chromosome-linked miR548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis.

Cell Death Dis 2019 Sep 11;10(9):673. Epub 2019 Sep 11.

Center for Gender Specific Medicine, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, Italy.

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http://dx.doi.org/10.1038/s41419-019-1888-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739406PMC
September 2019

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.

Aging Cell 2019 Jun 15;18(3):e12903. Epub 2019 Feb 15.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/acel.12903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516152PMC
June 2019

Down Syndrome, Ageing and Epigenetics.

Subcell Biochem 2019;91:161-193

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/978-981-13-3681-2_7DOI Listing
June 2019

Human Aging and Longevity Are Characterized by High Levels of Mitokines.

J Gerontol A Biol Sci Med Sci 2019 Apr;74(5):600-607

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Cusano Milanino.

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http://dx.doi.org/10.1093/gerona/gly153DOI Listing
April 2019

Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy.

J Cachexia Sarcopenia Muscle 2019 02 4;10(1):95-110. Epub 2018 Oct 4.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://doi.wiley.com/10.1002/jcsm.12355
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http://dx.doi.org/10.1002/jcsm.12355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438344PMC
February 2019

The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age.

Front Endocrinol (Lausanne) 2019 26;10:114. Epub 2019 Feb 26.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fendo.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400104PMC
February 2019

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice.

J Nutr Biochem 2018 06 20;56:152-164. Epub 2018 Mar 20.

Division of Human Nutrition, Wageningen University & Research, 6708 WE, Wageningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2018.01.001DOI Listing
June 2018

Sex disparity in cancer: roles of microRNAs and related functional players.

Cell Death Differ 2018 03 19;25(3):477-485. Epub 2018 Jan 19.

Oncology Unit, Center for Gender-specific Medicine Istituto Superiore di Sanita', Viale Regina Elena, 299 00161, Rome, Italy.

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http://dx.doi.org/10.1038/s41418-017-0051-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864217PMC
March 2018

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

Front Med (Lausanne) 2018 12;5:61. Epub 2018 Mar 12.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fmed.2018.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890129PMC
March 2018

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.

Ageing Res Rev 2017 Nov 9;40:95-119. Epub 2017 Sep 9.

Department of Molecular Medicine, University of Padova, 35121 Padova, Italy; IMDEA-Food, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.arr.2017.09.001DOI Listing
November 2017

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity.

Front Immunol 2017 15;8:982. Epub 2017 Aug 15.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.00982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559470PMC
August 2017

Mitochondria and mitochondria-induced signalling molecules as longevity determinants.

Mech Ageing Dev 2017 07 11;165(Pt B):115-128. Epub 2016 Dec 11.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy; Interdepartmental Centre "L. Galvani" (CIG) University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.mad.2016.12.002DOI Listing
July 2017

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

Cell Metab 2017 Jun 25;25(6):1374-1389.e6. Epub 2017 May 25.

Venetian Institute of Molecular Medicine, via Orus 2, 35129 Padova, Italy; Department of Biomedical Science, University of Padova, via G. Colombo 3, 35100 Padova, Italy; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462533PMC
June 2017

Mediterranean diet and inflammaging within the hormesis paradigm.

Nutr Rev 2017 06;75(6):442-455

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1093/nutrit/nux013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914347PMC
June 2017

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans.

Ageing Res Rev 2017 May 19;35:322-335. Epub 2016 Nov 19.

Department of Experimental, Diagnostic and Specialty Medicine, Interdepartmental Centre "L.Galvani" for Bioinformatics, Biophysics and Biocomplexity, Via San Giacomo, 12, University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.arr.2016.11.005DOI Listing
May 2017

Inflammaging and 'Garb-aging'.

Trends Endocrinol Metab 2017 03 24;28(3):199-212. Epub 2016 Oct 24.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.tem.2016.09.005DOI Listing
March 2017

tDCS and Robotics on Upper Limb Stroke Rehabilitation: Effect Modification by Stroke Duration and Type of Stroke.

Biomed Res Int 2016 31;2016:5068127. Epub 2016 Mar 31.

Neuroscience and Rehabilitation Department, Ferrara University Hospital, 44100 Ferrara, Italy.

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http://dx.doi.org/10.1155/2016/5068127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830702PMC
February 2017

Quantification of mitochondrial reactive oxygen species in living cells by using multi-laser polychromatic flow cytometry.

Cytometry A 2016 12 30;89(12):1106-1110. Epub 2016 Aug 30.

Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1002/cyto.a.22936DOI Listing
December 2016

Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective.

Trends Endocrinol Metab 2016 12 19;27(12):893-903. Epub 2016 Sep 19.

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.tem.2016.09.001DOI Listing
December 2016

N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters.

PLoS One 2015 20;10(3):e0119983. Epub 2015 Mar 20.

