Publications by authors named "Stefan Schulte-Merker"

100Publications

Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis.

Aging (Albany NY) 2020 Sep 25;12(18):18603-18621. Epub 2020 Sep 25.

Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany.

View Article and Find Full Text PDF
September 2020

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.

Blood 2020 Aug;136(7):831-844

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands.

View Article and Find Full Text PDF
August 2020

Zebrafish: Housing and husbandry recommendations.

Lab Anim 2020 Jun 11;54(3):213-224. Epub 2019 Sep 11.

Karolinska Institutet, Comparative Medicine, Stockholm, Sweden.

View Article and Find Full Text PDF
June 2020

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish.

PLoS Genet 2019 02 27;15(2):e1007941. Epub 2019 Feb 27.

Department of Biology and Biochemistry and Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, United Kingdom.

View Article and Find Full Text PDF
February 2019

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae.

Bio Protoc 2018 Dec;8(23):e3100

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, The United Kingdom.

View Article and Find Full Text PDF
December 2018

From fish embryos to human patients: lymphangiogenesis in development and disease.

Curr Opin Immunol 2018 08 23;53:167-172. Epub 2018 May 23.

Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence, University of Münster, Münster, Germany. Electronic address:

View Article and Find Full Text PDF
August 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
August 2018

Spine Patterning Is Guided by Segmentation of the Notochord Sheath.

Cell Rep 2018 02;22(8):2026-2038

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Regeneration Next, Duke University, Durham, NC 27710, USA. Electronic address:

View Article and Find Full Text PDF
February 2018

Report of Workshop on Euthanasia for Zebrafish-A Matter of Welfare and Science.

Zebrafish 2017 12 2;14(6):547-551. Epub 2017 Oct 2.

5 European Society for Fish Models in Biology and Medicine, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT) , Karlsruhe, Germany .

View Article and Find Full Text PDF
December 2017

How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos.

Dev Cell 2017 09;42(6):567-583

Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU Münster, Münster 48149, Germany; Cells-in-Motion Cluster of Excellence (EXC-1003), WWU Münster, 48149 Münster, Germany. Electronic address:

View Article and Find Full Text PDF
September 2017

An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.

Circ Res 2017 Apr 8;120(8):1263-1275. Epub 2017 Feb 8.

From the Hubrecht Institute, KNAW and UMC Utrecht, Utrecht, the Netherlands (T.K., S.A.v.d.P., J.P.-M., G.v.d.H., M.A., S.S.-M.); Institute of Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU Münster, Germany (Y.P., D.S., S.S.-M.); CiM Cluster of Excellence (EXC 1003-CiM), Münster, Germany (Y.P., D.S., S.S.-M.); Max Planck Institute for Molecular Biomedicine, Münster, Germany (C.D., F.K.); Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University, Suita, Japan (N.M., K.S.); and Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan (N.M.).

View Article and Find Full Text PDF
April 2017

Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.

Nat Commun 2017 01 10;8:13991. Epub 2017 Jan 10.

Department of Cell and Developmental Biology, Institute of Zoology (ZOO) Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 4, 76131 Karlsruhe, Germany.

View Article and Find Full Text PDF
January 2017

FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations.

Mol Syndromol 2016 Jul 18;7(3):144-52. Epub 2016 Jun 18.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

View Article and Find Full Text PDF
July 2016

Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.

Development 2015 May 1;142(9):1695-704. Epub 2015 Apr 1.

Hubrecht Institute - Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, 48149 Münster, Germany Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, Westfälische Wilhelms-Universität Münster (WWU), Mendelstrasse 7, 48149 Münster, Germany

View Article and Find Full Text PDF
May 2015

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Circ Res 2015 May 26;116(10):1660-9. Epub 2015 Mar 26.

From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).

View Article and Find Full Text PDF
May 2015

Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI.

Development 2015 Mar;142(6):1095-101

Hubrecht Institute - KNAW & University Medical Center Utrecht, Utrecht 3584 CT, The Netherlands EZO, WUR, Wageningen 6709 PG, The Netherlands Institute of Cardiovascular Organogenesis and Regeneration, University of Münster, Münster 48149, Germany Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, Münster 48149, Germany

View Article and Find Full Text PDF
March 2015

Identification of novel osteogenic compounds by an ex-vivo sp7:luciferase zebrafish scale assay.

Bone 2015 May 16;74:106-13. Epub 2015 Jan 16.

Department of Organismal Animal Physiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

View Article and Find Full Text PDF
May 2015

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish.

