Stefano Rivella

Stefano Rivella

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Stefano Rivella

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Genetic loss of alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia.

Haematologica 2019 Oct 28;104(10):e442-e446. Epub 2019 Feb 28.

Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA

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http://dx.doi.org/10.3324/haematol.2018.213371DOI Listing
October 2019

New potential players in hepcidin regulation.

Haematologica 2019 Sep;104(9):1691-1693

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Cell and Molecular Biology Graduate Group, University of Pennsylvania, Abramson Research Center, Philadelphia, PA, USA

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http://dx.doi.org/10.3324/haematol.2019.224311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717596PMC
September 2019

Lack of does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia.

Blood 2019 Aug 31;134(6):568-572. Epub 2019 May 31.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood.2019001057DOI Listing
August 2019

Gene therapy of hemoglobinopathies: progress and future challenges.

Hum Mol Genet 2019 Jul 19. Epub 2019 Jul 19.

Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris.

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http://dx.doi.org/10.1093/hmg/ddz172DOI Listing
July 2019

Gene Therapy for Beta-Hemoglobinopathies: Milestones, New Therapies and Challenges.

Mol Diagn Ther 2019 04;23(2):173-186

Hematology Division, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s40291-019-00383-4DOI Listing
April 2019

Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD.

Kidney Int Rep 2019 Mar 19;4(3):470-483. Epub 2018 Dec 19.

Joan and Sanford I. Weill Department of Medicine, Division of Nephrology and Hypertension, Weill Cornell Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409399PMC
March 2019

Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia.

Authors:
Stefano Rivella

Blood 2019 01 6;133(1):51-58. Epub 2018 Nov 6.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-07
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http://dx.doi.org/10.1182/blood-2018-07-815928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318430PMC
January 2019

Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia.

FASEB J 2018 07 26;32(7):3752-3764. Epub 2018 Feb 26.

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA.

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http://dx.doi.org/10.1096/fj.201700667RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998980PMC
July 2018

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia.

Adv Exp Med Biol 2017 ;1013:155-176

Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, 515 E. 71st St., S702, Box 284, New York, NY, 10021, USA.

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http://dx.doi.org/10.1007/978-1-4939-7299-9_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718882PMC
April 2018

Ineffective Erythropoiesis: Anemia and Iron Overload.

Hematol Oncol Clin North Am 2018 04 29;32(2):213-221. Epub 2017 Dec 29.

Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA; Children's Hospital of Philadelphia (CHOP), Cell and Molecular Biology Graduate Group (CAMB), University of Pennsylvania, Abramson Research Center, 3615 Civic Center Boulevard, Room 316B, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588173021
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http://dx.doi.org/10.1016/j.hoc.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824437PMC
April 2018

Emerging Therapies.

Hematol Oncol Clin North Am 2018 04 15;32(2):343-352. Epub 2017 Dec 15.

Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), Philadelphia, PA, USA; Cell and Molecular Biology Graduate Group (CAMB), University of Pennsylvania, 421 Curie Boulevard/6064 160 Biomedical Research Building (BRB) 2/3, Philadelphia, PA 19104-6064, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823282PMC
April 2018

Hepcidin agonists as therapeutic tools.

Blood 2018 04 9;131(16):1790-1794. Epub 2018 Mar 9.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2017-11-737411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909761PMC
April 2018

What can we learn from ineffective erythropoiesis in thalassemia?

Blood Rev 2018 03 3;32(2):130-143. Epub 2017 Oct 3.

Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), Philadelphia, PA, USA; Cell and Molecular Biology Graduate Group (CAMB), University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882559PMC
March 2018

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major.

Haematologica 2018 02 2;103(2):e46-e49. Epub 2017 Nov 2.

Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA

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http://dx.doi.org/10.3324/haematol.2017.181511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792284PMC
February 2018

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome.

Blood 2017 08 20;130(9):1144-1155. Epub 2017 Jul 20.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.

