Stefanie Schrauwen

Stefanie Schrauwen

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Stefanie Schrauwen

Stefanie Schrauwen

Publications by authors named "Stefanie Schrauwen"

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16Publications

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Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.

Cancer Res 2016 10 2;76(19):5719-5731. Epub 2016 Aug 2.

Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3342DOI Listing
October 2016

Five endometrial cancer risk loci identified through genome-wide association analysis.

Nat Genet 2016 06 2;48(6):667-674. Epub 2016 May 2.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/ng.3562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907351PMC
June 2016

CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.

Endocr Relat Cancer 2016 Feb 16;23(2):77-91. Epub 2015 Nov 16.

Department of Public Health and Primary CareCentre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UKDepartment of Genetics and Computational BiologyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, AustraliaWellcome Trust Centre for Human GeneticsUniversity of Oxford, Oxford OX3 7BN, UKAcademic Department of BiochemistryRoyal Marsden Hospital, London SW3 6JJ, UKDepartment of Clinical GeneticsSt George's Hospital Medical School, London SW17 0RE, UKDepartment of OncologyCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UKDepartment of Medical Epidemiology and BiostatisticsKarolinska Institutet, Stockholm SE-171 77, SwedenDepartment of MedicineDivision of Hematology/Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USADepartment of Gynecology and ObstetricsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyInstitute of Human GeneticsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyGynaecology Research UnitHannover Medical School, Hannover 30625, GermanyClinics of Gynaecology and ObstetricsHannover Medical School, Hannover 30625, GermanyDepartment of GynaecologyJena University Hospital - Friedrich Schiller University, Jena 07743, GermanyVesalius Research CenterLeuven 3000, BelgiumLaboratory for Translational GeneticsDepartment of Oncology, University Hospitals Leuven, Leuven 3000, BelgiumDepartment of Obstetrics and GynecologyDivision of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven 3000, BelgiumDepartment of Health Sciences ResearchMayo Clinic, Rochester, Minnesota 55905, USADepartment of BiostatisticsUniversity of Kansas Medical Center, Kansas City, Kansas 66160, USADepartment of Obstetrics and GynecologyDivision of G

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http://dx.doi.org/10.1530/ERC-15-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697192PMC
February 2016

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Authors:
Timothy H T Cheng Deborah Thompson Jodie Painter Tracy O'Mara Maggie Gorman Lynn Martin Claire Palles Angela Jones Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Graham G Giles Paul Pharoah Julian Peto Angela Cox Anthony Swerdlow Fergus Couch Julie M Cunningham Ellen L Goode Stacey J Winham Diether Lambrechts Peter Fasching Barbara Burwinkel Hermann Brenner Hiltrud Brauch Jenny Chang-Claude Helga B Salvesen Vessela Kristensen Hatef Darabi Jingmei Li Tao Liu Annika Lindblom Per Hall Magdalena Echeverry de Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Samuel Aguiar Jnr Manuel R Teixeira Alison M Dunning Joe Dennis Geoffrey Otton Tony Proietto Elizabeth Holliday John Attia Katie Ashton Rodney J Scott Mark McEvoy Sean C Dowdy Brooke L Fridley Henrica M J Werner Jone Trovik Tormund S Njolstad Emma Tham Miriam Mints Ingo Runnebaum Peter Hillemanns Thilo Dörk Frederic Amant Stefanie Schrauwen Alexander Hein Matthias W Beckmann Arif Ekici Kamila Czene Alfons Meindl Manjeet K Bolla Kyriaki Michailidou Jonathan P Tyrer Qin Wang Shahana Ahmed Catherine S Healey Mitul Shah Daniela Annibali Jeroen Depreeuw Nada A Al-Tassan Rebecca Harris Brian F Meyer Nicola Whiffin Fay J Hosking Ben Kinnersley Susan M Farrington Maria Timofeeva Albert Tenesa Harry Campbell Robert W Haile Shirley Hodgson Luis Carvajal-Carmona Jeremy P Cheadle Douglas Easton Malcolm Dunlop Richard Houlston Amanda Spurdle Ian Tomlinson

Sci Rep 2015 12 1;5:17369. Epub 2015 Dec 1.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/srep17369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664893PMC
December 2015

Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies.

Gynecol Oncol 2015 Oct 29;139(1):118-26. Epub 2015 Jul 29.