Dev Dyn 2015 Jan 17;244(1):1-9. Epub 2014 Nov 17.

Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

View Article and Find Full Text PDF
January 2015

Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology.

Development 2014 Aug;141(16):3103-4

Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim 61231, Germany.

View Article and Find Full Text PDF
August 2014

Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).

Dis Model Mech 2014 Jul 6;7(7):811-22. Epub 2014 Jun 6.

Hubrecht Institute - KNAW & UMC Utrecht, 3548CT Utrecht, The Netherlands. WUR, Experimental Zoology, 3700AH Wageningen, The Netherlands. Institute of Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, 48149 Münster, Germany.

View Article and Find Full Text PDF
July 2014

Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull.

Development 2014 Jun 12;141(11):2225-34. Epub 2014 May 12.

Institute for Biochemistry and Molecular Biology, Ulm University, 89081 Ulm, Germany

View Article and Find Full Text PDF
June 2014

Proteomics analysis of the zebrafish skeletal extracellular matrix.

PLoS One 2014 7;9(3):e90568. Epub 2014 Mar 7.

Laboratory of Biochemistry, Wageningen University, Wageningen, the Netherlands.

View Article and Find Full Text PDF
December 2014

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Development 2014 Mar 12;141(6):1239-49. Epub 2014 Feb 12.

Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4073, Australia.

View Article and Find Full Text PDF
March 2014

A bone to pick with zebrafish.

Bonekey Rep 2013 Nov 13;2:445. Epub 2013 Nov 13.

Hubrecht Institute-KNAW & University Medical Centre Utrecht , Utrecht, The Netherlands.

View Article and Find Full Text PDF
November 2013

A fisheye view on lymphangiogenesis.

Adv Anat Embryol Cell Biol 2014 ;214:153-65

Hubrecht Institute, KNAW and UMC Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

View Article and Find Full Text PDF
April 2014

Introductory remarks.

Adv Anat Embryol Cell Biol 2014 ;214:1-4

Mammalian Cell Signaling Laboratory, MPI for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany,

View Article and Find Full Text PDF
April 2014

Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4.

PLoS One 2013 12;8(9):e73693. Epub 2013 Sep 12.

Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

View Article and Find Full Text PDF
April 2014

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space.

Sci Signal 2013 Jul 23;6(285):rs12. Epub 2013 Jul 23.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

View Article and Find Full Text PDF
July 2013

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.

EMBO J 2013 Mar 8;32(5):629-44. Epub 2013 Jan 8.

Mammalian Cell Signaling Laboratory, Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

View Article and Find Full Text PDF
March 2013

Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish.

Proc Natl Acad Sci U S A 2012 Dec 12;109(52):21372-7. Epub 2012 Dec 12.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT, Utrecht, The Netherlands.

View Article and Find Full Text PDF
December 2012

Macrophage-stimulating protein and calcium homeostasis in zebrafish.

FASEB J 2012 Oct 11;26(10):4092-101. Epub 2012 Jul 11.

Hubrecht Institute, KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
October 2012

Apelin enhances cardiac neovascularization after myocardial infarction by recruiting aplnr+ circulating cells.

Circ Res 2012 Aug 2;111(5):585-98. Epub 2012 Jul 2.

FESC, Molecular Cardiology Laboratory, Ee2389a, Thoraxcenter Rotterdam, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 GE Rotterdam, The Netherlands.

View Article and Find Full Text PDF
August 2012

Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio).

PLoS One 2012 18;7(4):e34072. Epub 2012 Apr 18.

Experimental Zoology Group, Department of Animal Sciences, Wageningen University and Research Centre, Wageningen, The Netherlands.

View Article and Find Full Text PDF
November 2012

Zebrafish prox1b mutants develop a lymphatic vasculature, and prox1b does not specifically mark lymphatic endothelial cells.

PLoS One 2011 28;6(12):e28934. Epub 2011 Dec 28.

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences and University Medical Centre, Utrecht, The Netherlands.

View Article and Find Full Text PDF
May 2012

Zebrafish provides a novel model for lymphatic vascular research.

Methods Cell Biol 2011 ;105:223-38

Hubrecht Institute - KNAWand University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands.

View Article and Find Full Text PDF
January 2012

A zebrafish model for VHL and hypoxia signaling.

Methods Cell Biol 2011 ;105:163-90

Department of Medical Oncology, University Medical Center, Universiteitsweg 100, Utrecht, The Netherlands.

