Publications by authors named "Stefan Steinbacher"

42Publications

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

J Med Chem 2017 04 16;60(8):3511-3517. Epub 2017 Mar 16.

Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01836DOI Listing
April 2017

Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.

Acta Crystallogr D Struct Biol 2016 05 26;72(Pt 5):682-93. Epub 2016 Apr 26.

Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, England.

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http://dx.doi.org/10.1107/S2059798316004502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854315PMC
May 2016

A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

Bioorg Med Chem 2010 Nov 24;18(21):7486-96. Epub 2010 Sep 24.

AstraZeneca, Alderley Park, Macclesfield, Cheshire SK104TG, England, United Kingdom.

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http://dx.doi.org/10.1016/j.bmc.2010.08.052DOI Listing
November 2010

The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.

Biochemistry 2010 Sep;49(37):7972-4

OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735, USA.

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http://dx.doi.org/10.1021/bi100409wDOI Listing
September 2010

Design of selective Cathepsin inhibitors.

Bioorg Med Chem Lett 2009 Aug 27;19(16):4622-5. Epub 2009 Jun 27.

RIRA, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK.

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http://dx.doi.org/10.1016/j.bmcl.2009.06.090DOI Listing
August 2009

Structure of the murine unglycosylated IgG1 Fc fragment.

J Mol Biol 2009 Aug 24;391(3):599-608. Epub 2009 Jun 24.

Department Chemie and Center for Integrated Protein Science Munich, Technische Universität München, 85747 Garching, Germany.

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http://dx.doi.org/10.1016/j.jmb.2009.06.048DOI Listing
August 2009

Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase.

Structure 2004 Nov;12(11):1977-88

Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.str.2004.08.007DOI Listing
November 2004

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.

J Mol Biol 2004 Aug;341(4):1085-96

Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1016/j.jmb.2004.06.053DOI Listing
August 2004

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.

Acta Crystallogr D Biol Crystallogr 2004 Jul 22;60(Pt 7):1338-40. Epub 2004 Jun 22.

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://journals.iucr.org/d/issues/2004/07/00/ad5016/ad5016.p
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http://scripts.iucr.org/cgi-bin/paper?S0907444904009862
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http://dx.doi.org/10.1107/S0907444904009862DOI Listing
July 2004

The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase.

Plant Physiol 2004 Apr;134(4):1388-400

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1104/pp.103.034082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419816PMC
April 2004

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.

J Biol Chem 2003 Oct 6;278(43):42256-65. Epub 2003 Aug 6.

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1074/jbc.M307301200DOI Listing
October 2003

Structure of MrsD, an FAD-binding protein of the HFCD family.

Acta Crystallogr D Biol Crystallogr 2003 Aug 23;59(Pt 8):1414-21. Epub 2003 Jul 23.

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1107/s0907444903011831DOI Listing
August 2003

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis.

J Mol Biol 2003 Jun;329(5):973-82

Abteilung für Strukturforschung, Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://ac.els-cdn.com/S0022283603005278/1-s2.0-S002228360300
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http://dx.doi.org/10.1016/s0022-2836(03)00527-8DOI Listing
June 2003

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.

J Biol Chem 2003 May 5;278(20):18401-7. Epub 2003 Mar 5.

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1074/jbc.M300993200DOI Listing
May 2003

Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate.

J Mol Biol 2003 Mar;327(1):193-202

Max-Planck-Institut für Biochemie, Abteilung für Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/s0022-2836(03)00092-5DOI Listing
March 2003

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold.

J Mol Biol 2003 Mar;326(5):1463-73

Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152, Martinsried, Germany.

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http://dx.doi.org/10.1016/s0022-2836(03)00059-7DOI Listing
March 2003

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.

J Biol Chem 2002 Nov 27;277(44):41410-6. Epub 2002 Aug 27.

Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

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http://dx.doi.org/10.1074/jbc.M206863200DOI Listing
November 2002

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.

J Mol Biol 2002 May;318(5):1317-29

Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Martinsried, Germany.

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http://dx.doi.org/10.1016/s0022-2836(02)00116-xDOI Listing
May 2002

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.

J Mol Biol 2002 Feb;316(1):79-88

Abteilung für Strukturforschung, Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, Martinsried, D-82152, Germany.

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http://dx.doi.org/10.1006/jmbi.2001.5341DOI Listing
February 2002