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http://dx.doi.org/10.1182/blood-2017-05-787051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580276PMC
August 2017

Targeting iron metabolism in drug discovery and delivery.

Nat Rev Drug Discov 2017 Jun 3;16(6):400-423. Epub 2017 Feb 3.

Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/doifinder/10.1038/nrd.2016.248
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http://dx.doi.org/10.1038/nrd.2016.248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455971PMC
June 2017

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Blood 2017 03 1;129(11):1514-1526. Epub 2017 Feb 1.

Hunan Key Laboratory of Carcinogenesis and Cancer Invasion, Cancer Research Institute, Central South University, Ministry of Education, Changsha, China.

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http://dx.doi.org/10.1182/blood-2016-09-742387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356456PMC
March 2017

A Red Carpet for Iron Metabolism.

Cell 2017 01;168(3):344-361

Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2016.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706455PMC
January 2017

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

Nat Commun 2016 12 22;7:13817. Epub 2016 Dec 22.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.

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http://www.nature.com/articles/ncomms13817
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http://dx.doi.org/10.1038/ncomms13817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192182PMC
December 2016

A validated cellular biobank for β-thalassemia.

J Transl Med 2016 09 2;14:255. Epub 2016 Sep 2.

Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, 44121, Ferrara, Italy.

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http://dx.doi.org/10.1186/s12967-016-1016-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010737PMC
September 2016

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Blood 2016 08 12;128(8):1139-43. Epub 2016 Jul 12.

Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, NY; Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2016-01-691089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000846PMC
August 2016

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Blood 2016 07 6;128(2):265-76. Epub 2016 May 6.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY; and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2015-10-676742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946204PMC
July 2016

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Biomed Res Int 2015 4;2015:687635. Epub 2015 May 4.

Department of Life Sciences and Biotechnology, Biochemistry and Molecular Biology Section, Ferrara University, 44121 Ferrara, Italy ; Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassemia, Biotechnology Center, Ferrara University, 44121 Ferrara, Italy.

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http://dx.doi.org/10.1155/2015/687635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434229PMC
March 2016

New strategies to target iron metabolism for the treatment of beta thalassemia.

Ann N Y Acad Sci 2016 03 25;1368(1):162-8. Epub 2016 Feb 25.

Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.13018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271577PMC
March 2016

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

J Biol Chem 2015 Sep 19;290(39):23523-7. Epub 2015 Aug 19.

From the Department of Molecular and Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan 48109 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.C115.681643
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http://dx.doi.org/10.1074/jbc.C115.681643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583015PMC
September 2015

Altered erythropoiesis and iron metabolism in carriers of thalassemia.

Eur J Haematol 2015 Jun 11;94(6):511-8. Epub 2014 Nov 11.

Laboratório de Hematologia Clínica, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.1111/ejh.12464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393762PMC
June 2015

β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies.

Authors:
Stefano Rivella

Haematologica 2015 Apr;100(4):418-30

Department of Pediatrics Hematology-Oncology Department of Cell and Developmental Biology Weill Cornell Medical College New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2014.114827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380714PMC
April 2015

Recent trends in the gene therapy of β-thalassemia.

J Blood Med 2015 19;6:69-85. Epub 2015 Feb 19.

Laboratory for the Development of Gene and Pharmacogenomic Therapy of Thalassaemia, Biotechnology Centre of Ferrara University, Ferrara, Italy ; Associazione Veneta per la Lotta alla Talassemia, Rovigo, Italy ; Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy.

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http://www.dovepress.com/recent-trends-in-the-gene-therapy-o
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http://dx.doi.org/10.2147/JBM.S46256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342371PMC
March 2015

Cancer cells with irons in the fire.

Free Radic Biol Med 2015 Feb 14;79:337-42. Epub 2014 May 14.

Department of Pediatrics-Hematology/Oncology, Weill Cornell Medical College, New York, NY 10021, USA; Department of Cell and Development Biology, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232494PMC
February 2015

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.