View Article and Find Full Text PDF
January 2012

Rapid BAC selection for tol2-mediated transgenesis in zebrafish.

Development 2011 Oct 24;138(19):4327-32. Epub 2011 Aug 24.

Hubrecht Institute - KNAW and Utrecht Medical Center, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

View Article and Find Full Text PDF
October 2011

Trpv5/6 is vital for epithelial calcium uptake and bone formation.

FASEB J 2011 Sep 13;25(9):3197-207. Epub 2011 Jun 13.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre, Utrecht, The Netherlands.

View Article and Find Full Text PDF
September 2011

Lymphatic vascular morphogenesis in development, physiology, and disease.

J Cell Biol 2011 May;193(4):607-18

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands.

View Article and Find Full Text PDF
May 2011

Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin.

Dev Cell 2011 May;20(5):713-24

Biotechnology Center and Center for Regenerative Therapies, University of Technology Dresden, Tatzberg 47-49, 01307 Dresden, Germany.

View Article and Find Full Text PDF
May 2011

Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo.

Development 2011 May;138(10):2111-20

Department of Angiogenesis and Cardiovascular Pathology, Max-Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany.

View Article and Find Full Text PDF
May 2011

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.

Dis Model Mech 2011 Jan 2;4(1):57-66. Epub 2010 Nov 2.

Hubrecht Institute-KNAW and University Medical Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
January 2011

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting.

Nat Cell Biol 2010 Oct 26;12(10):943-53. Epub 2010 Sep 26.

Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

View Article and Find Full Text PDF
October 2010

Control of endothelial sprouting by a Tel-CtBP complex.

Nat Cell Biol 2010 Oct 12;12(10):933-42. Epub 2010 Sep 12.

Leiden University Medical Center (LUMC), Section of Growth Control and Transcription, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands.

View Article and Find Full Text PDF
October 2010

Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk.

Development 2010 Aug 7;137(16):2653-7. Epub 2010 Jul 7.

Hubrecht Institute-KNAW and University Medical Centre, Utrecht, the Netherlands.

View Article and Find Full Text PDF
August 2010

von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish.

Dis Model Mech 2010 May-Jun;3(5-6):343-53. Epub 2010 Mar 24.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands.

View Article and Find Full Text PDF
September 2010

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.

Development 2009 Dec;136(23):4001-9

Hubrecht Institute-KNAW & University Medical Centre, Utrecht, and Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
December 2009

Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling.

Development 2009 Dec;136(23):3991-4000

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & University Medical Centre, 3584CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
December 2009

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.

Nat Genet 2009 Apr 15;41(4):396-8. Epub 2009 Mar 15.

Hubrecht Institute-KNAW & University Medical Centre, Utrecht, The Netherlands.

View Article and Find Full Text PDF
April 2009

Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton.

Development 2008 Nov 16;135(22):3765-74. Epub 2008 Oct 16.

Hubrecht Institute, University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
November 2008

Zebrafish VEGF receptors: a guideline to nomenclature.

PLoS Genet 2008 May 30;4(5):e1000064. Epub 2008 May 30.

Hubrecht Laboratory (NIOB-KNAW NIOB), Utrecht, The Netherlands.

View Article and Find Full Text PDF
May 2008

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish.

Hum Mol Genet 2008 Aug 10;17(16):2424-32. Epub 2008 May 10.

Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
August 2008

LRRC50, a conserved ciliary protein implicated in polycystic kidney disease.

J Am Soc Nephrol 2008 Jun 2;19(6):1128-38. Epub 2008 Apr 2.

Hubrecht Institute, Developmental Biology and Stem Cell Research, University Medical Center Utrecht, Utrecht, Netherlands.

View Article and Find Full Text PDF
June 2008

Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.

Circ Res 2008 Jan 21;102(1):12-5. Epub 2007 Nov 21.

Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

View Article and Find Full Text PDF
January 2008

Early endocardial morphogenesis requires Scl/Tal1.

PLoS Genet 2007 Aug 9;3(8):e140. Epub 2007 Jul 9.

Hubrecht Institute, Utrecht, The Netherlands.

View Article and Find Full Text PDF
August 2007

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.

Proc Natl Acad Sci U S A 2005 Jan 3;102(2):407-12. Epub 2005 Jan 3.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
January 2005

Getting connected.

Dev Cell 2003 Nov;5(5):669-70

Exelixis Deutschland GmbH, Spemannstr. 35, D-72076 Tübingen, Germany.

View Article and Find Full Text PDF
November 2003