Department of Experimental, Diagnostic and Specialty Medicine Experimental Pathology, University of Bologna, Via S. Giacomo 12, Bologna, 40126, Italy; Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, Bologna, 40138, Italy; Interdepartmental Centre "L. Galvani" CIG, University of Bologna, Piazza di Porta S. Donato 1, Bologna, 40126, Italy; IRCCS, Institute of Neurological Sciences of Bologna, Bologna, 40124, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368037PMC
February 2016

Plasma N-Glycome Signature of Down Syndrome.

J Proteome Res 2015 Oct 14;14(10):4232-45. Epub 2015 Sep 14.

Center for Proteomics and Metabolomics, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.5b00356DOI Listing
October 2015

The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.

Biomed Res Int 2014 24;2014:560340. Epub 2014 Apr 24.

Department of Experimental, Diagnostic and Specialty Medicine Experimental Pathology, University of Bologna, Via S. Giacomo 12, 40126 Bologna, Italy ; Interdepartmental Centre "L. Galvani" (CIG), University of Bologna, Piazza di Porta S. Donato 1, 40126 Bologna, Italy ; IRCCS, Institute of Neurological Sciences of Bologna, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy ; CNR, Institute of Organic Synthesis and Photoreactivity (ISOF), Via P. Gobetti 101, 40129 Bologna, Italy.

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http://dx.doi.org/10.1155/2014/560340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017728PMC
September 2015

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver.

Mech Ageing Dev 2014 Nov-Dec;141-142:26-34. Epub 2014 Oct 1.

Interdepartmental Centre "L. Galvani" for Integrated Studies on Biophysics, Bioinformatics and Biocomplexity (CIG), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; IRCCS Institute of Neurological Sciences, 40139 Bologna, Italy; National Research Council of Italy, CNR, Institute for Organic Synthesis and Photoreactivity (ISOF), 40129 Bologna, Italy; National Research Council of Italy, CNR, Institute of Molecular Genetics, Unit of Bologna IOR, 40136 Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2014.09.003DOI Listing
September 2015

Genes of human longevity: an endless quest?

Curr Vasc Pharmacol 2014 ;12(5):707-17

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum- University of Bologna, Via S. Giacomo, 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.2174/1570161111666131219110301DOI Listing
July 2015

Age-related changes of adaptive and neuropsychological features in persons with Down Syndrome.

PLoS One 2014 24;9(11):e113111. Epub 2014 Nov 24.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Interdepartmental Centre "L. Galvani" - CIG, University of Bologna, Bologna, Italy; IRCCS Institute of Neurological Sciences, Bologna, Italy; National Research Council of Italy, CNR, Institute for Organic Synthesis and Photoreactivity (ISOF), Bologna, Italy; National Research Council of Italy, CNR, Institute of Molecular Genetics, Unit of Bologna, Bologna, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113111PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242614PMC
July 2015

Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes.

Biogerontology 2015 Jun 6;16(3):329-40. Epub 2015 Jan 6.

Department of Experimental, Diagnostic and Specialty Medicine and Interdepartmental Centre "L. Galvani" (CIG), University of Bologna, via S. Giacomo 12, 40126, Bologna, Italy,

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http://dx.doi.org/10.1007/s10522-014-9549-5DOI Listing
June 2015

Accelerated epigenetic aging in Down syndrome.

Aging Cell 2015 Jun 9;14(3):491-5. Epub 2015 Feb 9.

Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA; Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1111/acel.12325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406678PMC
June 2015

The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R.

J Biochem 2015 Feb 26;157(2):101-11. Epub 2014 Sep 26.

Department DiBEST, University of Calabria, Rende, 87036, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy; CIG, Interdepartmental Center "Luigi Galvani", University of Bologna, Bologna 40126, Italy; Department of Biology, University of Rome Tor Vergata, Rome 00100, Italy; and Istituto Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Rome, 00100, Italy

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http://dx.doi.org/10.1093/jb/mvu059DOI Listing
February 2015

Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design.

Mech Ageing Dev 2014 Mar-Apr;136-137:3-13. Epub 2013 Dec 14.

University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Via San Giacomo 12, 40126 Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.mad.2013.12.001DOI Listing
December 2014

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: a study on postmenopausal monozygotic twin pairs.

Aging Cell 2014 Oct 18;13(5):850-61. Epub 2014 Jul 18.

Department of Clinical and Molecular Sciences, Division of Pathology, Università Politecnica delle Marche, Ancona, Italy; Department of Clinical Pathology and Innovative Therapy, Advanced Technology Center for Aging Research, INRCA-IRCCS, Ancona, Italy.

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http://dx.doi.org/10.1111/acel.12245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331762PMC
October 2014

αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.

PLoS Pathog 2013 19;9(12):e1003806. Epub 2013 Dec 19.

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1371/journal.ppat.1003806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868510PMC
September 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies.

Exp Gerontol 2014 Aug 5;56:234-44. Epub 2014 Apr 5.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy; C.I.G. Interdepartmental Centre L. Galvani for Integrated Studies on Bioinformatics, Biophysics and Biocomplexity, University of Bologna, via S. Giacomo 12, 40126, Bologna, Italy.