Exp Hematol 2015 Jan 2;43(1):65-70. Epub 2014 Oct 2.

Department of Developmental & Regenerative Biology, Mount Sinai School of Medicine, New York, NY, United States; Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, United States; Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268327PMC
January 2015

Iron age: novel targets for iron overload.

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):216-21. Epub 2014 Nov 18.

Department of Pediatrics, Division of Hematology-Oncology, and Department of Cell and Developmental Biology, Weill Medical College, Cornell University, New York, NY.

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2014.1.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292264PMC
December 2014

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Cell 2014 Aug;158(4):849-860

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134511PMC
August 2014

Identification of erythroferrone as an erythroid regulator of iron metabolism.

Nat Genet 2014 Jul 1;46(7):678-84. Epub 2014 Jun 1.

1] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. [2] Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

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http://www.nature.com/articles/ng.2996
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http://dx.doi.org/10.1038/ng.2996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104984PMC
July 2014

Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations.

Cancer Res 2014 Jun 24;74(11):3104-13. Epub 2014 Mar 24.

Authors' Affiliations: Departments of Medicine, Biochemistry and Molecular Pharmacology; The NYU Cancer Institute, New York University School of Medicine; and Departments of Pediatrics and Cell and Biology Development, Weill Cornell School of Medicine, New York, New YorkAuthors' Affiliations: Departments of Medicine, Biochemistry and Molecular Pharmacology; The NYU Cancer Institute, New York University School of Medicine; and Departments of Pediatrics and Cell and Biology Development, Weill Cornell School of Medicine, New York, New YorkAuthors' Affiliations: Departments of Medicine, Biochemistry and Molecular Pharmacology; The NYU Cancer Institute, New York University School of Medicine; and Departments of Pediatrics and Cell and Biology Development, Weill Cornell School of Medicine, New York, New York

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040335PMC
June 2014

β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.

Int J Biochem Cell Biol 2014 Jun 6;51:89-92. Epub 2014 Apr 6.

Weill Cornell Medical College, Department of Pediatrics Hematology-Oncology, 515 E 71st Street, New York, 10021 NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083841PMC
June 2014

Iron and reactive oxygen species: friends or foes of cancer cells?

Antioxid Redox Signal 2014 Apr 15;20(12):1917-24. Epub 2013 Jan 15.

1 Department of Pediatrics-Hematology/Oncology, Weill Cornell Medical College , New York, New York.

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http://dx.doi.org/10.1089/ars.2012.5014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967355PMC
April 2014

FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis.

J Biol Chem 2014 Apr 7;289(14):9795-810. Epub 2014 Feb 7.

From the Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010.

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http://dx.doi.org/10.1074/jbc.M113.527150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975025PMC
April 2014

Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

Hematol Oncol Clin North Am 2014 Apr 18;28(2):375-86. Epub 2014 Jan 18.

Department of Pediatrics, Hematology-Oncology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.hoc.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970239PMC
April 2014

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus.

Blood 2014 Feb 19;123(8):1137-45. Epub 2013 Dec 19.

Department of Pediatric Hematology-Oncology, Children's and Cancer Blood Foundation Laboratories, Weill Cornell Medical College, New York, NY;

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http://dx.doi.org/10.1182/blood-2013-08-521625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931188PMC
February 2014

Enucleate or replicate? Ask the cytoskeleton.

Authors:
Stefano Rivella

Blood 2014 Jan;123(5):601-2

WEILL CORNELL MEDICAL COLLEGE.

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http://dx.doi.org/10.1182/blood-2013-11-535609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907748PMC
January 2014

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.

Proc Natl Acad Sci U S A 2013 Dec 26;110(50):E4922-30. Epub 2013 Nov 26.

Department of Molecular and Integrative Physiology and Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.

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http://dx.doi.org/10.1073/pnas.1314197110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864280PMC
December 2013

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

J Clin Invest 2013 Aug 25;123(8):3614-23. Epub 2013 Jul 25.