KU Leuven - University of Leuven, University Hospitals Leuven, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, B-3000 Leuven, Belgium; Gynaecological Oncology, Netherlands Cancer Institute-Antoni Van Leeuwenhoek, Amsterdam, The Netherlands. Electronic address:

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http://ac.els-cdn.com/S0090825815300895/1-s2.0-S009082581530
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http://dx.doi.org/10.1016/j.ygyno.2015.07.104DOI Listing
October 2015

The antitumor effect of metformin with and without carboplatin on primary endometrioid endometrial carcinoma in vivo.

Gynecol Oncol 2015 Aug 4;138(2):378-82. Epub 2015 Jun 4.

KU Leuven - University of Leuven, University Hospitals Leuven, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.06.006DOI Listing
August 2015

Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models.

Gynecol Oncol 2015 Jul 28;138(1):165-73. Epub 2015 Apr 28.

KU Leuven - University of Leuven, University Hospitals Leuven, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.04.028DOI Listing
July 2015

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Authors:
Jodie N Painter Tracy A O'Mara Jyotsna Batra Timothy Cheng Felicity A Lose Joe Dennis Kyriaki Michailidou Jonathan P Tyrer Shahana Ahmed Kaltin Ferguson Catherine S Healey Susanne Kaufmann Kristine M Hillman Carina Walpole Leire Moya Pamela Pollock Angela Jones Kimberley Howarth Lynn Martin Maggie Gorman Shirley Hodgson Ma Magdalena Echeverry De Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Erika Santos Manuel R Teixeira Luis Carvajal-Carmona Xiao-Ou Shu Jirong Long Wei Zheng Yong-Bing Xiang Grant W Montgomery Penelope M Webb Rodney J Scott Mark McEvoy John Attia Elizabeth Holliday Nicholas G Martin Dale R Nyholt Anjali K Henders Peter A Fasching Alexander Hein Matthias W Beckmann Stefan P Renner Thilo Dörk Peter Hillemanns Matthias Dürst Ingo Runnebaum Diether Lambrechts Lieve Coenegrachts Stefanie Schrauwen Frederic Amant Boris Winterhoff Sean C Dowdy Ellen L Goode Attila Teoman Helga B Salvesen Jone Trovik Tormund S Njolstad Henrica M J Werner Katie Ashton Tony Proietto Geoffrey Otton Gerasimos Tzortzatos Miriam Mints Emma Tham Per Hall Kamila Czene Jianjun Liu Jingmei Li John L Hopper Melissa C Southey Arif B Ekici Matthias Ruebner Nicola Johnson Julian Peto Barbara Burwinkel Frederik Marme Hermann Brenner Aida K Dieffenbach Alfons Meindl Hiltrud Brauch Annika Lindblom Jeroen Depreeuw Matthieu Moisse Jenny Chang-Claude Anja Rudolph Fergus J Couch Janet E Olson Graham G Giles Fiona Bruinsma Julie M Cunningham Brooke L Fridley Anne-Lise Børresen-Dale Vessela N Kristensen Angela Cox Anthony J Swerdlow Nicholas Orr Manjeet K Bolla Qin Wang Rachel Palmieri Weber Zhihua Chen Mitul Shah Juliet D French Paul D P Pharoah Alison M Dunning Ian Tomlinson Douglas F Easton Stacey L Edwards Deborah J Thompson Amanda B Spurdle

Hum Mol Genet 2015 Mar 6;24(5):1478-92. Epub 2014 Nov 6.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia,

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http://dx.doi.org/10.1093/hmg/ddu552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321445PMC
March 2015

Microsatellite instable and microsatellite stable primary endometrial carcinoma cells and their subcutaneous and orthotopic xenografts recapitulate the characteristics of the corresponding primary tumor.

Int J Gynecol Cancer 2015 Mar;25(3):363-71

*Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Gasthuisberg; †Department of Oncology, Laboratory for Translational Genetics, KU Leuven; and ‡Vesalius Research Center (VRC), VIB, Leuven; and §Department of Gynecology, AZ Groeninge Hospital, Kortrijk, Belgium.

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http://dx.doi.org/10.1097/IGC.0000000000000363DOI Listing
March 2015

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.

Hum Genet 2015 Feb 9;134(2):231-45. Epub 2014 Dec 9.

Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95616, USA,

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http://dx.doi.org/10.1007/s00439-014-1515-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291520PMC
February 2015

Increased expression of placental growth factor in high-grade endometrial carcinoma.

Oncol Rep 2013 Feb 10;29(2):413-8. Epub 2012 Dec 10.

Division of Gynecologic Oncology, Department of Oncology, KU Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.3892/or.2012.2178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583572PMC
February 2013