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http://dx.doi.org/10.1016/j.exger.2014.03.022DOI Listing
August 2014

Lamins are rapamycin targets that impact human longevity: a study in centenarians.

J Cell Sci 2014 Jan 23;127(Pt 1):147-57. Epub 2013 Oct 23.

National Research Council of Italy, Institute of Molecular Genetics, Unit of Bologna IOR, 40136 Bologna, Italy.

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http://dx.doi.org/10.1242/jcs.133983DOI Listing
January 2014

MicroRNAs linking inflamm-aging, cellular senescence and cancer.

Ageing Res Rev 2013 Sep 17;12(4):1056-68. Epub 2013 May 17.

Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, I.N.R.C.A. National Institute, Ancona, Italy.

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http://dx.doi.org/10.1016/j.arr.2013.05.001DOI Listing
September 2013

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

Curr Pharm Des 2013 ;19(4):702-18

Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.

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July 2013

Oxidative stress and the ageing endocrine system.

Nat Rev Endocrinol 2013 Apr 26;9(4):228-40. Epub 2013 Feb 26.

Department of Clinical Sciences and Community Health, University of Milan, Istituto Auxologico Italiano IRCCS, Via Zucchi 18, Cusano Milanino (MI) 20095, Italy.

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http://dx.doi.org/10.1038/nrendo.2013.29DOI Listing
April 2013

Charting the NF-κB pathway interactome map.

PLoS One 2012 5;7(3):e32678. Epub 2012 Mar 5.

CIG Luigi Galvani Interdept Center, University of Bologna, Bologna, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293857PMC
July 2012

Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB.

J Virol 2012 Jun 11;86(12):6555-62. Epub 2012 Apr 11.

Department of Experimental Pathology, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1128/JVI.00295-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393584PMC
June 2012

Complex patterns of gene expression in human T cells during in vivo aging.

Mol Biosyst 2010 Oct 5;6(10):1983-92. Epub 2010 Aug 5.

Department of Physics, University of Bologna, Viale Berti Pichat 6/2, 40127 Bologna, Italy.

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http://dx.doi.org/10.1039/c004635cDOI Listing
October 2010

Herpes simplex virus glycoproteins H/L bind to cells independently of {alpha}V{beta}3 integrin and inhibit virus entry, and their constitutive expression restricts infection.

J Virol 2010 Apr 10;84(8):4013-25. Epub 2010 Feb 10.

Department of Experimental Pathology, Section on Microbiology and Virology, Alma Mater Studiorum-University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.1128/JVI.02502-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849490PMC
April 2010

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

Cancer Immunol Immunother 2009 Dec 13;58(12):1909-17. Epub 2009 Jan 13.

Department of Experimental Pathology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/s00262-008-0639-6DOI Listing
December 2009

Propagation of a transmissible cytotoxic activity on cultures of human peripheral blood lymphocytes.

New Microbiol 2008 Jul;31(3):417-22

Centre for Diagnosis of Viral Diseases, Department of Laboratory Medicine, University Hospital of Modena and Reggio Emilia, Modena, Italy.

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http://www.newmicrobiologica.org/pub/allegati_pdf/2008/3/mic
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July 2008

Mitochondrial DNA involvement in human longevity.

Biochim Biophys Acta 2006 Sep-Oct;1757(9-10):1388-99. Epub 2006 Jun 7.

Department of Experimental Pathology, University of Bologna, via S Giacomo 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.bbabio.2006.05.040DOI Listing
December 2006

Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe.

Int J Cancer 2006 Oct;119(8):1811-8

Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.

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http://dx.doi.org/10.1002/ijc.22055DOI Listing
October 2006

Complexity of anti-immunosenescence strategies in humans.

Artif Organs 2006 Oct;30(10):730-42

Department of Experimental Pathology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/j.1525-1594.2006.00295.xDOI Listing
October 2006

The genetics of human longevity.

Ann N Y Acad Sci 2006 May;1067:252-63

CIG - Centro Interdipartimentale L. Galvani, University of Bologna, Italy.

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http://dx.doi.org/10.1196/annals.1354.033DOI Listing
May 2006

p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway.

Biochem Biophys Res Commun 2006 Apr 9;342(2):503-8. Epub 2006 Feb 9.

Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0600290
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http://dx.doi.org/10.1016/j.bbrc.2006.02.007DOI Listing
April 2006

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes.

Biochem Biophys Res Commun 2002 Dec;299(4):539-41

Department of Experimental Pathology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/s0006-291x(02)02691-8DOI Listing
December 2002

Early changes in intramitochondrial cardiolipin distribution during apoptosis.

Cell Growth Differ 2002 Sep;13(9):449-55

Department of Human Physiology, University of Malaga, Campus Teatinos, 29080 Malaga, Spain.

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September 2002