Department of Pathology, University of Virginia, School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1172/JCI68487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726169PMC
August 2013

Non-transfusion-dependent thalassemias.

Haematologica 2013 Jun;98(6):833-44

Department of Medicine and Medical Specialties, IRCCS Ca’ Granda Foundation Maggiore Policlinico Hospital, University of Milan, Milan, Italy.

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http://dx.doi.org/10.3324/haematol.2012.066845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669437PMC
June 2013

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia.

Expert Rev Hematol 2013 Jun;6(3):255-64

Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1586/ehm.13.24DOI Listing
June 2013

Gene therapy for hemoglobinopathies: progress and challenges.

Transl Res 2013 Apr 19;161(4):293-306. Epub 2013 Jan 19.

Weill Cornell Medical College, Department of Pediatrics, Division of Hematology-Oncology, New York, NY 10021, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S19315244120044
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http://dx.doi.org/10.1016/j.trsl.2012.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716457PMC
April 2013

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

Haematologica 2013 Mar 14;98(3):444-7. Epub 2012 Sep 14.

Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.3324/haematol.2012.069807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659953PMC
March 2013

In vivo gene transfer strategies to achieve partial correction of von Willebrand disease.

Hum Gene Ther 2012 Jun 25;23(6):576-88. Epub 2012 Jun 25.

Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1089/hum.2011.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392614PMC
June 2012

Do not super-excess me!

Authors:
Stefano Rivella

Blood 2012 May;119(22):5064-5

Weill Cornell Medical College.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-04-41
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http://dx.doi.org/10.1182/blood-2012-04-418590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585496PMC
May 2012

The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia.

Authors:
Stefano Rivella

Blood Rev 2012 Apr;26 Suppl 1:S12-5

Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1016/S0268-960X(12)70005-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697110PMC
April 2012

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.

Blood 2011 Oct 18;118(16):4321-30. Epub 2011 Jul 18.

New York Blood Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1182/blood-2011-03-283614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204905PMC
October 2011

beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload.

Adv Hematol 2010 19;2010:938640. Epub 2010 May 19.

Weill Cornell Medical College, Department of Pediatrics, Division of Hematology-Oncology, 515E 71st street, S702, New York, NY 10021, USA.

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http://www.hindawi.com/journals/ah/2010/938640/
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http://dx.doi.org/10.1155/2010/938640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873658PMC
July 2011

Crosstalk between Erythropoiesis and Iron Metabolism.

Adv Hematol 2010 24;2010. Epub 2010 Aug 24.

Division of Hematology-Oncology, Department of Pediatrics, Weill Cornell medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1155/2010/317095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938435PMC
July 2011

Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis.

Blood 2011 Jan 8;117(4):1379-89. Epub 2010 Nov 8.

Department of Pediatrics Hematology-Oncology, Children's Blood Foundation Laboratories, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2010-09-307462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056475PMC
January 2011

Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.

Hematol Oncol Clin North Am 2010 Dec 15;24(6):1089-107. Epub 2010 Oct 15.

Hematology-Oncology, Department of Pediatrics, Weill Cornell Medical College, 515 East 71st Street, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985881000115
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http://dx.doi.org/10.1016/j.hoc.2010.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991049PMC
December 2010

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.

Ann N Y Acad Sci 2010 Aug;1202:24-30

Division of Hematology-Oncology, Department of Pediatrics, Children's Blood Foundation Laboratories, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05596.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620601PMC
August 2010

A preclinical approach for gene therapy of beta-thalassemia.

Ann N Y Acad Sci 2010 Aug;1202:134-40

Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, Children's Blood and Cancer Foundation Laboratories, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05594.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068625PMC
August 2010

Hepcidin and Hfe in iron overload in beta-thalassemia.

Ann N Y Acad Sci 2010 Aug;1202:221-5

Division of Hematology-Oncology, Department of Pediatrics, Children's Cancer and Blood Foundation Laboratories, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05595.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652388PMC
August 2010

Future alternative therapies for β-thalassemia.

Expert Rev Hematol 2009 Dec;2(6):685

Weill College Medical Center, Department of Pediatrics, Division of Hematology, Oncology, 515 E 71st Street, S702, New York, NY 10021, USA, Tel.: +1 212 746 4941, ,

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http://dx.doi.org/10.1586/ehm.09.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823128PMC
December 2009

Gene therapy in thalassemia and hemoglobinopathies.

Mediterr J Hematol Infect Dis 2009 Nov 13;1(1):e2009008. Epub 2009 Nov 13.

Weill College Medical Center, Department of Pediatrics, Division of Hematology-Oncology, NY, USA.

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http://dx.doi.org/10.4084/MJHID.2009.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033156PMC
November 2009

Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells.

Proc Natl Acad Sci U S A 2009 Sep 26;106(36):15454-9. Epub 2009 Aug 26.

Sector of Neurobiology, International School for Advanced Studies, The Giovanni Armenise-Harvard Foundation Laboratory, and Consorzio per il Centro di Biomedicina Molecolare, AREA Science Park, Basovizza, 34012 Trieste, Italy.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0813216106
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http://dx.doi.org/10.1073/pnas.0813216106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732704PMC
September 2009

Ineffective erythropoiesis and thalassemias.

Authors:
Stefano Rivella

Curr Opin Hematol 2009 May;16(3):187-94

Department of Pediatric Hematology-Oncology, Children's Cancer and Blood Foundation Laboratories, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32832990a4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703923PMC
May 2009

Regulation of iron absorption in hemoglobinopathies.

Curr Mol Med 2008 Nov;8(7):646-62

Cancer Research Center, Chaim Sheba Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722362PMC
http://dx.doi.org/10.2174/156652408786241401DOI Listing
November 2008

Protective role of calreticulin in HFE hemochromatosis.

Free Radic Biol Med 2008 Jan 4;44(1):99-108. Epub 2007 Oct 4.

Iron Genes and Immune System, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.09.014DOI Listing
January 2008

Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy.

Hum Gene Ther 2007 Jan;18(1):1-9

Gene Transfer and Gene Expression Laboratory, Department of Medicine and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1089/hum.2006.151DOI Listing
January 2007

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

Br J Haematol 2006 Oct 25;135(1):129-38. Epub 2006 Aug 25.

Cancer Research Centre and Paediatric Haematology-Oncology, Safra Children's Hospital, Sheba Medical Centre and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06258.xDOI Listing
October 2006

Progress toward the genetic treatment of the beta-thalassemias.

Ann N Y Acad Sci 2005 ;1054:78-91

Gene Transfer and Gene Expression Laboratory, Memorial Sloan-Kettering Cancer Center, Box 182, 1275 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1196/annals.1345.010DOI Listing
July 2006

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia.

Ann N Y Acad Sci 2005 ;1054:417-22

Weill Medical College of Cornell University, Department of Pediatrics, Division of Hematology-Oncology, Children's Blood Foundation Laboratories, New York, New York 10021, USA.

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http://doi.wiley.com/10.1196/annals.1345.069
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July 2006

mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models.

Am J Hematol 2006 Jul;81(7):479-83

Cancer Research Centre and Pediatric Hematology-Oncology, Safra Children's Hospital, Sheba Medical Centre and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

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http://doi.wiley.com/10.1002/ajh.20549
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http://dx.doi.org/10.1002/ajh.20549DOI Listing
July 2006

Globin gene transfer for treatment of the beta-thalassemias and sickle cell disease.

Best Pract Res Clin Haematol 2004 Sep;17(3):517-34

Laboratory of Gene Transfer and Gene Expression, Gene Transfer and Somatic Cell Engineering Facility, Box 182 Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.beha.2004.08.002DOI Listing
September 2004